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Background: The health status, health awareness and health behavior of persons with a migration background often differ from the autochthonous population. Little is known about the proportion of patients with a migration background (PMB) that participate in primary care studies on oral antithrombotic treatment (OAT) in Germany, and whether the quality of their antithrombotic care differs from patients without a migration background. The aim of this paper was to use the results of a cluster-randomized controlled trial (PICANT) to determine the proportion of PMB at different stages of recruitment, and to compare the results in terms of sociodemographic characteristics and antithrombotic treatment.
Methods: This study used screening and baseline data from the PICANT trial on oral anticoagulation management in GP practices. For this analysis, we determined the proportion of PMB during the recruitment period at stage 1 (screening of potentially eligible patients), stage 2 (eligible patients invited to participate in the trial), and stage 3 (assessment of baseline characteristics of patients participating in the PICANT trial). In addition, we compared patients in terms of sociodemographic characteristics and quality of anticoagulant treatment. Statistical analysis comprised descriptive and bivariate analyses.
Results: The proportion of PMB at each recruitment stage declined from 9.1% at stage 1 to 7.9% at stage 2 and 7.3% at stage 3). A lack of German language skills led to the exclusion of half the otherwise eligible PMB. At stages 1 and 3, PMB were younger (stage 1: 70.7 vs. 75.0 years, p<0.001; stage 3: 70.2 vs. 73.5 years, p = 0.013), but did not differ in terms of gender. The quality of their anticoagulant care was comparable (100.0% vs. 99.1% were receiving appropriate OAT, 94.4% vs. 95.7% took phenprocoumon, or warfarin, and the most recent INR measurement of 60.8% vs. 69.3% was within their individual INR range).
Conclusions: In the potentially eligible population and among participants at baseline, the quality of anticoagulant care was high in all groups of patients, which is reassuring. To enable the inclusion of more PMB, future primary care research on OAT in Germany should address how best to overcome language barriers. This will be challenging, particularly because the heterogeneity of PMB means the resulting sample sizes for each specific language group are small.
Trial registration: Current Controlled Trials ISRCTN41847489.
Introduction: Reliable and cost-effective diagnostics for hepatitis E virus (HEV) infection are necessary. The aim of our study was to investigate which diagnostic test is most accurate to detect HEV infection in immunocompetent and immunosuppressed patients in a real world setting. Patients and Methods: We performed a retrospective analysis of 1165 patients tested for HEV antibodies and HEV PCR at the same time point. Clinical, laboratory and virological data were taken from patient charts. HEV IgA was measured in a subgroup of 185 patients. Results: HEV RNA was detectable in 61 patients (5.2%); most of them (n = 49, 80.3%/n = 43, 70.5%) were HEV IgM+ and IgG+; however, 12 patients (19.6%) were HEV RNA positive/HEV IgM negative and 17 patients (27.8%) were HEV RNA positive/HEV IgG negative. Ten HEV RNA positive patients (16.4%) had neither HEV IgG nor IgM antibodies. Importantly, all of them were immunosuppressed. HEV IgA testing was less sensitive than HEV IgM for HEV diagnosis. Conclusions: HEV infection can be overlooked in patients without HEV specific antibodies. Performing PCR is necessary to diagnose or exclude HEV infection in immunocompromised hosts. In immunocompetent patients, a screening based on HEV antibodies (IgG/IgM) is sufficient.
