Refine
Year of publication
- 2017 (380) (remove)
Document Type
- Article (329)
- Doctoral Thesis (31)
- Part of Periodical (11)
- Book (3)
- Contribution to a Periodical (3)
- Preprint (2)
- Report (1)
Language
- English (323)
- German (53)
- Multiple languages (3)
- Spanish (1)
Has Fulltext
- yes (380)
Is part of the Bibliography
- no (380) (remove)
Keywords
- glioblastoma (8)
- Inflammation (4)
- Neuroscience (4)
- OSCE (4)
- multiple sclerosis (4)
- Apoptosis (3)
- Denosumab (3)
- Kinematic analysis (3)
- Mechanisms of disease (3)
- Mitochondria (3)
- Molecular biology (3)
- Musculoskeletal disorder (3)
- OSPE (3)
- Parkinson’s disease (3)
- Stroke (3)
- bevacizumab (3)
- inflammation (3)
- p47phox (3)
- Apheresis (2)
- Biochemistry (2)
- Biomarker (2)
- Biomarkers (2)
- Breast cancer (2)
- COPD (2)
- CXCR4 (2)
- Cancer models (2)
- Cell biology (2)
- Chemotherapy (2)
- Clinical trial (2)
- Cuela (2)
- Dentist (2)
- Depression (2)
- Drug therapy (2)
- Forensic entomology (2)
- Gender (2)
- General practice (2)
- Genetics (2)
- Head and neck cancer (2)
- Human behaviour (2)
- Leukemias (2)
- Liver transplantation (2)
- MCI (2)
- NADPH oxidase (2)
- NK cells (2)
- Neuroinflammation (2)
- NoxO1 (2)
- Oncology (2)
- Osteoporosis (2)
- Prediction (2)
- Prädiktive Validität (2)
- Reliabilität (2)
- Research article (2)
- Respiratory chain (2)
- Sarcoma (2)
- Sex differences (2)
- Surgeons (2)
- Tissue engineering (2)
- Trauma (2)
- adjuvant therapy (2)
- adjuvante Therapie (2)
- anti-angiogenic therapy (2)
- antisocial behavior (2)
- apoptosis (2)
- autophagy (2)
- bibliometry (2)
- bioenergetics (2)
- clinical benefit (2)
- conduct disorder (2)
- data science (2)
- early breast cancer (2)
- elderly (2)
- epidemiology (2)
- epigenetics (2)
- frühes Mammakarzinom (2)
- glioma (2)
- information theory (2)
- klinischer Nutzen (2)
- miRNAs (2)
- mitochondria (2)
- natural killer cells (2)
- perception (2)
- phagocytosis (2)
- registry (2)
- schizophrenia (2)
- stability (2)
- (surface) partial differential equations (1)
- 3D spatio-temporal resolved mathematical models (1)
- A-PRF+ (1)
- ADHD (1)
- ALL (1)
- AMP-activated kinase (1)
- AMPK (1)
- ASA404 (1)
- AZD7762 (1)
- Academic health centres (1)
- Academic medicine (1)
- Academics (1)
- Accessibility (1)
- Activity control (1)
- Acute heart failure (1)
- Acute inflammation (1)
- Acute lymphoblastic leukemia (1)
- Acute myeloid leukaemia (1)
- Adherence (1)
- Adipose tissue (1)
- Adipose tissue-derived mesenchymal stem cells (1)
- Adult (1)
- Adult neurogenesis (1)
- Africa (1)
- Alcoholic liver disease (1)
- Allergy (1)
- Alternative oxidase (1)
- Alzheimer’s dementia (1)
- Amygdala (1)
- Amyloid-beta 42 (1)
- Andersen-Tawil syndrome (1)
- Angiogenesis (1)
- Angiogenèse (1)
- Anticoagulation (1)
- Antidepressant (1)
- Antikörper (1)
- Antiviral response (1)
- Area deprivation (1)
- Arteriogenesis (1)
- Artesunate (1)
- Aspergillus (1)
- Aspergillus fumigatus (1)
- Assessment (1)
- Asthma and allergic disorders (1)
- Atención centrada en el paciente (1)
- Atherosclerosis (1)
- Atrial fibrillation (1)
- Attack (1)
- Attention (1)
- Attitude (1)
- Autism spectrum disorders (1)
- Autoimmune encephalomyelitis (1)
- Autophagy (1)
- Azacitidine (1)
- B cell receptor (1)
- BCL6 (1)
- BDNF (1)
- BMC (1)
- BRAF (1)
- BRAF V600E (1)
- BRD4 (1)
- BRD4-NUT (1)
- BV6 (1)
- BadA, (1)
- Batten disease (1)
- Bias (1)
- Big Data (1)
- Biliary physiology (1)
- Bioinformatics (1)
- Biopsy (1)
- Bipolar disorder (1)
- Bladder cancer (1)
- Blood (1)
- Blow fly (1)
- Blowflies (1)
- Bone and joint mechanics (1)
- Bone marrow-derived mesenchymal stem cells (1)
- Bone metastasis (1)
- Bone tissue engineering (1)
- Brachial artery (1)
- Breast neoplasms (1)
- Breast reconstruction (1)
- Bronchodilator agents (1)
- C57BL/6J mice (1)
- C57BL/6N mice (1)
- CA (1)
- CAT (1)
- CD16 (1)
- CD56 (1)
- CD8 (1)
- CDK4/CDK6 (1)
- CGD (1)
- CPE (1)
- CRISPR/Cas9 (1)
- CT (1)
- CT-guidance (1)
- CUELA (1)
- CUP (1)
- Calliphoridae (1)
- Callous-unemotional traits (1)
- Cancer chemotherapy (1)
- Cancer detection and diagnosis (1)
- Cancer epigenetics (1)
- Cancer genetics (1)
- Cancer of unknown primary (1)
- Cancer treatment (1)
- Candida (1)
- Cardiac surgery (1)
- Cardiogenic shock (1)
- Cardiopulmonary bypass (1)
- Cardiovascular magnetic resonance (1)
- Career promotion (1)
- Case management (1)
- Catheter ablation (1)
- Cell adhesion (1)
- Cell metabolism (1)
- Cell processing (1)
- Cell signalling (1)
- Cell-assisted lipotransfer (1)
- Cellular imaging (1)
- Cellular inflammatory response (1)
- Centrifugation (1)
- Cerebrovascular (1)
- Cervical (1)
- Checkpoint kinase (1)
- Chemoradiotherapy (1)
- Children (1)
- Chondrocyte (1)
- Chondrocyte signalling (1)
- Chromosomal deletion (1)
- Chronic diseases (1)
- Cinryze® (1)
- Cirrhosis (1)
- Citation (1)
- Classification (1)
- Cleft palate (1)
- Clinical genetics (1)
- Clinical study (1)
- Clinical trials (1)
- Clinical variation (1)
- Cln3 (1)
- Cochlear Implant (1)
- Cognitive neuroscience (1)
- Cohort studies (1)
- Cold pain (1)
- Colonisation (1)
- Complexin 1 (1)
- Compliance (1)
