Refine
Year of publication
- 2011 (86) (remove)
Document Type
- Conference Proceeding (86) (remove)
Language
- English (60)
- German (24)
- Multiple languages (2)
Has Fulltext
- yes (86) (remove)
Is part of the Bibliography
- no (86)
Keywords
Institute
- Physik (42)
- Extern (6)
- Medizin (6)
- Universitätsbibliothek (4)
- Erziehungswissenschaften (3)
- Frankfurt Institute for Advanced Studies (FIAS) (3)
- Geowissenschaften (2)
- Geschichtswissenschaften (2)
- Informatik (2)
- Kulturwissenschaften (2)
CONTENTS: Keynote Address and Invited Plenary Lectures Symposia Debates and Panels Oral Presentations and Specific Topics Poster Presentations Workshop Presentations Case Study Presentations and Media Presentations Symposien Workshops
Over the past two decades the “one drug – one target – one disease” concept became the prevalent paradigm in drug discovery. The main idea of this approach is the identification of a single protein target whose inhibition leads to a successful treatment of the examined disease. The predominant assumption is that highly selective ligands would avoid unwanted side effects caused by binding to secondary non-therapeutic targets. In recent years the results of post-genomic and network biology showed that proteins rarely act in isolated systems but rather as a part of a highly connected network [1]. In addition this connectivity leads to more robust systems that cannot be interfered by the inhibition of a single target of that network and consequently might not lead to the desired therapeutic effect [2]. Furthermore studies prove that robust systems are rather affected by weak inhibitions of several parts than by a complete inhibition of a single selected element of that system [3]. Therefore there is an increasing interest in developing drugs that take effect on multiple targets simultaneously but is concurrently a great challenge for medicinal chemists. There has to be a sufficient activity on each target as well as an adequate pharmacokinetic profile [4]. Early design strategies tried to link the pharmacophors of known inhibitors, however these methods often lead to high molecular weight and low ligand efficacy. We present a new rational approach based on a retrosynthetic combinatorial analysis procedure [5] on approved ligands of multiple targets. These RECAP fragments are used to design a large combinatorial library containing molecules featuring chemical properties of each ligand class. The molecules are further validated by machine learning models, like random forests and self-organizing maps, regarding their activity on the targets of interest.
The LANSCE linear accelerator at Los Alamos National Laboratory provides H− and H+ beams to several user facilities that support Isotope Production, NNSA Stockpile Stewardship, and Basic Energy Science programs. These beams are initially accelerated to 750 keV using Cockcroft-Walton (CW) based injectors that have been in operation for over 37 years. They have failure modes which can result in prolonged operational downtime due to the unavailability of replacement parts. To reduce long-term operational risks and to realize future beam performance goals in support of the Materials Test Station (MTS) and the Matter-Radiation Interactions in Extremes (MaRIE) Facility, plans are underway to develop a Radio-Frequency Quadrupole (RFQ) based front end as a modern injector replacement for the existing CW injectors. Our progress to date will be discussed.
Beam test of the direct plasma injection scheme (DPIS) is carried out successfully for the first time in China, by setting up a comprehensive test and research platform of RFQ and laser ion source. The C6+ beam is accelerated successfully, and the peak beam current reaches more than 6mA which is measured by a Faraday cup of unique structure. The RF power coupled into the RFQ cavity is also examined, and results reveal that it is the RF power of about 195kW that can produce the peak beam current.
A CW RFQ prototype
(2011)
A short RFQ prototype was built for RF-tests of high power RFQ structures. We will study thermal effects and determine critical points of the design. HF-simulations with CST Microwave Studio and measurements were done. The cw-tests with 20 kW/m RF-power and simulations of thermal effects with ALGOR were finished successfully. The optimization of some details of the HF design is on focus now. First results and the status of the project will be presented.
