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Introduction: This study reports about antenatal characteristics of Roma minority population. The study was designed to investigate data about health behaviours known to be associated with reproductive outcomes of Roma women that have very good living conditions and relatively high resource availability.
Methods: A retrospective study included 204 Roma and 408 non-Roma hospitalised singleton births that occurred in the Maternity Ward of the General Hospital Virovitica in the period from 1991 to 2010. Data about women’s age, marital status, smoking, reproductive health (abortions, delivery), antenatal care, perinatal complications and gestational age were taken from hospital records and analysed.
Results: Roma women were averagely more than three years younger than non-Roma women, only 10.8% were married. Smoking was more frequent. The average number of births of Roma and non-Roma women was similar, averagely two children per woman. The rate of induced abortions in the Roma women was higher, while the frequency of spontaneous abortions was equal. Inadequate antenatal care of Roma women was associated with two times higher incidence of perinatal complications. A higher frequency of deliveries at home without professional assistance in Roma pregnancy resulted in lower perinatal outcomes. It was confirmed that Roma mothers give birth earlier (38+6 vs. 39+4 weeks) and have a higher incidence of premature births (9.3% vs. 2.2%).
Conclusions: In the comparison of antenatal parameters between the two researched groups, poorer prenatal outcomes in the Roma population were found, despite full integration and considerable improvement in living standards of this ethnic Roma population.
The article consists in a comparative reading of three novels: Um rio chamado tempo by Mia Couto, Le pain des corbeaux by Lhoussain Azergui and Paw królowej by Dorota Masłowska. In spite of the difference of the historical circumstances of Mozambique, Morocco and Poland, these three books meet at an intersecting point: the emergence of an intelligentsia that uses literacy and writing as an instrument to deconstruct the post-colonial concept of nation and to operate a trans-colonial renegotiation of identity. By the notion of trans-colonial, I understand the opposition against new kinds of symbolic violence that emerged after the end of the colonial period; here this new form of oppression is related to the concept of national unity – an artificial construct that leaves no place for a dualism or pluralism of cultural reality (two shores of the Zambezi river, Arab and Berber dualism in Morocco, "small homelands" in Poland).
The young heroes of the novels grasp the pen in order to break through the falseness or the taboos created by the fathers, establishing, at the same time, the relation of solidarity with the world of the grandfathers. The act of writing becomes an actualization of the ancestral universe of magic. The settlement of accounts with the parental generation concerns the vision of nation built upon the resistance against the colonizer (it also refers to the Polish cultural formation, based on the tradition of uprisings and resistance against the Russians).
OBJECTIVE: To compare efficacy, safety, and tolerability of an oral enzyme combination (OEC) containing proteolytic enzymes and bioflavonoid vs diclofenac (DIC), a nonselective nonsteroidal anti-inflammatory drug in the treatment of osteoarthritis of the knee.
MATERIALS AND METHODS: This was an individual patient-level pooled reanalysis of patient-reported data from prospective, randomized, double-blind, parallel-group studies in adult patients with moderate-to-severe osteoarthritis of the knee treated for at least 3 weeks with OEC or DIC. Appropriate trials were identified with a systemic literature and database search. Data were extracted from the original case-report forms and reanalyzed by a blinded evaluation committee. The primary end point was the improvement of the Lequesne algofunctional index (LAFI) score at study end vs baseline. Secondary end points addressed LAFI response rates, treatment-related pain-intensity changes, adverse events, and laboratory parameters.
RESULTS: Six trials were identified that enrolled in total 774 patients, of whom 759 had post-baseline data for safety analysis, 697 (n=348/349 with OEC/DIC) for intent to treat, 524 for per protocol efficacy analysis, and 500 for laboratory evaluation. LAFI scores - the primary efficacy end point - decreased comparably with both treatments and improved with both treatments significantly vs baseline (OEC 12.6±2.4 to 9.1±3.9, DIC 12.7±2.4 to 9.1±4.2, effect size 0.9/0.88; P<0.001 for each). In parallel, movement-related 11-point numeric rating-scale pain intensity improved significantly (P<0.001) and comparably with both treatments from baseline (6.4±1.9/6.6±1.8) to study end (3.8±2.7/3.9±2.5). Overall, 55/81 OEC/DIC patients of the safety-analysis population (14.7%/21.1%, P=0.022) reported 90/133 treatment-emergent adverse events, followed by premature treatment discontinuations in 22/39 patients (5.9%/10.2%, P=0.030). Changes in laboratory parameters were significantly less with OEC vs DIC: on average 18.8% vs 86.3% of patients presented a decrease with respect to hemoglobin, hematocrit, or erythrocyte count (P<0.001), and 28.2% vs 72.6% showed an increase in AST, ALT, or GGT (P<0.001).
