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The elliptic, v2, triangular, v3, and quadrangular, v4, azimuthal anisotropic flow coefficients are measured for unidentified charged particles, pions, and (anti-)protons in Pb–Pb collisions at √sNN=2.76 TeV with the ALICE detector at the Large Hadron Collider. Results obtained with the event plane and four-particle cumulant methods are reported for the pseudo-rapidity range |η|<0.8 at different collision centralities and as a function of transverse momentum, pT, out to pT=20 GeV/c. The observed non-zero elliptic and triangular flow depends only weakly on transverse momentum for pT>8 GeV/c. The small pT dependence of the difference between elliptic flow results obtained from the event plane and four-particle cumulant methods suggests a common origin of flow fluctuations up to pT=8 GeV/c. The magnitude of the (anti-)proton elliptic and triangular flow is larger than that of pions out to at least pT=8 GeV/c indicating that the particle type dependence persists out to high pT.
The production cross section of electrons from semileptonic decays of beauty hadrons was measured at mid-rapidity (|y|<0.8) in the transverse momentum range 1<pT<8 GeV/c with the ALICE experiment at the CERN LHC in pp collisions at a center of mass energy √s=7 TeV using an integrated luminosity of 2.2 nb−1. Electrons from beauty hadron decays were selected based on the displacement of the decay vertex from the collision vertex. A perturbative QCD calculation agrees with the measurement within uncertainties. The data were extrapolated to the full phase space to determine the total cross section for the production of beauty quark–antiquark pairs.
The inclusive transverse momentum (pT) distributions of primary charged particles are measured in the pseudo-rapidity range |η|<0.8 as a function of event centrality in Pb–Pb collisions at √sNN=2.76 TeV with ALICE at the LHC. The data are presented in the pT range 0.15<pT<50 GeV/c for nine centrality intervals from 70–80% to 0–5%. The results in Pb–Pb are presented in terms of the nuclear modification factor RAA using a pp reference spectrum measured at the same collision energy. We observe that the suppression of high-pT particles strongly depends on event centrality. The yield is most suppressed in central collisions (0–5%) with RAA≈0.13 at pT=6–7 GeV/c. Above pT=7 GeV/c, there is a significant rise in the nuclear modification factor, which reaches RAA≈0.4 for pT>30 GeV/c. In peripheral collisions (70–80%), only moderate suppression (RAA=0.6–0.7) and a weak pT dependence is observed. The measured nuclear modification factors are compared to other measurements and model calculations.
Long-range angular correlations on the near and away side in p–Pb collisions at √sNN=5.02 TeV
(2013)
Angular correlations between charged trigger and associated particles are measured by the ALICE detector in p–Pb collisions at a nucleon–nucleon centre-of-mass energy of 5.02 TeV for transverse momentum ranges within 0.5<pT,assoc<pT,trig<4 GeV/c. The correlations are measured over two units of pseudorapidity and full azimuthal angle in different intervals of event multiplicity, and expressed as associated yield per trigger particle. Two long-range ridge-like structures, one on the near side and one on the away side, are observed when the per-trigger yield obtained in low-multiplicity events is subtracted from the one in high-multiplicity events. The excess on the near-side is qualitatively similar to that recently reported by the CMS Collaboration, while the excess on the away-side is reported for the first time. The two-ridge structure projected onto azimuthal angle is quantified with the second and third Fourier coefficients as well as by near-side and away-side yields and widths. The yields on the near side and on the away side are equal within the uncertainties for all studied event multiplicity and pT bins, and the widths show no significant evolution with event multiplicity or pT. These findings suggest that the near-side ridge is accompanied by an essentially identical away-side ridge.
The essay by Adorno and Horkheimer about The Culture Industry (in the volume Dialectic of Enlightment) represents for Alberto Abruzzese the starting point of a reasoning on the intellectuals' role, the crisis of humanistic and academic knowledge and the new “screen and network” society. The author uses The Culture Industry as a text on the western civilization's sunset and at the same time on the metamorphosis of mass cultural production. Abruzzese refers to those scholars who deepened these issues with passion and acumen. From Benjamin to Canetti, from Debord to Foucault, from Lukacs to McLuhan: Abruzzese analyses a whole research path in media culture with the frankness of a personal self-examination.