Human cytomegalovirus (CMV) is a significant cause of morbidity and mortality in patient groups at risk. We have previously shown that the anti-CMV IgG seroprevalence in an urban region of Germany has changed over the last decades. Overall, a decline from 63.7 to 57.25% had been observed between 1988–1997 and 1998–2008 (p < 0,001). Here, we continuously follow the trends to the most recent decade 2009 to 2018. In a retrospective analysis, we determined the seroprevalence of CMV IgG antibodies in our patient cohort, stratified by gender and selected groups at risk (e.g., patients with HIV infection; women of childbearing age). The overall prevalence of anti-CMV IgG non-significantly declined further from 57.25% in 1998–2008 to 56.48% in 2009–2018 (p = 0.881). Looking at gender differences, overall CMV seroprevalence in males declined to 52.82% (from 55.54% in 1998–2008; p = 0.0254), while it non-significantly increased in females to 59.80%. The high seroprevalence in patients with a known HIV infection further increased from 87.46% in 1998–2008 to 92.93% in the current period (p = 0.9999). In women of childbearing age, no significant changes over the last three decades could be observed. The CMV seroprevalence in oncological patients was determined to be 60.64%. Overall, the former significant decline of CMV seroprevalence between the decades 1988–1997 and 1998–2008 in this urban region of Germany slowed down to a non-significant decrease of 0.77% (1998–2008 vs. 2009–2018). This might be an indicator that CMV seroprevalence has reached a plateau.
Die Übersetzung, insbesondere die literarische, ist vor allem eine Art Kulturübertragung. Neben der Beherrschung der Sprachen setzt sie die Kenntnis des Allgemeinen und Besonderen des Landes wie Kultur, Tradition, Glauben, geschichtliche und gesellschaftliche Begebenheiten und auch soziale Strukturen voraus. Wenn die Sprachen und Kulturen tiefgreifend wahrgenommen werden, können die übersetzten Texte die Adressaten erreichen, d.h., dass die Ausgangssprache und -kultur für die Zielrezipienten verständlich sein können. So wird der Übersetzer als Kulturträger angenommen. Cornelius Bischoff ist beispielsweise ein wohlbekannter Name für den deutschen und türkischen Literaturkreis. Er ist vor allem bekannt als "der deutscheste Türke und der türkischste Deutsche" sowie als eine Brücke zwischen Deutschland und der Türkei. Das Ziel der vorliegenden Arbeit ist es, Cornelius Bischoff, einen Kulturträger zwischen der deutschen und türkischen Übersetzung, zu behandeln. Als ein "Haymatloser" fand er in der Türkei die Möglichkeit, die türkische Sprache und Kultur wesentlich kennenzulernen und viele türkische Werke ins Deutsche zu übersetzen. Als ein Übersetzer trug er zuallererst dazu bei, die türkische Literatur, die bedeutenden türkischen Schriftsteller, die türkische Kultur und Tradition sowie den türkischen Sprachgebrauch in Deutschland bekannt zu machen. In der vorliegenden Arbeit wird die Besonderheit Bischoffs in der Übersetzungswelt im Hinblick auf drei Aspekte diskutiert: zuerst im Hinblick auf den Zusammenhang seiner Wurzeln in der Türkei und im Türkischen - schon in seinen Wurzeln, besonders mütterlicherseits, wurde das Türkische verinnerlicht -, dann auf die in der Türkei verbrachten Jahre - die Jahre, in denen er "haymatlos" genannt wurde - und zuletzt auf die Wahrnehmung und Aneignung der türkischen Sprache, Kultur und Gesellschaft - was auf ihn lebenslang einwirkte. In diesem Kontext wird versucht, sein Leben, seine Werke und seine Wirkung im Rahmen der übersetzerischen Tätigkeit zu analysieren.
Genel Edebiyat Biliminin bir dalı olan "Karşılaştırmalı Edebiyat", farklı dillerde yazılmış edebi eserlerin, benzerlik ve farklılıklar yönünden karşılaştırılmasıdır. Karşılaştırmaya dayalı analizlerdeki amaç, iki ya da daha fazla eserin, biçim, üslup, motif ve ya tema gibi edebi unsurlar açısından ortak ve ya farklı öğelerini belirlemektir. Edebi metinlerde kullanılan dilsel öğeleri inceleme alanı olan "Biçembilim", okuyucunun metinleri anlamasını sağlayan en önemli araçlardan biridir. Karşılaştırmalı Edebiyat bilimi kapsamında çevirinin önemi yadsınamaz ve bir metin ile çevirisi, mukayeseli çalışma alanlarından biridir. Bu araştırmanın özünü, kaynak metin ve erek metin arasındaki benzerlik ve farklılıkları örneklendirmek adına karşılaştırmalı edebi çeviri örneği oluşturmaktadır. Bu bağlamda, bu çalışmada, William Shakespeare'in "Sonnet 66" şiirinin Türk edebiyatçı Can Yücel tarafından "66. Sone" olarak çevirisinin, Katharina Reiss'in "içerik odaklı" çeviri modeline dayanarak nasıl yorumlandığı incelenmiştir.