- Conditional gene trap (1)
- Connective tissue (1)
- Consciousness (1)
- Conservative (1)
- Constrained posture (1)
- Contact precautions (1)
- Coronary heart disease (1)
- Critical care and emergency medicine (1)
- Crosscorrelation (1)
- Cryptococcus (1)
- CyberKnife (1)
- Cytokines (1)
- DILI (1)
- DMXAA (1)
- DSS /AOM (1)
- Data science (1)
- Death rates (1)
- Decision (1)
- Denervation (1)
- Density equalizing mapping (1)
- Dentistry (1)
- Deutschland (1)
- Developmental biology (1)
- Diabetes mellitus (1)
- Diagnostic markers (1)
- Dialog-Konsens- Methoden (1)
- Differential expression (1)
- Differentiation (1)
- Difficult Airway Management (1)
- Digenic model (1)
- Diphosphonates (1)
- Direct current electrical stimulation (1)
- Disintegration (1)
- Dose optimization (1)
- Drug resistance/synergy (1)
- Drug screens (1)
- E-Learning (1)
- E-cadherin (1)
- E-cadhérine (1)
- ECLS (1)
- ECMO (1)
- EDTA-plasma (1)
- EEG-fMRI (1)
- EGF (1)
- ERSCongress (1)
- ESBL (1)
- Economic benchmarks (1)
- Edinger, Ludwig (1)
- Education (1)
- Efficacy (1)
- Elderly (1)
- Embolization (1)
- Endoplasmic reticulum (1)
- Endosomes (1)
- Endothelial nitric oxide synthase (1)
- Endotoxins (1)
- Enfermedades crónicas (1)
- Enteral nutrition (1)
- Epidemiology (1)
- Epilepsy (1)
- Equity (1)
- Europe (1)
- European Union (1)
- Euthanasie <Nationalsozialismus> (1)
- Evaluation (1)
- Evaluation in microsurgery (1)
- Everolimus (1)
- Evidence-based dentistry (1)
- Evidence-based medicine (1)
- Evolutionary biology (1)
- Exacerbations (1)
- Experimental autoimmune encephalomyelitis (1)
- Experimental models of disease (1)
- Extension study (1)
- Extracellular vesicles (1)
- Extracorporeal circulation (1)
- Extreme hypo-fractionation (1)
- FEV1 (1)
- FREEDOM (1)
- Falciparum (1)
- Family Physician (1)
- Fascia (1)
- Feasibility (1)
- Feline bartonellosis (1)
- Finite Volumes (1)
- Flexibility (1)
- Flow cytometry (1)
- Fluorescence imaging (1)
- Foam rolling (1)
- Frailty (1)
- Frankfurt microsurgery course (1)
- Functional characterization (1)
- Fusion Proteins, BCR-ABL (1)
- G-CSF (1)
- G9a/EHMT2/KMT1C (1)
- GRX1-roGFP2 (1)
- Gaba (1)
- Gadobutrol (1)
- Gemcitabine (1)
- Gender equality (1)
- Gene ontology (1)
- Gene set analysis (1)
- General practitioners (1)
- Genetic causes of cancer (1)
- Genetic testing (1)
- Genome-wide association studies (1)
- Germany (1)
- Geschichte 1930-1940 (1)
- Geschichte 1939-1940 (1)
- Gesetzentwurf (1)
- Global health (1)
- Glomerular diseases (1)
- Glucose metabolism (1)
- Goldstein, Kurt (1)
- Growth factor (1)
- Growth factor signalling (1)
- Guidelines (1)
- HDR-Brachytherapie (1)
- HIF (1)
- HIV-1 (1)
- HLA class I loss (1)
- Health services research (1)
- Healthcare worker (1)
- Heart failure (1)
- Heat pain (1)
- Hematology (1)
- Hepatitis C virus (1)
- Hepatocytes (1)
- Her2-neu (1)
- Hereditary angioedema (1)
- Hig1 (1)
- High-income countries (1)
- High-risk cardiac surgery (1)
- High-throughput screening (1)
- Hippocampal volume (1)
- Hippocampus (1)
- Hispanic people (1)
- Histology (1)
- Hochfrequenz-Katheterablation (1)
- Homeostasis (1)
- Hsp70 (1)
- Human experimental pain models (1)
- Human genetics (1)
- Hypertension (1)
- Hypoxia (1)
- I-PRF (1)
- IHC (1)
- IL -17 (1)
- IL -23 (1)
- IL 23p19 knockout mouse (1)
- IgG4-related disease (1)
- Immune receptor signaling (1)
- Immunsuppression (1)
- In-Hospital Emergencies (1)
- Indeterminate biliary stricture (1)
- Index (1)
- Indonesia (1)
- Infection control (1)
- Infectious disease (1)
- Insula (1)
- Insulin secretion (1)
- Integration (1)
- Integrins (1)
- Interview (1)
- Iridium-192 (1)
- KCNJ2 mutation (1)
- Kaiserschnitt (1)
- Knochenevaluation (1)
- Komplikation (1)
- Konversion (1)
- LCMV (1)
- LTB4 (1)
- Laryngeal Tube (1)
- Lateral recess stenosis (1)
- Laufökonomie (1)
- Le carcinome épidermoïde oral (1)
- Leadership (1)
- Learning algorithms (1)
- Learning and memory (1)
- Leber congenital amaurosis (1)
- Lebertransplantation (1)
- Les macrophages associés aux tumeurs (1)
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive (1)
- Leukocytes (1)
- Leukotriene (1)
- Linear regression analysis (1)
- Lipid signalling (1)
- Liver diseases (1)
- Localized prostate cancer (1)
- Low back pain (1)
- Lpar2 (1)
- Lumbar spinal canal stenosis (1)
- Lumbar spine (1)
- Luminex (1)
- Lung failure (1)
- Lymph node (1)
- Lysophosphatidic acids (1)
- MEG (1)
- MICA (1)
- MRSA (1)
- MTT assay (1)
- Machine-learning (1)
- Macroautophagy (1)
- Macrophages (1)
- Magnetic resonance imaging (1)
- Malaria (1)
- Manatee invariant (1)
- Mandible (1)
- Mandibula (1)
- Massive Online Open Course (1)
- Material (1)
- Mathematical model (1)
- Mathematical models (1)
- Measurement equipment (1)
- Median nerve (1)
- Medical management (1)
- Medical student (1)
- Medication Appropriateness Index (1)
- Medicine (1)
- Medizindidaktik (1)
- Medizinische Lehre (1)
- Mesenchymal stem cells (1)
- Mice (1)
- Micrognathia (1)
- Microsurgery (1)
- Microwave ablation (1)
- Midkine (1)
- Mild cognitive impairment (1)
- Mitochondrial disease (1)
- Mitochondrial dysfunction (1)
- Mitochondrial shuttles (1)
- Mitosis (1)