Selbständig Texte verschiedener Textsorten zu verfassen gehört zum Gegenstand jeglicher Schulausbildung und zu den Kernaufgaben des Deutschunterrichts. Welche Schreib- bzw. Textkompetenzen und Standards dafür notwendig sind, ist Gegenstand der aktuellen fachdidaktischen Diskussion (vgl. etwa Becker–Mrotzek/Schindler 2007, Feld-Knapp 2006, Feilke 2012). Die Sprachdidaktik/Fremdsprachendidaktik befasst sich mit praxisbezogenen Problemen, die das Erforschen der Lern- und Lehrprozesse betreffen. In der Gegenwart sind sich alle Sprachdidaktiker darüber einig, dass es ohne Texte keinen effektiven und sinnvollen Fremdsprachenunterricht gibt, denn die sprachliche Kommunikation und sprachliches Handeln vollzieht sich in Texten. Zu den elementaren Aufgaben der Hochschule gehört es also, diejenigen fachlichen und sprachlichen Kompetenzen ihrer Studierenden von Studienbeginn an gezielt zu fördern, die zum festen Bestandteil der Curricula gehören. Hierzu zählt die gezielte Entwicklung akademischer Schreib- und Textkompetenz in der Erst- bzw. Zweitsprache Deutsch. Gleichzeitig soll die Forschung auf diesem Gebiet weiter ausgebaut und verbessert werden. Im Folgenden sollen einige wichtige Dimensionen (Phänomene) der Text– und Schreibkompetenz diskutiert werden, die die Routinen der Studierenden in der schriftlichen Textproduktion fördern. Sie gehören nämlich zur unabdingbaren Voraussetzung ihrer professionellen Entwicklung...
240 Jahre nach dem Tod des großen Frankfurter Forschers : sie
entziffert Senckenbergs Tagebücher
(2013)
The three-dimensional structure determination of RNAs by NMR spectroscopy relies on chemical shift assignment, which still constitutes a bottleneck. In order to develop more efficient assignment strategies, we analysed relationships between sequence and 1H and 13C chemical shifts. Statistics of resonances from regularly Watson– Crick base-paired RNA revealed highly characteristic chemical shift clusters. We developed two approaches using these statistics for chemical shift assignment of double-stranded RNA (dsRNA): a manual approach that yields starting points for resonance assignment and simplifies decision trees and an automated approach based on the recently introduced automated resonance assignment algorithm FLYA. Both strategies require only unlabeled RNAs and three 2D spectra for assigning the H2/C2, H5/C5, H6/C6, H8/C8 and H10/C10 chemical shifts. The manual approach proved to be efficient and robust when applied to the experimental data of RNAs with a size between 20 nt and 42 nt. The more advanced automated assignment approach was successfully applied to four stemloop RNAs and a 42 nt siRNA, assigning 92–100% of the resonances from dsRNA regions correctly. This is the first automated approach for chemical shift assignment of non-exchangeable protons of RNA and their corresponding 13C resonances, which provides an important step toward automated structure determination of RNAs.
Credit boom detection methodologies (such as threshold method) lack robustness as they are based on univariate detrending analysis and resort to ratios of credit to real activity. I propose a quantitative indicator to detect atypical behavior of credit from a multivariate system - a monetary VAR. This methodology explicitly accounts for endogenous interactions between credit, asset prices and real activity and detects atypical credit expansions and contractions in the Euro Area, Japan and the U.S. robustly and timely. The analysis also proves useful in real time.
Eine empirische Arbeit, auf Basis der teilnehmenden Beobachtung nach Malinowski, bei Dealern im bürgerlichen Milieu. Der Fokus liegt auf einer ethnologischen Herangehensweise; d.h., dass am Leben der Dealer weitestgehend und möglichst vorurteilsfrei teilgenommen wird. Hieraus ergeben sich Einblicke, die mit anderen Forschungsmethoden nicht möglich sind.
We show that the presence of high frequency trading (HFT) has significantly mitigated the frequency and severity of end-of-day price dislocation, counter to recent concerns expressed in the media. The effect of HFT is more pronounced on days when end of day price dislocation is more likely to be the result of market manipulation on days of option expiry dates and end of month. Moreover, the effect of HFT is more pronounced than the role of trading rules, surveillance, enforcement and legal conditions in curtailing the frequency and severity of end-of-day price dislocation. We show our findings are robust to different proxies of the start of HFT by trade size, cancellation of orders, and co-location.
We examine the impact of stock exchange trading rules and surveillance on the frequency and severity of suspected insider trading cases in 22 stock exchanges around the world over the period January 2003 through June 2011. Using new indices for market manipulation, insider trading, and broker-agency conflict based on the specific provisions of the trading rules of each stock exchange, along with surveillance to detect non-compliance with such rules, we show that more detailed exchange trading rules and surveillance over time and across markets significantly reduce the number of cases, but increase the profits per case.
