Refine
Year of publication
- 1985 (1)
Document Type
- Article (1)
Language
- English (1)
Has Fulltext
- yes (1) (remove)
Is part of the Bibliography
- no (1)
Keywords
Institute
- Biochemie und Chemie (1) (remove)
The recently developed stereospecific sodium salt glycosylation procedure has been successfully applied to the synthesis of the β-ᴅ-2′-deoxyribofuranosides of benzimidazole, 5,6-dihalogeno benzimidazoles, and some 2-substituted analogues in high yield. The 5,6-dibromo analogue was obtained by bromination of the parent nucleoside. These have all been characterized by spectroscopic methods, including 1H NMR, which permitted analyses of their solution conformations and comparison with those of the corresponding ribofuranosides. Some biological aspects, including preliminary results on cytotoxicity and antiviral activity, are briefly considered.