CONCLUSION: When compared with DIC, OEC showed comparable efficacy and a superior tolerability/safety profile associated with a significantly lower risk of treatment-emergent adverse events, related study discontinuations, and changes in laboratory parameters.
The PANDA experiment will be one of the flagship experiments at the future Facility for Antiproton and Ion Research (FAIR) in Darmstadt, Germany. It is a versatile detector dedicated to topics in hadron physics such as charmonium spectroscopy and nucleon structure. A DIRC counter will deliver hadronic particle identification in the barrel part of the PANDA target spectrometer and will cleanly separate kaons with momenta up to 3.5 GeV/c from a large pion background. An alternative DIRC design option, using wide Cherenkov radiator plates instead of narrow bars, would significantly reduce the cost of the system. Compact fused silica photon prisms have many advantages over the traditional stand-off boxes filled with liquid. This work describes the study of these design options, which are important advancements of the DIRC technology in terms of cost and performance. Several new reconstruction methods were developed and will be presented. Prototypes of the DIRC components have been built and tested in particle beam, and the new concepts and approaches were applied. An evaluation of the performance of the designs, feasibility studies with simulations, and a comparison of simulation and prototype tests will be presented.
Orientation: Lack in congruence amongst industrial and organisational psychologists (IOPs) as to the conceptualisation of its profession poses a significant risk as to the relevance, longevity and professional identity of the profession within the South African context. Research purpose: This study aimed to explore the professional identity of IOPs within the South African context. Specifically, the aim of this study was four-fold: (1) to develop a contemporary definition for IOP, (2) to investigate IOP roles, (3) to determine how the profession should be labelled and (4) to differentiate IOP from human resource management (HRM) from IOPs’ perspectives within South Africa. Motivation for the study: IOPs do not enjoy the same benefits in stature or status as other professions such as medicine, finances and engineering in the world of work. IOPs need to justify its relevance within organisational contexts as a globally shared understanding of ‘what it is’, ‘what it does’ and ‘what makes it different from other professions’, which is non-existent. In order to enhance its perceived relevance, clarity as to IOPs professional identity is needed. Research design, approach and method: A post-positivistic qualitative content analytic and descriptive research design was employed in this study. Data from practising industrial and organisational psychology (IOP) within South Africa (N = 151) were gathered through an electronic web-based survey and were analysed through thematic content analysis. Main findings: The results indicate that IOP in South Africa seeks to optimise the potential of individuals, groups, organisations and the community by implementing scientific processes to support both individual and organisational wellness and sustainability. ‘Work Psychology’ was considered a more fitting professional designation or label than industrial and/or organisational psychology. The industrial psychologist’s major roles related to the well-being and development of employees. A clear distinction between a more dynamic, pro-active approach of IOP compared to a more transactional approach of HRM was also evident. IOP within South Africa appears to have a community development function. Practical/managerial implications: The longevity, relevance and impact of IOP as a profession requires alignment amongst practitioners as to shared common professional identity. Contribution/value-add: This study provides a contemporary understanding of the roles, functions, labels and unique value proposition of industrial and organisational psychology within the South African context.
Im Rahmen des FAIR Projektes wurde ein neuartiger Prototyp eines nicht strahlzerstörenden Bunch Struktur Monitors (BSM) am GSI UNILAC entwickelt. Ziel ist es, ein zuverlässiges Diagnosegerät zu entwickeln, welches die longitudinale Struktur der Ionenbunche innerhalb des LINACs untersuchen kann. Notwendig ist hierbei eine effektive Zeitauflösung deutlich unter 100 ps, bei möglichst wenigen Makropuls Mittelungen. Nach der erfolgreichen Inbetriebnahme soll der BSM Prototyp dazu dienen, die Umsetzbarkeit eines weiteren nichtinvasiven Geräts für den geplanten Proton-LINAC bei FAIR mit einer notwendigen Zeitauflösung von 10 ps zu beurteilen.