‘Çeviribilim’ olarak adlandırılan araştırma alanında geride bırakılan son birkaç on yıla bakıldığında bilim ve kültürde yaşanan kimi olay ve gelişmelerin Almanya ve Avrupa merkezli ‘çeviri’ araştırmalarına yön verdiği söylenebilir. Bilişim konusundaki gelişmeler, eylem kuramının ve iletişimbilimin dönüşümü, işlevselciliğin yeniden yorumlanması; edimbilimin evrimi, bilişsel felsefedeki yeni gelişmeler, yeni bakış açılarını ortaya çıkarmıştır. Bu bakış açılarının birer sonucu olarak ‘çeviribilim’ olarak adlandırılan çeviri odaklı düşünmelerde yeni ağırlık noktaları ve buradan hareketle ‘kuram’ ya da ‘yaklaşım’ biçiminde ifade edilen çalışmalar oluşmuştur. Kuramcıların belli olgulara bakış açıları onların nesneye yaklaşım biçimlerini ve algılarını etkiler. Çeviri olgusuna dönük savlar ortaya koyan kuramcılara bakıldığında ‘olgular bütünü’ ya da ‘karmaşık olgu’ olarak değerlendirilebilecek bir olguya dair farklı yaklaşım ve tutum alışlardan söz edilmektedir. Bu noktada, karmaşık bir dünyayı temsil eden çok boyutlu bir olgu olarak ‘çeviri’nin kendine özgü niteliği, 90’lı yıllardan başlayarak günümüze kadar gelen süreçte, ‘çeviribilimin’ psikoloji alanı ile ilişkilendirilmesi sonucunu beraberinde getirmiştir. Bu çerçevede araştırmaların ilgisi, ‘çeviri gerçekliği’nde merkeze oturtulan ‘çevirmen’e yönelmiş, ‘çevirmen’in bir ürün olarak ‘çeviri’yi hangi tutum ve ruhsal duruma dayanarak ortaya koyduğuna ilişkin araştırma yönelimi önem kazanmıştır. “Belli koşullar altında bir çevirmeni belli bir çeviri çıktısına, diğer bir deyişle belli bir çeviri metne götüren olay örgüsü nedir?” ya da “çeviri sırasında hangi zihinsel işlemler gerçekleşiyor?” gibi sorulardan hareket eden yaklaşımların bir üst bakışla ele alınması bu çalışmanın ana konusunu oluşturmaktadır.
Das lebensbegleitende Lernen – sei es institutionell oder nicht institutionell – dient offen oder verdeckt einer bestimmten Absicht. Von der vorbestimmten Absicht aus betrachtet wird jedes Gelernte einer Prüfung unterzogen. Im Rahmen dieses Referats wird eine literarische Prüfung eines DaF-Seminars mit Vorbedingungen und Nachwirkungen diskutiert. In wissenschaftlichen Arbeiten beschäftigt man sich überwiegend mit der Rolle der Lehrenden, der Lernenden und mit der Unterrichtsgestaltung. All diese Themen sind für den Unterricht, speziell für den Fremdsprachenunterricht, unumstritten. Ebenso von Bedeutung sollte die Bewertung der vermittelten bzw. angeeigneten Fremdsprachenkenntnisse sein. Das Referat wird das Prüfungsverfahren eines fremdsprachlichen Literaturseminars kritisch darstellen. Wichtiges Kriterium bei der Bewertung der Prüfungsergebnisse ist die Reflexion von produktiven Verfahren. Ausgehend vom 'produktiven Verfahren', werden Multiple Choice und offene Fragen – sei es Abfragen von gelernten Inhalten oder allgemeinen Kenntnissen in individuellen Aussagen – kontrastiv diskutiert. Das bevorzugte Prüfungsverfahren wird nach den Gütekriterien Validität, Reliabilität und Objektivität überprüft.
Else Lasker-Schüler, Tino und Jussuf, viele Namen, die sie sich selber gab, führen zu einer einzigartigen, starken Frau, die ihr Leben in Literatur umgesetzt hat. Zu einer Frau, die einer der führenden expressionistischen Persönlichkeiten wurde, ihr Leben literarisierend vermarktete und doch im wahrsten Sinne des Wortes nie mit sich und der Umwelt zufrieden werden konnte und auch werden wollte.
The present study is about note taking techniques in consecutive translation and their application. In the beginning we analyzed in the relevant literature, consecutive interpretation among translation techniques, note taking, and the function and features of note taking in consecutive translation. Afterwards, we presented the problems that an interpreter might face in consecutive interpretation with concrete examples and provided possible methods and techniques to overcome these. Hereby, we emphasized that note taking techniques are an important feature to remember while translating and its function as a memory supporting tool. In the last section we discussed the roles of a consecutive interpreter and emphasized within this context the usage of the earlier mentioned note taking techniques (use of acronyms, signs, and symbols). Moreover we highlighted that each interpreter has to have his/her own techniques and improve these continuously.
Characterization of mouse NOA1 : subcellular localizaion, G-Quadruplex binding and proteolysis
(2013)
Mitochondria contain their own protein synthesis machinery with mitoribosomes that are similar to prokaryotic ribosomes. The thirteen proteins encoded in the mitochondrial genome are members of the respiratory chain complexes that generate a proton gradient, which is the electromotoric force for ATP synthesis.