- Mobilization (1)
- Molecular medicine (1)
- Molecularly targeted therapy (1)
- Monotherapie (1)
- Morphogenesis (1)
- Motivating factor (1)
- Mouse models (1)
- Multidrug resistance (1)
- Multidrug-resistant bacteria (1)
- Multimorbidity (1)
- Multimorbilidad (1)
- Multinucleated giant cells (1)
- Multiomics (1)
- Multiple sclerosis (1)
- Muscle atrophy (1)
- Music (1)
- Music chair concepts (1)
- Musician (1)
- Myelodysplastic syndrome (1)
- N-cadherin (1)
- N-cadhérine (1)
- NF-ĸB (1)
- NF-κB pathway (1)
- NHEJ (1)
- NK receptors (1)
- NKG2D (1)
- NK cells (1)
- National catalogue of competence-based learning objectives in dentistry (1)
- Neonatal outcome (1)
- Nepal (1)
- Network analysis (1)
- Neural networks (1)
- Neuroblastoma (1)
- Neurochemistry (1)
- Neurodegenerative diseases (1)
- Neurologe (1)
- Neurologisches Institut <Frankfurt am Main> (1)
- Neuronal homeostasis (1)
- Neuronal networks (1)
- Neuronal nitric oxide synthase (1)
- Neurovascular lesion (1)
- Nierentransplantation (1)
- Nociception (1)
- Non-REM sleep (1)
- Non-interventional study (1)
- Non-operative (1)
- Novel treatment target (1)
- Nox (1)
- Nox1 (1)
- NoxA1 (1)
- Nrf2 (1)
- Nucleolus (1)
- Nurses (1)
- Nutrition risk stratification (1)
- OSF-2 KI-S2 (1)
- Observational (1)
- Obstetric care (1)
- Oldest-old (1)
- Omics (1)
- Onkomodulation (1)
- Oral anticoagulation (1)
- Organ dysfunctions (1)
- Organ preservation (1)
- Orthodontist (1)
- Oswestry Disability Score (1)
- Outcome assessment (1)
- Outpatients (1)
- Ovarian cancer (1)
- Ovarian carcinoma (1)
- Oxygen-derived free radicals (1)
- PARK4 (1)
- PC12 neuronal differentiation (1)
- PCR (1)
- PEM-technology (1)
- PTEN p53 Survivin (1)
- PXA (1)
- Pain (1)
- Pain scale MWA (1)
- Pancreatic islet (1)
- Pathologic changes (1)
- Pathology Section (1)
- Patient Blood Management (PBM) (1)
- Patient education (1)
- Patient knowledge (1)
- Patient-centred care (1)
- Pattern recognition receptors (1)
- Pediatric (1)
- Pediatric fracture (1)
- Pediatric neuroimaging (1)
- Pediatric patients (1)
- Percutaneous pinning (1)
- Peripheral vascular disease (1)
- Persistence (1)
- Petri net (1)
- Pharmaco-nutrition (1)
- Phase I trials (1)
- Philadelphia Chromosome (1)
- Phospho-tau (1)
- Phosphorylation (1)
- Physicians (1)
- Physiology (1)
- Pierre Robin sequence (1)
- Plasmacytoid dendritic cell (1)
- Plasmodium (1)
- Platelet-rich fibrin (1)
- Platelets (1)
- Plerixafor (1)
- Point-of-Care Testing (POCT) (1)
- Post surgery pain (1)
- Post-translational modifications (1)
- Postoperative nutritional management (1)
- Postoperative radiochemotherapy (1)
- Posttraumatic stress disorder (1)
- Posttraumatische Belastungsstörung (1)
- Posture analysis (1)
- Potassium channel Kir2.1 (1)
- Practical skills (1)
- Practice-based research network (1)
- Pressure pain (1)
- Prevention (1)
- Primary Care Health Centre (1)
- Primary care (1)
- Primary sclerosing cholangitis (1)
- Prognosis (1)
- Prognostic (1)
- Prognostic markers (1)
- Projekte Seltene Erkrankungen (1)
- Prostatakarzinom (1)
- Protein Kinase Inhibitors (1)
- Psychiatric disorders (1)
- Psychology (1)
- Publication (1)
- Pulmonary disease, chronic obstructive (1)
- Pulmonary veins (1)
- Pulsed SILAC (1)
- Quality of Teaching and Learning (1)
- Quality of life (1)
- Qualitätssicherung der Lehre (1)
- Quantitative sensory testing (1)
- Quantitative trait (1)
- Quinine (1)
- R programming language (1)
- RBC-depletion (1)
- RD cells (1)
- REM sleep (1)
- RH30 cells (1)
- RNA Biology (1)
- RNA binding proteins (1)
- RNA isolation (1)
- RNA, long noncoding (1)
- ROS (1)
- RPE65 (1)
- RUCAM (1)
- Radiochemotherapy (1)
- Radiology and imaging (1)
- Radiotherapy (1)
- Rahmenbedingungen der Lehre (1)
- Random forest (1)
- Rapid eye movement sleep behavior disorder (1)
- Rare Diseases/ Orphan Diseases (1)
- Rcf1 (1)
- Reactive oxygen species (1)
- Rectal cancer (1)
- Redox-sensitive GFP (1)
- Registries (1)
- Reperfusion (1)
- Replication study (1)
- Respiration (1)
- Respiratory Syncytial Virus (1)
- Restricted posture (1)
- Reticulon (1)
- Reverse transcription polymerase chain reaction (1)
- Robotic Radiosurgery (1)
- Roussel Uclaf Causality Assessment Method (1)
- Rtn3 (1)
- Running Economy (1)
- SCCHN (1)
- SDF-1 (1)
- SIADH (1)
- SIRT1 (1)
- SNP (1)
- STING (1)
- SUN1 (1)
- SUN2 (1)
- Safety (1)
- Salmonella choleraesuis (1)
- Schilddrüsenfunktion (1)
- Scientifi c competence (1)
- Scientometry (1)
- Secondary injury cascades (1)
- Sectio (1)
- Selection bias (1)
- Selective autophagy (1)
- Self-myofascial release (1)
- Seltene Erkrankungen (1)
- Seltene Erkrankungen in der Lehre (1)
- Severe malaria (1)
- Sexual Dysfunctions (1)
- Sexual child abuse (1)
- Sexual violence (1)
- Sexuelle Dysfunktionen (1)
- Sexuelle Gewalt (1)
- Sexueller Kindesmissbrauch (1)
- Signaling pathway (1)
- Simulation and modeling (1)
- Single-treatment (1)
- Sirolimus (1)
- Skills (1)
- Socio-economic analysis (1)
- Spanish National Health System (1)
- Species identification (1)
- Speciesidentification (1)
- Speech (1)
- Sphingolipids (1)
- Spinal cord (1)
- Spleen (1)
- Spread of Excitation (1)
- Staatsexamen (1)
