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The neutron sensitivity of the C6D6 detector setup used at n_TOF facility for capture measurements has been studied by means of detailed GEANT4 simulations. A realistic software replica of the entire n_TOF experimental hall, including the neutron beam line, sample, detector supports and the walls of the experimental area has been implemented in the simulations. The simulations have been analyzed in the same manner as experimental data, in particular by applying the Pulse Height Weighting Technique. The simulations have been validated against a measurement of the neutron background performed with a natC sample, showing an excellent agreement above 1 keV. At lower energies, an additional component in the measured natC yield has been discovered, which prevents the use of natC data for neutron background estimates at neutron energies below a few hundred eV. The origin and time structure of the neutron background have been derived from the simulations. Examples of the neutron background for two different samples are demonstrating the important role of accurate simulations of the neutron background in capture cross-section measurements.
Die slowakische Übersetzung des Kleinen Katechismus Doktor Martin Luthers erschien 1581 (im Weiteren: Bartfelder Katechismus 1581) in der ostslowakischen Stadt Bardejov/Bartfeld in der Verlagsdruckerei von David Guttgesell. Es handelt sich um das erste gedruckte slowakische Buch, das als ein wertvolles Zeugnis des kulturellen und geistigen Erbes der Slowaken betrachtet wird. Es ist umso wertvoller, als dass von der gesamten Auflage bloß ein einziges, beschädigtes Exemplar erhalten wurde, welches in der Slowakischen Nationalen Bibliothek in Martin aufbewahrt wird...
Sprache als ein Bestandteil des biologisch-kognitiven Einklangs angeborener menschlicher Fähigkeiten wird in kognitiv-linguistischer Leseart nicht als ein vom Menschen unabhängiges, abstraktes sowie autonomes System betrachtet. Sprache ist mit Bedeutung demzufolge als Verknüpfung von verschiedenen Wissensaspekten in der menschlichen Kognition verankert. Die bestimmten Spielarten der kognitiven Linguistik, die Sprache als Teil der menschlichen Kognition begreift, versuchen, besonders den Einfluss der menschlichen Wahrnehmungsprozesse auf Sprache und sprachliche Strukturen zu analysieren...
U ovome radu autor će, na osnovu vlastitih istraživanja, pokušati dati sumaran prikaz akcenatskih svojstava govora otoka Iža, smještenog u zadarskom arhipelagu. Namjera mu je smjestiti iški govor i akcenatski sustav među drugim čakavskim otočkim govorima, dati fonetski i fonološki opis pojedinih akcenata i potkrijepiti ih primjerima koje je čuo od iških govornika i, konačno, pokušati utvrditi fonološki status čakavskog akuta u iškome govoru. Budući da su istraživanja bila ograničenoga karaktera, ovaj rad nije zamišljen kao konačan opis, već kao polažišna točka za buduća istraživanja koja je potrebno izvršiti na osnovu kojih će se moći napraviti što iscrpniji i potpuniji opis iškoga govora i akcenatskoga sustava.
The spitting spider Scytodes fusca Walckenaer, 1837 is recorded for the first time in Central Europe from both Germany and Slovakia. The species was found in two localities, within the Botanical Garden in Bratislava (Slovakia), specifically from a heated greenhouse with high humidity, and the "Tropical Islands", a tropical holiday resort in Krausnick (Germany). It seems that this Pantropical species has probably been introduced here along with imported plants. A description of diagnostic characters, as well as figures, is given.
Carinostoma elegans new to the Slovakian harvestmen fauna (Opiliones, Dyspnoi, Nemastomatidae)
(2014)
A new genus and species of small harvestman was found for the first time in Slovakia – Carinostoma elegans (Sorensen, 1894). One male and two females were collected in the Mlyňany arboretum of the Slovak Academy of Science (western Slovakia). Descriptions and photographs of both sexes of C. elegans are provided. Additional comments, and a map of distribution of all species of this genus, are provided.
U članku je riječ o sklonidbi i naglasku imenica srednjega roda o-sklonidbe u mjesnom govoru sela Jevšček pokraj Livka (općina Kobarid, Slovenija), koji pripada nadiškomu dijalektu slovenskoga, i to sa sinkronijskoga i dijakronijskoga aspekta. S aspekta jezikoslovnoga opisa prikazani su nastavci i njihova distribucija s obzirom na osnovu te naglasni tipovi i njihove paradigme. U jezičnopovijesnome dijelu određuje se povijesni izvod pojedinih nastavaka i naglasnih tipova. Opisani oblici i naglasni sustav postavljaju se u širi slovenski i slavenski kontekst.
Sprachkorpora sind heute Informationsquellen, die Sprachwissenschaftlern für die Erforschung der Sprachen und für den Vergleich von Sprachen als ein unentbehrliches Instrument zur Verfügung stehen und man kann bei einer effizienten Erforschung von Sprachen sowie bei der Datenerhebung um Korpora gar nicht herumkommen. Sprachkorpora kann man jedoch auch für eine effektive Vermittlung jeder Sprache nutzen. Die schnelle Verbreitung der Computertechnik und der schnelle Zugang zu Informationen hat auch stark die immense Entwicklung im Bereich der Sprachverarbeitung beeinflusst und bedeutete zudem eine rasante Entwicklung der Korpuslinguistik. Deswegen erscheinen als große Defizite die ungenügende Vermittlung der Kenntnisse und das Fehlen der praktischen Fähigkeiten im Umgang mit korpuslinguistischen Tools bei Studierenden der philologischen Fachrichtungen. Die als Lehrbuch konzipierte Publikation hat eine gute Chance, diese Lücke im Lehrwerkangebot zu füllen...
U članku se analiziraju pojedina značenja perceptivnih glagola vidjeti i gledati u hrvatskome jeziku te njihova vidska obilježja. Glagol vidjeti u značenjima fizičke percepcije funkcionira u rečenici kao svršeni i kao nesvršeni glagol. Glagol gledati u značenju fizičke percepcije u rečenici funkcionira kao prototipni nesvršeni glagol, dok njegov svršeni parnjak pogledati funkcionira kao prototipni i kao neprototipni svršeni glagol, ovisno o značenju.
U hrvatski su jezik tijekom povijesti ulazile riječi ponajviše iz zemljopisno najbližih jezika, najčešće i službenih ili glavnih jezika nekadašnjih zajedničkih država. Nedvojbeno je velik utjecaj imao i latinski jezik jer je bio temelj nadgradnje hrvatskoga književnog i standardnog jezika te sredstvo očuvanja identiteta hrvatske nacije i hrvatskoga jezika. Ruski jezik ne pripada teritorijalno bliskim jezicima, a nema ni spomenutu vrijednost latinskoga jezika. Njegov je utjecaj na hrvatski jezik kulturološki: kroz književnost te nacionalnu i društvenu politiku. Rusizmi u hrvatski jezik ulaze tijekom triju razdoblja: 1. razdoblje ilirskoga pokreta (uz izravni utjecaj B. Šuleka), 2. razdoblje poslijeratne Jugoslavije i Sovjetskoga Saveza (sovjetizmi), 3. razdoblje nakon raspada socijalističkih država i oblikovanja demokratskih i samostalnih zemalja – Republike Hrvatske i Ruske Federacije. U posljednjemu razdoblju gotovo je dokinuta upotreba sovjetizama, no aktivirali su se drugi rusizmi. Rječnik stranih riječi Bratoljuba Klaića kulturno je dobro hrvatskoga jezika te je ujedno i pokazatelj utjecaja političkih i kulturoloških čimbenika na razvoj hrvatskoga jezika. Kroz Rječnik se tako može pratiti i sudbina rusizama u hrvatskome jeziku. Cilj je ovoga rada prikazati položaj i opis rusizama u hrvatskome jeziku kroz odabrana izdanja Rječnika.
U uvodu rada diferenciraju se morfološka (i „pravomorfološka”) i pravopisna norma, pri čemu se govori i o svojevrsnome paradoksu pravopisne norme. Metodom komparativne i kontrastivne analize u središnjem se dijelu rada raščlanjuju neki relevantni morfološki aspekti koji sudjeluju u definiranju pravopisnih načela i pravopisnih pravila. Cilj je rada osvješćivanje teorijsko-metodoloških aspekata kojima se naznačuju vidovi svojevrsna preklapanja morfologije i pravopisa, i to kroz prizmu hrvatske pravopisne norme, ali i norme nekih slavenskih jezika. U skladu s tim u zaključku se progovara o povezanosti pravopisne norme s morfološkom normom, odnosno kako posebnosti morfološke norme postaju pitanje pravopisne norme.
In der Islamischen Theologie gilt die Vorherbestimmung als einer der wichtigsten und zu meist diskutiertesten Themen. Es ist eine Frage, die die Menschen schon immer beschäftigt und dass seit Jahrhunderten ihre Aktualität bewahrt hat. Es wurde schon vor der islamischen Zeit von Philosophen und Theologen aufgegriffen. Auch in anderen monotheistischen Religionen wie im Christentum oder Judentum hat das Thema Vorherbestimmung ihre Wichtigkeit beibehalten. Seit den Anfängen des Islams wird dieses Themengebiet bis heute diskutiert. Es wurde sowohl in der vorislamischen Zeit als auch in der Zeit des Propheten Muhammed behandelt. Auch nach seinem Dahinscheiden war es vor allem durch die Begegnung der Muslime mit anderen Kulturen und Religionen ein unumgängliches Thema. Mit der Entwicklung der islamischen Wissenschaften bildete sich auch die Systematische Theologie (kalām) als eine gesonderte Wissenschaftsdisziplin. Einer der großen Themenschwerpunkte war hierbei die Vorherbestimmung. Über diese Frage wurde über die ganzen Jahrhunderte bis in die Moderne hinein sehr viel geschrieben. Auch in der Moderne wurde dieses Themenspektrum aus islamischer Sicht aufgegriffen. Als einer der einflussreichsten Islamdenker der Neuzeit reflektiert Bediüzzaman Said Nursi über den Islam mit neuem Ansatz und zeigt auf theologischer, philosophischer und gesellschaftlicher Ebene neue Perspektiven. Ibrahim M. Abu-Rabi‘ erwähnt in seinem Vorwort zum Buch Islam in modern Turkey: an intellectual biography of Bediuzzaman Said Nursi von Şükran Vahide (Mary F. Weld), dass über die Gedanken moderner Islamdenker wie Ǧamāl ad-Dīn al-Afġānī (1838-1897), Sir Aḥmad Ḫān (1817-1898), Muḥammad ʿAbduh (1849-1905), Rašīd Riḍā (1865-1935), Muḥammad Iqbāl (1877-1938) und anderen führenden muslimischen Gelehrten in westlichen Sprachen reichliche Literatur vorhanden ist. Er führt weiter aus, dass es höchste Zeit ist, dass auch Said Nursi zu diesen geistlichen Persönlichkeiten gezählt und als einer der wichtigsten von ihnen gesehen werden sollte. Des Weiteren ist er der Meinung, dass in der intellektuellen Biografie des Bediüzzaman Said Nursi verdeutlicht wird warum Nursi solch eine Position im Denken und in der Praxis der islamischen Moderne verdient. Wolf fügt im Vorwort des Buches hinzu: “Said Nursis Beitrag zum Diskurs der Moderne aus gläubiger Reflektion wurde lange übersehen.“ Akgündüz ist der Auffassung, dass die wissenschaftliche Persönlichkeit von Bediüzzaman Said Nursi selbst in der Türkei insbesondere unter Wissenschaftlern nicht ausreichend bekannt ist. In dieser Arbeit möchte ich dem Leser, insbesondere neue und unbekannte Ansätze des Gelehrten Bediüzzaman Said Nursi in Bezug auf die Frage der Vorherbestimmung hinsichtlich seiner theologischen Methode vorstellen. Der gläubige Mensch soll nach Nursi dadurch im Stande sein seinen Glauben im Alltag zu fühlen. Es ist ein Diskurs, der das Nachdenken, die Vernunft und die Reflexion zentralisiert und somit die Vereinbarkeit des Glaubens mit der Moderne aufzeigen möchte. Meine Arbeit besteht aus fünf Kapiteln. Den Schwerpunkt meiner Arbeit bildet hierbei die Frage der Vorherbestimmung bei Said Nursi. Daher möchte ich zunächst im ersten Kapitel seine Biographie sowie sein Werk in allgemeinen Zügen darstellen. Um seine Positionen bezüglich der Vorherbestimmung besser zu verstehen, werden im zweiten Kapitel seine theologischen Grundgedanken dargelegt. Als ein Einstieg in den Hauptteil der Arbeit ist eine allgemeine Darstellung der Vorherbestimmung im Koran und in der sunnitischen Theologie gedacht. Des Weiteren wird im vierten Kapitel die Vorherbestimmung sowie die Willensfreiheit des Menschen bei Nursi erörtert. Auf Basis dieser Ausführungen werde ich mich im letzten Kapitel der spezifischen Fragestellung der Arbeit widmen. Wenn der Koran und ihm folgend Nursi die Kohärenz der Vorherbestimmung Gottes und die Willensfreiheit des Menschen annehmen, wie lassen sie sich dann beide in Einklang bringen? Wie versucht Nursi diese scheinbar sich gegenseitig ausschließenden ‚Realitäten‘ zu harmonisieren? Nach Darlegung seiner Antworten werden im Fazit die Ergebnisse zusammengefasst und besprochen. Nursi verwendet eine sehr metaphorische Sprache in seinen Darstellungen. Um die Authentizität seiner Schilderungen beizubehalten, werde ich mich bei der Beschreibung seiner Ideen daran orientieren. Bei der Darstellung der Thematik und der Untersuchung der Fragen verwende ich die Primärquellen, sprich die Werke von Said Nursi im osmanisch-türkischen Original sowie ihre Übersetzungen in Deutsch und Englisch. Darüber hinaus ziehe ich Sekundärquellen, die sich direkt mit Nuris Gedanken auseinandersetzen, heran und bemühe ebenso Werke, die genannte Themen im Allgemeinen erläutern. Ich verwende in meiner Arbeit die Koranübersetzung von Max Henning. Für die Begriffe „Allah“ und „Kalāmwissenschaften“ werden die deutschsprachigen Entsprechungen „Gott“ und „Systematische Theologie“ verwendet. Alttürkische (osmanische) Personen- und Städtenamen werden im Text so geschrieben wie in der türkischen Lateinschrift, in der auch das Werk Nursis gedruckt wurde. Arabische Fachtermini werden gemäß der DMG transkribiert. Termini, die in den zitierten Übersetzungen anders transkribiert wurden, werden jedoch so belassen. Begriffe wie Koran, Scharia etc., die sich im Deutschen eingebürgert haben, werden nicht transkribiert.