Die vorliegende Studie bietet eingangs allgemeine Erwägungen über die Rolle des literarischen Kanons im 21. Jahrhundert und über eine mögliche Redefinition von Rollen der Akteur/innen der Kanonisierungsprozesse. Auf dieser Grundlage wird ein Konzept entworfen, dessen Ziel es ist, die Nützlichkeit und Notwendigkeit einer neuen Sicht auf vergessene und nichtkanonisierte Texte zu zeigen. Die Materialbasis bildet diesbezüglich die deutschgeschriebene Literatur aus der Mährischen Walachei, die auch in groben Zügen als literarisches Phänomen skizziert wird. Analysiert werden ausgewählte poetische Werke der aus diesem Gebiet der Böhmischen Länder stammenden und weitgehend unbekannten Autorin Susanne Schmida (1894–1981).
Der in Prag situierte Roman Café Slavia (1985) von Ota Filip, einem deutschschreibenden Autor, der in den 1970er Jahren die Tschechoslowakei aus politischen Gründen verlassen musste und sich nach seiner Ausbürgerung in München niederließ, erzählt die wechselvolle Geschichte Mitteleuropas vom Anfang des 20. Jahrhunderts bis zum Prager Frühling 1968, eingeleitet durch eine Rahmenhandlung, die sich an der Karlsbrücke in Prag abspielt. Der Beitrag versucht, die Symbolik der im Roman zentralen "Brücke" in ihrer Vielschichtigkeit offenzulegen. Im Mittelpunkt der Analyse steht die Brücke als Erzählkonstruktion, die den Blick von der Gegenwart aus auf die Vergangenheit richtet und dabei sowohl die "kleine" als auch die "große" Geschichte im Blick behält. Dabei bekommt sie als topographischer Verbindungsort zwischen dem rechten und linken Moldauufer weitere Bedeutungszuschreibungen und steht für die Überschreitung nicht nur zwischen Raum und Zeit, sondern auch zwischen Faktualität und Fiktionalität.
Background: The newly introduced German pediatric screening examination at the end of the third year of life (U7a) incorporates visual function testing in particular; there is no ophthalmic screening during childhood in Germany. The purpose of this study is to investigate the relationship between participation in U7a and visual function at the preschool health examination (PHE) in the sixth year of life. Methods: This study evaluated PHE data from school enrollment years 2009/2010 to 2014/2015 of Rhineland-Palatinate, Germany. Visual acuity (VA) at PHE was assessed with Rodenstock visual acuity test device (tumbling E) wearing glasses if present. The relationship between participation in U7a and VA <0.7 at PHE was calculated for reduced monocular and binocular VA using multiple logistic regression adjusted for potential confounders. Results: Data from 189,704 children (91,041 girls) in 35 out of 36 districts were included. The first children to participate in U7a were enrolled in 2011/2012 school year. In total, 90,339 children (47.6%) had U7a before PHE, while 99,365 (52.4%) had not. VA <0.7 in at least one eye was measured at PHE in 8429 (4.4%) children, and in both eyes in 4345 (2.3%) children. Participation in U7a was not associated with VA <0.7 at PHE (odds ratio 0.99; 95% confidence interval: 0.94–1.04). Conclusions: The proportion of children with VA <0.7 at PHE was high. No beneficial effect of newly introduced German U7a pediatric screening examination was found for reduced VA at PHE.