NOA1 (Nitric Oxide Associated Protein-1) is a nuclear encoded GTPase that positively influences mitochondrial respiration and ATP production. Although a role in mitoribosome assembly was assigned to NOA1 the underlying molecular mechanism is poorly understood. This work shows that the multi-domain protein NOA1 serves multiple purposes for the function of mitochondria. NOA1 is a dual localized protein that makes a detour through the nucleus before mitochondrial import. The nuclear shuttling is mediated by a nuclear localization signal and the now identified nuclear export signal. SELEX (Systemic Evolution of Ligands by Exponential Enrichment) analysis revealed a G-quadruplex binding motif that characterizes NOA1 as ribonucleoprotein (RNP). G-quadruplex binding was coupled to the GTPase activity and increased the GTP hydrolysis rate. The sequence of localization events and the identification of NOA1 being a RNP lead to the discussion of an alternative import pathway for RNPs into mitochondria. The short-lived NOA1 contains ClpX recognition motifs and is specifically degraded by the mitochondrial matrix protease ClpXP. NOA1 is the first reported substrate of ClpXP in higher eukaryotes and augments the contribution of the ClpXP protease for mitochondrial metabolism. To assess the direct action of NOA1 on the mitoribosome co-sedimentation assays were performed. They showed that the interaction of NOA1 and the mitoribosome is dependent on the GTPase function and the nascent peptide chain. In vitro, NOA1 facilitated the membrane insertion of newly translated and isotope labeled mitochondrial translation products into inverted mitochondrial inner membrane vesicles. In conclusion, NOA1 is a G-quadruplex-RNP that acts as mitochondrial membrane insertion factor for mtDNA-encoded proteins.
This thesis provides a comprehensive model of the molecular function of NOA1 and is the basis for future research. The identification of NOA1 as ClpXP substrate is a major contribution to the field of mitochondrial research.
Considering migration to be a gendered experience, in this article, I focus on the gender-specific processes of cultural production and tradition-building in the context of migration and pose the following questions: What happens to gendered biographies in a migration context? What role does gender play with respect to the rupture, renewal, or building of traditions in migration processes? Drawing on the basic assumption that "gender fundamentally organizes the social relations and structures," which in turn shapes the processes of migration (cf. Curran, 2006, 199), I make use of the concept of gender defined as an accomplishment, as a performance in daily interaction practices:
When we view gender as an accomplishment, an achieved property of situated conduct, our attention shifts from matters internal to the individual, and focuses on interactional and, ultimately, institutional arenas. (West et al., 1987, 126)
The present study is a compilation of moss flora of Western Himalayas (India). This compilation listed 745 species of mosses, belonging to 19 orders; 55 families and 230 genera. Out of these 17 species have been reported endemic from Western Himalayas. 196 species have been synonymized and status of 86 species is still doubtful i.e. unresolved name. At present out of 745 only 463 species are validly known from this mountain range of India
In the present study the level of S, Cu, Cr, Cd, Zn, Pb and Cr was estimated in samples of the common thalloid liverwort Plagiochasma rupestre (G. Frost) Stephani, from Ranthambhore National park, Rajasthan (India). High metallic load was observed both in substrate as well as in plant tissue at locations adjacent to higher vehicular load, during winter the metallic content is highest, followed by summer and monsoon season. Elemental concentration in substrate for Plagiochasma rupestre was in the order of Zn> S> Pb> Cu> Cd> Cr, while in plant tissue it showed S> Zn> Pb> Cu> Cd> Cr, which is indicative of air borne trace elemental load. Quantitative analysis of these elements in vegetative thalli of Plagiochasma rupestre and the substrate showed an increase in metallic content during winter, which reveals the significance of this liverwort as a biological sink of mineral elements present in the soil and air and may provide an important tool in estimation of both aerial pollution and mineral enrichment in soil.
The present contribution is an enumerated account of mosses of Munsyari (Pithoragarh), Western Himalayas. The study revealed the presence 8 orders, 20 families, 32 genera and 44 species in the area. Moss species viz. Anoectangium walkeri Broth., Actinothuidium hookeri (Mitt.) Broth. Stereophyllum ligulatum Jaeg., Anomodon minor (Hedw.) Fŭrnr., Hageniells assamica Dixon, Schoenobryum cocavifolia (Griff.) Gang., Entodon luteonitens Ren. et Card. and Physcomitrium pulchellum (Grif.) Mitt. are reported for the first time from Munsiyari hills as well as western Himalayas as welcome additions to the bryoflora of Uttarakhand (Western Himalaya).
Similipal Biosphere Reserve is a part of biotic province of Chhotanagpur Plateau. It has a representative ecosystem under Mahanadian biogeographic region. Its biodiversity is an assemblage representation of Western Ghats and North-East India. Regarding bryophytes this area was rather unexplored and the current investigation shows the occurrence of 33 taxa of bryophytes in this biosphere reserve and its neighboring areas. Each species has been enumerated with its ecological and distributional details.
The present contribution revealed the occurrence of Hypnum plumaeforme Wilson belonging to family Hypnaceae (Bryopsida) for the first time in Munsiyari region of Uttarakhand state, which is a new addition to the bryoflora of Western Himalayas. Earlier this species was known only from eastern Himalayas (Nepal).
Scanning electron microscope analyses of sporoderm of 7 species of 3 genera of Marchantiales are presented in this study. In the studied species, sporoderm exhibit a broad range of morphology and have taxonomic specificity. The structurally rigid sporoderms have specific sculpturing and characteristic patterning. Peculiar architectures are found in different taxa, which revealed that and stable architectures may be present within an order. Sporoderms usually have specific surface markings which are often one of the best parameters to identify any species.
