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This afterword addresses the complex temporal and global dynamics of the coronavirus pandemic. After considering some of the new social rhythms that have emerged in the wake of Covid-19 around the world, it turns to the role of collective memory before, during and after corona. The aim is to provide a basic grid for how the Covid-19 pandemic could be addressed using memory studies expertise and concepts such as premediation, memorability, memory (ab)use, national memory, colonial memory, racial stereotypes, the digital archive, generational memory, or Anthropocene time.
Given the ongoing global SARS-CoV-2-vaccination efforts, clinical awareness needs to be raised regarding the possibility of an increased incidence of SARS-CoV-2-vaccine-related immune-mediated thrombocytopenia in patients with intracerebral hemorrhage (ICH) secondary to cerebral sinus and vein thrombosis (CVT) requiring (emergency) neurosurgical treatment in the context of vaccine-induced immune thrombotic thrombocytopenia (VITT). Only recently, an association of vaccinations and cerebral sinus and vein thrombosis has been described. In a number of cases, neurosurgical treatment is warranted for these patients and special considerations are warranted when addressing the perioperative coagulation. We, herein, describe the past management of patients with VITT and established a literature-guided algorithm for the treatment of patients when addressing the impaired coagulation in these patients. Increasing insights addressing the pathophysiology of SARS-CoV-2-vaccine-related immune-mediated thrombocytopenia guide physicians in developing an interdisciplinary algorithm taking into account the special considerations of this disease.
Zielsetzung: Untersuchung der Auswirkungen der Covid-19-Pandemie auf Angebote der vor allem niedrigschwelligen Drogenhilfe und Reaktionen der Klientel auf geänderte Angebote. Methodik: Verwendet wurden in erster Linie Daten aus einer asynchronen qualitativen Onlinebefragung für Mitarbeiter_innen der ambulanten Drogenhilfe, ergänzt durch Zahlen aus einer quantitativen Onlinebefragung für dieselbe Zielgruppe. Ergebnisse: Während übliche Infektionsschutzmaßnahmen nahezu überall angewendet wurden, reichte die Spanne der tatsächlichen Auswirkungen von Komplettschließungen bis zu eher geringen Einschränkungen. Schwerpunkte wurden zumeist auf Überlebenshilfe und Straßensozialarbeit gelegt. Beratung wurde oft per Telefon durchgeführt, was für viele Anliegen als sinnvoll erachtet wurde, Beziehungsarbeit aber erschwerte. Vor allem stark verelendete Klient_innen nutzten weiterhin häufig Hilfsangebote. Schlussfolgerungen: Es zeigen sich unterschiedliche Umgangsweisen der Drogenhilfe mit den pandemiebedingten Maßnahmen. Oft entwickelte man kreative Lösungen zur Umsetzung, mit Schwerpunktsetzung auf Existenzsicherung. Sowohl Mitarbeiter_innen als auch Klientel waren durch die Pandemie zahlreichen Belastungen ausgesetzt.
The ancestral SARS-CoV-2 strain that initiated the Covid-19 pandemic at the end of 2019 has rapidly mutated into multiple variants of concern with variable pathogenicity and increasing immune escape strategies. However, differences in host cellular antiviral responses upon infection with SARS-CoV-2 variants remain elusive. Leveraging whole-cell proteomics, we determined host signaling pathways that are differentially modulated upon infection with the clinical isolates of the ancestral SARS-CoV-2 B.1 and the variants of concern Delta and Omicron BA.1. Our findings illustrate alterations in the global host proteome landscape upon infection with SARS-CoV-2 variants and the resulting host immune responses. Additionally, viral proteome kinetics reveal declining levels of viral protein expression during Omicron BA.1 infection when compared to ancestral B.1 and Delta variants, consistent with its reduced replication rates. Moreover, molecular assays reveal deferral activation of specific host antiviral signaling upon Omicron BA.1 and BA.2 infections. Our study provides an overview of host proteome profile of multiple SARS-CoV-2 variants and brings forth a better understanding of the instigation of key immune signaling pathways causative for the differential pathogenicity of SARS-CoV-2 variants.