"Finnegans Wake" has struck many of its exegetes as the epitome of the postmodern text. The oddity of James Joyce's last work has been and still is a provocation not only for literary criticism and theory but for every reader of the work. It provokes us to reflect on our preconceptions concerning such fundamental issues as reading, meaning and understanding. Due to this very quality, the work has been a fertile intellectual stimulus for an illustrious band of thinkers of the ―post-projects. Its singularity has provoked and facilitated the further development of theoretical frameworks beyond the confines of literary theory proper. This essay will trace the elaborate theoretical responses of Umberto Eco and Jacques Lacan to Joyce's grand literary arcanum. Eco's concept of the openness of modern works of art and Lacan's elaboration of his psychoanalytic concepts of the symptom and of the Borromean knot were inspired by their study of Joyce. As an extreme instance of literariness, Finnegans Wake thus constitutes an ideal opportunity to consider the scope and boundaries of the scholarly study of literary texts more generally.
Die Grenzen und Möglichkeiten der Philologie im Holocaust-Diskurs : das Beispiel Theresienstadt
(2011)
Philology seems to have come to a crossroads. One path leads back to the save haven of established core strengths and competences, the other path promises new perspectives through further expansion into the vastness of cultural studies. If philology is to continue as a discipline relevant to society as a whole, retreat into pure philology — concentrating only on the text itself, adhering to national boundaries — is no viable option. Instead, by opening itself up for the questions and methods of truly interdisciplinary inquiry, philology can emerge in new shape, powerful enough to adequately address issues of interdisciplinary, intercultural and intergenerational importance. This essay will argue for such an extension of philology into cultural studies through an examination of texts, songs and plays written in and about the Terezín ghetto. The songs of Leo Strauß and Manfred Greiffenhagen, the ghetto opera "Der Kaiser von Atlantis" (The Emperor of Atlantis), as well as Roy Kift's play "Camp Comedy" and Frido Mann's parable "Terezín" will exemplify the potential of philology’s conjunction with history, sociology and cultural studies.
Most texts that deal with Martin tom Dieck’s black-and-white comic "hundert Ansichten der Speicherstadt" (Zürich: Arrache Cœur, 1997, French title: Vortex) claim that it depicts the eponymous warehouse district (Speicherstadt) in Hamburg. As this paper shows, this claim is inaccurate: although the architecture in tom Dieck’s drawings clearly refers to buildings in the warehouse district, the differences in the details are so obvious, that to speak of a straightforward depiction of the Speicherstadt is oversimplifying. After a brief comparison with Christoph Schäfer’s picture book "Die Stadt ist unsere Fabrik" (Leipzig: Spector Books, 2010), the paper concludes with a discussion of the depiction of urban environments in general and in tom Dieck's book in particular.
Es ist eine alte Debatte. Auf der einen Seite steht die althergebrachte Maxime, alles, was wert ist, gesagt zu werden, müsse in jeder Sprache gesagt werden können - umso mehr dann, wenn es sich um die Wissenschaft handelt, die den Anspruch erhebt, universelle Wahrheiten zu erfassen. Demgegenüber steht ein immer wieder anzutreffender Gedanke, dessen wohl inspirierteste Formulierung von Wilhelm von Humboldt stammt, nämlich, dass die Verschiedenheit der Sprachen nicht nur eine von „Schällen und Zeichen“, sondern eine der „Weltansichten selbst“ sei. Thema dieses Vortrags ist die Frage, wo die Wahrheit zwischen diesen scheinbaren Gegensätzen liegt.