The measurement of dielectrons (electron-positron pairs) allows to investigate the properties of strongly interacting matter, in particular the Quark-Gluon Plasma (QGP), which is created in relativistic heavy-ion collisions at the LHC. The evolution of the collision can be probed via dielectrons since electrons do not interact strongly and are created during all stages of the collision. One of the interests in dielectron measurements is motivated by possible modifications of the electromagnetic emission spectrum in the QGP, where pp collisions are used as a medium-free reference. The dielectron spectrum consists of contributions from various processes. In order to estimate contributions of known dielectron sources, simulations of the so-called dielectron cocktail are performed. In this thesis, dielectron cocktails in minimum bias pp collisions at p s = 7 TeV, p–Pb collisions at p sNN = 5.02 TeV and in central (0-10%) and semi-central (20-50%) Pb–Pb collisions at p sNN = 2.76 TeV at the LHC are presented.
Dil öğretiminde geleneksel öğretmen merkezli ve dilbilgisi ağırlıklı metotlardan gitgide uzaklaşılmaktadır. Bu çalışmada işitsel ve görsel araçlardan biri olarak tiyatronun ders dışı sosyal aktivite olarak kullanımı ve öğrenimi hızlandırıcı etkisi incelenmiştir.
Bu amaç ile Akdeniz Üniversitesi Yabancı Diller Yüksekokulu tarafından Türkiye Burslusu 43 farklı ülkeden 70 öğrenciye (Tablo1) 30 Eylül 2013-27 Haziran 2014 tarihleri arasında verilen Türkçe eğitimi programı kullanılmıştır. Öğrencilere 960 saat Türkçe eğitimi verilmesinin yanı sıra haftada 2 saatten az olmamak üzere sosyal aktivite adı altında ek çalışmalara (koro, dans, tiyatro vs.) yönlendirilmişlerdir.
Bu çalışmada, hedef dilin öğretilmesinde tiyatro tekniğinin/ çalışmalarının öğrencinin hedef dildeki performansına etkisini belirlemek amacıyla ön test-son test kontrol gruplu yarı deneysel araştırma deseni kullanılmıştır.
Çalışma sonunda; Konuşma becerisi açısından bakıldığında Yabancı Dil Olarak Türkçe'nin Öğretilmesi (YDT) konusunda Akdeniz Üniversitesi Yabancı Diller Yüksekokulu bünyesinde ders dışında ‒ sosyal etkinlik olarak ‒ uygulanmakta olan Tiyatro Çalışmalarının öğrencilerin dil edinme performanslarına etkisinin olumlu olduğu bulgusuna ulaşılmıştır. Bununla beraber, üç alt bulgu da tespit edilmiştir: Konuşma becerisi açısından bakıldığında tiyatro çalışmalarını takip eden öğrenciler ile bu çalışmalara katılmayan öğrencilerin sınav sonuçları arasında belirli bir farklılığın olduğu sınav sonuçlarının analizi ile ortaya konulmuştur. Ayrıca, Yeterlik sınav sonucu değerlendirildiğinde tiyatro çalışmalarını takip eden öğrenciler ile bu çalışmalara katılmayan öğrencilerin sınav sonuçları arasında belirli bir farklılığın da tespiti yapılmıştır. Bunlara ek olarak, "Motivasyon açısından bakıldığında, tiyatro çalışmalarını takip eden öğrenciler ile bu çalışmalara katılmayan öğrencilerin sınav sonuçları arasında belirli bir farklılık var mıdır?" alt hipotezi de tiyatro çalışmalarının öğrenci motivasyonunu arttırdığı belirlenmiştir.
Bu bağlamda, her hafta hazırlanan öğrenci gelişim raporu ile öğrencinin dil gelişimi, motivasyonu ve öğrencinin ilgi alanları (müzik, dans, drama vs.) danışman öğretim elemanları tarafından değerlendirilmesi uygulamalarına gelecek akademik yıllarda da devam edilmesi kurumca kararlaştırılmıştır.
"Mais pourquoi, Madonna, ma pensée était-elle souvent inquiète de vous et sou-cieuse, bien que je fisse effort pour imaginer que vous étiez auprès de cette femme admirable, dont le visage s’est associé malgré moi dans mon âme au souvenir de grandes oeuvres d’art!" So heißt es in einem Brief, den Rilke Madeleine Annette de Broglie im August 1906 von der Sommerresidenz seines Gönners Karl von der Heydt aus zukommen ließ. Mit feiner Feder ist ihm eingeschrieben, wie die Adelige mit italienischen Wurzeln auf den Dichter gewirkt haben mag, sie, die "Madonna", wie Rilke sie nannte. Über mehrere Jahre – die Korrespondenz erstreckt sich von 1906 bis 1909 – stand Rilke mit ihr, deren zweite Ehe mit Prince Robert de Broglie 1906 gerichtlich für ungültig erklärt wurde, in Verbindung.
Imitation paradigms are used in various domains of developmental psychological research to assess various cognitive processes such as memory (deferred imitation), action perception and action understanding (mainly direct imitation), as well as categorization and learning about objects (deferred imitation with a change in target objects and generalized imitation). Although these processes are most likely not independent from each other, their relations are still largely unclear. On the one hand, deferred imitation studies have shown that infants' performance improves with increasing age, resulting in the reproduction of more target actions after longer delay intervals. On the other hand, imitation studies focusing on infants' action understanding have found that infants do not necessarily imitate the model's exact actions – actions or action steps that seem to be irrational or irrelevant are omitted by infants under certain circumstances (selective imitation). Additionally, findings of imitation studies that require a transfer of the target actions to novel objects have demonstrated that infants do not only learn about actions, but also about objects, when they engage in imitation.
The present dissertation aims at integrating different perspectives of imitation research by testing 12- and 18-month-old infants in deferred imitation tests consisting of functional vs. arbitrary target actions, and by combining deferred imitation with eye tracking in half of the experiments. A deferred imitation paradigm was chosen to assess memory performance. Systematic variation of target action characteristics enabled the assessment of infants' imitation pattern, i.e., if they would imitate one kind of target actions more frequently than the other. Functionality was chosen as the action characteristic in focus because function is an object's most important property, thus this variation might shed some light on infants' learning about objects in the context of an imitation test. The main goal of the eye tracking experiments was to tackle the relations between infants' visual attention to, and deferred imitation of, different kinds of target actions.
The behavioral experiments revealed that both 12- and 18-month-olds imitated significantly more functional than arbitrary target actions after a delay of 30 minutes. In addition, while 12-month-olds showed a memory effect only for functional actions, 18-month-olds showed a memory effect for both kinds of actions. Thus, 12-month-olds imitated strictly selectively, and 18-month-olds imitated more exactly. This shows that the well established memory effect is modulated by target action functionality, which affects 12- and 18-month-olds' imitation differently. Furthermore, when retested after a two weeks delay, 18-month-olds' performance rates of functional and arbitrary target actions decreased parallel. This suggests that selective imitation is not affected by the duration of the retention interval, and that selection of target actions takes place at an earlier stage of action perception and memory processes.
In the eye tracking experiments, both 12- and 18-month-olds' imitation patterns replicated the findings of the behavioral experiments, showing consistently higher imitation rates of functional than arbitrary target actions. Contrary to this, infants' fixation times to the target actions were not affected by target action functionality. This contrast was supported by statistical analyses that found no clear correspondence between visual attention to and deferred imitation of target actions. This suggests that selective imitation cannot be explained by selective visual attention. Nevertheless, finer-grained analyses of gaze and imitation data in the 18 months old group suggested that infants' increased attention to the social-communicative context of the imitation task was related to more exact imitation, i.e. imitation of not only functional, but also arbitrary target actions.
The findings are discussed against the background of imitation theories, with regard to the relations between different cognitive processes underlying infants' imitation, such as memory, action perception and learning about objects.
In Deutschland erhalten jährlich etwa 12.500 Patienten die Diagnose Leukämie. Unter ihnen befinden sich ca. 6 % Kinder, welche mit 33,8 % den größten Anteil der kindlichen Krebsneuerkrankungen repräsentieren. Die überwiegende Form im Kindesalter ist die akute lymphatische Leukämie (ALL), deren genetische Ursache meistens in einem hyperdiploiden Karyotyp oder einer chromosomalen Translokation zu finden ist. Bei 8 % der pädiatrischen ALLs ist ein Rearrangement des MLL-Gens involviert. Unter Beteiligung des häufigsten Translokationspartnergens (TPG) AF4 entsteht die t(4;11)(q21;q23)-Translokation mit den beiden Fusionsproteinen AF4•MLL sowie MLL•AF4. Die Therapie erfolgt in der Regel gemäß Hochrisikoprotokollen aufgrund der extrem schlechten Prognose und der mit hoher Therapieresistenz assoziierten Rezidivrate. Eine Studie zur Korrelation zwischen klinischen Merkmalen und molekularen Charakteristika belegte die Abhängigkeit des Outcomes von der Verteilung des Bruchpunkts im MLL-Gen. Bei älteren Patienten treten die Bruchpunkte überwiegend in MLL Intron 9 oder 10 auf und bedeuten eine signifikant bessere Prognose im Vergleich zu den besonders bei Säuglingen präsenten Bruchpunkten im MLL Intron 11. Die damit verbundene Verkürzung der Plant Homeodomain (PHD) 1 kann neben einer modifizierten Funktion des PHD1 auch in einer veränderten Konformation der gesamten PHD-Domäne resultieren. Besondere Bedeutung hat die PHD1-3-Domäne wegen der Fähigkeit des PHD3 einerseits H3K4me-Signaturen zu erkennen und auf der anderen Seite mit CYP33 zu interagieren. Die mit transkriptionell aktivem Chromatin assoziierten H3K4me-Signaturen sowie die CYP33-vermittelte repressive Aktivität bedingen einen ambivalenten Charakter des MLL-Proteins. Daneben ist der PHD3 allein interessant wegen des Vorkommens von 4 differenten Varianten mit keinen, 3, 11 oder 14 fehlenden Aminosäuren, welche durch alternatives Spleißen an der MLL Exon 15/16-Verknüpfung entstehen (PHD3-0, PHD3-3, PHD3 11 und PHD3-14). Semiquantitative Bestimmungen in verschiedenen Zelllinien verdeutlichen die nahezu ähnliche Transkription aller 4 Varianten. Weiterführende Untersuchungen mit dem Yeast Two-Hybrid (Y2H)-System sowie folgende Koimmunpräzipitations (CoIP)-Experimente zeigten, dass der PHD3-0 die beste Dimerisierungsfähigkeit aufweist. Dagegen ist der am schlechtesten dimerisierende PHD3-3 allein in der Lage, CYP33 bzw. dessen RRM-Domäne zu binden. Die Interaktion mit inhibitorischen Proteinen und die folgende Funktion als transkriptioneller Repressor sind allein mit der PHD3-3-Variante möglich. Bei Betrachtung der gesamten PHD1-3-Domäne sowie deren verkürzter Variante (ΔPHD1-3) fällt die reduzierte Bindungsfähigkeit der ΔPHD1-3-Domäne an die CYP33 RRM-Domäne sowie deren fehlende Dimerisierung auf. Über die resultierende geringere Bindung an inhibitorische Proteine kann die transkriptionell repressive Aktivität reduziert werden, während die transkriptionell aktive Funktion an Bedeutung gewinnt. Neben der Untersuchung der PHD-Domänen des MLL-Proteins wurde das Y2H-System zur weiteren Aufklärung der AF4- und AF4•MLL-Multiproteinkomplexe (MPC) verwendet. Ähnlich den Wildtypproteinen MLL und AF4 sind auch die beiden aus der t(4;11)(q21;q23)-Translokation resultierenden Fusionsproteine an der Assemblierung von MPCs beteiligt. Besonders das reziproke AF4•MLL scheint bezüglich des Therapieerfolgs für die Leukämogenese entscheidend zu sein. Die Identifizierung und Verifizierung sowohl bekannter als auch neuer Komponenten der AF4- und AF4•MLL-MPCs gelang in verschiedenen Experimenten. Allerdings wurde meist nur die Präsenz der Proteine im MPC nachgewiesen. Die Y2H-Untersuchungen konnten Interaktionen zwischen den verschiedenen Proteinen der Komplex identifizieren und damit die Kenntnis über die Zusammensetzung der MPCs wesentlich erweitern und vertiefen. Aufgrund der Beteiligung viraler Proteine an der Krebsentstehung sowie der Rekrutierung von Transkriptionsfaktoren der Wirtszelle für die virale Replikation erscheint auch die Nutzung der Superelongationskomplexe (SEC) durch virale Proteine plausibel. Die Funktion des AF4-Proteins als Kofaktor von viralen Proteinen, besonders der HCMV und EBV immediate early (IE)-Proteine, wurde bereits gezeigt. Außerdem konnte der Einfluss des HCMV IE1 auf AF4-abhängige Effekte sowie dessen Beteiligung am AF4-MPC nachgewiesen werden. Mithilfe der Y2H-Experimente konnten nicht nur Interaktionen des HCMV IE1 sondern auch Wechselwirkungen der Onkoproteine E6/E7 des HPV mit den Proteinen der AF4- und AF4•MLL-MPCs identifiziert werden.