Die numerische Simulation von Materialien, welche dem Hochstrom-Ionenstrahl ausgesetzt sind, zeigten einen sehr hohen thermischen Stress. Daher wurde der Ansatz eines nicht strahlzerstörenden Diagnosegerätes verfolgt. Das Design beruht auf der Erzeugung von Sekundärelektronen durch Strahl-Restgas Kollisionen im Strahlrohr. Durch das Anlegen eines homogenen Hochspannungspotentials von bis zu -31 kV, wird ein Elektronenstrahl erzeugt, welcher die zeitliche Struktur des Ionenbunches trägt. Die zeitliche Information des Elektronenstrahles wird beim Durchfliegen eines HF-Ablenkers, welcher resonant an die 36 MHz des Beschleunigers gekoppelt ist, in eine räumliche Intensitätsverteilung umgewandelt. Anschließend wird die Elektronenverteilung auf einem bildgebenden MCP-Phosphor-Detektor durch eine CCD-Kamera detektiert und in die Bunch Struktur überführt.
Intensive Untersuchungen der BSM Eigenschaften ergaben eine höchste Auflösung von 37 ±6.3 ps bei gleichzeitig akzeptabler Intensität auf dem MCP-Detektor. Unter anderem wurden auch stabile Einzelschussmessungen durchgeführt, welche für die Profilmessung nur einen einzelnen Makropuls benötigten, statt über typischerweise 8-32 Pulse zu mitteln.
Durch die systematische Manipulation der Bunchlänge durch einen Rebuncher sind nicht gaußförmige Profile von 280 ps bis 650 ps detektiert worden, welche als Studie für eine Emittanzbestimmung genutzt worden sind. In Abhängigkeit des Analyseverfahrens sind Werte von εGauss = 1.42 ±0.14 keV/u ns bis εSD = 3.03 ±0.33 keV/u ns für die Emittanz bestimmt worden.
Des Weiteren ist ein Finite-Elemente Modell erstellt worden, um die Zeitstruktur der Sekundärelektronen innerhalb des elektronenoptischen Systems zu bestimmen. Für das Setup mit der höchsten Auflösung von 37 ps ergab sich eine zusätzliche Zeitverbreiterung von 5.6 ps, welche nur geringfügig die experimentell bestimmte Auflösung verschlechtert.
Der nicht strahlzerstörende BSM liefert eine ausreichend hohe zeitliche Auflösung für detailreiche Untersuchung der longitudinalen Bunchstruktur, ohne negative Einflüsse auf den Ionenstrahl auszuüben. Fortgeschrittene Messungen, wie longitudinale Emittanzbestimmung und Makropulsanalysen, sind möglich und werden dazu beitragen, die LINAC Strukturen besser zu verstehen und weiter zu optimieren.
Obwohl bei der Umsetzung des Arbeitsprinzips für den geplanten Proton-LINAC die veränderten Strahlparameter berücksichtigt werden müssen, zeigen die Ergebnisse, wie die Zeitstrukturuntersuchung und die erreichte Phasenauflösung von 0.5° bei 36 MHz, dass zeitliche Auflösungen bei Aufrechterhaltung der Phasenauflösung von bis zu 10 ps für einen neuen BSM Prototypen möglich sind.