Celiac disease (CD) is an immune-mediated enteropathy that is characterized by intraepithelial lymphocytosis, crypt hyperplasia, and villous atrophy. Prevalence is high and has been estimated to range between 0.5% and 1.5%. Capsule endoscopy (CE) has a sensitivity and specificity of approximately 90%. CD is an important differential diagnosis for diagnostic workup for anemia, malabsorption, or diarrhea, and must be recognized reliably by the investigator. Moreover, CE is the preferred method to screen for complications in CD, such as enteropathy-associated T-cell lymphoma, ulcerative jejunitis, and small bowel adenocarcinoma. This article is part of an expert video encyclopedia.
Small bowel tumors are detected in approximately 10% of patients with small bowel endoscopies for obscure or overt mid-intestinal bleeding. Small bowel tumors may be of malignant or benign etiology. Malignant etiologies include adenocarcinoma, neuroendocrine tumors, or lymphoma, whereas benign lesions are typically lipomas, inflammatory polyps, or adenomas. Within the group of nonneoplastic lesions inflammatory polyps are most frequent. Significant bleeding and bowel obstruction due to intussusception might occur, and surgical or endoscopic treatment has been reported for symptomatic patients. A case is demonstrated with an inflammatory fibroid polyp detected by capsule endoscopy and confirmed by balloon enteroscopy. This article is part of an expert video encyclopedia.
Peutz–Jeghers syndrome (PJS) is a rare autosomal-dominant inherited disorder characterized by gastrointestinal hamartomas, mucocutaneous pigmentation, and an elevated cancer risk. Moreover, intussusception risk may be as high as 50% at the age of 20 years and is caused by large polyps. There is some evidence that endoscopic surveillance of PJS patients with removal of small intestinal polyps with a diameter of more than 15 mm efficiently prevents intussusceptions. In recent years, capsule endoscopy (CE) has largely replaced small-bowel radiography techniques to screen for small-bowel polyps. Magnetic resonance imaging may be equally efficient as CE for screening of large polyps. Balloon enteroscopy may be used for endoscopic snare resection of polyps. This article is part of an expert video encyclopedia.
The small intestine is a part of the gastrointestinal tract in which digestion and absorption of nutrients takes place. The small bowel follows the stomach and is followed by the large intestine, reaching from the pylorus to the valve of Bauhin and is separated into the duodenum, the jejunum, and the ileum.
Capsule endoscopy (CE) has the potential to offer a perfect overview of the small-bowel mucosa and complete visualization of the entire small bowel is achieved in most cases. In this video, there is an overview offered on normal findings in small-bowel CE and typical anatomical landmarks are indicated. This article is part of an expert video encyclopedia.
This is an example of capsule endoscopy (CE) revealing terminal ileitis in an young male patient with recurrent abdominal pain who had previously been investigated with colonoscopy and esophagogastroduodenoscopy without any significant findings. CE revealed severe inflammation of the terminal ileum. This article is part of an expert video encyclopedia.
Small bowel varices may be found in less than 5% of patients with suspected small bowel bleeding. These varices are associated with portal hypertension or thrombosis of mesenteric venous vessels and with altered abdominal vascular anatomy with or without prior small bowel surgery. In bleeding small bowel varices, therapeutic options include endoscopic injection of tissue adhesives, endovascular approaches such as balloon-occluded retrograde transvenous or percutaneous obliteration and transjugular intrahepatic portosystemic shunt, and surgical resection. This is a case report of a 53-year-old patient with ethylic liver cirrhosis who presented with severe, life-threatening hematochezia due to small bowel varices. This article is part of an expert video encyclopedia.
Small-bowel tumors are rare and account for approximately 5% of all gastrointestinal tumors. Approximately 65% of small-bowel tumors are malignant, and approximately 40% of these tumors are adenocarcinomas. Similar to colorectal adenocarcinoma, premalignant adenomas of the small bowel may progress to carcinoma. This occurs both sporadically and in the context of hereditary tumor syndromes such as familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer (Lynch syndrome). Herein cases with small-bowel adenocarcinomas visualized with both capsule endoscopy and double-balloon enteroscopy are presented. This article is part of an expert video encyclopedia.
The author presents the case of a patient with severe bleeding from a duodenal ulcer that could not be controlled by endoscopic application of metal clips and injection of fibrin glue. Angiographic embolization with placement of coils into the feeding vessel stopped the bleeding. However, 3 days later, a fistula emerged from coil material penetrating into the dorsal duodenum and a peritoneal leakage developed. The fistula was completely closed by placing an over-the-scope clip on the enteral opening of the fistula. This article is part of an expert video encyclopedia.
Here the authors report the case of an elderly woman who had upper abdominal pain, upper gastrointestinal hemorrhage, and jaundice (a symptomatic triad termed the ‘Quincke’ triad) a few days after endoscopic sphincterotomy. Abdominal ultrasonography demonstrated an echo-rich filling of the choledochus consistent with hemobilia. Endoscopic retrograde cholangiography was immediately performed and blood clots were removed from the common bile duct. A nasobiliary catheter was placed to irrigate the bile duct for prevention of recurring obstruction of the bile ducts from blood clots. Further follow-up of the patient was uneventful. This article is part of an expert video encyclopedia.