Yoko Tawada é um dos nomes mais importantes da Literatura Contemporânea. Seu projeto literário trata das questões acerca da identidade através do processo de estranhamento. Em "Das nackte Auge" tem-se uma jovem garota vietnamita, cujo nome nunca é revelado, que, por conta de um engano, desembarca na cidade de Paris. Ela não fala francês e se vê incapaz de compreender o meio estrangeiro que a cerca. No entanto, encontra no cinema, mais especificamente nas personagens de Catherine Deneuve, um local de refúgio e identificação. Cada capítulo trata de um filme cuja narrativa progressivamente se mistura e influencia a narrativa da personagem. Já no primeiro capítulo, "Repulsion", uma referência ao filme de Roman Polanski, pode-se perceber diversos elementos comuns à obra fílmica e de fundamental importância na construção de "Das nackte Auge". Tal construção intermidiática é apresentada com o objetivo de suscitar questões acerca do sujeito contemporâneo e seu olhar (desnudado) sobre o estranho, o estrangeiro.
Combining the methods of linguistics and literary criticism, this article takes a fresh look at two texts that have been analysed ad nauseam: Henry James’s The Portrait of a Lady and Edith Wharton’s The Age of Innocence. I use James’s late style as a touchstone to compare and contrast the two texts. Analysing syntax by means of close textual analysis of the novels’ opening paragraphs as well as their metaphorical language, and employing the corpus analysis programme AntConc to survey the entire texts, I aim to show that James’s 1880 text anticipates his late style and Wharton’s 1920 text appropriates it to suit her own agenda. However, in respectively anticipating and appropriating this style, James and Wharton create different effects. James intensifies his female protagonist’s ‘world of thought and feeling’ (Eliot 1963: 56), creating a fictional world with literary equality for both genders, while Wharton subverts gender roles in a scathing critique of Gilded Age society, which did not allow for this other ‘world of thought and feeling’. In addition to positioning both novels as feminist, this article compares Wharton’s writing to James’s, but without presupposing the latter’s influence on the former. Instead, acknowledging the fluidity of style, I aim to put forward a convincing case that there are subtle differences that make these authors’ styles Jamesian and Whartonian, respectively.
The shared communicative act of theatrical texts in performance: a relevance theoretic approach
(2020)
This article adopts a relevance theoretic approach to meaning making in theatrical texts and performances. Theatrical texts communicate immediately to multiple audiences: readers, actors, directors, producers, and designers. They communicate less directly to the writer’s ultimate audience – the playgoer or spectator – through the medium of performance. But playgoers are not passive receptacles for interpretations distilled in rehearsal, enacted through performance, or developed in study and reflection. Rather, in the framework of communication postulated by relevance theory, the audience is an active participant in making meaning. I will briefly review a range of approaches to meaning making in theatre, and then outline my view of a relevance theoretic account of the vital contributions of the audience in constructing the interpretation of performance, treating it as a communicative act.
"You don’t mind my calling you Harry?" : Terms of address in John Updike’s "Rabbit" tetralogy
(2020)
This paper examines the use of address terms in John Updike’s Rabbit tetralogy (Updike 1995). The first part of the analysis provides a comprehensive overview of the great variety of terms used to address the protagonist, Harry Angstrom, in the decades covered by the novels. The second part focuses on two important side characters, Reverend Eccles and Harry’s mother-in-law. It demonstrates how address term usage with these two characters reflects ongoing changes in their relationship with Harry. The main aim of the paper is to demonstrate the potential of fictional data for the study of address terms and, in return, to capture the manifold functions of address terms as a literary device in fiction.
Four main informational elements have been suggested and studied as central aspects of narrative discourse: causality, character, location, time. The research that scholars have previously undertaken on these aspects has been primarily on Indo-European languages, and more specifically on the European side of that language family. The linguistic limitations have indicated that character is the aspect of narrative that readers/listeners attend to most closely. However, in examining narrative discourses from non-Indo-European languages, challenges to the presumed primacy of character emerge. In a partial report on field work conducted in Borneo in 2012-2015, I compare and contrast patterns in the rankings of the four main aspects of narrative in three languages, English, Hobongan and Daqan. I also note the strategies by which the languages make their respective rankings clear, including focus particles (Hobongan), specificity of description (each), and amount of information provided about the aspects (each). I suggest that analyses of the patterns and rankings of information in narrative be included in typological categorizations and linguistic descriptions of languages.