The spider genus Zaitunia Lehtinen, 1967 (Araneae, Filistatidae) is revised. It was found to include 24 species distributed in the Eastern Mediterranean, Middle East and Central Asia: ♀ Z. afghana (Roewer, 1962) (Afghanistan), ♀ Z. alexandri Brignoli, 1982 (Iran), ♀ Z. akhanii Marusik & Zamani, 2015 (Iran), ♂♀ Z. annulipes (Kulczyński, 1908) (Cyprus), ♂♀ Z. beshkentica (Andreeva & Tyshchenko, 1969) (Tajikistan, Uzbekistan), ♀ Z. brignoliana sp. nov. (Iran), ♂♀ Z. ferghanensis sp. nov. (Kyrgyzstan, Uzbekistan), ♀ Z. feti sp. nov. (Turkmenistan), ♀ Z. halepensis sp. nov. (Syria), ♀ Z. huberi sp. nov. (Afghanistan), ♀ Z. inderensis Ponomarev, 2005 (Kazakhstan), ♂♀ Z. kunti sp. nov. (Cyprus, Turkey), ♂♀ Z. logunovi sp. nov. (Kazakhstan, Kyrgyzstan), ♂♀ Z. maracandica (Charitonov, 1946) (Uzbekistan, Kazakhstan), ♂♀ Z. martynovae (Andreeva & Tyshchenko, 1969) (Tajikistan, Turkmenistan), ♀ Z. medica Brignoli, 1982 (Iran), ♂♀ Z. minoica sp. nov. (Greece), ♀ Z. minuta sp. nov. (Uzbekistan), ♀ Z. persica Brignoli, 1982 (Iran), ♂ Z. psammodroma sp. nov. (Turkmenistan), ♂♀ Z. schmitzi (Kulczyński, 1911), the type species (Egypt, Israel), ♂♀ Z. spinimana sp. nov. (Kazakhstan, Turkmenistan), ♂♀ Z. wunderlichi sp. nov. (Kyrgyzstan) and ♀ Z. zonsteini Fomichev & Marusik, 1969 (Kazakhstan). Twelve above-listed species are newly described, and males of Z. annulipes, Z. beshkentica, Z. maracandica and Z. martynovae are described for the first time. Two new combinations are established: Z. annulipes (Kulczyński, 1908) comb. nov., ex Filistata, and Pholcoides monticola (Spassky, 1941) comb. nov., ex Zaitunia. New data on distribution of the considered taxa are provided.
Epigenetic signatures such as methylation of the monoamine oxidase A (MAOA) gene have been found to be altered in panic disorder (PD). Hypothesizing temporal plasticity of epigenetic processes as a mechanism of successful fear extinction, the present psychotherapy-epigenetic study for we believe the first time investigated MAOA methylation changes during the course of exposure-based cognitive behavioral therapy (CBT) in PD. MAOA methylation was compared between N=28 female Caucasian PD patients (discovery sample) and N=28 age- and sex-matched healthy controls via direct sequencing of sodium bisulfite-treated DNA extracted from blood cells. MAOA methylation was furthermore analyzed at baseline (T0) and after a 6-week CBT (T1) in the discovery sample parallelized by a waiting time in healthy controls, as well as in an independent sample of female PD patients (N=20). Patients exhibited lower MAOA methylation than healthy controls (P<0.001), and baseline PD severity correlated negatively with MAOA methylation (P=0.01). In the discovery sample, MAOA methylation increased up to the level of healthy controls along with CBT response (number of panic attacks; T0–T1: +3.37±2.17%), while non-responders further decreased in methylation (−2.00±1.28%; P=0.001). In the replication sample, increases in MAOA methylation correlated with agoraphobic symptom reduction after CBT (P=0.02–0.03). The present results support previous evidence for MAOA hypomethylation as a PD risk marker and suggest reversibility of MAOA hypomethylation as a potential epigenetic correlate of response to CBT. The emerging notion of epigenetic signatures as a mechanism of action of psychotherapeutic interventions may promote epigenetic patterns as biomarkers of lasting extinction effects.
Importance of latrine communication in European rabbits shifts along a rural–to–urban gradient
(2016)
Background: Information transfer in mammalian communication networks is often based on the deposition of excreta in latrines. Depending on the intended receiver(s), latrines are either formed at territorial boundaries (between-group communication) or in core areas of home ranges (within-group communication). The relative importance of both types of marking behavior should depend, amongst other factors, on population densities and social group sizes, which tend to differ between urban and rural wildlife populations. Our study is the first to assess (direct and indirect) anthropogenic influences on mammalian latrine-based communication networks along a rural-to-urban gradient in European rabbits (Oryctolagus cuniculus) living in urban, suburban and rural areas in and around Frankfurt am Main (Germany).
Results: The proportion of latrines located in close proximity to the burrow was higher at rural study sites compared to urban and suburban ones. At rural sites, we found the largest latrines and highest latrine densities close to the burrow, suggesting that core marking prevailed. By contrast, latrine dimensions and densities increased with increasing distance from the burrow in urban and suburban populations, suggesting a higher importance of peripheral marking.
Conclusions: Increased population densities, but smaller social group sizes in urban rabbit populations may lead to an increased importance of between-group communication and thus, favor peripheral over core marking. Our study provides novel insights into the manifold ways by which man-made habitat alterations along a rural-to-urban gradient directly and indirectly affect wildlife populations, including latrine-based communication networks.