Die Antike bildet einen zentralen Bezugspunkt für Identitätskonstruktionen in den europäischen Kulturen. Das Wissen davon, was Antike ist, ist jedoch keineswegs statisch: "Die Antike" formiert sich historisch stets im Wechselspiel mit dem Selbstverständnis der rezipierenden Kulturen. Diese bipolare Konstruktion griff die interdisziplinäre Tagung "Das Geschlecht der Antike" auf, die Anna Heinze (Berlin) und Friederike Krippner (Berlin) im Juni an der Humboldt-Universität zu Berlin veranstalteten. Sie verfolgte einerseits die Frage, welche Rolle die Kategorie "Geschlecht" bei verschiedenen Epochenentwürfen der Antike spielt, und richtete den Blick andererseits darauf, was die Referenz auf die Antike bei der Konstruktion von Geschlechterverhältnissen in nachantiken Gesellschaften leistet.
Im Jahr 2006 brachte Saul Friedländer seine weithin beachtete Gesamtdarstellung „Nazi Germany and the Jews“ mit dem zweiten Band „The Years of Extermination“ zum Abschluss. Das Buch lese sich wie ein Roman, so und ähnlich urteilten Rezensenten über dessen literarische Qualitäten. Auf erzählerische Stärken verweisen auch Kommentare zu Christopher Brownings jüngster Studie „Remembering Survival“ (2010). Das Erzählen in der Geschichtswissenschaft ist seit längerem wieder Gegenstand der Diskussion: Forscherinnen und Forscher auf einem Symposium auf dem Alten Schloss Dornburg bei Jena gingen im Juni 2011 dieser Frage speziell für den Bereich der Holocaust-Historiographie nach.
Meeting Abstract : 82. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. Freiburg i. Br., 01.-05.06.2011.
Ca. 3 Millionen Erwachsene in der Bundesrepublik Deutschland leiden unter Tinnitus, wobei eine bei jedem dieser Patienten zur Heilung führende Therapie bisher noch nicht existiert. Ansatzpunkt einer neuartigen Therapie ist die Wiederherstellung des normalen elektrischen Entladungsmusters im Hörnerv mittels elektrischer Stimulation. Hiermit berichten wir über unsere ersten Erfahrungen mit dem Tinnelec, einem Implantat mit einer einzelnen Stimulations-Elektrode die in der Rundfensternische platziert wird.
Zurzeit haben wir 4 einseitig ertaubten Patienten mit Tinnitus auf dem betroffenen Ohr jeweils ein Tinnelec-System implantiert. Die Dauer des Tinnitus betrug mindestens ein Jahr und gängige Tinnitus-Therapien wie z.B. Infusionstherapie waren erfolglos geblieben. Ein psychogener Tinnitus wurde ausgeschlossen. Der durch den Tinnitus verursachte Leidensdruck wurde anhand einer VAS Scala (Visuelle Analog Scala) und eines Tinnitus-Handicap-Inventory (THI) Fragebogens beurteilt. Die Reizapplikation betrug mind. 4 Stunden täglich. Als Stimulationsparameter wurde eine Reizmusterannäherung an den Tinnitus angestrebt.
Bei drei Patienten wurde unter der Stimulation der Tinnitus erträglicher, eine zeitweise komplette Unterdrückung des Tinnitus schon innerhalb der ersten Therapie-Wochen wurde jedoch nur in einem der Fälle berichtet. Diese Ergebnisse wurden auch durch das THI und VAS unterstützt.
Die Tinnelec-Implantation erscheint für Tinnitus Erfolg versprechend zu sein. Weitere Studien bei Tinnitus-Patienten ohne zusätzliche Hörbeeinträchtigung sind jedoch notwendig bis endgültige Schlussfolgerungen betreffend dieses Implantats gezogen werden können. In jedem Fall bleibt die Option einer Cochlea-Implantation im selben Ohr, nach Explantation des Tinnelec, bestehen.
