Selectivity of the ubiquitin-binding modules
- Ubiquitin-binding modules are constituents of cellular proteins that mediate the effects of ubiquitylation by making transient, non-covalent interactions with ubiquitin molecules. While some ubiquitin-binding modules bind single ubiquitin moieties, others are selective for specific ubiquitin chains of different linkage types and lengths. In recent years, functions of ubiquitin chains that are polymerized through their Lys or N-terminal Met (i.e. linear chains) residues have been linked to a variety of cellular processes. Selectivity of ubiquitin-binding modules for different ubiquitin chain types appears as a key to the distinct regulatory consequences during protein quality control pathways, receptor endocytosis, gene transcription, signaling via the NF-κB pathway, and autophagy.
| Author: | Simin Rahighi, Ivan ĐikićORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-766974 |
| DOI: | https://doi.org/10.1016/j.febslet.2012.04.053 |
| ISSN: | 0014-5793 |
| Parent Title (English): | FEBS Letters |
| Publisher: | Elsevier |
| Place of publication: | Amsterdam |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2012/05/05 |
| Date of first Publication: | 2012/05/05 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2023/10/16 |
| Tag: | Ubiquitin signaling; Ubiquitin-binding module; Ubiquitylation |
| Volume: | 586 |
| Issue: | 17 |
| Page Number: | 6 |
| First Page: | 2705 |
| Last Page: | 2710 |
| HeBIS-PPN: | 516390155 |
| Institutes: | Medizin |
| Fachübergreifende Einrichtungen / Buchmann Institut für Molekulare Lebenswissenschaften (BMLS) | |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit | |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International |