Operatively altered anatomy might provide a challenge for endoscopic retrograde cholangiopancreatography. However, with the support of the balloon-assisted enteroscopy technique the access route to the biliary system even in long-limb Roux-Y anastomosis is feasible in most cases.
In this video case report, an 81-year-old woman was symptomatic for stone obstruction of the common bile duct (CBD). Complete gastrectomy had been performed in this patient for stomach cancer many years earlier. Balloon-assisted enteroscopy was used for retrograde access of the duodenum via a Roux-Y anastomosis. There was major difficulty in intubating the CBD via the native papilla in this case because access was prevented by the tangential approach of the enteroscope. After performing an incomplete papillectomy, the insertion of a guidewire into the CBD was feasible and the bile duct stone was removed. This article is part of an expert video encyclopedia.
Small bowel endoscopy is indicated for patients with an unidentified bleeding site in esophago-gastro-duodenoscopy and ileo-colonoscopy and symptoms of intestinal blood loss or unexplained anemia. In approximately two-thirds of these cases, capsule endoscopy (CE) detects a lesion within the small bowel that explains the patient's symptoms. In few cases, though, lesions outside of the small bowel might be revealed by CE. Therefore, attention to all intestines that are visualized by CE might be necessary not to overlook bleeding sites that had not been discovered by prior flexible endoscopy.
The authors present the case of a 71-year-old male patient who presented to their outpatient clinic for unexplained anemia. Small bowel CE revealed minor bleeding from an adenocarcinoma in the cecum. This article is part of an expert video encyclopedia.
Small bowel endoscopy is indicated for patients with an unidentified bleeding site in esophagogastroduodenoscopy and ileocolonoscopy and symptoms of intestinal blood loss or unexplained anemia. In approximately two-thirds of these cases, capsule endoscopy (CE) detects a lesion within the small bowel that explains the patient's symptoms. In few cases, though, lesions outside of the small bowel might be revealed by CE. Therefore, attention to all intestines that are visualized by CE might be necessary not to overlook bleeding sites that had not been discovered by prior flexible endoscopy.
Here the case of a 71-year-old male patient with unexplained anemia is presented by the authors. Small-bowel CE revealed minor bleeding from a neoplastic mass in the cecum. The final diagnosis of an adenocarcinoma of the ascending colon was established after the patient underwent a right hemicolectomy. This article is part of an expert video encyclopedia.
Stent insertion is an established technique of endoscopic retrograde cholangiopancreatography (ERCP) to treat symptomatic malignant or benign biliary strictures, and stent placement is accomplished by using the over-the-wire (OTW) method. In some cases, however, it might be challenging and sometimes time consuming to pass a complex biliary stricture with the guidewire. Stent-exchange technique with a guidewire left in place during stent removal might therefore be helpful to guarantee successful and time-sparing interventions.
A simple method is presented to remove the stent with the guidewire left in place, using the OTW stent-exchange method in ERCP. This technique simplifies stent OTW exchange by using a simple endoscopy snare. This article is part of an expert video encyclopedia.
Persistent neuropathic pain is a frequent consequence of peripheral nerve injuries, particularly in the elderly. Using the IntelliCage we studied if sciatic nerve injury obstructed learning and memory in young and aged mice, each in wild type and progranulin deficient mice, which develop premature signs of brain aging. Both young and aged mice developed long-term nerve injury-evoked hyperalgesia and allodynia. In both genotypes, aged mice with neuropathic pain showed high error rates in place avoidance acquisition tasks. However, once learnt, these aged mice with neuropathic pain showed a significantly stronger maintenance of the aversive memory. Nerve injury did not affect place preference behavior in neither genotype, neither in young nor aged mice. However, nerve injury in progranulin deficient mice impaired the learning of spatial sequences of awarded places, particularly in the aged mice. This task required a discrimination of clockwise and anti-clockwise sequences. The chaining failure occurred only in progranulin deficient mice after nerve injury, but not in sham operated or wildtype mice, suggesting that progranulin was particularly important for compensatory adaptations after nerve injury. In contrast, all aged mice with neuropathic pain, irrespective of the genotype, had a long maintenance of aversive memory suggesting a negative alliance and possibly mutual aggravation of chronic neuropathic pain and aversive memory at old age.
The analyses of intersectoral linkages of Leontief (1941) and Hirschman (1958) provide a natural way to study the transmission of risk among interconnected banks and to measure their systemic importance. In this paper we show how classic input-output analysis can be applied to banking and how to derive six indicators that capture different aspects of systemic importance, using a simple numerical example for illustration. We also discuss the relationship with other approaches, most notably network centrality measures, both formally and by means of a simulated network.