In dieser Arbeit soll der Einsatz von Filmen als audiovisuelles Unterrichtsmaterial im Fremdsprachenunterricht erörtert werden. Bei räumlichen und kulturellen Entfernungen zum Zielsprachenland ermöglicht Filmmaterial sprachliche und landeskundliche Inhalte in den Unterricht zu bringen. In diesem Rahmen bieten Filme, die Alltagssprache und Alltagsthemen des Zielsprachenlandes präsentieren, vielfältige Einsatzmöglichkeiten zur Erweiterung der sprachlichen und kulturellen Kompetenzen von Lernenden. Kein anderes Medium verfügt über ein so hohes Potential, die Neugierde der Lerner auf das Zielsprachenland und seine Menschen zu wecken, die Lerner zu motivieren, Emotionen auszulösen und Sprech- und Diskussionsanlässe zu schaffen. Der Einsatz von Filmen leistet einen wichtigen Beitrag zur Gestaltung von effizientem Fremdsprachenunterricht.
Der vorliegende Artikel befasst sich mit den Schwierigkeiten der Übersetzung von Humor und verschiedenen möglichen Übersetzungsstrategien für die Übertragung von Humor von einer Sprache bzw. Kultur in eine andere. Er enthält ferner eine Fallstudie, die sich mit den sehr erfolgreichen Synchronisationen des Synchronregisseurs und -sprechers Rainer Brandt in den 1970er/ 80er Jahren befasst. Dabei wird gezeigt, dass Kreativität und Mut zum Risiko in manchen Fällen sogar die synchronisierte Fassung erfolgreicher als das Original machen können. Es zeigt sich also, dass es sinnvoll ist, auch in der Synchronisation öfter vom Postulat der unbedingten Treue zum Original abzuweichen.
Ergebnisse von Tauchgängen in hessischen Gewässern durch Mitglieder des Hessischen Tauchsportverbands im Rahmen des Projektes "Tauchen für den Naturschutz" werden mitgeteilt. Es wurden 12 Gewässer intensiv untersucht. Bemerkenswerte Funde betreffen Alisma gramineum, Ceratophyllum submersum, Chara filiformis, Myriophyllum heterophyllum und Nitella capillaris.
Buchbesprechungen
(2020)
Es werden folgende Publikation rezensiert: Jürgen Feder 2016: Feders phantastische Stadtpflanzen; Paar et al. 2018: Waldzustandsbericht 2018; Gerald Parolly & Jens G. Rohwer (Herausgeber) 2019: Die Flora Deutschlands und angrenzender Länder. Ein Buch zum Bestimmen aller wildwachsenden und häufig kultivierten Gefäßpflanzen; Marcus Schmidt & Peter Meyer 2018: Hessische Naturwaldreservate im Portrait. Wattenberg und Hundsberg; Indra Starke-Ottich & Georg Zizka 2019: Stadtnatur in Frankfurt – vielfältig, schützenswert, notwendig; Technische Universität Ilmenau (Herausgeber) 2020: Flora Incognita.
Die Fundmeldungen in Band 32 von Botanik und Naturschutz in Hessen stammen von: Dirk Bönsel, Peter Dyballa, Wolfgang Ehmke, Christian Feuring, Thomas Gregor, Arthur Händler, Sylvain Hodvina, Hasko Friedrich Nesemann, Janina Püschel, Bernd Sauerwein, Lisa Schäfer, Indra Starke-Ottich, Dietmar Teuber, Maja Willis und Gerhard Winter.