- Statistical data (1)
- Status quo Seltene Erkrankungen (1)
- Stem cell (1)
- Stem-cell therapies (1)
- Stereotactic body radiation therapy (1)
- Stimulation experiments (1)
- Stimulus-secretion coupling (1)
- Studiendauer (1)
- Subgroup identification (1)
- Subjekt (1)
- Superoxide (1)
- Supplemental parenteral nutrition (1)
- Supraglottic Airway Devices (1)
- Surgery (1)
- Surgical and invasive medical procedures (1)
- Sustainable Development (1)
- Switzerland (1)
- Symptoms (1)
- Synaptic dysfunction (1)
- Systematic reviews (1)
- Systemic inflammatory response (1)
- T cell (1)
- T-cell homing (1)
- T-cell receptor (1)
- TGF-β (1)
- TLR (1)
- Tailored medicine (1)
- Tas2r126 (1)
- Tas2r135 (1)
- Tas2r143 (1)
- Tau (1)
- Tau acetylation (1)
- Teaching and Learning conditions (1)
- Technicians (1)
- Thailand (1)
- Three-dimensional echocardiography (1)
- Time optimization (1)
- Time series (1)
- Tissue Engineering (1)
- Tissue stiffness (1)
- Toll-like receptors (1)
- Torque (1)
- Training (1)
- Transesophageal echocardiography (1)
- Transfusionsmedizin (1)
- Transient (1)
- Transient ischemic attack (1)
- Transition invariant (1)
- Transmission (1)
- Transplantation (1)
- Treatment (1)
- Twist (1)
- Type 2 Diabetes mellitus (1)
- UVA (1)
- Ubiquitin kinase PINK1 (1)
- Ubiquitination (1)
- Ultrasound (1)
- Underfeeding (1)
- Urologie (1)
- Urothelial carcinoma (1)
- Urothelkarzinom (1)
- VIS (1)
- VRE (1)
- Vascular endothelial growth factor A (1)
- Vascular endothelial growth factor receptor 2 (1)
- Vascularization (1)
- Vector-borne infections (1)
- Vertigo (1)
- VirB (1)
- Volume reduction of thyroid nodules (1)
- Voxel-based morphometry (1)
- Wait and see (1)
- Wakefulness (1)
- Wing morphometry (1)
- Women in medicine (1)
- Women in science (1)
- YK-4-279 (1)
- Zika fever (1)
- Zika virus (1)
- Zoonosis (1)
- ablation (1)
- academic (1)
- acceptable change limit (1)
- acetaminophen (1)
- adaptation plan (1)
- adiposity (1)
- adjustment disorder (1)
- adolescence (1)
- adolescents’ health (1)
- adult neurogenesis (1)
- age-related macular degeneration (1)
- alcohol (1)
- allogeneic transplantation (1)
- anal cancer (1)
- anesthesiology (1)
- angiogenesis (1)
- anti-epileptic drug (1)
- antifungal host response (1)
- antioxidants (1)
- anxiety (1)
- architecture (1)
- arm (1)
- assay development (1)
- atrial fibrillation (1)
- attention (1)
- authorship (1)
- autoimmune diabetes (1)
- autoimmune encephalomyelitis (1)
- autophagic cell death (1)
- bile duct stenosis (1)
- biokompatibilni materijali (1)
- biologicals (1)
- biomarkers (1)
- bleomycin (1)
- blood (1)
- brain imaging (1)
- brain metastases (1)
- brain structure (1)
- brain tumor (1)
- brain-derived neurotrophic factor (1)
- breast cancer (1)
- bulimia nervosa (1)
- cGMP (1)
- calbindin (1)
- caloric restriction (1)
- cancer (1)
- cancer stem cells (1)
- cancer therapy (1)
- cannabinoid receptor type 1 (1)
- canonical (1)
- cardiolipin (1)
- catheter ablation (1)
- cell death (1)
- cell fusion (1)
- cell signaling (1)
- cell therapy (1)
- ceramide (1)
- cerebral infarct (1)
- chemoattractant (1)
- chemoconvulsant (1)
- chemoembolization (1)
- chemoprevention (1)
- chemosensory cells (1)
- chemotherapy (1)
- children (1)
- chimeric antigen receptor (1)
- chronic colitis (1)
- chronic granulomatous disease (1)
- chronic kidney disease (CKD) (1)
- chronic thromboembolic pulmonary hypertension (1)
- chronotype (1)
- circadian (1)
- citation (1)
- climate change (1)
- clinical competency (1)
- clinical tool (1)
- cluster of differentiation 4 (CD4) (1)
- cognition (1)
- cognitive control (1)
- cognitively stimulating leisure activities (1)
- cold induced pain (1)
- colon cancer (1)
- colonization (1)
- colorectal cancer (1)
- community violence exposure (1)
- complexity theory (1)
- computational modeling (1)
- computational virology (1)
- computed tomography (1)
- concentric (1)
- conditioning (1)
- consensus (1)
- crista junction (1)
- cristae (1)
- critical care unit (1)
- critical ill patients (1)
- criticality (1)
- cryoballoon (1)
- curcumin (1)
- cyclophilin A (1)
- cytochrome c oxidase (complex IV) (1)
- cytokine-induced killer cells (1)
- dabrafenib (1)
- daily activity protocols (1)
- damage-associated molecular pattern (1)
- data quality check (1)
- deletion 5q (1)
- density equalizing mapping (1)
- dentate gyrus (1)
- depression (1)
- diabetes mellitus (1)
- diagnostic biomarkers (1)
- dialogue consensus methods (1)
- dialysis (1)
- diarrhoeal disease (1)
- diastolic function (1)
- differentiation (1)
- dihydroceramide (1)
- direct antiviral (1)
- direct-acting antivirals (1)
- directed forgetting (1)
- disease-modifying antirheumatic drugs (1)
- disease-modifying therapy (1)
- diurnal (1)
- doublecortin (1)
- drug induced liver injury (1)
- dual bronchodilators (1)
- early infection (1)
- eating disorders (1)
- eccentric (1)
- echocardiography (1)
- ectopic pregnancy (1)
- electrophiles (1)
- emotional climate (1)
- endocannabinoids (1)
- endoscopic retrograde cholangiopancreatography (1)
- endoscopy (1)
- endothelial cells (1)
- endothelium (1)
- endotoxemia (1)