In 2003, a number of banks adopted the Equator Principles (EPs), a voluntary Code of Conduct based on the International Finance Corporation’s (IFC) performance standards, to ensure the ecological and social sustainability of project finance. These so called Equator Principles Financial Institutions (EPFI) commit to requiring their borrowers to adopt sustainable management plans of environmental and social risks associated with their projects. The Principles apply to the project finance business segment of the banks and cover projects with a total cost of US $10 million or more. While for long developing countries relied on World Bank and other public assistance to finance infrastructure projects there has occurred a shift in recent years to private funding. The NGOs have been frustrated by this shift of project finance as they had spent their resources to exercise pressure on the public financial institutions to incorporate environmental and social standards in their project finance activities. However, after a shift of NGO pressure to private financial institutions the latter adopted the EPs for fear of reputational risks. NGOs had laid down their own more ambitious ideas about sustainable finance in the Collevecchio Declaration on Financial Institutions and Sustainability. Legally speaking, the EPs are a self-regulatory soft law instrument. However, it has a hard law dimension as the Equator Banks require their borrowers to comply with the EPs through covenants in the loan contracts that may trigger a default in a case of violation. ...
[Tagungsbericht] Making finance sustainable: Ten years equator principles – success or letdown?
(2013)
In 2003, a number of banks adopted the Equator Principles (EPs), a voluntary Code of Conduct based on the International Finance Corporation’s (IFC) performance standards, to ensure the ecological and social sustainability of project finance. These so called Equator Principles Financial Institutions (EPFI) commit to requiring their borrowers to adopt sustainable management plans of environmental and social risks associated with their projects. The Principles apply to the project finance business segment of the banks and cover projects with a total cost of US $10 million or more. While for long developing countries relied on World Bank and other public assistance to finance infrastructure projects there has occurred a shift in recent years to private funding. The NGOs have been frustrated by this shift of project finance as they had spent their resources to exercise pressure on the public financial institutions to incorporate environmental and social standards in their project finance activities. However, after a shift of NGO pressure to private financial institutions the latter adopted the EPs for fear of reputational risks. NGOs had laid down their own more ambitious ideas about sustainable finance in the Collevecchio Declaration on Financial Institutions and Sustainability. Legally speaking, the EPs are a self-regulatory soft law instrument. However, it has a hard law dimension as the Equator Banks require their borrowers to comply with the EPs through covenants in the loan contracts that may trigger a default in a case of violation. ...
Can be a world order shaped by equivalents in the framework of the supranational model of Europe with the same legitimacy and with the same effectiveness? In this study was argued that Civilizing World Order (CWO) by Transnational Norm-Building Networks (TNNs) should have the legitimacy and effectiveness of the European Union supranational order. In this context, the concept of decentration (supra: centralization and infra: decentralization) which includes the nexus of voice (democratic participation) and entitlement (legal-social rights and duties) was examined. In this study as methodology published secondary data, online resources were used in order to reinforce the hypothesis.
Die transitorische Verortungskrise : das Fliegen als menschliche Fortbewegung der besonderen Art
(2013)
Die Unmöglichkeit, gleichzeitig an verschiedenen Orten zu sein, fordert die Menschheit zu technischen Erfindungen heraus. Ihr erklärtes Ziel: die Gebundenheit an Ort und Zeit zu überwinden. Der Traum des Ikarus blieb keine Fantasie, er weckte die Neugier der Ingenieure. Mit dem Bau von flugfähigen Maschinen gelingt es den Menschen, ihre Flugunfähigkeit und Bodenverhaftung zu überwinden oder zumindest zu kompensieren – aber um welchen Preis?
We would study not style as such, but style 'at the scale of the sentence': the lowest level, it seemed, at which style as a distinct phenomenon became visible. Implicitly, we were defining style as a combination of smaller linguistic units, which made it, in consequence, particularly sensitive to changes in scale—from words to clauses to whole sentences.
Nikotinische Acetylcholin Rezeptoren (nAChR) sind ligandengesteuerte Ionenkanäle der pentameren Cys-Loop Familie, welche nach Bindung des Neurotransmitters Acetylcholin exzitatorische Signale in Muskeln und Neuronen vermitteln. Während die Funktion der Rezeptoren an der synaptischen Membran relativ gut untersucht wurde, gibt es bis heute kaum Erkenntnisse über die intrazellulären Prozesse und Proteine, die der selektiven Assemblierung von homologen Untereinheiten zu funktionalen Rezeptorpentameren zugrundeliegen.