Die Gleichgültigkeit der Natur gegenüber der menschlichen Existenz wird bei Rainer Maria Rilke in seiner letzten Schaffensphase in der Schweiz mit einer ähnlichen Radikalität sprachlich-dichterisch kompensiert wie er früher das restlose Hineinbilden (nicht Abbilden!) der Welt in das Sprachkonstrukt nach den Vorbildern von Baudelaire, Rodin und Cézanne – um hier nur die wichtigsten zu nennen – vom eigenen Sprachinstrument forderte. Ich nehme an, daß Rilkes späteste Dichtung und Poetologie nur in engster Verbindung mit dem Konzept des Verzichts ausgelegt werden kann. Exemplarisch für die Poetik dieses lyrischen Ausgleichs im Kontext des spätesten Werkes ist die Sinnfigur der Fontäne, die Produktionsweise und Funktion der dichterischen Bilder illustriert und eine immanente Reflexion auf den Sinn und die Zielvorstellungen des dichterischen Schaffens enthält.
Croatian negative indefinite expressions, or the so-called ni-words, are complex forms made by adding the prefix ni- to simple forms of indefinite pronouns. The Croatian standard norm prescribes that in prepositional phrases involving negative idefinite pronouns (the so-called ni-pronouns), the negative element ni should be separated from the pronoun and put in front of the preposition. However, in everyday communication one may often notice the use of the word order P + negative indefinite pronoun, and this word order has also made its way into newspapers and other media. This paper attempts to determine whether there is a significant difference in meaning between the order ni + P + indefinite pronoun and the order P + negative indefinite pronoun to account for such a change in language. We also analyze the frequency of use of these two different word orders in the Croatian National Corpus, examining eleven most frequent prepositions and six simple indefinite pronouns.
U radu se ukratko prikazuje Klaićev opis bizovačkoga govora i podjela donjopodravskih govora na dva međusobno ponešto različita tipa: valpovački akcenatski tip govora – okolica Bizovca do Donjega Miholjca – i šaptinovački akcenatski tip – od Donjega Miholjca prema Virovitici. Obilježja bizovačkoga govora uspoređuju se s govorom Podravskih Podgajaca.
The term culture of knowledge has become a commonplace today and is circulating with a confusing diversity of meanings throughout various disciplines and fields, like Cultural Studies, Science Studies, History of Science, Epistemology, Sociology and History of Knowledge. This paper investigates the origins of the term culture of knowledge and discusses its various meanings, applications, and misconceptions in Cultural Theory, History of Science, Historical Epistemology and History of Knowledge. Finally, Ludwik Fleck's theory of thought-styles is proposed as an ideal model for describing specific cultures of knowledge.
BACKGROUND: Transient episodes of ischemia in a remote organ or tissue (remote ischemic preconditioning, RIPC) can attenuate myocardial injury. Myocardial damage is associated with tissue remodeling and the matrix metalloproteinases 2 and 9 (MMP-2/9) are crucially involved in these events. Here we investigated the effects of RIPC on the activities of heart tissue MMP-2/9 and their correlation with serum concentrations of cardiac troponin T (cTnT), a marker for myocardial damage.
METHODS: In cardiosurgical patients with cardiopulmonary bypass (CPB) RIPC was induced by four 5 minute cycles of upper limb ischemia/reperfusion. Cardiac tissue was obtained before as well as after CPB and serum cTnT concentrations were measured. Tissue derived from control patients (N = 17) with high cTnT concentrations (≥0.32 ng/ml) and RIPC patients (N = 18) with low cTnT (≤0.32 ng/ml) was subjected to gelatin zymography to quantify MMP-2/9 activities.
RESULTS: In cardiac biopsies obtained before CPB, activities of MMP-2/9 were attenuated in the RIPC group (MMP-2: Control, 1.13 ± 0.13 a.u.; RIPC, 0.71 ± 0.12 a.u.; P < 0.05. MMP-9: Control, 1.50 ± 0.16 a.u.; RIPC, 0.87 ± 0.14 a.u.; P < 0.01), while activities of the pro-MMPs were not altered (P > 0.05). In cardiac biopsies taken after CPB activities of pro- and active MMP-2/9 were not different between the groups (P > 0.05). Spearman's rank tests showed that MMP-2/9 activities in cardiac tissue obtained before CPB were positively correlated with postoperative cTnT serum levels (MMP-2, P = 0.016; MMP-9, P = 0.015).
CONCLUSIONS: Activities of MMP-2/9 in cardiac tissue obtained before CPB are attenuated by RIPC and are positively correlated with serum concentrations of cTnT. MMPs may represent potential targets for RIPC mediated cardioprotection.
TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT00877305.
Die großen Dichter der Römer haben in der abendländischen - und nicht zuletzt in der deutschen - Literatur des 20. Jahrhunderts ein äußerst produktives Nachleben genossen. In seinem 'Tod des Vergil' (1945) befasst sich Hermann Broch einfühlsam mit Leben und Werk des Dichters der Äneis. In Christoph Ransmayrs 'Die letzte Welt' (1988) tritt Ovid als Person nie in Erscheinung, aber die Forschungen des Romanhelden enthüllen das problematische Verhältnis von Fiktion und Wirklichkeit im Leben Ovids während seines Exils im fernen Tomis und in den Erzählungen seiner Metamorphosen. Günter Grass' Roman örtlich betäubt (1969) bietet unter anderem eine einsichtsvolle Analyse der Bedeutung Senecas als Seismograph für jeweils drei Generationen von Deutschen der Bundesrepublik. Und Lukrez?
Titus Lucretius Carus (circa 94-54 v.Chr.), der in der Geschichte der lateinischen Literatur als epischer Dichter neben, ja manchmal sogar über Vergil gestellt wird und vor allem als wichtigster Befürworter des Epikureismus im Rom des ersten Jahrhunderts v.Chr. galt, spielt in der Literatur des 20. Jahrhunderts kaum noch eine Rolle. Wenn auch die atomistischen und vermeintlich antireligiösen Lehren seines 'De Rerum Natura' während des christlichen Mittelalters abgelehnt wurden, schätzten ihn sogar seine Gegner als einen großen Sprachkünstler. Nach seiner Wiederentdeckung in der Renaissance wurde er zunehmend als Philosoph und Naturwissenschaftler geschätzt. Aber nachdem sein Einfluss im 19. Jahrhundert bei vielen Dichtern noch hochstand, wurde sein Name danach immer seltener erwähnt. Seit der wichtigen Vortragsreihe George Santayanas über Lucretius, Dante und Goethe - Three Philosophical Poets (1910) - haben sich zwar immer wieder akademische Philosophen mit seinem Denken befasst; aber die einzige ausführliche Studie über Lukrez und die Moderne kann nur wenige literarische Beispiele heranziehen: neben den Italienern Italo Calvino und Primo Levi und dem Österreicher Raoul Schrott, die im Vorübergehen erwähnt werden, werden nur einige anglo-amerikanische Dichter zitiert, die sich aber nie ausführlich mit Lukrez oder seinem Werk beschäftigen. In einer wichtigen deutschen Forschung zur Antikerezeption wird nach Goethe nur noch Heinrich Mann erwähnt, in dessen Roman 'Die Vollendung des Königs Henri Quatre' (1938) Zitate aus mehreren lateinischen Dichtern, einschließlich Lukrez, vorkommen.
Warum dieses Schweigen?
Theater der Spur
(2014)
Reduction and deletion processes occur regularly in conversational speech. A segment that is affected by such reduction and deletion processes in many Germanic languages (e.g., Dutch, English, German) is /t/. There are similarities concerning the factors that influence the likelihood of final /t/ to get deleted, such as segmental context. However, speakers of different languages differ with respect to the acoustic cues they leave in the speech signal when they delete final /t/. German speakers usually lengthen a preceding /s/ when they delete final /t/. This article investigates to what extent German listeners are able to reconstruct /t/ when they are presented with fragments of words where final /t/ has been deleted. It aims also at investigating whether the strategies that are used by German depend on the length of /s/, and therefore whether listeners are using language-specific cues. Results of a forced-choice segment detection task suggest that listeners are able to reconstruct deleted final /t/ in about 45% of the times. The length of /s/ plays some role in the reconstruction, however, it does not explain the behavior of German listeners completely.
This paper is the first to conduct an incentive-compatible experiment using real monetary payoffs to test the hypothesis of probabilistic insurance which states that willingness to pay for insurance decreases sharply in the presence of even small default probabilities as compared to a risk-free insurance contract. In our experiment, 181 participants state their willingness to pay for insurance contracts with different levels of default risk. We find that the willingness to pay sharply decreases with increasing default risk. Our results hence strongly support the hypothesis of probabilistic insurance. Furthermore, we study the impact of customer reaction to default risk on an insurer’s optimal solvency level using our experimentally obtained data on insurance demand. We show that an insurer should choose to be default-free rather than having even a very small default probability. This risk strategy is also optimal when assuming substantial transaction costs for risk management activities undertaken to achieve the maximum solvency level.
Halting biological invasions in Europe : from data to decisions ; a message from NEOBIOTA 2012
(2014)
The NEOBIOTA conferences initiated by the European Group on Biological Invasions represents a forum for exchange of ideas and discussion of topics related to biological invasions as well as an interface between science, application and policies (Kowarik and Starfinger 2009). The 7th NEOBIOTA conference (http://neobiota2012.blogspot.com.es/), held in Pontevedra (Spain) from 12–14 September 2012, brought together 288 participants (ecologists, conservationists, representatives of governmental agencies and stake-holders), from 24 European countries and 9 non-European ones (namely, Australia, Brazil, Canada, Chile, Colombia, New Zealand, South Africa, United States and Venezuela).
Die randomisierte, dreiarmig kontrollierte Studie zu täglicher, peroraler Zusatzkost (ONS) bei Hämodialysepatienten (CHD) im Endstadium der Niereninsuffizienz (ESRD) über 6 Monate zeigte keine signifikanten Verbesserungen hinsichtlich folgender Nutritions-/Retentions- und Inflammationsparameter: Subjective Global Assessment (SGA); Body Mass Index (BMI); Querschnitt des Muskulus Iliopsoas,Oberarmumfang und Dicke des Unterhautfettgewebes (MRT); örperzellmasse und Phasenwinkel (Bioimpedanzanalyse BIA); Tumornekrosefaktor α (TNFα); Interleukin 1β und 6 (IL-1β und IL-6); C-Reaktives Protein (CRP). Der Querschnitt des Muskulus biceps brachii blieb in der Kontrollgruppe anfangs und zum Ende höher wie in den Interventionsgruppen. Der Serumkreatininwert der Interventionsgruppe mit HIV war anfangs geringer als in den übrigen Gruppen, die glomeruläre Filtrationsrate entsprechend besser, zum Ende waren diese Unterschiede nivelliert. Der Hauptbefund liegt in der hohen Mortalitätsrate der HIV-positiven Hämodialysepatienten (2 von 7 Pat., 28,6%), von denen beide im SGA als schwer mangel-/fehlernährt eingestuft wurden. Die Therapie eines Malnutritions-Infalmmations-Komplexes ist nicht allein durch orale Zusatzkost möglich. Weitere Studien müssen multimodale Konzepte zur Diagnose und zur Therapie erforschen. Hierzu kann perorale Zusatzkost ein einfach durchzuführendes Mittel als Teil der Behandlungsstrategie sein, zur erweiterten Diagnose kann die Bioimpedanzanalyse eine Möglichkeit sein, um den Teilaspekt der Nutritionskontrolle zu erfüllen.
