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At present, there are no quantitative, objective methods for diagnosing the Parkinson disease. Existing methods of quantitative analysis by myograms suffer by inaccuracy and patient strain; electronic tablet analysis is limited to the visible drawing, not including the writing forces and hand movements. In our paper we show how handwriting analysis can be obtained by a new electronic pen and new features of the recorded signals. This gives good results for diagnostics. Keywords: Parkinson diagnosis, electronic pen, automatic handwriting analysis
Hazar Lake sunken city
(2006)
In November 2005, a survey was begun of the wells in and around Hagia Sophia Church in Istanbul. The long-term goal of the survey is the understanding of the function of the tunnels and the water systems used for Hagia Sophia and its surroundings during the Byzantine and the Ottoman periods. Alternate research methods, such as geophysical research, will be used in future surveys. The 2005 survey examined the channels that run from under the narthex and continue northwards and the southwards of the building as well as channels that run towards the atrium, hippodrome, and garden in the north. The survey resulted in the first photos of the well-bottoms in the history of Hagia Sophia.
Proton pumping respiratory complex I (NADH:ubiquinone oxidoreductase) is a major component of the oxidative phosphorylation system in mitochondria and many bacteria. In mammalian cells it provides 40% of the proton motive force needed to make ATP. Defects in this giant and most complicated membrane-bound enzyme cause numerous human disorders. Yet the mechanism of complex I is still elusive. A group exhibiting redox-linked protonation that is associated with iron-sulfur cluster N2 of complex I has been proposed to act as a central component of the proton pumping machinery. Here we show that a histidine in the 49-kDa subunit that resides near iron-sulfur cluster N2 confers this redox-Bohr effect. Mutating this residue to methionine in complex I from Yarrowia lipolytica resulted in a marked shift of the redox midpoint potential of iron-sulfur cluster N2 to the negative and abolished the redox-Bohr effect. However, the mutation did not significantly affect the catalytic activity of complex I and protons were pumped with an unchanged stoichiometry of 4 H+/2e−. This finding has significant implications on the discussion about possible proton pumping mechanism for complex I.
This paper revisits the question of whether propositions in situation semantics must be persistent (Kratzer (1989)). It shows that ignoring persistence causes empirical problems to theories which use quantification over minimal situations as a solution for donkey anaphora (Elbourne (2005)), while at the same time modifying these theories to incorporate persistence makes them incompatible with the use of situations for contextual restriction (Kratzer (2004)).
The paper investigates the interaction of focus and adverbial quantification in Hausa, a Chadic tone language spoken in West Africa. The discussion focuses on similarities and differences between intonation and tone languages concerning the way in which adverbial quantifiers (AQs) and focus particles (FPs) associate with focus constituents. It is shown that the association of AQs with focused elements does not differ fundamentally in intonation and tone languages such as Hausa, despite the fact that focus marking in Hausa works quite differently. This may hint at the existence of a universal mechanism behind the interpretation of adverbial quantifiers across languages. From a theoretical perspective, the Hausa data can be taken as evidence in favour of pragmatic approaches to the focus-sensitivity of AQs, such as e.g. Beaver & Clark (2003).