Accelerator Driven Systems (ADS) are promising tools for the efficient transmutation of nuclear waste products in dedicated industrial installations, called transmuters. The Myrrha project at Mol, Belgium, placed itself on the path towards these applications with a multipurpose and versatile system based on a liquid PbBi (LBE) cooled fast reactor (80 MWth) which may be operated in both critical and subcritical modes. In the latter case the core is fed by spallation neutrons obtained from a 600 MeV proton beam hitting the LBE coolant/target. The accelerator providing this beam is a high intensity CW superconducting linac which is laid out for the highest achievable reliability. The combination of a parallel redundant and of a fault tolerant scheme should allow obtaining an MTBF value in excess of 250 hours that is required for optimal integrity and successful operation of the ADS. Myrrha is expected to be operational in 2023. The forthcoming 4-year period is fully dedicated to R&D activities, and in the field of the accelerator they are strongly focused on the reliability aspects and on the proper shaping of the beam trip spectrum.
Chromatic, geometric and space charge effects on laser accelerated protons focused by a solenoid
(2011)
We studied numerically emittance and transmission effects by chromatic and geometric aberrations, with and without space charge, for a proton beam behind a solenoid in the laser proton experiment LIGHT at GSI. The TraceWin code was employed using a field map for the solenoid and an initial distribution with exponential energy dependence close to the experiment. The results show a strong effect of chromatic, and a relatively weak one of geometric aberrations as well as dependence of proton transmission on distance from the solenoid. The chromatic effect has an energy filtering property due to the finite radius beam pipe. Furthermore, a relatively modest dependence of transmission on space charge is found for p production intensity below 1011.
n order to reach the desired intensities of heavy ion beams for the experiments at FAIR, SIS18 and SIS100 have to be operated with intermediate charge states. Operation with intermediate charge state heavy ions at the intensity level of about 1011 ions per cycle has never been demonstrated elsewhere and requires a dedicated upgrade program for SIS18 and a dedicated machine design for SIS100. The specific problems coming along with the intermediate charge state operation in terms of charge exchange processes at collisions with residual gas atoms, pressure bumps by ion induced desorption and corresponding beam loss appears far below the typical space charge limits. Thus, new design concepts and new technical equipment addressing these issues are developed and realized with highest priority. The upgrade program of SIS18 addressing the goal of minimum ionization beam loss and stable residual gas pressure conditions has been defined in 2005. A major part of this upgrade program has been successfully realized, with the result of a world record in accelerated number of intermediate charge state heavy ions.
Erstmalig wurde im Jahr 2011 auf BURG FÜRSTENECK eine Hessische Schülerakademie für die Mittelstufe (7-9) durchgeführt. 60 Schülerinnen und Schüler nahmen während der Herbstferien für die Dauer von zehn Tagen an Haupt- und Wahlkursen aus Themenbereichen der Chemie, Biologie, Mathematik, Wirtschaftsethik sowie der Kulturwissenschaften und ästhetischen Bildung teil.
How critical is criticality?
(2011)
Vom 17. bis 19. Februar 2011 luden Jens Eder, Joseph Imorde und Maike Sarah Reinerth für die Filmwissenschaft / Mediendramaturgie der Universität Mainz und die Kunstgeschichte der Universität Siegen Forscher und Forscherinnen unterschiedlicher Disziplinen zu einem Workshop mit dem Thema "Medium Menschenbild" ein. Förderer waren der Forschungsschwerpunkt "Medienkonvergenz" der Johannes Gutenberg-Universität Mainz und das Labor Neue Kunst Siegen. Ziel der Tagung war, das grundsätzliche Verhältnis von Medialität und Menschenbild zu analysieren, die Spezifik medial vermittelter Menschenbilder im interdisziplinären Austausch zu diskutieren sowie auf die in ihnen implizit enthaltenen konzeptuellen Vorstellungen hinzuweisen. ...
Schließlich untersuchte die Kunsthistorikerin HELEN BARR (Frankfurt am Main) den "neuen Menschen" in Werbeanzeigen illustrierter Zeitschriften der 1920er-Jahre. Das breite Spektrum der Werbung für Pflegeprodukte und Genussmittel suggeriere Orientierungshilfe in der urbanisierten Welt und propagiere ideale Menschenbilder der Moderne. ...