Zur Flora von Deutschland gehören sieben Arten der Wintergrüngewächse, die alle auch in Sachsen-Anhalt heimisch sind: Dolden-Winterlieb (Chimaphila umbellata [L.] BARTON), Einblütiges Wintergrün (Moneses uniflora [L.] A. GRAY), Birngrün (Orthilia secunda [L.] HOUSE), Grünblütiges Wintergrün (Pyrola chlorantha SW.), Mittleres Wintergrün (Pyrola media SW.), Kleines Wintergrün (Pyrola minor L.) und Rundblättriges Wintergrün (Pyrola rotundifolia L.). Im Mittelpunkt dieses Beitrages steht nur die aktuelle Verbreitung im Bundesland mit Bezug auf MTB-Q4, und zwar bezogen auf zwei Perioden von jeweils 10 Jahren: Nachweise im MTB-Q4 von 2005 bis 2014, sowie Nachweise im MTB-Q4 von 1995 bis 2004.
This dataset represents a registry of species that are not native but recorded to live in the wild of at least one of the four countries that comprise the Two Seas Area, i.e. Great Britain, France, Belgium and the Netherlands. For each of the 6,661 species, subspecies and hybrids listed, we provide detailed information on its status in each country, taxonomic affiliation and environment inhabited. The data were collected by review of 36 web- and print-based sources over an eight-month period. Further systematic scanning of three of the most relevant scientific journals, i.e. Neobiota, Aquatic Invasions and BioInvasions Records, recovered 19 additional relevant publications from which information was included in the registry. As a result, the registry will serve as a basis for developing effective, cross-boundary strategies to manage and control non-native species, which can have severe ecological and economic impacts. The registry can further be used as a general reference for both scientists and practitioners, as well as a tool to assess reliability and comprehensiveness of other well-known databases such as the DAISIE portal.
Plexins are widely expressed transmembrane proteins that mediate the cellular effects of semaphorins. The molecular mechanisms of plexin-mediated signal transduction are still poorly understood. Here we show that signalling via B-family plexins leading to the activation of the small GTPase RhoA requires activation of the IκB kinase (IKK)-complex. In contrast, plexin-B-dependent regulation of R-Ras activity is not affected by IKK activity. This regulation of plexin signalling depends on the kinase activity of the IKK-complex, but is independent of NF-κB activation. We confirm that the IKK-complex is active in tumour cells and osteoblasts, and we demonstrate that plexin-B-dependent tumour cell invasiveness and regulation of osteoblast differentiation require an active IKK-complex. This study identifies a novel, NF-κB-independent function of the IKK-complex and shows that IKK directs plexin-B signalling to the activation of RhoA.
Ziel dieser Arbeit war, mittels einer (n,γ)-Aktivierung, 129Te zu erzeugen und eine Teilchenzahlbestimmung durchzuführen. Aktivierung der Probe am Forschungsreaktor TRIGA und Spektrenaufnahme mittels eines HPGe-Detektors erfolgten im Mai 2014 am Institut für Kernchemie der Johannes Gutenberg Universität in Mainz.
Die Teilchenzahl des Tochternuklids 129I kann anhand der Teilchenzahlen des Isomers und des Grundzustandes von 129Te berechnet werden. In den Aktivierungen #2 bis #6 wurden (14.27 ± 0.53)x10exp12 Iodnuklide erzeugt. Angegeben ist die maximal mögliche Anzahl von Iodteilchen bei unendlich langer Wartezeit und vollständigem Zerfall aller Tellurnuklide.
Beobachtet werden konnte die Abnahme der Grundzustandsaktivität bis zum Erreichen des Gleichgewichts aus Nachbevölkerung durch das Isomer und Zerfall. Die Grundzustandslinien der Energien von 459.60 keV, 487 keV, 1083 KeV und 1111 keV konnten zu dieser Untersuchung herangezogen werden. Diese 4 Linien erfüllen die erforderten Konsistenzkriterien bezüglich der Systematik und können daher zur Teilchenzahlbestimmung des Grundzustandes verwendet werden (Seite 31).
Der Einfluss der Eigenabsorption ist noch zu untersuchen, da die genaue Position der Probe im Polyethylenbehältnis nicht bestimmt werden konnte. Weiterhin ist die Datenanalyse der ersten Aktivierung aufgrund des Detektorwechsels noch nicht erfolgt. Der Austausch war wegen technischer Probleme notwendig. Ziel weiterführender Untersuchungen ist, eine erneute Halbwertszeitbestimmung des radioaktiven 129I vorzunehmen. Sie ist von Interesse, angesichts des Widerspruchs zweier Veröffentlichungen. Die Halbwertszeit des 129I kann Aufschluss über stellare Bedingungen des s-Prozesses geben.
Justice, not development : Sen and the hegemonic framework for ameliorating global inequality
(2014)
Starting from the merits of Sen's "Development as freedom", the article also explores its shortcomings. It argues that they are related to an uncritical adoption of the discourse of "development", which is the hegemonic framework for ameliorating global inequality today. This discourse implies certain limitations of thought and action, and the article points out three areas where urgent questions of global justice have been largely ignored by development theory and policy as a consequence. Struggles for justice on a global scale, this is the conclusion, should not take the detour of "development".
In the past sixty years, excessive water consumption and dam construction have significantly influenced natural flow regimes and surface freshwater ecosystems throughout China, and thus resulted in serious environmental problems. In order to balance the competing water demands between human and environment and provide knowledge on sustainable water management, assessments on anthropogenic flow alterations and their impacts on aquatic and riparian ecosystems in China are needed.
In this study, the first evaluation on quantitative relationships between anthropogenic flow alterations and ecological responses in eleven river basins and watersheds in China was performed based on the data that could be obtained from published case studies. Quantitative relationships between changes in average annual discharge, seasonal low flow and seasonal high flow and changes in ecological indicators (fish diversity, fish catch and vegetation cover, etc.) were analyzed. The results showed that changes in riparian vegetation cover as well as changes in fish diversity and fish catch were strongly correlated with the changes in flow magnitude (r = 0.77, 0.66), especially with changes in average annual river discharge. In addition, more than half of the variations in vegetation cover could be explained by changes in average annual river discharge (r² = 0.63) and roughly 50 % changes in fish catch in arid and semi-arid region and 60% changes of fish catch in humid region could be related to alterations in average annual river discharge (r² = 0.53, 0.58).
In a supplementary analysis of this study, the first estimation on quantitative relationships between decreases in native fish species richness and anthropogenic flow alterations in 34 river basins and sub-basins in China was conducted. Linear relationships between losses of native fish species and five ecologically relevant flow indicators were analyzed by single and multiple regression models. For the single regression analysis, significant linear relationships were detected for the indicators of long-term average annual discharge (ILTA) and statistical low flow Q90 (IQ90). For the multiple regressions, no indicator other than ILTA has significant relationships with changes in number of fish species mainly due to collinearity. Two conclusions emerged from the analysis: 1) losses of fish species were positively correlated with changes in ILTA in China and 2) indicator of ILTA was dominant over other flow indicators included in this research for the given dataset. These results provide a guideline for the sustainable water resources management in rivers with high risk of fish extinction in China.
The investigated haloarchaeal species, Halobacterium salinarum, Haloferax mediterranei, and H. volcanii, have all been shown to be polyploid. They contain several replicons that have independent copy number regulation, and most have a higher copy number during exponential growth phase than in stationary phase. The possible evolutionary advantages of polyploidy for haloarchaea, most of which have experimental support for at least one species, are discussed. These advantages include a low mutation rate and high resistance toward X-ray irradiation and desiccation, which depend on homologous recombination. For H. volcanii, it has been shown that gene conversion operates in the absence of selection, which leads to the equalization of genome copies. On the other hand, selective forces might lead to heterozygous cells, which have been verified in the laboratory. Additional advantages of polyploidy are survival over geological times in halite deposits as well as at extreme conditions on earth and at simulated Mars conditions. Recently, it was found that H. volcanii uses genomic DNA as genetic material and as a storage polymer for phosphate. In the absence of phosphate, H. volcanii dramatically decreases its genome copy number, thereby enabling cell multiplication, but diminishing the genetic advantages of polyploidy. Stable storage of phosphate is proposed as an alternative driving force for the emergence of DNA in early evolution. Several additional potential advantages of polyploidy are discussed that have not been addressed experimentally for haloarchaea. An outlook summarizes selected current trends and possible future developments.
Haloferax volcanii uses extracellular DNA as a source for carbon, nitrogen, and phosphorous. However, it can also grow to a limited extend in the absence of added phosphorous, indicating that it contains an intracellular phosphate storage molecule. As Hfx. volcanii is polyploid, it was investigated whether DNA might be used as storage polymer, in addition to its role as genetic material. It could be verified that during phosphate starvation cells multiply by distributing as well as by degrading their chromosomes. In contrast, the number of ribosomes stayed constant, revealing that ribosomes are distributed to descendant cells, but not degraded. These results suggest that the phosphate of phosphate-containing biomolecules (other than DNA and RNA) originates from that stored in DNA, not in rRNA. Adding phosphate to chromosome depleted cells rapidly restores polyploidy. Quantification of desiccation survival of cells with different ploidy levels showed that under phosphate starvation Hfx. volcanii diminishes genetic advantages of polyploidy in favor of cell multiplication. The consequences of the usage of genomic DNA as phosphate storage polymer are discussed as well as the hypothesis that DNA might have initially evolved in evolution as a storage polymer, and the various genetic benefits evolved later.
Die französischen Gedichte Rilkes können trotz einiger Interpretationen, die ausschließlich die späteren Gedichte betreffen, noch weitgehend als oeuvre inconnue bezeichnet werden, dies gilt im besonderen Maße für die vor 1923 entstandenen Gedichte, die im Allgemeinen als wenig interessant gelten. Dass das 1920 in Bern entstandene Gedicht "Nénuphar" durchaus literarische Qualitäten hat, soll im Folgenden
gezeigt werden.
Nach der Entdeckung und strukturellen Aufklärung des Ribosoms war bekannt, dass neben den Proteinen auch regulatorische RNA Sequenzen für die Steuerung biologischer Prozesse im Organismus verantwortlich sind. Dazu zählt unter anderem das trans-activation responsive element (TAR) aus HIV-1, welches am terminalen 5' Bereich (1-59) aller HIV-1 mRNAs eine identische bulge-loop Struktur ausbildet. Die basale Trans-kription des integrierten HIV Promotors ist in Abwesenheit des viralen trans-activator of transcription (Tat) sehr gering (und abhängig von zellulären Transkriptionsfaktoren). Sobald Tat exprimiert wird, bindet es zusammen mit dem humanen positive trancription elongation factor b (p-TEFb) spezifisch an TAR und aktiviert die Transkriptionsrate des viralen Genoms und die Bildung von volllängen Transkripten drastisch. Die Notwendigkeit der Tat-vermittelten Aktivierung als Grundlage einer funktionierenden HIV Replikation macht dieses System zu einem hoch interessanten Target für eine antivirale HIV Therapie. Basierend auf der Hemmung des Tat/TAR Komplexes wurde in den vergangen Jahren eine Reihe von Verbindungen identifiziert, die zwar in-vitro eine inhibierende Wirkung zeigten, aber keine von ihnen konnte bis jetzt als Therapeutikum Verwendung finden. So wäre die noch ausstehende Entdeckung eines effizienten Tat Antagonisten, der ohne die zelleigene Transkription zu beeinträchtigen eine Reduzierung der Virusreplikation von 80 - 90 % akut infizierter Zellen bewirkt, ein bedeutender Durchbruch in der HIV Forschung. Durch eine längere Behandlung von chronisch infizierten Zellen könnte so die Transkription des viralen Genoms abgeschaltet und dadurch eine Eliminierung latenter HIV Reservoirs ermöglichen werden.
Das Ziel dieser Arbeit war die Entwicklung neuartiger TAR Liganden, zunächst auf Grundlage eines nicht auf Strukturmodellen beruhenden Ligandenscreenings, gefolgt von einem strukturbasierten Ligandendesign. Bei der Suche nach potentiellen Wirkstoffen, beschränkte man die Auswahl der untersuchten Verbindungen auf Guanidin- und Amidinanaloga. Dazu zählten einfache Guanidinderivate mit unterschiedlichen aromatischen Resten sowie heterocyclische Verbindungen, wie Isochinoline, Chinazoline, Perimidine und Phenanthridine. Die Bindungsaffinitäten dieser Wirkstoffkandidaten in Bezug zu TAR wurden über einen FRET Assay nach Matsumoto[1] bestimmt. Eine Auswahl an Verbindungen wurde zudem über eine NMR Titration charakterisiert (AK Schwalbe). Dadurch konnte beobachtet werden, an welcher Position die Liganden mit der TAR RNA in Wechselwirkung treten. Bei diesen Untersuchungen zählten 1,7-
Diaminochinolin (IC50 = 150 µM), 2,4,6-Triaminochinazolin (IC50 = 40 µM) sowie 6,8-Diaminophenanthridin (IC50 = 15 µM) zu den aktivsten Verbindungen.
