Refine
Year of publication
- 2018 (60) (remove)
Document Type
- Conference Proceeding (60) (remove)
Has Fulltext
- yes (60)
Is part of the Bibliography
- no (60) (remove)
Keywords
- Bahasa Indonesia (1)
- Balibar, Étienne / Es gibt keinen Staat in Europa (1)
- Coworking (1)
- Deklination (1)
- Derrida, Jacques / Das andere Kap (1)
- Deutsche Gebärdensprache (1)
- Digital Literacy (1)
- Doku Mittelstufe (1)
- Doku Oberstufe (1)
- Europa (1)
Institute
- Physik (23)
- Gesellschaftswissenschaften (10)
- Medizin (3)
- Universitätsbibliothek (3)
- Wirtschaftswissenschaften (3)
- Mathematik (2)
- Biowissenschaften (1)
- Center for Scientific Computing (CSC) (1)
- Extern (1)
- Frankfurt Institute for Advanced Studies (FIAS) (1)
Ḥoveret taḳtsirim : kenes ha-Ḥevrah ha-Geologit 2018 : Yiśraʿel-Ḳafrisin 25.03.2018 - 29.03.2018
(2018)
This lecture is about the history of the "Naier idisher teater" in Riga, the construction process of the building since 1913, the people and organisations that were involved, the theatre opening, playing schedules, companies, cooperation and actors as well as about the intercultural, economic and social environments and activities around the theatre until it was closed forcibly by the German troupes in 1941.
Von der Gruppenarbeit zum Community Building - der "Digital Creative Space" der SUB Göttingen
(2018)
Die Förderung der digitalen Kompetenzen von Studierenden und die Entwicklung adaptiver, interaktiver und multimedialer (digitaler), diversitätsorientierter Lernumgebungen sind Schwerpunkte der Digitalen Hochschulbildung. Dies hat auch erheblichen Einfluss auf die konzeptionelle Planung und Gestaltung von physischen Lernraumangeboten wissenschaftlicher Bibliotheken. Ein deutliches Desiderat ist dabei die Bereitstellung niedrigschwelliger, kollaborativ nutzbarer Lernumgebungen, in denen Studierende (und auch Lehrende) gemeinsam digitale Kenntnisse erwerben, explorativ erproben und stärken können, um den Anforderungen sowohl im Studium als auch im späteren Berufsleben gerecht werden zu können. Gemeinsam mit dem Service für Digitales Lernen und Lehren und der Abteilung IT der Universität Göttingen hat die Benutzungsabteilung der SUB Göttingen ein Raumkonzept für ein "Digital Creative Space" erarbeitet, das in gemeinsamen Workshops mit Studierenden und Lehrenden des Göttinger Campus weiterentwickelt wurde. Sein Start in der hochfrequentierten Zentralbibliothek ist für 2018 geplant. Das Ergebnis dieses Prozesses ist eine Bündelung interdisziplinärer Labs verschiedenster technischer Ausstattung und interdisziplinärer Gruppenarbeit - das "Digital Creative Space". Ziel ist, den Nutzenden das eigenständige Entwickeln digitaler Kompetenzen zu ermöglichen und kreative Prozesse zu unterstützen - und dabei "communities of practice" zu initiieren oder zu befördern. Das Konzept, seine Entwicklungs- und weiteren Umsetzungsschritte einschließlich der Darstellung des partizipativen Prozesses sind Inhalt dieses Vortrags.
I describe an analysis of valence-changing verbal morphology implemented as a library extending the LinGO Grammar Matrix customization system. This analysis is based on decomposition of these operations into rule components, which in turn are expressed as lexical rule supertypes that implement specific, isolatable constraints. I also show how common variations of these constraints can be abstracted and parameterized by their axes of variation. I then demonstrate how these constraints can be recomposed in various combinations to provide broad coverage of the typological variation of valence change found in the world's languages. I evaluate the coverage of this library on five held-out world languages that exhibit these phenomena, achieving 79% coverage and 2% overgeneration.
We report on the status of ongoing investigations aiming at locating the deconfinement critical point with standard Wilson fermions and Nf = 2 flavors towards the continuum limit (standard Columbia plot); locating the tricritical masses at imaginary chemical potential with unimproved staggered fermions at Nf = 2 (extended Columbia plot); identifying the order of the chiral phase transition at μ = 0 for Nf = 2 via extrapolation from non integer Nf (alternative Columbia plot).