- enforced viral replication (1)
- eosinophilic cholangitis (1)
- epigenomics (1)
- epilepsy (1)
- epileptogenesis (1)
- ergometry (1)
- esophageal cancer (1)
- ex vivo stimulation (1)
- exosomes (1)
- expressed emotion (1)
- extracellular matrix (1)
- fatigue (1)
- female health (1)
- fibrin (1)
- fibroblasts (1)
- fibrogenesis (1)
- fibronectin (1)
- first-line chemotherapy (1)
- follow-up (1)
- frontal fibrosierende Alopezie (1)
- function, sorting (1)
- galunisertib monohydrate (LY2157299) (1)
- gastric cancer (1)
- gender (1)
- gender equality (1)
- gender equality plan (1)
- gene regulation (1)
- gene therapy (1)
- gliomatosis cerebri growth pattern (1)
- guideline (1)
- hMOF/KAT8 (1)
- head and neck cancer (1)
- health economics (1)
- health information exchange (1)
- health literacy (1)
- healthcare professional (1)
- hematopoiesis (1)
- hematopoietic cells (1)
- hematopoietic stem cell transplantation (1)
- hepatic tumor (1)
- hepatitis B (1)
- hepatitis C (1)
- hepatitis C virus (1)
- heterogeneity of plasticity effects (1)
- high-throughput sequencing (1)
- hippocampal sclerosis (1)
- hippocampus (1)
- histone deacetylase (1)
- homologna transplantacija (1)
- hotspot loci (1)
- household chaos (1)
- human experimental pain (1)
- human resources (1)
- hypertension, pulmonary (1)
- hyponatremia (1)
- hypothermia (1)
- ignition (1)
- imiquimod (1)
- immune escape (1)
- immune microenvironment (1)
- immune reconstitution (1)
- immune system (1)
- immune-modulating therapy (1)
- immunity (1)
- immunology (1)
- immunotherapy (1)
- in situ gene correction (1)
- indacaterol/glycopyrronium (1)
- inducible nitric oxide synthase (1)
- infiltration (1)
- inflammatory arthritis (1)
- infomax (1)
- inhibition (1)
- integration (1)
- inter-assay precision (1)
- interleukin-22 (1)
- internal time (1)
- intervention study (1)
- interview (1)
- intoxication (1)
- intraarterial induction chemotherapy (1)
- intracerebral haemorrhage (1)
- invasive fungal infection (1)
- invasive growth (1)
- in vivo (1)
- ischemia (1)
- isušenje (1)
- kidney transplantation (1)
- klinische Kompetenz (1)
- laminin (1)
- length of study (1)
- leptomeningeal disease (1)
- leukemia (1)
- leukocytosis (1)
- leukopenia (1)
- lipid signaling (1)
- lipocalin-2 (1)
- liver abscess (1)
- liver damage (1)
- liver metastases (1)
- locomotor rhythm (1)
- long noncoding RNAs (1)
- low intellectual abilities (1)
- lung (1)
- lung cancer (1)
- lymph nodes (1)
- lysosomes (1)
- mRNA (1)
- mTOR (1)
- mTORC (1)
- macrophage (1)
- macrophage polarization (1)
- magnetic resonance imaging (1)
- massively parallel multigrid solvers (1)
- mathematical models of viral RNA cycle (1)
- medical education (1)
- medical teaching (1)
- melanoma (1)
- melatonin (1)
- membrane protein complex (1)
- membrane structure (1)
- memory performance (1)
- meningioma (1)
- mesenchymal stromal cells (1)
- metabolism (1)
- metabolomics (1)
- metastability (1)
- metastatic colorectal cancer (1)
- microRNA (1)
- microRNAs (1)
- microdeletions (1)
- migration (1)
- mindfulness (1)
- monoclonal antibody (1)
- monocrotaline (1)
- monocytes (1)
- morbidity (1)
- motor neuron disease (1)
- mouse (1)
- mouse model (1)
- mucormycete (1)
- multifocal (1)
- mutated neoantigens (1)
- myelodysplastic syndrome (1)
- myeloperoxidase (1)
- nadomjesci za kost (1)
- natural killer cell (1)
- natural killer cell cultivation (1)
- natural killer cell cytotoxicity (1)
- natural killer cell expansion (1)
- natural killer cell therapy (1)
- negative symptoms (1)
- neoplasms (1)
- neovascularization, physiologic (1)
- nerve growth factor (NGF) (1)
- network (1)
- neural adaptation (1)
- neural computation (1)
- neural development (1)
- neuroblastoma regression (1)
- neurodevelopmental (1)
- neuroimaging (1)
- neuronal avalanches (1)
- neutropenia (1)
- neutrophils (1)
- nitric oxide (1)
- non-canonical (1)
- non-coding RNA (1)
- non-homologous end joining (1)
- non-linear dynamics (1)
- non-receptor tyrosine kinase (nRTK) (1)
- noncoding RNA (1)
- nuclear envelope (1)
- nuclear import (1)
- nuclear pore complex (1)
- obesity (1)
- older people (1)
- oncogenes (1)
- oral squamous cell carcinoma (1)
- oscillation (1)
- oxidative stress (1)
- oxygen metabolism (1)
- p22phox (1)
- p53 (1)
- p67phox (1)
- pSMAD2 (1)
- paediatric nephrology (1)
- paired continuous theta burst stimulation (1)
- parathormone (PTH) (1)
- parenting (1)
- paricalcitol (1)
- partial information decomposition (1)
- pathogenesis (1)
- patient blood management (PBM) (1)
- patient safety (1)
- patient-derived xenograft (1)
- pediatric cancer (1)
- peg-interferon lambda (1)
- perfusion-weighted imaging (1)
- peripheral blood mononuclear cells (1)
- phagocytes (1)
- phase 2 clinical trials (1)
- pilot study (1)
- plasticity (1)
- platelet-rich fibrin (1)
- platelets (1)
- pleomorphic xanthoastrocytoma (1)
- point-of-care testing (POCT) (1)
- poly-L-lysine (1)
- polymorphism (1)
- polytrauma (1)
- population-based (1)
- postnatal neurogenesis (1)
- predialysis (1)
- predictive coding (1)
- predictive timing (1)
- predictive validity (1)
- preeclampsia (1)
- premotor cortex (1)
- primary brain tumors (1)