Um eine Aussage über die Bindungsposen treffen zu können, wurde mittels HF-docking Methoden die Komplexgeometrie energetisch optimiert. Ausgehend von diesen Bindungsmodellen entwickelte man eine Leitstruktur, die als Grundlage eines strukturbasierten Ligandendesigns diente. Im Fokus stand hierbei die Entwicklung einer GC-Basenpaar erkennenden Untereinheit. Mit 3,5-Diamino-9-methyl-3,4,9,10-tetrahydro-1H-pyrrolo[3,4-b]phenanthridin-8(2H)-on (IC50 = 45 µM) konnte ein Ligand identifiziert werden, der im NMR Titrationsexperiment ausschließlich am Basenpaar G26/C39 von TAR eine Verschiebung der Iminoprotonen induzierte. In einem weiteren Projekt versuchte man eine Selektivitätssteigerung durch simultane Adressierung zweier Bindungsstellen zu erreichen. Nachdem im NMR Experiment gezeigt werden konnte, dass 2,4,6-Triaminochinazolin mit hoher Affinität an zwei verschiedenen Bereichen der RNA bindet, wurden eine Reihe dimerer 2,4,6-Triaminochinazolinderivate mit unterschiedlich langen Linkern hergestellt. Mit diesem Ansatz gelang es den hoch affinen Liganden N6,N6'-(1,4-phenylenbis(methylen))bis(chinazolin-2,4,6-triamin) (IC50 = 150 nM) zu identifizieren.
Philologe im "Kriegseinsatz" : der Frankfurter Germanist Julius Petersen und der Erste Weltkrieg
(2014)
Vorlesungen für Studenten und Bildungsangebote für Bürger – wie lässt sich dieser Anspruch der jungen Stiftungsuniversität auch in Zeiten des Krieges realisieren, wenn Professoren wie Studenten ins Feld ziehen müssen? Das Beispiel des Germanisten Julius Petersen zeigt, welche Anstrengungen zwischen 1914 und 1918 unternommen wurden, um "Volksbildung" und "Vaterländischen Unterricht" zu ermöglichen. Dazu gehörten Vorträge an der Front ebenso wie Bürgervorlesungen in der Heimat.
The paper discusses the problem of the possible relation between psychoanalytic concepts and social critique in the perspective of Adorno's social thought. The title refers to Adorno's idea that psyche as individual spontaneity has now lost the weight it used to have in the liberal era. As a brief introductory remark, I clarify the status of theory for Adorno, i.e., the circularity between interpretation and description as grounded by the nature of the social object itself. Then I analyse his core idea of “social objectivity” as an impersonal mechanism which is at the same time produced by men and reified, heteronomous for them, and I argue that, for Adorno, the discontinuity existing between individual and society prevents an immediate shift of psychoanalytic concepts to the social world: the example of fascism clearly proves that the determining social forces today, while instrumentally exploiting deep psychical materials, are not themselves psychological. In the final part, I show how, for Adorno, psychology and sociology nevertheless need to be mediated with each other, while avoiding the superficial synthesis the so-called “revised psychoanalysis” aims to, and I point out some similarities between psychoanalytic practice and social critique as conceived by him.
Taxonomic revision of North American Eusphalerum Kraatz, 1857 (Coleoptera, Staphylinidae, Omaliinae)
(2014)
The North American species of the genus Eusphalerum Kraatz (Coleoptera, Staphylinidae, Omaliinae) are revised. The taxonomic history, natural history, geographical distribution of the genus, characters, species groups, diversity, and biogeography of North American species are presented. Two main phylogenetic lineages and 13 species groups are provisionally recognized. The following new synonymies are proposed: Eusphalerum farrarae (Hatch, 1944) = E. lawrencei Hatch, 1957; Eusphalerum californicum (Fauvel, 1878) = E. atriventre (Casey, 1894), = E. nigerrimum (Casey, 1894), = E. gilvipenne (Casey, 1894), = E. dichroum (Fall, 1922), = E. bonnelli (Hatch, 1944), = E. lunae Hatch, 1957; Eusphalerum fraternum (Casey, 1894) = E. minskae (Hatch, 1944); Eusphalerum rugulosum (Mäklin, 1853) = E. grayae (Hatch, 1944); Eusphalerum orientale (Bernhauer, 1912) = E. frosti (Bernhauer, 1928). The following lectotypes are designated: E. subangulatum (Casey), E. californicum (Fauvel), E. gilvipenne (Casey), E. diversicolle (Casey), E. convexum (Fauvel), E. fraternum (Casey), E. horni (Fauvel), E. orientale (Bernhauer), E. pothos (Mannerheim), and E. punctatum (Casey). The following new species are described: Eusphalerum pilosum (California); E. klimaszewskii (British Columbia); E. chatzimanolisi (California); E. carolinensis (Kentucky, Missouri, North Carolina, Ohio, Pennsylvania, Tennessee, Virginia); E. caterinoi (California); E. luteipes (California); E. thayeranum (Alberta, British Columbia, Idaho, Indiana (doubtful record), Oregon, Washington); E. margaretae (Tennessee); E. newtoni (British Columbia, Oregon, California); E. parvispiculum (California, Oregon); E. uncinatum (British Columbia, California, Oregon, Washington). Eusphalerum lapponicum (Mannerheim, 1830) is excluded from the North American fauna. The following new combination is proposed: Xylodromus segmentarius (Mäklin, 1852: 322) (ex Omalium), wrongly attributed to Eusphalerum in the literature. Omalium marginatum Say, 1832 is considered a doubtful species, probably not Eusphalerum. A key to the 27 recognized North American Eusphalerum species and a catalog of the species are provided.
A survey of spiders of the genus Scytodes Latreille, 1804 in Iran resulted in six species occurring in this country: Scytodes fusca Walckenaer, 1837, S. strandi Spassky, 1941, S. thoracica (Latreille, 1802), S. univittata Simon, 1882 and – recorded for the first time – S. arwa Rheims, Brescovit & van Harten, 2006 and S. makeda Rheims, Brescovit & van Harten, 2006. Illustrations of the newly recorded species and a key to all known Iranian species are presented.
We analyze the risk premium on bank bonds at origination with a special focus on the role of implicit and explicit public guarantees and the systemic relevance of the issuing institutions. By looking at the asset swap spread on 5,500 bonds, we find that explicit guarantees and sovereign creditworthiness have a substantial effect on the risk premium. In addition, while large institutions still enjoy lower issuance costs linked to the TBTF framework, we find evidence of enhanced market disciple for systemically important banks which face, since the onset of the financial crisis, an increased premium on bond placements.
Cryo-electron tomography provides a snapshot of the cellular proteome. With template matching, the spatial positions of various macromolecular complexes within their native cellular context can be detected. However, the growing awareness of the reference bias introduced by the cross-correlation based approaches, and more importantly the lack of a reliable confidence measurement in the selection of these macromolecular complexes, has restricted the use of these applications. Here we propose a heuristic, in which the reference bias is measured in real space in an analogous way to the R-free value in X-ray crystallography. We measure the reference bias within the mask used to outline the area of the template, and do not modify the template itself. The heuristic works by splitting the mask into a working and a testing area in a volume ratio of 9:1. While the working area is used during the calculation of the cross-correlation function, the information from both areas is explored to calculate the M-free score. We show using artificial data, that the M-free score gives a reliable measure for the reference bias. The heuristic can be applied in template matching and in sub-tomogram averaging. We further test the applicability of the heuristic in tomograms of purified macromolecules, and tomograms of whole Mycoplasma cells.
Cryo-electron tomography (CET) is a unique technique to visualize biological objects under near-to-native conditions at near-atomic resolution. CET provides three-dimensional (3D) snapshots of the cellular proteome, in which the spatial relations between macromolecular complexes in their near native cellular context can be explored. Due to the limitation of the electron dose applicable on biological samples, the achievable resolution of a tomogram is restricted to a few nanometers, higher resolution can be achieved by averaging of structures occurring in multiples. For this purpose, computational techniques such as template matching, sub-tomogram averaging and classification are essential for a meaningful processing of CET data.
This thesis introduces the techniques of template matching and sub-tomogram averaging and their applications on real biological data sets. Subsequently, the problem of reference bias, which restricts the applicability of those techniques, is addressed. Two methods that estimate the reference bias in Fourier and real space are demonstrated. The real space method, which we have named the “M-free” score, provides a reliable estimation of the reference bias, which gives access to the reliability of the template matching or sub-tomogram averaging process. Thus, the “M-free” score makes those approaches more applicable to structural biology. Furthermore, a classification algorithm based on Neural Networks (NN) called “KerDenSOM3D” is introduced, which is implemented in 3D and compensates for the missing-wedge. This approach helps extracting different structural states of macromolecular complexes or increasing the class purity of data sets by eliminating outliers. A comprehensive comparison with other classification methods shows superior performance of KerDenSOM3D.
A recent paper on the phylogenetic relationships of species within the cephalopod family Mastigoteuthidae meant great progress in stabilizing the classification of the family. The authors, however, left the generic placement of Mastigoteuthis pyrodes unresolved. This problem is corrected here by placing this species in a new monotypic genus, Mastigotragus, based on unique structures of the photophores and the funnel/mantle locking apparatus.
Examination of the type series of Schizotus gibbifrons Lewis 1887 and Pyrochroa higoniae Lewis 1895, together with examination of the historical Lewis collection of Pseudopyrochroa japonica (Heyden 1879), provide hints as to the conspecifi city of these binomials. This evidence, together with concurrent collection events spanning more than 100 years and general anatomy suggests Pseudopyrochroa japonica (Heyden 1879) and Pseudopyrochroa gibbifrons (Lewis 1887) are conspecifi c. Schizotus gibbifrons Lewis is proposed as a new junior synonym of Pyrochroa japonica Heyden, where it joins the established synonym, Pyrochroa higoniae Lewis (1895). Schizotus theresae Pic 1911 is also proposed as a new junior synonym of Pyrochroa basalis Pic 1906, where it joins a long list of synonyms. Complete synonymies are presented for both species.
Sundapyrochroa, a new genus of pyrochroine Pyrochroidae, is described from three Sunda Shelf species most recently assigned to Pseudopyrochroa Pic: Sundapyrochroa atricolor (Pic), comb. nov., recorded from Peninsular Malaysia, Sundapyrochroa nigripennis (Pic), comb. nov., recorded from Peninsular Malaysia, and Sundapyrochroa sumatrensis (Pic), comb. nov., recorded from Borneo (Malaysia: Sabah) and Sumatra (Indonesia). Schizotus rotundicollis Pic, syn. nov., is proposed as a junior synonym of S. sumatrensis. No evidence could be found to support subspecifi c categories for S. nigripennis, thus, Pseudopyrochroa nigripennis notaticeps Pic, syn. nov., is proposed as a junior synonym of S. nigripennis. Gross anatomy of the cranium (female, male), antennae (female, male), and genitalia (male) are both diagnostic and enigmatic, suggesting no clear relationships with other pyrochroine genera.
The endophallic structure of the genus Laius is studied and discussed based on the examination of 19 species from Asia to the Indian Ocean. The structure contains two primary sclerites (named gonoporal piece and ligula), a secondary sclerite on the basal part of the gonoporal piece (named additional sclerite) in some species, and a membranous basal area closely covered with many spines (named spinous area). Five species groups are recognized based on the morphology of the endophallic sclerites. The sympatric species have different body sizes and quite distinguishable endophallic sclerites (= different species group), while the allopatric species have overlapping body sizes and similar endophallic sclerites (= same species group). Three new species are described and six previously known species are redescribed with endophallic sclerites, and the descriptions of endophallic sclerites of the remaining ten species are added. The larva of Laius rodriguesensis sp. nov. is also described. The genus
Nossibeus Evers, 1994 is synonymised with Laius Guérin-Méneville, 1830.
Orisa Ibeji
(2014)
Ahmed Yerima's play celebrates the phenomenon of twins among the Yoruba people. Orisa Ibeji is also about man's fear of death and love of life; destiny and reincarnation; and the place of the gods in human affairs. Yerima employs simple and beautiful language, dynamic characters and deft skill to navigate the labyrinth that is Orisa Ibeji.
The Fourth Masquerade
(2014)
As one of the most important Nigerian poets who continue to write the nation in verse, Yeibo, in this fifth collection of poems, has strategically fashioned a kind of poetry that does not only derive its idiom from the prosody and folk tradition of the Izon of Nigeria, it equally advances the poet's vision through form and structure. His recourse to folklore and reliance on oral materials in the image making process gives coherence and form to the poems. However, what distinguishes this collection from the previous ones is the question of the form through which he demonstrates an intense awareness of the Nigerian experience.
Cancer is a disease characterized by uncontrolled cell growth and the capacity to disseminate to distant organs. The properties of cancers are caused by genetic and epigenetic alterations when compared to their normal counterparts. Genetic mutations occur in oncogenes and tumor suppressor genes and are the initial drivers of cellular transformation (Lengauer et al., 1998; Vogelstein and Kinzler, 2004). In addition, epigenetic alterations, which influence the expression of oncogenes and tumor suppressor genes independently from sequence alterations, are also involved in the transformation process (Esteller and Herman, 2001; Sharma et al., 2010). Genetic alterations and epigenetic regulatory signals cooperate in tumor etiology. Glioblastoma multiforme (GBM) is a frequent and aggressive malignant brain tumor in humans. The median survival of GBM patients is about 15 months after diagnosis. Like in other cancers, genetic and epigenetic alterations can be detected in GBM. Genetic alterations in GBM affect cell growth, apoptosis, angiogenesis, and invasion; however, epigenetic alterations in GBM also affect the expression of oncogenes or tumor suppresser genes that increase tumor malignancy (Nagarajan and Costello, 2009).
