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Phase transitions in a non-perturbative regime can be studied by ab initio Lattice Field Theory methods. The status and future research directions for LFT investigations of Quantum Chromo-Dynamics under extreme conditions are reviewed, including properties of hadrons and of the hypothesized QCD axion as inferred from QCD topology in different phases. We discuss phase transitions in strong interactions in an extended parameter space, and the possibility of model building for Dark Matter and Electro-Weak Symmetry Breaking. Methodological challenges are addressed as well, including new developments in Artificial Intelligence geared towards the identification of different phases and transitions.
Leaving aside elliptical coordinations, it is striking that no agreement has been reached on the structure of basic coordinate constructions. We propose that:
- coordinate constructions are structurally asymmetric: the conjunction makes a subconstituent with one of the conjuncts.
- such constituents can have several functions: coordinate daughter, adjunct daughter or main clause.
In order to show that some conjuncts should be analysed as adjuncts, we focus on asymmetric cases of coordination, in which the order of the conjuncts cannot be reversed, taking examples from French, Welsh and Korean. We present an HPSG analysis which treats the coordinating conjunctions as weak heads, with lexical subtypes, and coordinate phrases as multi-headed constructions, with different subtypes.
Of all French functional elements, the form de has without question the widest variety of uses, and presents the greatest challenge for linguistic description and analysis. Historically a preposition, it still has a number of prepositional uses in modern French, but in many contexts it calls for an altogether different treatment. We begin by outlining a general distinction between oblique and non-oblique uses of de. We then develop a detailed account of constructions where de combines with an N'. We provide a unitary analysis of de in three constructions (quantifier extraction, "quantification at a distance", and negative contexts) which have been not been considered to be related in previous accounts.
Comparative correlative (CC) constructions have received much attention in recent years. Major issues have been whether they involve special constructions and whether they have symmetric or asymmetric structures. Evidence from Romance suggests that they require special constructions and that they may be either symmetric or asymmetric. French has a single construction which is asymmetric for some speakers and symmetric for others. Spanish has two distinct constructions, one asymmetric and the other symmetric with quite different properties. The facts can be accommodated in a straightforward way within construction-based HPSG.
While French degree words in French have been assigned several syntactic categories, we show that they are rather highy polymorphic adverbs (they occur in all syntactic domains), which select the expression they modify on a purely semantic basis. Like French adverbs in general, they occur both to the left and to the right of the head they modify. Following previous work (a.o. van Noord and Bouma 1994, Abeillé and Godard 1997, Bouma et al. 2000), we assign them two different grammatical functions, adjuncts and complements. Semantically, they differ from quantifiers. We follow Kennedy (2000) who analyzes them as scalar predicate modifiers. Finally, the specific syntactic constraints that characterize a subset of them can be shown to follow from, or be related to, their weight properties (Abeillé and Godard 2000). We conclude that their apparently idiosyncratic properties fit into a more general theory of grammar.
In French, Italian, and Romanian, forms inherited from the Latin paradigm 'esse' are used for the copula, the passive auxiliary and tense or perfective auxiliaries. We show that the copula and the passive auxiliary should be identified, while the tense or perfective auxiliaries are different lexemes. Moreover, the copula has the same description across all the Romance languages. While they all are argument inheritance verbs, the copula and the tense or perfective auxiliaries differ with respect to their complement structure: (i) the second only have one complement structure (the complement participle is complement unsaturated), the copula has two complement structures (the predicate is either complement saturated or unsaturated); (ii) French and Italian tense auxiliaries are the head of a flat VP, where the participle is sister to its subcategorized complements, the Romanian perfective auxiliary is the head of a verbal complex; (iii) when the complement predicate is unsaturated, the Romance copula is the head of a flat VP.
Two consequences of the analysis are worth mentioning. First, the copula (and the passive auxiliary) should not be taken into account when stating the environments for auxiliary selection in French and Italian. Second, argument inheritance and complement structure are different phenomena, and argue in favor of theories which systematically distinguish between valence features and constituent structures.
We contrast two types of sentences with a preposed NP in French in a construction based HPSG grammar. They differ with respect to different grammatical aspects (syntax, semantics, pragmatics and phonology), which cluster uniquely into constructions. Both are colloquial, a reason why they have been recognized only recently (see Zribi-Hertz 1986, 1996, Sabio 1995, 2006). Accordingly, we rely for the data on spoken corpora (Corpaix, CFRP) as well as on our intuitions. Both constructions involve a partitioned semantics but this mode of composition is associated with different effects. One construction is characterized semantically: the preposed NP is the theme of a categorical proposition. The other construction is characterized pragmatically: it is associated with an independent declarative clause, a typical use of which is to signal a break in the interaction.
The annotation of texts and other material in the field of digital humanities and Natural Language Processing (NLP) is a common task of research projects. At the same time, the annotation of corpora is certainly the most time- and cost-intensive component in research projects and often requires a high level of expertise according to the research interest. However, for the annotation of texts, a wide range of tools is available, both for automatic and manual annotation. Since the automatic pre-processing methods are not error-free and there is an increasing demand for the generation of training data, also with regard to machine learning, suitable annotation tools are required. This paper defines criteria of flexibility and efficiency of complex annotations for the assessment of existing annotation tools. To extend this list of tools, the paper describes TextAnnotator, a browser-based, multi-annotation system, which has been developed to perform platform-independent multimodal annotations and annotate complex textual structures. The paper illustrates the current state of development of TextAnnotator and demonstrates its ability to evaluate annotation quality (inter-annotator agreement) at runtime. In addition, it will be shown how annotations of different users can be performed simultaneously and collaboratively on the same document from different platforms using UIMA as the basis for annotation.
Over the past two decades the “one drug – one target – one disease” concept became the prevalent paradigm in drug discovery. The main idea of this approach is the identification of a single protein target whose inhibition leads to a successful treatment of the examined disease. The predominant assumption is that highly selective ligands would avoid unwanted side effects caused by binding to secondary non-therapeutic targets. In recent years the results of post-genomic and network biology showed that proteins rarely act in isolated systems but rather as a part of a highly connected network [1]. In addition this connectivity leads to more robust systems that cannot be interfered by the inhibition of a single target of that network and consequently might not lead to the desired therapeutic effect [2]. Furthermore studies prove that robust systems are rather affected by weak inhibitions of several parts than by a complete inhibition of a single selected element of that system [3]. Therefore there is an increasing interest in developing drugs that take effect on multiple targets simultaneously but is concurrently a great challenge for medicinal chemists. There has to be a sufficient activity on each target as well as an adequate pharmacokinetic profile [4]. Early design strategies tried to link the pharmacophors of known inhibitors, however these methods often lead to high molecular weight and low ligand efficacy. We present a new rational approach based on a retrosynthetic combinatorial analysis procedure [5] on approved ligands of multiple targets. These RECAP fragments are used to design a large combinatorial library containing molecules featuring chemical properties of each ligand class. The molecules are further validated by machine learning models, like random forests and self-organizing maps, regarding their activity on the targets of interest.
Introduction: aims and points of departure. 1. The problem of the knowledge of law: whether previous general rules may support a casuistic decision. 2. The problem of legal ethics: whether there are autonomous rights, which do not depend on positive law. 3. The ways of modern dogmatics to deal with these problems. 4. The question remains the same.