Im Rahmen einer Kartierung und FFH-Bewertung von für den Klettersport genutzten Felsen im Werra-Meißner-Kreis wurde Asplenium fontanum (Jura-Streifenfarn) im Gebiet des "Ellersteines" nordöstlich der Ortschaft Hundelshausen bei Witzenhausen 2014 mit einer Pflanze erstmals nachgewiesen (Rasterfeld 4625/3). Vorher galt der Jura-Streifenfarn, eine in Deutschland sehr seltene Art, in Hessen seit circa 1950 als erloschen. Mit den Populationen in der Schwäbischen Alb, am Kyffhäuser und bei Wolfstein (Rheinland-Pfalz) bildete dieser A.-fontanum-Fund die bekannten Vorkommen der letzten Jahre in Deutschland. Bei dem hessischen A.-fontanum-Vorkommen im Bereich des Ellerstein-Felskomplexes handelte sich um das nördlichste Vorkommen an einem natürlichen Standort in Deutschland. Der Wuchsort des Farnes befindet sich in einem Buchenwald auf einem kleinen Dolomit-Felsblock vor einer Felswand, die zum Bouldern genutzt wird (Klettern ohne Seilsicherung in Absprunghöhe). Aufgrund der Position und Ungeschütztheit des Wuchsortes erschien der Farn ausgesprochen gefährdet gegenüber mechanischem Abrieb durch Kletterer. Der von 2014 bis 2018 beobachtete Farn trieb 2019 nicht mehr aus. Die Ursachen dafür sind nicht eindeutig. So könnte die extreme und außergewöhnlich lang anhaltende Dürre im Jahr 2018 mit anschließenden meist zu trockenen Winter- und Frühjahrsmonaten verantwortlich sein. Verbiss oder negative Auswirkungen des Klettersports auf den Farn sind jedoch nicht auszuschließen. Daher werden die für den Farn im Ellerstein-Felskomplex festgestellten Gefährdungen in der vorliegenden Arbeit diskutiert und Empfehlungen für Artenhilfsmaßnahmen gegeben. Insbesondere wird ein vollständiger Verzicht auf Klettern und ein Aussetzen der Waldbewirtschaftung am Wuchsort und an potenziellen Siedlungsstellen der unmittelbaren Umgebung vorgeschlagen. Entsprechende Maßnahmen gelten sinngemäß für andere sehr seltene oder stark gefährdete Pflanzenarten, die in exponierten, ungeschützten Positionen an Felsen wachsen.
Die vorliegende Arbeit dokumentiert die Existenz folgender Assoziationen in Hessen mittels Vegetationstabellen: Potentillo anserinae-Festucetum arundinaceae, Chaerophylletum bulbosi, Stellario uliginosae-Scirpetum setacei und Chenopodietum rubri. Alle Vegetationsaufnahmen stammen aus dem Taunus. Die Dokumentation wird durch Angaben zu Häufigkeit und Standort der Assoziationen im Taunus komplettiert.
Weitere Notiz zum Erscheinungsdatum der "Flora der Gegend um Frankfurt am Main" von Johannes Becker
(2020)
Der zweite Band von Johannes Beckers "Flora der Gegend um Frankfurt am Main" (Cryptogamie) wurde offenbar zusammen mit dem ersten Teil bereits 1827 herausgegeben. Lediglich ein kleiner Teil ("Zweiter Theil. Kernschwämme") sowie wenige Seiten Nachträge zu Teil 1 wurden vor dem 5. September 1828 publiziert. Dank einer Notiz des Verlegers sowie eines Schreibens Beckers an den Senat der Stadt Frankfurt muss das Erscheinungsdatum dieser Teile nunmehr vorverlegt werden.
Die Bestände des in Deutschland stark gefährdeten Sand-Zwerggrases Mibora minima, für deren Erhalt das Land Hessen eine besondere Verantwortung trägt, gehen seit vielen Jahren zurück. In dieser Arbeit wurden als Beitrag zum Artenhilfsprogramm der Botanischen Vereinigung für Naturschutz in Hessen (BVNH) die noch vorhandenen Populationen erfasst sowie die botanischen und edaphischen Gegebenheiten an den Standorten untersucht. Dabei wurde durch Vergleich von Flächen mit und ohne Bewuchs des Zwerggrases der Frage nachgegangen, ob und inwieweit die Verbreitung der Art durch die Beschaffenheit und Nährstoffversorgung des Bodens bestimmt wird. Es wurde ein weiterer deutlicher Rückgang der südhessischen Populationen um etwa 60 % seit 1999 festgestellt, der am stärksten die Standorte um Mörfelden-Walldorf betrifft. Dagegen haben sich die Bestände bei Rüsselsheim-Königstädten möglicherweise durch Pflegemaßnahmen stabilisiert. Ein bestimmender Einfluss edaphischer Parameter auf die Verteilung der Art innerhalb der kalkfreien Flugsande konnte nicht festgestellt werden. Der indigene floristische Status der Art wird in Frage gestellt und stattdessen ihre Einstufung als Epökophyt westmediterraner Herkunft angenommen.