Reprogramming is a cellular process in which somatic cells can be induced to assume the properties of less differentiated stem cells. This process can be mediated through epigenetic modifications of the genome of somatic cells by the action of four defined transcription factors (Oct4, Sox2, Klf4 and Myc) or by the action of the miR 302/367 cluster (Anokye-Danso et al., 2011; Takahashi and Yamanaka, 2006; Takahashi et al., 2007) and result in the generation of induced pluripotent stem cells (iPS cells). Reprogramming of somatic cells by the miR 302/367 cluster can generate nontumorigenic iPS cells through the inhibition of the epithelial to mesenchymal transition (EMT), cell cycle regulatory genes and epigenetic modifiers (Lin and Ying, 2013).
King of the Jungle
(2014)
In King of the Jungle, the bouts of ethno-religious violence in Jos are fused with the heartbreaking story of two brothers who go through life unaware of each other's existence. Carefully crafted with local colour which evokes memories of pre-2001 Jos, Bizuum Yadok's first novel weaves humour, urban realism, tragedy and redemption.
Heme-copper oxidases (HCOs) are the terminal enzymes of the aerobic respiratory chain in the inner mitochondrial membrane or the plasma membrane in many prokaryotes. These multi-subunit membrane protein complexes catalyze the reduction of oxygen to water, coupling this exothermic reaction to the establishment of an electrochemical proton gradient across the membrane in which they are embedded. The energy stored in the electrochemical proton gradient is used e.g. by the FOF1-ATP synthase to generate ATP from ADP and inorganic phosphate. The superfamily of HCOs is phylogenetically classified into three major families: A, B and C. The A-family HCOs, represented by the well-studied aa3-type cytochrome c oxidases (aa3-CcOs), are found in mitochondria and many bacteria. The B-family of HCOs contains a number of bacterial and archaeal oxidases. The C-family comprises only the cbb3-type cytochrome c oxidase (cbb3-CcO) and is most distantly related to the mitochondrial respiratory oxidases.
Permanent conflict resolution at the high courts was one of the Holy Roman Empire’s main characteristics. This applies even to conflicts between rural communities and their lords, who could be dealt with, at least under certain circumstances, at the Imperial Chamber Court or the Aulic Council. These trials, however, were embedded in complicated processes of establishing and legitimizing claims on a local level as well as attempts to achieve a solution by violence or by arbitration. Researchers have stated that conflict resolution underwent, in the long run, a process of “juridification” (“Verrechtlichung”). This working paper proposes a method, based on Niklas Luhmann’s theory of procedural legitimation (“Legitimation durch Verfahren”), which possibly allows to detect elements of juridification and conflict resolution in the actions of parties and courts.
Ziel: Die Evaluation der DEGUM-Mammasonografiekurse nach objektivierbaren Kriterien war Ziel dieser Arbeit. Damit sollte die Qualität der Kurse überprüft werden, um eine flächendeckende Fort- und Weiterbildung auf hohem Niveau anzubieten.
Material und Methoden: 10 Qualitätskriterien, orientierend an den Vorgaben der KBV-Ultraschallvereinbarungen wurden als Qualitätsparameter definiert. Alle Kursleiter des Arbeitskreises Mammasonografie der DEGUM wurden angeschrieben. Dabei wurden die 10 definierten Qualitätskriterien überprüft.
Ergebnisse: Alle Kurse erfüllten die Voraussetzungen bezüglich der Qualität des Kursleiters, der Kursdauer und Unterrichtseinheiten sowie der Anzahl an Kursteilnehmern pro Ultraschallgerät. In 1 von 9 Kursen wurde die Zeit der praktischen Übungen, gefordert sind 50 %, unterschritten. Die Voraussetzungen für den Abschlusskurs (200 selbst durchgeführte und dokumentierte Fälle) sind in den Kursankündigungen zum Teil nicht klar definiert. Ein strukturierter Lehrkatalog fehlt.
Schlussfolgerung: Die DEGUM-Mammasonografiekurse werden auf hohem Niveau angeboten und erfüllen zum größten Teil die Anforderungen der KBV. Trotz der hohen Qualität der DEGUM-Kurse sind Optimierungsoptionen im Bereich Kursankündigung und strukturierter Lehrkatalog möglich.
Hintergrund: Das Monitoring von unfraktioniertem Heparin (UFH) bei extrakorporaler Zirkulation (EKZ) erfolgt standardmäßig mit Phospholipid-abhängigen Gerinnungstests wie „Activated Clotting Time“ [ACT, (sec)] bzw. „aktivierte partielle Prothrombinzeit“ [aPTT, (sec)]. Durch die im Rahmen von Autoimmunerkrankungen wie dem Antiphospholipid-Syndrom (APLS) auftretenden Antiphospholipid-Antikörper (aPL) ist die Aussagekraft dieser Tests bei solchen Patienten durch eine Verlängerung der Gerinnungszeit deutlich eingeschränkt. Die Wirkung von UFH kann auch mit der photometrischen Messung der aXa-Aktivität bestimmt werden. Ziel der vorliegenden Studie war es zu erfassen, ob die aXa-Aktivitiät mit der ACT korreliert und ob es Cut-off-Werte gibt, die bei der Steuerung der Antikoagulation von kardiochirurgischen Patienten z.B. mit Antiphospholipid-Antikörpern während EKZ hilfreich sein können.
Methodik: Nach einem positiven Ethikvotum wurden in diese prospektive Studie Patienten eingeschlossen, die sich einem erstmaligen elektiv geplanten kardiochirurgischen Eingriff unterzogen. Ausschlusskriterien waren Alter < 18 Jahren, bekanntes Antiphospholipidsyndrom, bekannte Heparin-induzierte Thrombozytopenie und Schwangerschaft. Die ACT-gesteuerte Antikoagulation mit UFH (ACT > 400 sec während EKZ) und dessen Reversierung mit Protamin (ACT ≤ 100 sec) wurden auf der Grundlage klinikinterner Standards durchgeführt. Für jeden perioperativ analysierten ACT-Wert (prä-, intra- und postoperativ) wurde die korrespondierende aXa-Aktivität erfasst. Abhängig von EKZ-Dauer ergaben sich bis zu 14 Messzeitpunkte mit insgesamt 144 Messungen. Die statistische Auswertung umfasste u.a. Spearman Rangkorrelation und die Receiver Operative Characteristic (ROC)-Kurve.
Ergebnisse: Es wurden die Daten von n = 15 Patienten in dieser Studie ausgewertet. Das Hauptergebnis zeigte eine hochsignifikante lineare Korrelation (r = 0.771, p < 0.0001) zwischen den Ergebnissen der ACT und der jeweils korrespondierenden aXa-Aktivität. Der optimale Cut-off-Wert der aXa-Aktivität zur Indikation einer ACT > 400 sec betrug 1.135 IU/ml (Fehlklassifikationsrate: 9.4%). Die Fläche unter der ROC betrug 0.899. Es wurde ein optimaler Cut-off-Wert von 0.55 IU/ml (Fehlerklassifikation: 13.3%, AUC: 0.867) analysiert, der eine ACT von ≤ 100 sec vor der Gabe von UFH und nach der Gabe von Protamin indiziert.
Zusammenfassung: Die aXa-Aktivität korreliert mit der ACT und kann für das Monitoring der Antikoagulation mit UFH während EKZ geeignet sein. Die im Rahmen dieser Studie ermittelten aXa-Cut-off-Werte können dazu beitragen, die Antikoagulation mittels UFH zu steuern, wenn die Messwerte von aPTT und ACT nicht aussagekräftig sind
Die Dissertation gliedert sich in zwei Teile – einen methodisch-wissenschaftstheoretischen bzw. biografisch-dogmenhistorischen und einen wirtschaftsethischen Bereich. Beide Abschnitte sind wechselseitig miteinander verzahnt. Im ersten Teil geht es vorwiegend um biografische und theoriegeschichtliche Fragestellungen. Der erste Aufsatz – On the Affiliation of Phenomenology and Ordoliberalism – beschäftigt sich mit dem wechselseitigen Einfluss von Husserl, Rudolf und Walter Eucken. Der erste Aufsatz – On the Affiliation of Phenomenology and Ordoliberalism – beschäftigt sich mit dem wechselseitigen Einfluss von Husserl, Rudolf und Walter Eucken. Dabei wird eine Drei-Ebenen-Unterscheidung vorgenommen: Einflüsse lassen sich demnach nicht nur auf der biografischen, sondern gleichfalls auf der wissenschaftstheoretischen und sozialphilosophischen Ebene ausmachen. Dennoch ist Vorsicht geboten, denn der Einfluss der Phänomenologie auf das Werk Walter Euckens sollte nicht überbetont werden, in dem Sinne, dass man Eucken als angewandten Phänomenologen und die Husserlsche Phänomenologie als Metatheorie des Ordoliberalismus darstellt. Vielmehr ist von einem eklektischen Denkmuster in den Schriften Euckens auszugehen, das maßgeblich vom Werk seines Vaters beeinflusst wurde (d.i., Walter Eucken als Rudolf Euckenianer) – und dies sowohl im Bereich der Wissenschaftstheorie und Methodik als auch im Kontext des sozialphilosophischen Topos der Gesellschaftskrisis. Der zweite Aufsatz – An Ordoliberal Interpretation of Adam Smith – geht den Parallelen im Denken Adam Smiths und Euckens nach. Auffallend ist, dass Eucken Smith meist im Zusammenhang mit seiner Kritik am laissez faire- respektive Paläoliberalismus zitiert. Dabei ist seine Bezugnahme auf Smith von verzerrten Stereotypen geprägt – und dies obwohl es einige bemerkenswerte Parallelen nicht nur zwischen Eucken und Smith, sondern auch zwischen Smith und Kant gibt. Der Übergang vom sogenannten Paläo- bzw. klassischen Liberalismus hin zum Ordoliberalismus ist somit gradueller, nicht jedoch revolutionärer Art. Im Mittelpunkt des zweiten Hauptteils stehen wirtschaftsethische Themenstellungen, die eine große Affinität zum Forschungsprogramm des Exzellenzclusters 'Die Herausbildung normativer Ordnungen' aufweisen. Dabei geht es wesentlich um die Herausarbeitung des ethischen Gehalts und der stark normativen Komponenten des Ordoliberalismus. Die ersten Essays im zweiten Teilbereich der Dissertation beziehen sich primär auf Eucken und die Freiburger Schule. Die letzten beiden Aufsätze jedoch sind bestrebt, über Eucken hinauszugehen und den Ordoliberalismus i.e.S. um den Soziologischen Neoliberalismus bzw. den Wirtschafts- und Sozialhumanismus Rüstows und Röpkes zu erweitern. Die Aufsätze 'Über die normativen Implikationen des Ordoliberalismus für die moderne Wirtschaftsethik' und 'On the Economic Ethics of Walter Eucken' geben dem Leser einen Überblick über die Wirtschaftsethik der Freiburger Schule im Allgemeinen und Walter Euckens im Besonderen. Dabei wird insbesondere das ordoliberale Staats- sowie das (in der kantischen Tradition stehende) Freiheitsverständnis herausgearbeitet und der Versuch unternommen, Eucken für die moderne Wirtschaftsethik anschlussfähig zu machen. Als Ergebnis wird Euckens Ordoliberalismus, dem es um ein ausgewogenes Verhältnis von Eigeninteresse und Gemeinwohl und die Realisierung des Ideals einer funktionsfähigen und menschenwürdigen Gesellschaftsordnung geht, im Spannungsfeld von Homannscher Moralökonomik und Ulrichs Integrativer Wirtschaftsethik porträtiert. Ergänzt wird dieser Einblick in die ordoliberale Wirtschaftsethik durch das Kapitel 'Von Hayek and Ordoliberalism on Justice', das die Gerechtigkeitskonzeptionen Euckens, Rüstows und Röpkes mit derjenigen von von Hayek kontrastiert. Derart werden u.a. die Unterschiede zwischen Ordoliberalismus und Evolutorischem Liberalismus deutlich. Das Kapitel 'Individual versus Regulatory Ethics: An Economic-Ethical and Theoretical-Historical Analysis of German Neoliberalism' untersucht im Anschluss an Foucaults ‚Ambiguitätsthese‘ das Verhältnis von Individual- und Ordnungsethik und kommt zu dem Ergebnis, dass es die Besonderheit des Ordoliberalismus ist, eine weitreichende, integrative Einheit beider Ebenen vorzunehmen. Aufbauend auf der Unterscheidung von Individual- und Ordnungsethik werden im vorletzten Kapitel – 'Ordoliberalism and the Evolution of Norms' – schließlich die divergierenden Normengenese-Prozesse im Ordoliberalismus einer Analyse unterzogen. Das verblüffende Resultat lautet, dass im Ordoliberalismus zwei unterschiedliche Arten der Entstehung von Normen nebeneinander existieren – eine kulturell-evolutionäre und eine elitär-expertokratische. Mithilfe dieser Unterscheidung ist eine weitere Differenzierung zwischen von Hayek und dem Ordoliberalismus möglich. Das letzte Kapitel – Beyond Ordoliberalism? – fasst zentrale Kritikpunkte am Ordoliberalismus noch einmal zusammen und geht der Frage nach, inwiefern es realistisch erscheint, auf eine Renaissance eines aktualisierten Ordoliberalismus zu hoffen?