- primary sclerosing cholangitis (1)
- proactive aggression (1)
- prognostic biomarker (1)
- progressive neoplastic disease (1)
- proliferation (1)
- prostaglandin E (1)
- prostaglandins (1)
- prostatic cancer (1)
- protein phosphorylation (1)
- proteomics (1)
- psoriasis (1)
- psychosis (1)
- public health (1)
- pulmonary endarterectomy (1)
- pulmonary hypertension (1)
- pulmonary vein isolation (1)
- qualitative Methode (1)
- qualitative analysis (1)
- quality indicators (1)
- quantification (1)
- quantum biology (1)
- quantum neurobiology (1)
- rRNA (1)
- radiofrequency ablation (1)
- rapamycin (1)
- rare disesases (1)
- rat (1)
- reactive aggression (1)
- reactive oxygen species (1)
- realistic geometries (1)
- recommendation (1)
- reference values (1)
- regeneration (1)
- reliability (1)
- remission (1)
- remodelling (1)
- reproduction biology (1)
- research (1)
- research in academic medicine (1)
- resting-state functional connectivity (1)
- resveratrol (1)
- retinal degeneration (1)
- retinal detachment (1)
- retrospective trial (1)
- rhabdomyosarcoma (1)
- riociguat (1)
- second mitochondria-derived activator of caspases mimetic (1)
- secondary data analysis (1)
- secondary hyperparathyroidism (sHPT) (1)
- seizure (1)
- selective autophagy (1)
- self-organisation (1)
- sepsis (1)
- serum (1)
- serum concentrations (1)
- sex (1)
- sex differences (1)
- short tandem repeats (1)
- signal transducer and activator of transcription 3 (1)
- signal transducer and activator of transcription-1 (1)
- signal transduction (1)
- skill mix (1)
- skills shortage (1)
- small leucine-rich proteoglycan (1)
- smooth muscle cells (1)
- soft tissue sarcoma (1)
- somatoform disorder (1)
- sphingolipid (1)
- sphingolipid metabolism (1)
- sphingolipid sphingosine-1-phosphate (1)
- sphingolipids (1)
- sphingosine 1-phosphate (1)
- sphingosine-1-phosphate (1)
- sphingosine-1-phosphate receptor (1)
- sphingosine-1-phosphate receptor 5 (1)
- squamous cell carcinomas oral cavity (1)
- staff capacity (1)
- staff fluctuation (1)
- state exams (1)
- status epilepticus (1)
- sterile α motif (SAM) (1)
- strength (1)
- structure (1)
- subject selection (1)
- subjective theories (1)
- subjektive Theorien (1)
- supervised machine-learning (1)
- supplementary motor area (SMA) (1)
- surface marker reversion (1)
- surface-based morphometry (1)
- synaptic plasticity (1)
- synchronization (1)
- synergy (1)
- systemic sclerosis (1)
- tehnika dekalcifikacije (1)
- temporal lobe epilepsy (1)
- therapy monitoring (1)
- tissue Doppler imaging (1)
- tissue at risk (1)
- toll-like receptors (1)
- tolvaptan (1)
- training program (1)
- transcranial magnetic stimulation (1)
- transcription factor (1)
- transcription factors (1)
- transcriptional regulation of autophagy (1)
- transfer (1)
- transfusion medicine (1)
- transition (1)
- transmitted founder virus (1)
- trauma (1)
- treatment choice (1)
- treatment preference (1)
- trophoblast (1)
- tuft cells (1)
- tumor progression (1)
- tumor suppressor (1)
- tumor-associated macrophages (1)
- tumor-infiltrating-lymphocytes (1)
- tumour microenvironment (1)
- type I interferon (1)
- vadimezan (1)
- vascular biology (1)
- vascular disrupting agents (1)
- vascular remodeling (1)
- vector-borne disease (1)
- viral dynamics (1)
- vitamin D (1)
- weight loss (1)
- whole-brain modeling (1)
- within-host viral modelling (1)
- work productivity (1)
- working conditions (1)
- working memory (1)
- wound complications (1)
- wound healing (1)
- yeast (1)
- zinc (1)
- α-synuclein (1)
Institute
- Medizin (380) (remove)
Mathematical models of virus dynamics have not previously acknowledged spatial resolution at the intracellular level despite substantial arguments that favor the consideration of intracellular spatial dependence. The replication of the hepatitis C virus (HCV) viral RNA (vRNA) occurs within special replication complexes formed from membranes derived from endoplasmatic reticulum (ER). These regions, termed membranous webs, are generated primarily through specific interactions between nonstructural virus-encoded proteins (NSPs) and host cellular factors. The NSPs are responsible for the replication of the vRNA and their movement is restricted to the ER surface. Therefore, in this study we developed fully spatio-temporal resolved models of the vRNA replication cycle of HCV. Our simulations are performed upon realistic reconstructed cell structures—namely the ER surface and the membranous webs—based on data derived from immunostained cells replicating HCV vRNA. We visualized 3D simulations that reproduced dynamics resulting from interplay of the different components of our models (vRNA, NSPs, and a host factor), and we present an evaluation of the concentrations for the components within different regions of the cell. Thus far, our model is restricted to an internal portion of a hepatocyte and is qualitative more than quantitative. For a quantitative adaption to complete cells, various additional parameters will have to be determined through further in vitro cell biology experiments, which can be stimulated by the results deccribed in the present study.