Das aus dem Taunus (Hessen) bisher nur durch drei Vegetationsaufnahmen belegte Ranunculo-Alopecuretum (Molinio-Arrhenatheretea, Potentillo-Polygonetalia, Potentillion anserinae) wird durch 11 weitere Aufnahmen dokumentiert und das für Hessen (Deutschland) bisher in der Literatur nicht erwähnte seltene Alopecuretum aequalis (Bidentetea, Bidentetalia, Bidention) durch zwei Aufnahmen belegt. In dem im Taunus gelegenen FFH-Gebiet "Eichkopf bei Ober-Mörlen" wächst Alopecurus aequalis in einer Pflanzengesellschaft, die nicht der nach ihm benannten Assoziation zugeordnet werden kann, sondern zwischen der Vegetationsklasse Isoëto-Nanojuncetea und Pionierstadien der Phragmitetea vermittelt.
Im Taunus konnten folgende Pflanzengesellschaften der Ordnung Agropyretalia intermedio-repentis durch Vegetationsaufnahmen belegt werden: Convolvulo arvensis-Agropyretum repentis, Cardario drabae-Agropyretum repentis, Falcario vulgaris-Agropyretum repentis, Diplotaxio tenuifoliae-Agropyretum repentis, Agropyro repentis-Rumicetum thyrsiflori, Poo compressae-Anthemidetum tinctoriae, Poo compressae-Tussilaginetum farfarae und Poa-compressa-Poa-pratensis-[Convolvulo-Agropyrion]-Gesellschaft.
Im Rahmen einer Untersuchung der Bahnsteige und des Gleisbereichs von insgesamt 31 Bahnhöfen des Taunus und seines Vorlandes konnten insgesamt acht Geranium-Arten nachgewiesen werden. Die bei weitem häufigste Art war G. robertianum (28 Bahnhöfe), mit weitem Abstand gefolgt von G. columbinum (10). Das bisher im Taunus nur einmal nachgewiesene G. purpureum wurde immerhin an sieben Bahnhöfen gefunden. Die weiteren angetroffenen Gerania waren G. molle (6 Bahnhöfe), G. pusillum (5) sowie G. dissectum, G. pyrenaicum und G. sanguineum (je 1 Bahnhof). Bei Letzterem handelte es sich offensichtlich um einen Kulturflüchtling. Höchstwahrscheinlich sind im Untersuchungsgebiet auch spontane Hybriden von G. purpureum und G. robertianum vorhanden.
Schistosomiasis is a severe neglected tropical disease caused by trematodes and transmitted by freshwater snails. Snails are known to be highly tolerant to agricultural pesticides. However, little attention has been paid to the ecological consequences of pesticide pollution in areas endemic for schistosomiasis, where people live in close contact with non-sanitized freshwaters. In complementary laboratory and field studies on Kenyan inland areas along Lake Victoria, we show that pesticide pollution is a major driver in increasing the occurrence of host snails and thus the risk of schistosomiasis transmission. In the laboratory, snails showed higher insecticide tolerance to commonly found pesticides than associated invertebrates, in particular to the neonicotinoid Imidacloprid and the organophosphate Diazinon. In the field, we demonstrated at 48 sites that snails were present exclusively in habitats characterized by pesticide pollution and eutrophication. Our analysis revealed that insensitive snails dominated over their less tolerant competitors. The study shows for the first time that in the field, pesticide concentrations considered “safe” in environmental risk assessment have indirect effects on human health. Thus we conclude there is a need for rethinking the environmental risk of low pesticide concentrations and of integrating agricultural mitigation measures in the control of schistosomiasis.