Freiburg School of Law and Economics, Freiburg (Lehrstuhl-)Tradition and the Genesis of Norms
(2014)
The paper analyzes the parallels and differences between the Freiburg School of Law and Economics represented by the works of Eucken (and Röpke) and the Freiburg (Lehrstuhl-)Tradition represented by the works of Hayek and Vanberg. The parallels are illustrated by making use of the constitutional economics concepts Ordnungspolitik (i.e., order of rules/choices over rules) as well as freedom of privileges and discrimination. The differences, which have received surprisingly little attention, include the following aspects: 1. philosophy of science and epistemology, 2. genesis of norms, and 3. political philosophy. The paper tackles these issues in three steps. The second chapter presents Vanberg’s constitutional economics theory with special emphasis on the concepts of citizen sovereignty and normative individualism. The third chapter reviews the ordoliberal concepts of science and the state which are – to a certain degree – elitist and expertocratic, that is, they rely to a considerable degree on intellectual experts (in particular, scientists) being part of the societal elite. The fourth chapter differentiates two kinds of genesis of norms: an evolutionary one and an elitist-expertocratic one allowing for a differentiation between Eucken’s and Röpke’s Ordoliberalism on the on the hand and Vanberg’s Hayekian -- and Buchanan-style constitutional economics approach on the other hand. The paper ends with a summary of the main findings.
Changes in vitamin D serum levels have been associated with inflammatory diseases, such as inflammatory bowel disease (IBD), rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis (MS), atherosclerosis, or asthma. Genome- and transcriptome-wide studies indicate that vitamin D signaling modulates many inflammatory responses on several levels. This includes (i) the regulation of the expression of genes which generate pro-inflammatory mediators, such as cyclooxygenases or 5-lipoxygenase, (ii) the interference with transcription factors, such as NF-κB, which regulate the expression of inflammatory genes and (iii) the activation of signaling cascades, such as MAP kinases which mediate inflammatory responses. Vitamin D targets various tissues and cell types, a number of which belong to the immune system, such as monocytes/macrophages, dendritic cells (DCs) as well as B- and T cells, leading to individual responses of each cell type. One hallmark of these specific vitamin D effects is the cell-type specific regulation of genes involved in the regulation of inflammatory processes and the interplay between vitamin D signaling and other signaling cascades involved in inflammation. An important task in the near future will be the elucidation of the regulatory mechanisms that are involved in the regulation of inflammatory responses by vitamin D on the molecular level by the use of techniques such as chromatin immunoprecipitation (ChIP), ChIP-seq, and FAIRE-seq.
Recently a considerable amount of effort has been put into quantifying how interactions of the carbon and nitrogen cycle affect future terrestrial carbon sinks. Dynamic vegetation models, representing the nitrogen cycle with varying degree of complexity, have shown diverging constraints of nitrogen dynamics on future carbon sequestration. In this study, we use LPJ-GUESS, a dynamic vegetation model employing a detailed individual- and patch-based representation of vegetation dynamics, to evaluate how population dynamics and resource competition between plant functional types, combined with nitrogen dynamics, have influenced the terrestrial carbon storage in the past and to investigate how terrestrial carbon and nitrogen dynamics might change in the future (1850 to 2100; one representative "business-as-usual" climate scenario). Single-factor model experiments of CO2 fertilisation and climate change show generally similar directions of the responses of C–N interactions, compared to the C-only version of the model as documented in previous studies using other global models. Under an RCP 8.5 scenario, nitrogen limitation suppresses potential CO2 fertilisation, reducing the cumulative net ecosystem carbon uptake between 1850 and 2100 by 61%, and soil warming-induced increase in nitrogen mineralisation reduces terrestrial carbon loss by 31%. When environmental changes are considered conjointly, carbon sequestration is limited by nitrogen dynamics up to the present. However, during the 21st century, nitrogen dynamics induce a net increase in carbon sequestration, resulting in an overall larger carbon uptake of 17% over the full period. This contrasts with previous results with other global models that have shown an 8 to 37% decrease in carbon uptake relative to modern baseline conditions. Implications for the plausibility of earlier projections of future terrestrial C dynamics based on C-only models are discussed.
Recently a considerable amount of effort has been put into quantifying how interactions of the carbon and nitrogen cycle affect future terrestrial carbon sinks. Dynamic vegetation models, representing the nitrogen cycle with varying degree of complexity, have shown diverging constraints of nitrogen dynamics on future carbon sequestration. In this study, we use the dynamic vegetation model LPJ-GUESS to evaluate how population dynamics and resource competition between plant functional types, combined with nitrogen dynamics, have influenced the terrestrial carbon storage in the past and to investigate how terrestrial carbon and nitrogen dynamics might change in the future (1850 to 2100; one exemplary "business-as-usual" climate scenario). Single factor model experiments of CO2 fertilisation and climate change show generally similar directions of the responses of C–N interactions, compared to the C-only version of the model, as documented in previous studies. Under a RCP 8.5 scenario, nitrogen limitation suppresses potential CO2 fertilisation, reducing the cumulative net ecosystem carbon uptake between 1850 and 2100 by 61%, and soil warming-induced increase in nitrogen mineralisation reduces terrestrial carbon loss by 31%. When environmental changes are considered conjointly, carbon sequestration is limited by nitrogen dynamics until present. However, during the 21st century nitrogen dynamics induce a net increase in carbon sequestration, resulting in an overall larger carbon uptake of 17% over the full period. This contradicts earlier model results that showed an 8 to 37% decrease in carbon uptake, questioning the often stated assumption that projections of future terrestrial C dynamics from C-only models are too optimistic.
River corridor plants in Central Europe account for an above-average proportion of endangered species. The main objective of this study was to examine the effects of habitat fragmentation and abiotic conditions on the survival and changes in population size of four endangered, long-lived river corridor plant species (Euphorbia palustris, Pseudolysimachion longifolium, Sanguisorba officinalis, and Senecio paludosus) over the course of at least ten years. We sampled altogether 138 populations in the Weser and Elbe river systems in Northwestern Germany.
Overall, 33% of the populations went extinct during the study period. Extinction rates and changes in population size were related to initial population sizes, but not to population isolation and only marginally so to habitat quality. Large populations (> 100 individuals) had a much higher probability to survive or increase in size (to > 1000 individuals) than smaller populations. There was no general decline in population size in surviving populations, and extinction rates and changes in population size were independent of time. We therefore conclude that the high extinction rates in small populations are best explained by sudden short-term environmental events, such as changes in land use, rather than by long-term negative effects of, for example, genetic deterioration. A projection matrix for the next 117 years, however, predicted that 85% of the surveyed populations will have gone extinct. Since any establishment of new populations in the study area is unlikely owing to the lack of potential habitats and dispersal limitation, river corridor plants will probably continue to decline. Apart from preventing further habitat deterioration it will be crucial to maintain or establish an appropriate management, and to avoid sudden and adverse changes in land use.
Our focus is the identification, characterisation and functional analysis of different MLL fusions. In general, MLL fusion proteins are encoded by large cDNA cassettes that are difficult to transduce into haematopoietic stem cells. This is due to the size limitations of the packaging process of those vector-encoded RNAs into retro- or lentiviral particles. Here, we present our efforts in establishing a universal vector system to analyse different MLL fusions. The universal cloning system was embedded into the backbone of the Sleeping Beauty transposable element. This transposon has no size limitation and displays no integration preference, thereby avoiding the integration into active genes or their promoter regions. We utilised this novel system to test different MLL fusion alleles (MLL-NEBL, NEBL-MLL, MLL-LASP1, LASP1-MLL, MLL-MAML2, MAML2-MLL, MLL-SMAP1 and SMAP1-MLL) in appropriate cell lines. Stable cell lines were analysed for their growth behaviour, focus formation and colony formation capacity and ectopic Hoxa gene transcription. Our results show that only 1/4 tested direct MLL fusions, but 3/4 tested reciprocal MLL fusions exhibit oncogenic functions. From these pilot experiments, we conclude that a systematic analysis of more MLL fusions will result in a more differentiated picture about the oncogenic capacity of distinct MLL fusions.
Der Umzug ins Altersheim ist in der Realität wie im Film auch ein Auszug aus der gewohnten Lebenswelt, in einen Ort außerhalb des Alltags. Das Heim ist zugleich in institutioneller Ort, dem Krankenhaus verwandt, in dem die Beziehungen zwischen Bewohnern und Betreuern resp. der Einrichtung hinsichtlich Haftpflicht, Fürsorge etc. durch einen eigenen Regelapparat abgesichert sind. Der Bewohner des Altersheims tritt aus dem Dunstkreis des selbstverantwortlichen Subjekts heraus; er wird in eine neue juristische Person transformiert, tritt in einen eigenen Kreis von Regeln, Zuständigkeiten und Abhängigkeiten ein. Und es ist ein dramatischer Ort, weil die Beziehungen zwischen den Bewohnern ebenso dramatische Konfliktpotentiale umfassen wie die der Bewohner zu den Pflegenden bzw. zur Institution „Altersheim“.
Fernando Birri wurde als Nachkomme italienischer Auswanderer am 13.3.1925 in Santa Fe de la Vera Cruz (Argentinien) geboren. Er ist nicht nur (Dokumentarfilm-) Regisseur, sondern auch Theoretiker, Dichter und Puppenspieler. Birri studierte Film am Centro Sperimentale di Cinematografia in Rom; schon vor dem Abschluss (1952) entstand der kurze Dokumentarfilm Selinunte (1951), kurz danach Alfabeto Notturno (über eine Abendschule im sizilianischen Toretta, in der Analphabeten lesen lernen). Zusammen mit dem renommierten Regisseur Mario Verdone, der als Professor am Centro Sperimentale arbeitete, führte er bei Immagini popolari siciliane sacree profane Regie (1953). Mitwirkungen an Filmen von Carlo Lizzani und Vittorio de Sica folgten ebenso wie Kleinauftritte als Schauspieler und Arbeiten als Drehbuchautor.
In Fortführung der Bibliographie der Filmmusik (Medienwissenschaft/Hamburg: Berichte und Papiere, 87, 2008; rev. 2012, <http://berichte.derwulff.de/0087_08.pdf>, setzen wir das Verzeichnis der immer noch rasant ansteigenden Publikationen der Filmmusikforschung vor. Unseren Lesern sind wir dankbar für Hinweise auf Übersehenes und Neuerscheinungen (hwulff@uos.de) – das vorliegende Verzeichnis soll nach angemessener Zeit fortgeschrieben werden.
Die folgenden über hundert Einträge versammeln die Musikanten der Schlager-, Musik-, Operettenund Revuefilme der Jahre von 1945–65, ohne im einzelnen zwischen den Genres zu differenzieren. Versammelt wurden ausschließlich Musik-Interpreten, die in mehreren Filmen auftraten (Sänger und Sängerinnen, Instrumentalsolisten, Gesangsgruppen, Tänzer und Tänzerinnen). Zu den einzelnen Interpreten sind nur Filme der Zeit von 1945–65 dokumentiert, die schlagerfilmaffin waren (darunter v.a. Komödien, Operettenstoffe u.ä.); alle anderen Produktionen bleiben unerwähnt; nur im begründeten Ausnahmefall werden auch solche Filme nachgewiesen, in denen Musik- und Schlagerstars ohne Gesangsnummern in Hauptrollen (und ggf. in größeren Nebenrollen) agieren. Nach Möglichkeit werden die dargebotenen Musiktitel genannt (meist nach einer Autopsie der Filme). Interpreten und Gruppen, die keine Auftritte haben oder Rollen spielen, sondern nur die Filmmusik ohne Auftritte realisiert haben, bleiben undokumentiert. Auch die wenigen bibliographischen Hinweise sind strikt selektiv; insbesondere wurde auf die Dokumentation der Zeitungsliteratur verzichtet.
Ebenso wie einzelne Menschen können auch ganze Nationen traumatischen Erfahrungen ausgesetzt sein. Sie werden, nicht anders als Siege, in die identitätschaffenden nationalen Gründungsmythen eingearbeitet. Das Trauma deutscher Erniedrigung, das nach dem Zweiten Weltkrieg vom Trauma deutscher Täterschaft abgelöst wurde, war bis nach dem Ersten Weltkrieg, der jenes erste Trauma aktualisierte, der Dreißigjährige Krieg. Das war der längste Krieg in Deutschland, oder genauer: eine Reihe von Kriegen europäischer Großmächte auf deutschem Boden, die eine Spur der Verwüstung und Entvölkerung von der Ostsee bis in den deutschen Südwesten zogen. Dass Christenmenschen aufs barbarischste gegeneinander kämpften, erschütterte den christlichen Glauben bis in die Grundfesten.
Zum Begriff des Turnens
(2014)
Die Sportkultur war immer ein Spiegel der Gesellschaft. Sie wandelte sich mit ihr und stand immer in einem Zusammenhang mit soziokulturellen und politischen Bedingungen der Gesellschaft. Die bunte Welt von Sport und Spiel erweckt schon immer das Interesse vieler Menschen, und zwar sowohl als Zuschauer als auch als Sporttreibende...
Background: Hepatitis delta frequently leads to liver cirrhosis and hepatic decompensation. As treatment options are limited, there is a need for biomarkers to determine disease activity and to predict the risk of disease progression. We hypothesized that anti-HDV IgM could represent such a marker.