Background: Invasive off- or on-pump cardiac surgery (elective and emergency procedures, excluding transplants are routinely performed to treat complications of ischaemic heart disease. Randomised controlled trials (RCT) evaluate the effectiveness of treatments in the setting of cardiac surgery. However, the impact of RCTs is weakened by heterogeneity in outcome measuring and reporting, which hinders comparison across trials. Core outcome sets (COS, a set of outcomes that should be measured and reported, as a minimum, in clinical trials for a specific clinical field) help reduce this problem. In light of the above, we developed a COS for cardiac surgery effectiveness trials.
Methods: Potential core outcomes were identified a priori by analysing data on 371 RCTs of 58,253 patients. We reached consensus on core outcomes in an international three-round eDelphi exercise. Outcomes for which at least 60% of the participants chose the response option "no" and less than 20% chose the response option "yes" were excluded.
Results: Eighty-six participants from 23 different countries involving adult cardiac patients, cardiac surgeons, anaesthesiologists, nursing staff and researchers contributed to this eDelphi. The panel reached consensus on four core outcomes: 1) Measure of mortality, 2) Measure of quality of life, 3) Measure of hospitalisation and 4) Measure of cerebrovascular complication to be included in adult cardiac surgery trials.
Conclusion: This study used robust research methodology to develop a minimum core outcome set for clinical trials evaluating the effectiveness of treatments in the setting of cardiac surgery. As a next step, appropriate outcome measurement instruments have to be selected.
The Gini index is a measure of the inequality of a distribution that can be derived from Lorenz curves. While commonly used in, e.g., economic research, it suffers from ambiguity via lack of Lorenz dominance preservation. Here, investigation of large sets of empirical distributions of incomes of the World’s countries over several years indicated firstly, that the Gini indices are centered on a value of 33.33% corresponding to the Gini index of the uniform distribution and secondly, that the Lorenz curves of these distributions are consistent with Lorenz curves of log-normal distributions. This can be employed to provide a Lorenz dominance preserving equivalent of the Gini index. Therefore, a modified measure based on log-normal approximation and standardization of Lorenz curves is proposed. The so-called UGini index provides a meaningful and intuitive standardization on the uniform distribution as this characterizes societies that provide equal chances. The novel UGini index preserves Lorenz dominance. Analysis of the probability density distributions of the UGini index of the World’s counties income data indicated multimodality in two independent data sets. Applying Bayesian statistics provided a data-based classification of the World’s countries’ income distributions. The UGini index can be re-transferred into the classical index to preserve comparability with previous research.
Background: Modulation of cortical excitability by transcranial magnetic stimulation (TMS) is used for investigating human brain functions. A common observation is the high variability of long-term depression (LTD)-like changes in human (motor) cortex excitability. This study aimed at analyzing the response subgroup distribution after paired continuous theta burst stimulation (cTBS) as a basis for subject selection.
Methods: The effects of paired cTBS using 80% active motor threshold (AMT) in 31 healthy volunteers were assessed at the primary motor cortex (M1) corresponding to the representation of the first dorsal interosseous (FDI) muscle of the left hand, before and up to 50 min after plasticity induction. The changes in motor evoked potentials (MEPs) were analyzed using machine-learning derived methods implemented as Gaussian mixture modeling (GMM) and computed ABC analysis.
Results: The probability density distribution of the MEP changes from baseline was tri-modal, showing a clear separation at 80.9%. Subjects displaying at least this degree of LTD-like changes were n = 6 responders. By contrast, n = 7 subjects displayed a paradox response with increase in MEP. Reassessment using ABC analysis as alternative approach led to the same n = 6 subjects as a distinct category.
Conclusion: Depressive effects of paired cTBS using 80% AMT endure at least 50 min, however, only in a small subgroup of healthy subjects. Hence, plasticity induction by paired cTBS might not reflect a general mechanism in human motor cortex excitability. A mathematically supported criterion is proposed to select responders for enrolment in assessments of human brain functional networks using virtual brain lesions.
Mobilization of hematopoietic stem cells (HSCs) from the bone marrow to the peripheral blood is a complex mechanism that involves adhesive and chemotactic interactions of HSCs as well as their bone marrow microenvironment. In addition to a number of non-genetic factors, genetic susceptibilities also contribute to the mobilization outcome. Identification of genetic factors associated with HSC yield is important to better understand the mechanism behind HSC mobilization. In the present study, we enrolled 148 Korean participants (56 healthy donors and 92 patients) undergoing HSC mobilization for allogeneic or autologous HSC transplantation. Among a total of 53 polymorphisms in 33 candidate genes, one polymorphism (rs11264422) in relaxin/insulin-like family peptide receptor 4 (RXFP4) gene was significantly associated with a higher HSC yield after mobilization in Koreans. However, in a set of 101 Europeans, no association was found between circulating CD34+ cell counts and rs11264422 genotype. Therefore, we suggest that the ethnic differences in subjects’ genetic background may be related to HSC mobilization. In conclusion, the relaxin—relaxin receptor axis may play an important role in HSC mobilization. We believe that the results of the current study could provide new insights for therapies that use relaxin and HSC populations, as well as a better understanding of HSC regulation and mobilization at the molecular level.
The former and current multiple sclerosis (MS) classifications are essential for describing different phenotypes and disease dynamics. To establish personalized treatment regimes, further clinical and paraclinical parameters have to be considered such as imaging, cerebrospinal fluid (CSF) findings, past disease-modifying therapies (DMTs), and disease activity under these therapies. In clinical practice, this information is often difficult to overview. Especially, patients with a long course of disease offer an extensive medical history so that comprehending all of the necessary information can be very time consuming.
A randomised, double-blind, placebo-controlled trial of trichuris suis ova in active crohn's disease
(2017)
BACKGROUND AND AIMS To investigate the efficacy and safety of three different dosages of embryonated, viable eggs of Trichuris suis [TSO] versus placebo for induction of remission in mildly-to-moderately active ileocolonic, uncomplicated Crohn's disease [CD].