This article uses survey data from the German Socio-Economic Panel (GSOEP) to analyze the persistence of educational attainment across three generations in Germany. I obtain evidence of a robust effect of grandparents’ education on respondents’ own educational attainment in West Germany, net of parental class, education, occupational status, family income, parents’ relationship history, and family size. I also test whether the grandparent effect results from resource compensation or cumulative advantage and find empirical support for both mechanisms. In comparison, the intergenerational association between grandparents’ and respondents’ education is considerably weaker in East Germany and is also mediated completely by parental education. There are hardly any gender differences in the role of grandparents for respondents’ educational attainment, except for the fact that resource compensation is found to be exclusively relevant for women’s attainment in both West Germany and in East Germany after German reunification and the associated transition to an open educational system.
A new Iranian, probably pholeophilous species of the scarabaeine genus Onthophagus Latreille, 1802, O. roessneri n. sp., is described, illustrated, and its placement in the semicornis group within the subgenus Palaeonthophagus Zunino, 1979 is discussed. A key to the species of the group is presented.
In 2014, 56 localities in four provinces of Lesser Himalaya in Pakistan were studied. A total of 28 species have been recorded. A female of the data deficient, threatened species Coeliccia vacca was recorded from Charhaan. The record of Drepanosticta carmichaeli is a new addition to the list of Odonata of Pakistan, and expand the range of this species further to the west. The taxonomical status of Ischnura aurora aurora – considered common in Pakistan, following baseline literature of Fraser (1933) – now turns out to be Ischnura aurora rubilio.
Xenorhabdus and Photorhabdus bacteria are gaining more and more attention as a subject of research because of their unique yet similar life cycle with nematodes and insects. This work focused on the secondary metabolites that are produced by Xenorhabdus and Photorhabdus. With the help of modern HPLC-MS methodologies and increasingly available bacterial genome sequences, the structures of unknown secondary metabolites could be elucidated and thus their biosynthesis pathways could be proposed, too.
The first paper reported 17 depsipeptides termed xentrivalpeptides produced by the bacterium Xenorhabdus sp. 85816. Xentrivalpeptide A could be isolated from the bacterial culture as the main component. The structure of xentrivalpeptide A was elucidated by NMR and the Marfey´s method. The remaining xentrivalpeptides were exclusively identified by feeding experiments and MS fragmentation patterns.
The second paper described the discovery and isolation of xenoamicin A from Xenorhabdus mauleonii DSM17908. Additionally, other xenoamicin derivatives from Xenorhabdus doucetiae DSM17909 were analyzed by means of feeding experiments and MS fragmentation patterns. The xenoamicin biosynthesis gene cluster was identified in Xenorhabdus doucetiae DSM17909.
The manuscript for publication focused on the biosynthesis of anthraquinones in Photorhabdus luminescens. The Type II polyketide synthase for the biosynthesis of anthraquinone derivatives was discovered in P. luminescens in a previous publication by the Bode group,1 in which a partial reaction mechanism for the biosynthesis has been proposed. The manuscript reported in this thesis however elucidated the biosynthetic mechanisms in a greater detail as compared to the previous publication. Particularly, the biosynthetic mechanism was deciphered through heterologous expression of anthraquinone biosynthesis (ant) genes in E. coli. Additionally, deactivation of the genes antG encoding a putative CoA ligase and antI encoding a putative hydrolase, was performed in P. luminescens. Selected ant genes were over-expressed in E. coli as well as the corresponding proteins purified for in vitro assays. Model compounds were chemically synthesized as possible substrates of AntI and were used for in vitro assays. Here, it was revealed that the CoA ligase AntG played an essential role in the activation of the ACP AntF. Furthermore, a chain shortening mechanism by the hydrolase AntI was identified and was further confirmed by in vitro assays using model compounds. Additionally, this chain shortening mechanism was supported by homology based structural modeling of AntI.
