Chronic myeloid leukemia: a model disease of the past, present and future

Chronic myeloid leukemia (CML) has been a “model disease” with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achievi
Chronic myeloid leukemia (CML) has been a “model disease” with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after targeted therapies, we describe here the journey of CML, focusing on molecular pathways relating to signaling, metabolism and the bone marrow microenvironment. We highlight current strategies for combination therapies aimed at eradicating the CML stem cell; hopefully the final destination of this long voyage.
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Metadaten
Author:Valentina R. Minciacchi, Rahul Kumar, Daniela Sandra Krause
URN:urn:nbn:de:hebis:30:3-577036
DOI:http://dx.doi.org/10.3390/cells10010117
ISSN:2073-4409
Parent Title (English):Cells
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2021/01/10
Date of first Publication:2021/01/10
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/01/12
Tag:bone marrow microenvironment; chronic myeloid leukemia; combination therapies; history; metabolism; targeted therapy
Volume:10
Issue:Article 117
Pagenumber:23
HeBIS PPN:475950976
Institutes:Medizin
Georg-Speyer-Haus
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0

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