METHODS Adults with active CD [n = 252] randomly received six fortnightly doses of 250, 2500, or 7500 TSO/15 ml suspension/day [TSO 250, TSO 2500, TSO 7500], or 15 ml placebo solution/day, in a double-blind fashion, with 4 weeks' follow-up. Primary endpoint was the rate of clinical remission [Crohn's Disease Activity Index [CDAI] < 150] at end of treatment, ie at Week 12 or withdrawal. Secondary endpoints included the course of clinical remission, rate of clinical response, change in CDAI, change in markers of inflammation, mucosal healing, and Physician's Global Assessment.
RESULTS Clinical remission at Week 12 occurred in 38.5%, 35.2%, and 47.2% of TSO 250, TSO 2500, and TSO 7500 patients, respectively, and in 42.9% of placebo recipients. TSO induced a dose-dependent immunological response. There was no response regarding laboratory markers of inflammation. Other secondary efficacy variables also showed no advantage of TSO over placebo for treatment of active CD. Administration of TSO did not result in any serious adverse drug reaction. Review of non-serious suspected adverse drug reactions following TSO did not reveal any safety concerns.
CONCLUSIONS Administration of 250-7500 TSO fortnightly over 12 weeks was safe and showed a dose-dependent immunological response, but no TSO dose showed a clinically relevant effect over placebo for induction of clinical remission or response in mildly-to-moderately active, ileocolonic CD.
Introduction: DACCORD is an observational, non-interventional study being conducted in German primary and secondary care centres. The study aims to describe the impact of disease (including exacerbations) and treatments over 2 years on ‘real-life’ patients with chronic obstructive pulmonary disease (COPD).
Materials and methods: Patients had a clinical and spirometry diagnosis of COPD, were aged ≥40 years and, on recruitment, were initiating or changing COPD maintenance medication. The only exclusion criteria were asthma and randomised clinical trial participation. Exacerbations data were collected every 3 months. COPD medication, COPD Assessment Test (CAT) and forced expiratory volume in 1 s (FEV1) were recorded at baseline and after 1 and 2 years.
Results: A total of 6122 patients were recruited, 3137 (51.2%) of whom completed the 2-year visit. The mean age of these patients was 65.6 years, 59% were male, 69% had mild or moderate airflow limitation, and their mean COPD Assessment Test (CAT) total score was 20.3. Overall, there was a trend towards decreasing COPD exacerbation rates over the 2-year follow-up period, with rates of 0.390 during Year 1 and 0.347 during Year 2. Rates were lower in patients with no exacerbation during the 6 months prior to entry (0.263 and 0.251 during Years 1 and 2, respectively), with 51.6% of patients having no exacerbation during the 6 months prior to entry and over the 2-year follow-up. Approximately 50% of the overall population experienced a clinically relevant improvement from baseline in CAT total score at Year 1 and 2. When assessed by treatment class (or classes), persistence to medication was high (77.8% in Year 1 and 71.4% in Year 2).
Conclusions: Overall, the 2-year follow-up data from DACCORD suggest that for most patients with COPD exacerbations are a rare event. For the majority of patients, the focus should be on managing symptoms, and the impact that these symptoms have on their daily lives. Even for those patients who do exacerbate, although prevention of exacerbations is an important factor, management of symptoms should be a key consideration. DACCORD also suggests that COPD disease progression is not inevitable – providing patients are receiving pharmacological treatment.
Background: Health care accessibility is known to differ geographically. With this study we focused on analysing accessibility of general and specialized obstetric units in England and Germany with regard to urbanity, area deprivation and neonatal outcome using routine data.
Methods: We used a floating catchment area method to measure obstetric care accessibility, the degree of urbanization (DEGURBA) to measure urbanity and the index of multiple deprivation to measure area deprivation.
Results: Accessibility of general obstetric units was significantly higher in Germany compared to England (accessibility index of 16.2 vs. 11.6; p < 0.001), whereas accessibility of specialized obstetric units was higher in England (accessibility index for highest level of care of 0.235 vs. 0.002; p < 0.001). We further demonstrated higher obstetric accessibility for people living in less deprived areas in Germany (r = − 0.31; p < 0.001) whereas no correlation was present in England. There were also urban–rural disparities present, with higher accessibility in urban areas in both countries (r = 0.37–0.39; p < 0.001). The analysis did not show that accessibility affected neonatal outcomes. Finally, our computer generated model for obstetric care provider demand in terms of birth counts showed a very strong correlation with actual birth counts at obstetric units (r = 0.91–0.95; p < 0.001).
Conclusion: In Germany the focus of obstetric care seemed to be put on general obstetric units leading to higher accessibility compared to England. Regarding specialized obstetric care the focus in Germany was put on high level units whereas in England obstetric care seems to be more balanced between the different levels of care with larger units on average leading to higher accessibility.
Background: Cytogenetic aberrations such as deletion of chromosome 5q (del(5q)) represent key elements in routine clinical diagnostics of haematological malignancies. Currently established methods such as metaphase cytogenetics, FISH or array-based approaches have limitations due to their dependency on viable cells, high costs or semi-quantitative nature. Importantly, they cannot be used on low abundance DNA. We therefore aimed to establish a robust and quantitative technique that overcomes these shortcomings.
Methods: For precise determination of del(5q) cell fractions, we developed an inexpensive multiplex-PCR assay requiring only nanograms of DNA that simultaneously measures allelic imbalances of 12 independent short tandem repeat markers.
Results: Application of this method to n=1142 samples from n=260 individuals revealed strong intermarker concordance (R²=0.77–0.97) and reproducibility (mean SD: 1.7%). Notably, the assay showed accurate quantification via standard curve assessment (R²>0.99) and high concordance with paired FISH measurements (R²=0.92) even with subnanogram amounts of DNA. Moreover, cytogenetic response was reliably confirmed in del(5q) patients with myelodysplastic syndromes treated with lenalidomide. While the assay demonstrated good diagnostic accuracy in receiver operating characteristic analysis (area under the curve: 0.97), we further observed robust correlation between bone marrow and peripheral blood samples (R²=0.79), suggesting its potential suitability for less-invasive clonal monitoring.
Conclusions: In conclusion, we present an adaptable tool for quantification of chromosomal aberrations, particularly in problematic samples, which should be easily applicable to further tumour entities.