We study the effect of thermal charm production on charmonium regeneration in high energy nuclear collisions. By solving the kinetic equations for charm quark and charmonium distributions in Pb+Pb collisions, we calculate the global and differential nuclear modification factors RAA(Npart) and RAA(pt) for J/ψ s. Due to the thermal charm production in hot medium, the charmonium production source changes from the initially created charm quarks at SPS, RHIC and LHC to the thermally produced charm quarks at Future Circular Collider (FCC), and the J/ψ suppression (RAA<1) observed so far will be replaced by a strong enhancement (RAA>1) at FCC at low transverse momentum.
Four new species of the genus Coecobrya, C. gejianbangi sp. nov., C. annulata sp. nov., C. ciliata sp. nov., and C. oculata sp. nov., are described from Guangxi caves as the representative of the genus in China. Coecobrya oculata sp. nov. of the boneti-group has 1+1 eyes and a serrate outer edge of the unguiculus. The other three species, devoid of eyes and with a tiny outer tooth on the unguiculus, are assigned here to the tenebricosa-group, assuming that the large tooth on the unguiculus is transformed into a tiny one in cave-obligate species. Clypeal chaetae in Entomobryoidea are systematically surveyed for the first time, and are found to be well diversified at species level. They have a potential taxonomical value in discriminating taxa of morphologically conserved groups.
West African Savanna ecosystems are undergoing severe changes in their vegetation composition due to the impact of human land use and changes in climatic conditions. This study aims to examine the effect of climate, land use, and their interaction on species richness and composition of West African herbaceous vegetation. Plot based vegetation sampling was done in Burkina Faso. Specific richness and diversity indices were used to determine the effect of land use, climate, and their interaction. An importance value was computed to determine herbaceous species dominating the communities. Frequency of species is used to examine their distribution pattern. The results showed that climate significantly influenced herbaceous specific richness more than land use. However, land use had a significant effect on herbaceous vegetation composition. Herbaceous species diversity changed with environmental conditions. The floristic composition of dominant species is driven by both climate and land use. The frequency of distribution demonstrated that herbaceous species occurrences were more influenced by the mixed effect of climate and land use than their separate effects. Occasional and rare species are the most important part of herbaceous vegetation. Thus heterogeneity of Savanna ecosystem and vulnerability of herbaceous species are high.
A new technique developed for measuring nuclear reactions at low momentum transfer with stored beams in inverse kinematics was successfully used to study isoscalar giant resonances. The experiment was carried out at the experimental heavy-ion storage ring (ESR) at the GSI facility using a stored 58Ni beam at 100 MeV/u and an internal helium gas-jet target. In these measurements, inelastically scattered α-recoils at very forward center-of-mass angles (θcm ≤ 1.5°) were detected with a dedicated setup, including ultra-high vacuum compatible detectors. Experimental results indicate a dominant contribution of the isoscalar giant monopole resonance at this very forward angular range. It was found that the monopole contribution exhausts 79+12−11% of the energy-weighted sum rule (EWSR), which agrees with measurements performed in normal kinematics. This opens up the opportunity to investigate the giant resonances in a large domain of unstable and exotic nuclei in the near future. It is a fundamental milestone towards new nuclear reaction studies with stored ion beams.
Streptococcus pneumoniae is the most frequent cause of community-acquired pneumonia. The infection process involves bacterial cell surface receptors, which interact with host extracellular matrix components to facilitate colonization and dissemination of bacteria. Here, we investigated the role of host-derived extracellular RNA (eRNA) in the process of pneumococcal alveolar epithelial cell infection. Our study demonstrates that eRNA dose-dependently increased S. pneumoniae invasion of alveolar epithelial cells. Extracellular enolase (Eno), a plasminogen (Plg) receptor, was identified as a novel eRNA-binding protein on S. pneumoniae surface, and six Eno eRNA-binding sites including a C-terminal 15 amino acid motif containing lysine residue 434 were characterized. Although the substitution of lysine 434 for glycine (K434G) markedly diminished the binding of eRNA to Eno, the adherence to and internalization into alveolar epithelial cells of S. pneumoniae strain carrying the C-terminal lysine deletion and the mutation of internal Plg-binding motif were only marginally impaired. Accordingly, using a mass spectrometric approach, we identified seven novel eRNA-binding proteins in pneumococcal cell wall. Given the high number of eRNA-interacting proteins on pneumococci, treatment with RNase1 completely inhibited eRNA-mediated pneumococcal alveolar epithelial cell infection. Our data support further efforts to employ RNAse1 as an antimicrobial agent to combat pneumococcal infectious diseases.