Das C. elegans Genom kodiert für mehr als 29 nAChR Untereinheiten-Gene und besitzt damit die größte Anzahl bekannter Homologe innerhalb der untersuchten Arten. An der neuromuskulären Synapse (NMJ) des Nematoden sind zwei Typen von nAChR bekannt: der heteromere Levamisolrezeptor (L-AChR) und der homomere Nikotinrezeptor (N-AChR). Innerhalb dieser Arbeit wurde der funktionale Zusammenhang zwischen den nikotinischen Rezeptoren der NMJ von C. elegans und einem neuen rezeptorassoziierten ER-Proteinkomplex der Proteine NRA-2 und NRA-4 untersucht. Ihre vertebraten Homologe Nicalin und Nomo wurden zuerst im ER vom Zebrafisch im Zusammenhang mit dem TGF-β Signalweg beschrieben. Mutation der Proteine hat einen Agonist-spezifischen Einfluss auf die Aktivität von L-AChR und N-AChR. Die subzellulären Lokalisationsstudien demonstrierten, dass die beiden Proteine im ER von Muskelzellen wirken und dort mit Rezeptoruntereinheiten co-lokalisieren. Weiterhin ließ sich nachweisen, dass die relative Menge einzelner L-AChR-Untereinheiten an der synaptischen Oberfläche reduziert bzw. erhöht ist. Da die Rezeptoraktivität in Zusammenhang mit der Untereinheiten Komposition steht, wurde die Rolle von zusätzlichen Untereinheiten wie ACR-8 untersucht. Dies zeigte, dass die zusätzliche Mutation der Untereinheit acr-8 in nra-2 Mutanten den Einfluss der nra-2 Einzelmutation auf die Aktivität des L-AChR revertiert. Basierend auf diesen Ergebnissen lässt sich die Hypothese formulieren, dass der NRA-2/NRA-4 Komplex im ER von C. elegans als Kontrollinstanz fungiert welche dafür sorgt, dass nur die jeweils „korrekten“ Untereinheiten in funktionale Rezeptoren eingebaut bzw. andere vom Einbau in das Pentamer abgehalten werden. Durch Fehlen des aktiven Komplexes in Mutanten können nicht vorgesehene -Untereinheiten (z. B. ACR-8) in funktionale Pentamere mit veränderter Funktionalität eingebaut werden.
Nucleation of aerosol particles from trace atmospheric vapours is thought to provide up to half of global cloud condensation nuclei. Aerosols can cause a net cooling of climate by scattering sunlight and by leading to smaller but more numerous cloud droplets, which makes clouds brighter and extends their lifetimes. Atmospheric aerosols derived from human activities are thought to have compensated for a large fraction of the warming caused by greenhouse gases. However, despite its importance for climate, atmospheric nucleation is poorly understood. Recently, it has been shown that sulphuric acid and ammonia cannot explain particle formation rates observed in the lower atmosphere. It is thought that amines may enhance nucleation, but until now there has been no direct evidence for amine ternary nucleation under atmospheric conditions. Here we use the CLOUD (Cosmics Leaving Outdoor Droplets) chamber at CERN and find that dimethylamine above three parts per trillion by volume can enhance particle formation rates more than 1,000-fold compared with ammonia, sufficient to account for the particle formation rates observed in the atmosphere. Molecular analysis of the clusters reveals that the faster nucleation is explained by a base-stabilization mechanism involving acid–amine pairs, which strongly decrease evaporation. The ion-induced contribution is generally small, reflecting the high stability of sulphuric acid–dimethylamine clusters and indicating that galactic cosmic rays exert only a small influence on their formation, except at low overall formation rates. Our experimental measurements are well reproduced by a dynamical model based on quantum chemical calculations of binding energies of molecular clusters, without any fitted parameters. These results show that, in regions of the atmosphere near amine sources, both amines and sulphur dioxide should be considered when assessing the impact of anthropogenic activities on particle formation.
Spreading throughout a new ecosystem is the last step of an exotic species to become invasive. In the case of invasive aquatic molluscs, tolerance to air exposure is one of the main mechanisms allowing overland translocation and spreading. The mudsnail Potamopyrgus antipodarum (Hydrobiidae, Mollusca) is native to New Zealand but it has spread worldwide, invading ecosystems in Europe, Australia, America and Asia. The aim of our study is to assess mudsnail tolerance to air exposure, which may contribute to the successful overland translocation of this species. We conducted a laboratory experiment with four levels of air exposure (9, 18, 24 and 36 hours in a controlled climatic chamber). Snails were placed for 60 seconds in a laboratory paper filter to remove surface snail water. Then they were placed back in empty vessels during the four periods of air exposure, except the control group, which was immediately returned to water. At the end of each period of air exposure all vessels were filled with water and the cumulative mortality was monitored after 24, 96, 168 and 264 hours of rehydration. The calculated Lethal Times (i.e. the time of air exposure (in hours) necessary to cause the death of 50% (LT50) or 99% (LT99) of the population) and their 95% confidence limits at 24, 96, 168 and 264 hours were 28.1 (25.2–31.9), 26.9 (24.2–30.1), 25.9 (23.4–28.9) and 25.9 (23.4–28.9) hours, respectively for LT50, and 49.6 (42.7–63.3), 45.6 (39.9–56.5), 43.2 (38.0–53.0) and 43.2 (38.0–53.0) hours, respectively for LT99. Therefore an air exposure time over 43 hours caused the death of all studied individuals during all monitoring periods. Extending the monitoring period beyond 24 hours did not significantly change lethal times. Therefore, we recommend exposing fishing tools or boats at open air during at least 53 hours as a low cost measure to control mudsnail spread in early stages of invasion.