We study the properties of the survival probability of an unstable quantum state described by a Lee Hamiltonian. This theoretical approach resembles closely Quantum Field Theory (QFT): one can introduce in a rather simple framework the concept of propagator and Feynman rules, Within this context, we re-derive (in a detailed and didactical way) the well-known result according to which the amplitude of the survival probability is the Fourier transform of the energy distribution (or spectral function) of the unstable state (in turn, the energy distribution is proportional to the imaginary part of the propagator of the unstable state). Typically, the survival probability amplitude is the starting point of many studies of non-exponential decays. This work represents a further step toward the evaluation of the survival probability amplitude in genuine relativistic QFT. However, although many similarities exist, QFT presents some differences w.r.t. the Lee Hamiltonian which should be studied in the future.
Introduction: Ferroptosis has recently been identified as a form of programmed cell death caused by an accumulation of lipid reactive oxygen species (ROS). However, little is yet known about the role in hepatocellular carcinoma (HCC) and its signalling mechanism as well the modulation of ROS.
Material and methods: Human HCC cell lines were treated with different concentrations of ROS modulators (Auranofin, Erastin, BSO). Cell death was determined by analysis of PI-stained nuclei using flow cytometry. ROS production and lipid peroxidation were analysed at early time points before cell death starts. For mechanistic studies we performed Western Blot and a Proteome array. Different inhibitors of cell death target proteins, ROS-scavengers as well as lipoxygenase inhibitors were used. To investigate the functional relevance of NAPDH oxidases (NOX) 1 and 4 for ROS modulation and ferroptosis we genetically silenced its genes using three distinct siRNAs and we used the NOX1/4-inhibitor GKT137831.
Results and discussions: Compared to the single treatment, Auranofin/BSO-cotreatment as well as Erastin/BSO-cotreatment acted in concert to trigger cell death and to reduce cell viability of HCC cells in a dose- and time-dependent manner. Furthermore, both cotreatments induce ROS production, lipid peroxidation and ferroptotic cell death, which could be inhibited by the use of Ferrostatin-1 (inhibitor of lipid peroxidation) and Liproxstatin-1 (specific inhibitor of ferroptosis). The broad-range caspase inhibitor zVAD.fmk failed to rescue cells from Auranofin/BSO- or Erastin/BSO-cotreatment induced cell death. No activation of caspases-3 could be seen in the proteome profiler apoptosis assay. Importantly, the selective lipoxygenase (LOX) inhibitor Baicalain and the pan-LOX inhibitor NDGA protect HCC cells from Auranofin/BSO- and Erastin/BSO-cotreatment stimulated lipid peroxidation, ROS generation and cell death, indication that the induction of ferroptosis may bypass apoptosis resistance of HCC cells. Mechanistic studies showed that Auranofin/BSO-cotreatment decreased TrxR-activity, led to Nrf2 accumulation and promoted the activation of HO-1. In contrast, NOX 1 and 4 were involved in Erastin/BSO-mediated cell death and the use of the NOX1/4-inhibitor GKT137831 rescued HCC cells from the Erastin/BSO-induced cell death.
Conclusion: By providing new insights into the molecular regulation of ROS and ferroptosis, our study contributes to the development of novel treatment strategies to reactivate programmed cell death in HCC cells.
We examine the fine structure of clausal right-node raising constructions in Japanese, and argue that there are sentences in which a tensed verb is right-node-raised out of coordinated tensed clauses as well as sentences in which a verb stem is right-node-raised out of coordinated tenseless phrases. In the latter case, the tense morpheme has to be assumed to take a tenseless complement clause, and we note that the existence of such a structure contradicts the so-called lexicalist hypothesis, according to which a verb stem and the tense morpheme immediately following it always form a morphosyntactic constituent.
We study tetraquark resonances with lattice QCD potentials computed for two static quarks and two dynamical quarks, the Born-Oppenheimer approximation and the emergent wave method of scattering theory. As a proof of concept we focus on systems with isospin I = 0, but consider different relative angular momenta l of the heavy b quarks. We compute the phase shifts and search for S and T matrix poles in the second Riemann sheet. We predict a new tetraquark resonance for l = 1, decaying into two B mesons, with quantum numbers I(JP) = 0(1−), mass MeV and decay width MeV.
n this contribution we lay down a lattice setup that allows for the nonperturbative study of a field theoretical model where a SU(2) fermion doublet, subjected to non-Abelian gauge interactions, is also coupled to a complex scalar field doublet via a Yukawa and an “irrelevant” Wilson-like term. Using naive fermions in quenched approximation and based on the renormalizedWard identities induced by purely fermionic chiral transformations, lattice observables are discussed that enable: a) in theWigner phase, the determinations of the critical Yukawa coupling value where the purely fermionic chiral transformation become a symmetry up to lattice artifacts; b) in the Nambu-Goldstone phase of the resulting critical theory, a stringent test of the actual generation of a fermion mass term of non-perturbative origin. A soft twisted fermion mass term is introduced to circumvent the problem of exceptional configurations, and observables are then calculated in the limit of vanishing twisted mass.