A new type of biocide GCSC-BtA, named from "Germany-China Scientific Cooperation-Bacillus thuringiensis-Abamectin", was successfully developed by conjugating delta-endotoxin of Bacillus thuringiensis (B.t.) with Abamectin from Streptomyces avermitilis through conjugator EDC for control of different agricultural arthropod pests. The laboratory results of efficiency of biocide GCSC-BtA to four different arthropod pests and its side-effect on two species of predators are presented in this paper. The results showed significant differences in the mortalities of Tetranychus cinnabarinus (BOISD.) (Acari, Tetranychidae), Frankliniella occidentalis PERGANDE (Thys., Thripidae), Aphis fabae SCOPOLI (Hom., Aphididae) and Cameraria ohridella DESCHKA ET DIMI´C (Lep., Gracillariidae) caused by treatment of 0.6250 mg/ml of formulated product of GCSC-BtA, B.t., Abamectin and Cypermethrin. GCSC-BtA treatment caused higher mortalities of 86.37%, 94.82%, 94.15% and 93.23% in T. cinnabarinus, F. occidentalis, A. fabae and C. ohridella, respectively. Mortalities caused by Abamectin treatment were 73.92%, 63.3%, 86.52% and 73.48%, and by Cypermethrin treatment were 44.29%, 57.28%, 97.68% and 51.26%, respectively. B.t. could only kill C. ohridella with 87.62% mortality. Pesticidal treatment gave variations in mortalities of Orius strigicollis POPPIUS (Het., Anthocoridae) and Stethorus cantonensis PANG (Col., Coccinellidae) predators at p < 0.01, where 0.6250 mg/ml GCSC-BtA caused 21.76% and 32.42% mortalities, while the same rate of products of Abamectin with 73.26% and 87.67% as well as Cypermethrin with 86.43% and 93.83% mortalities, respectively. It is concluded that the biocide GCSC-BtA has increased efficacies as well as host ranges of B.t. and Abamectin, but displayed safer to some predators.
Elliptic flow analysis at RHIC with the Lee-Yang Zeroes method in a relativistic transport approach
(2006)
The Lee-Yang zeroes method is applied to study elliptic flow (v_2) in Au+Au collisions at sqrt s =200 A GeV, with the UrQMD model. In this transport approach, the true event plane is known and both the nonflow effects and event-by-event v_2 fluctuations exist. Although the low resolutions prohibit the application of the method for most central and peripheral collisions, the integral and differential elliptic flow from the Lee-Yang zeroes method agrees with the exact v_2 values very well for semi-central collisions.
We propose to measure correlations of heavy-flavor hadrons to address the status of thermalization at the partonic stage of light quarks and gluons in high-energy nuclear collisions, shown on the example of azimuthal correlations of D-Dbar pairs. We show that hadronic interactions at the late stage can not disturb these correlations significantly. Thus, a decrease or the complete absence of these initial correlations indicates frequent interactions of heavy-flavor quarks in the partonic stage. Therefore, early thermalization of light quarks is likely to be reached. PACS numbers: 25.75.-q
Background The reciprocal (9;22) translocation fuses the bcr (breakpoint cluster region) gene on chromosome 22 to the abl (Abelson-leukemia-virus) gene on chromosome 9. Depending on the breakpoint on chromosome 22 (the Philadelphia chromosome – Ph+) the derivative 9+ encodes either the p40(ABL/BCR) fusion transcript, detectable in about 65% patients suffering from chronic myeloid leukemia, or the p96(ABL/BCR) fusion transcript, detectable in 100% of Ph+ acute lymphatic leukemia patients. The ABL/BCRs are N-terminally truncated BCR mutants. The fact that BCR contains Rho-GEF and Rac-GAP functions strongly suggest an important role in cytoskeleton modeling by regulating the activity of Rho-like GTPases, such as Rho, Rac and cdc42. We, therefore, compared the function of the ABL/BCR proteins with that of wild-type BCR. Methods We investigated the effects of BCR and ABL/BCRs i.) on the activation status of Rho, Rac and cdc42 in GTPase-activation assays; ii.) on the actin cytoskeleton by direct immunofluorescence; and iii) on cell motility by studying migration into a three-dimensional stroma spheroid model, adhesion on an endothelial cell layer under shear stress in a flow chamber model, and chemotaxis and endothelial transmigration in a transwell model with an SDF-1α gradient. Results Here we show that both ABL/BCRs lost fundamental functional features of BCR regarding the regulation of small Rho-like GTPases with negative consequences on cell motility, in particular on the capacity to adhere to endothelial cells. Conclusion Our data presented here describe for the first time an analysis of the biological function of the reciprocal t(9;22) ABL/BCR fusion proteins in comparison to their physiological counterpart BCR.