Methods: Samples of 120 HDV-infected patients recruited in an international multicenter treatment trial (HIDIT-2) were studied. Anti-HDV IgM testing was performed using ETI-DELTA-IGMK-2-assay (DiaSorin). In addition, fifty cytokines, chemokines and angiogenetic factors were measured using multiplex technology (Bio-Plex System). A second independent cohort of 78 patients was studied for the development of liver-related clinical endpoints (decompensation, HCC, liver transplantation or death; median follow up of 3.0 years, range 0.6–12).
Results: Anti-HDV IgM serum levels were negative in 18 (15%), low (OD<0.5) in 76 (63%), and high in 26 (22%) patients of the HIDIT-2 cohort. Anti-HDV IgM were significantly associated with histological inflammatory (p<0.01) and biochemical disease activity (ALT, AST p<0.01). HDV replication was independent from anti-HDV IgM, however, low HBV-DNA levels were observed in groups with higher anti-HDV IgM levels (p<0.01). While high IP-10 (CXCL10) levels were seen in greater groups of anti-HDV IgM levels, various other antiviral cytokines were negatively associated with anti-HDV IgM. Associations between anti-HDV IgM and ALT, AST, HBV-DNA were confirmed in the independent cohort. Clinical endpoints occurred in 26 anti-HDV IgM positive patients (39%) but in only one anti-HDV IgM negative individual (9%; p = 0.05).
Conclusions: Serum anti-HDV IgM is a robust, easy-to-apply and relatively cheap marker to determine disease activity in hepatitis delta which has prognostic implications. High anti-HDV IgM levels may indicate an activated interferon system but exhausted antiviral immunity.
In the present work, three different techniques are used to separate ice-nucleating particles (INP) and ice particle residuals (IPR) from non-ice-active particles: the Ice Selective Inlet (ISI) and the Ice Counterflow Virtual Impactor (Ice-CVI), which sample ice particles from mixed phase clouds and allow for the analysis of the residuals, as well as the combination of the Fast Ice Nucleus Chamber (FINCH) and the Ice Nuclei Pumped Virtual Impactor (IN-PCVI), which provides ice-activating conditions to aerosol particles and extracts the activated ones for analysis. The collected particles were analyzed by scanning electron microscopy and energy-dispersive X-ray microanalysis to determine their size, chemical composition and mixing state. Samples were taken during January/February 2013 at the High Alpine Research Station Jungfraujoch. All INP/IPR-separating techniques had considerable abundances (median 20–70%) of contamination artifacts (ISI: Si-O spheres, probably calibration aerosol; Ice-CVI: Al-O particles; FINCH + IN-PCVI: steel particles). Also, potential measurement artifacts (soluble material) occurred (median abundance < 20%). After removal of the contamination particles, silicates and Ca-rich particles, carbonaceous material and metal oxides were the major INP/IPR particle types separated by all three techniques. Minor types include soot and Pb-bearing particles. Sea-salt and sulfates were identified by all three methods as INP/IPR. Lead was identified in less than 10% of the INP/IPR. It was mainly present as an internal mixture with other particle types, but also external lead-rich particles were found. Most samples showed a maximum of the INP/IPR size distribution at 400 nm geometric diameter. In a few cases, a second super-micron maximum was identified. Soot/carbonaceous material and metal oxides were present mainly in the submicron range. ISI and FINCH yielded silicates and Ca-rich particles mainly with diameters above 1 μm, while the Ice-CVI also sampled many submicron particles. Probably owing to the different meteorological conditions, the INP/IPR composition was highly variable on a sample to sample basis. Thus, some part of the discrepancies between the different techniques may result from the (unavoidable) non-parallel sampling. The observed differences of the particles group abundances as well as the mixing state of INP/IPR point to the need of further studies to better understand the influence of the separating techniques on the INP/IPR chemical composition.
This book is about home. With Malawi as its focus, it seeks to understand ideas about home as expressed through poetry written by Malawians in English. Although African Literatures are studied those of Malawi have not received agreeable attention. This book surveys poetry by five Malawian writers - Felix Mnthali, Frank Chipasula, Jack Mapanje, Lupenga Mphande, and Steve Chimombo. The discussion negotiates scribed experience of exile, engendered by Dr. Banda's regime, and shows that the selected poets effectively converse with a sense of home, reflecting on its transformations in their work. Interrogating the strict definitions of home, the argument highlights that far from home-less exiles in fact clarify the sense of what 'home' is. The manoeuvre is one of thinking towards an unboundaried 'home'. This book will be of value not only to readers interested in the cultures of Africa but to all those with an interest in worldwide literary phenomena, and ideas therein of home and exile.
Information theory allows us to investigate information processing in neural systems in terms of information transfer, storage and modification. Especially the measure of information transfer, transfer entropy, has seen a dramatic surge of interest in neuroscience. Estimating transfer entropy from two processes requires the observation of multiple realizations of these processes to estimate associated probability density functions. To obtain these necessary observations, available estimators typically assume stationarity of processes to allow pooling of observations over time. This assumption however, is a major obstacle to the application of these estimators in neuroscience as observed processes are often non-stationary. As a solution, Gomez-Herrero and colleagues theoretically showed that the stationarity assumption may be avoided by estimating transfer entropy from an ensemble of realizations. Such an ensemble of realizations is often readily available in neuroscience experiments in the form of experimental trials. Thus, in this work we combine the ensemble method with a recently proposed transfer entropy estimator to make transfer entropy estimation applicable to non-stationary time series. We present an efficient implementation of the approach that is suitable for the increased computational demand of the ensemble method's practical application. In particular, we use a massively parallel implementation for a graphics processing unit to handle the computationally most heavy aspects of the ensemble method for transfer entropy estimation. We test the performance and robustness of our implementation on data from numerical simulations of stochastic processes. We also demonstrate the applicability of the ensemble method to magnetoencephalographic data. While we mainly evaluate the proposed method for neuroscience data, we expect it to be applicable in a variety of fields that are concerned with the analysis of information transfer in complex biological, social, and artificial systems.
One of the motivations for establishing a European banking union was the desire to break the ties with between national regulators and domestic financial institutions in order to prevent regulatory capture. However, supervisory authority over the financial sector at the national level can also have valuable public benefits. The aim of this policy letter is to detail these public benefits in order to counter discussions that focus only on conflicts of interest. It is informed by an analysis of how financial institutions interacted with policy-makers in the design of national bank rescue schemes in response to the banking crisis of 2008. Using this information, it discusses the possible benefits of close cooperation between financial institutions and regulators and analyzes these in the wake of a European banking union.
In this work we study basic properties of unstable particles and scalar hadronic resonances, respectively, within simple quantum mechanical and quantum field theoretical (effective) models. The term 'particle' is usually assigned to entities, described by physical theories, that are able to propagate over sufficiently large time scales (e.g. from a source to a detector) and hence could be identified in experiments - one especially should be able to measure some of their distinct properties like spin or charge. Nevertheless, it is well known that there exists a huge amount of unstable particles to which it seems difficult to allocate such definite values for their mass and decay width. In fact, for extremely short-lived members of that species, so called resonances, the theoretical description turns out to be highly complicated and requires some very interesting concepts of complex analysis.
In the first chapter, we start with the basic ideas of quantum field theory. In particular, we introduce the Feynman propagator for unstable scalar resonances and motivate the idea that this kind of correlation function should possess complex poles which parameterize the mass and decay width of the considered particle. We also brie
y discuss the problematic scalar sector in particle physics, emphasizing that hadronic loop contributions, given by strongly coupled hadronic intermediate states, dominate its dynamics. After that, the second chapter is dedicated to the method of analytic continuation of complex functions through branch cuts. As will be seen in the upcoming sections, this method is crucial in order to describe physics of scalar resonances because the relevant functions to be investigated (namely, the Feynman propagator of interacting quantm field theories) will also have branch cuts in the complex energy plane due to the already mentioned loop contributions. As is consensus among the physical community, the understanding of the physical behaviour of resonances requires a deeper insight of what is going on beyond the branch cut. This will lead us to the idea of a Riemann surface, a one-dimensional complex manifold on which the Feynman propagator is defined.
We then apply these concepts to a simple non-relativistic Lee model in the third chapter and demonstrate the physical implications, i.e., the motion of the propagator poles and the behaviour of the spectral function. Besides that, we investigate the time evolution of a particle described by such a model. All this will serve as a detailed preparation in order to encounter the rich phenomena occuring on the Riemann surface in quantum field theory. In the last chapter, we finally concentrate on a simple quantm field theoretical model which describes the decay of a scalar state into two (pseudo)scalar ones. It is investigated how the motion of the propagator poles is in
uenced by loop contributions of the two (pseudo)scalar particles. We perform a numerical study for a hadronic system involving a scalar seed state (alias the σ-meson) that couples to pions. The unexpected emergence of a putative stable state below the two-pion threshold is investigated and it is claeifieed under which conditions such a stable state appears.
Memory Concerns, Memory Performance and Risk of Dementia in Patients with Mild Cognitive Impairment
(2014)
Background: Concerns about worsening memory (“memory concerns”; MC) and impairment in memory performance are both predictors of Alzheimer's dementia (AD). The relationship of both in dementia prediction at the pre-dementia disease stage, however, is not well explored. Refined understanding of the contribution of both MC and memory performance in dementia prediction is crucial for defining at-risk populations. We examined the risk of incident AD by MC and memory performance in patients with mild cognitive impairment (MCI).
Methods: We analyzed data of 417 MCI patients from a longitudinal multicenter observational study. Patients were classified based on presence (n = 305) vs. absence (n = 112) of MC. Risk of incident AD was estimated with Cox Proportional-Hazards regression models.
Results: Risk of incident AD was increased by MC (HR = 2.55, 95%CI: 1.33–4.89), lower memory performance (HR = 0.63, 95%CI: 0.56–0.71) and ApoE4-genotype (HR = 1.89, 95%CI: 1.18–3.02). An interaction effect between MC and memory performance was observed. The predictive power of MC was greatest for patients with very mild memory impairment and decreased with increasing memory impairment.
Conclusions: Our data suggest that the power of MC as a predictor of future dementia at the MCI stage varies with the patients' level of cognitive impairment. While MC are predictive at early stage MCI, their predictive value at more advanced stages of MCI is reduced. This suggests that loss of insight related to AD may occur at the late stage of MCI.
Este trabajo actualiza el conocimiento sobre la presencia de cochinillas protegidas en el olivo, Olea europaea Linnaeus (Oleaceae), en Brasil. Aonidiella aurantii (Maskell), Hemiberlesia cyanophylli (Signoret), Hemiberlesia lataniae (Signoret) y Pinnaspis strachani (Cooley) son nuevos registros en olivos en Brasil. Melanaspis obscura (Comstock) es la primera cita en O. europaea en el mundo y una nueva sinonimia se propone: Melanaspis jaboticabae (Hempel) = Melanaspis obscura (Comstock).
The article focuses on Jacob Grimm's linguistic scholarship, taking into account biographical details, Grimm's conception of law and freedom, and his morality. Examples consist of original citations from Grimm's works, primarily his "Deutsche Grammatik" and "Deutsches Wörterbuch".
Background: In this study, we examined patients who had non-progressive disease for at least 2 years after diagnosis of inoperable locoregional recurrent or metastatic breast cancer under continuous trastuzumab treatment. Our primary goal was to assess the long-term outcome of patients with durable response to trastuzumab.
Methods: 268 patients with HER2-positive inoperable locally recurrent or metastatic breast cancer and non-progressive disease for at least 2 years under trastuzumab treatment were documented retrospectively or prospectively in the HER-OS registry, an online documentation tool, between December 2006 and September 2010 by 71 German oncology centers. The study end point was time to tumor progression.
Results: Overall, 47.1% of patients (95% confidence interval (CI): 39.9–54.1%) remained in remission for more than 5 years, while the median time to progression was 4.5 years (95% CI: 4.0–6.6 years). Lower age (<50 years) and good performance status (ECOG 0) at time of trastuzumab treatment initiation as well as complete remission after initial trastuzumab treatment were associated with longer time to progression. Interruption of trastuzumab therapy correlated with shorter time to progression.
Conclusions: HER2-positive patients, who initially respond to palliative treatment with trastuzumab, can achieve a long-term tumor remission of several years.
This study included 30 patients with diagnosed rheumatoid arthritis (RA) and 30 test subjects without RA (control group). The objective of the study was to examine both groups for the presence of temporomandibular disorders (TMD) and morphological changes of the temporomandibular joint (TMJ). All individuals were examined using a systematic detailed clinical TMD examination as well as magnetic resonance imaging (MRI). The clinical TMD examination yielded significant differences between the RA patients and the control group concerning crepitus of the TMJ, and palpation tenderness of the masticatory muscles as well as the unassisted mandibular opening. The evaluation of the MRI images for the RA group showed significantly more frequent deformations of the condyle, osteophyte formations and erosions in the condylar compacta, and degenerative changes in the spongiosa. Increased intra-articular accumulation of synovial liquid and signs of inflammatory changes of the spongiosa were only found in the RA group. Statistical analysis showed a significant correlation between crepitus and specific osteoarthrotic changes (MRI), respectively, and between crepitus and a complete anterior disk displacement without reduction (MRI). The duration of the RA disease correlated neither with the anamnestic and clinical dysfunction index by Helkimo nor with RA-specific MRI findings.