Currently, the genus Polypedates comprises 26 species distributed in South, Southeast, and East Asia. Because of their relatively low dispersal capability and intolerance to seawater, this genus is ideal for the study of terrestrial range evolution that extends into the island archipelagos of southeastern Asia. In this study, based on data compiled for Polypedates from previous studies and partial mitochondrial and nuclear genes collected in this study, we performed systematic biogeographical analysis. We confirmed a Sundaland origin for the extant genus and showed northward dispersal into mainland Southeast Asia and Asia, which coincided with the timing of paleoclimatic change from the Oligocene to Middle Miocene. Climate fluctuations had a profound impact on species diversification within the genus Polypedates. Furthermore, the Red River did not mediate species exchange between Southeast Asia and mainland Asia until the end of the Miocene, with the sudden onset of northward dispersal in several clades independently at that time. Alternatively, the lineage of widespread insular P. leucomystax strongly supports the hypothesis of terrestrial connection between island archipelagos of Southeast Asia during the Mid-Pleistocene paleoclimate fluctuations. Our biogeographical analysis also supports the recent introduction of P. leucomystax to the Philippines and Ryukyus, as previously suggested.
We contribute to the foundations of tropical geometry with a view toward formulating tropical moduli problems, and with the moduli space of curves as our main example. We propose a moduli functor for the moduli space of curves and show that it is representable by a geometric stack over the category of rational polyhedral cones. In this framework, the natural forgetful morphisms between moduli spaces of curves with marked points function as universal curves.
Our approach to tropical geometry permits tropical moduli problems—moduli of curves or otherwise—to be extended to logarithmic schemes. We use this to construct a smooth tropicalization morphism from the moduli space of algebraic curves to the moduli space of tropical curves, and we show that this morphism commutes with all of the tautological morphisms.
2019 hat Frankfurt einen Rekord geknackt: Am 25. Juli wurde im Stadtteil Westend die Tageshöchsttemperatur von 40,2 Grad Celsius erreicht. Damit war Frankfurt der heißeste Ort Hessens seit Beginn der Wetteraufzeichnungen im Jahr 1881. Ein Superlativ, der zeigt: Der Klimawandel stellt auch die Städte vor große Herausforderungen. Gesucht werden Wege, um mit seinen Folgen zurechtzukommen.
URPOSE: Today, the majority of medical graduates in countries such as the UK, the US or Germany are female. This poses a major problem for workforce planning especially in urology. We here use first the first time the previously established Brüggmann Groneberg (BG) index to assess if female academic career options advance in urology.
METHODS: Different operating parameters (student population, urology specialist population, urology chair female:male (f:m) ratio) were collected from the Federal Office of Statistics, the Federal Chamber of Physicians and the medical faculties of 36 German universities. Four time points were monitored (2000, 2005, 2010 and 2015). From these data, female to male (f:m) ratios and the recently established career advancement (BG) index have been calculated.
RESULTS: The German hospital urology specialists' f:m ratios were 0.257 (499 female vs. 1944 male) for 2015, 0.195 for 2010, 0.133 for 2005 and 0.12 for 2000. The career advancement (BG) index was 0.0007 for 2000, 0,0005 for 2005, 0.094 for 2010 and 0.073 for 2015. The decrease from 2010 to 2015 was due to an increase in the f:m ratio of hospital urologists and female medical students.
CONCLUSION: The BG index clearly illustrated that there is an urgent need for special academic career funding programs to counteract gender problems in urology. The BG index has been shown to be an excellent tool to assess female academic career options and will be very helpful to assess and document positive or negative changes in the next decades.
Was man schon weiß, gibt jedem die Stärke, weiter zu lernen und höhere Erfolgsziele zu erreichen. Im Tertiärsprachenunterricht ergreift der Lerner im Kontext Deutsch als Fremdsprache nach Englisch (DaFnE) günstige Lerngelegenheiten aus der ersten Fremdsprache Englisch. Durch die Sensibilisierung des Sprachvergleichs und der Bewusstmachung von Sprachlernerfahrungen, können Lernende mit ihren vorhandenen Sprachkenntnissen sichere Lernerfolge im DaF-Unterricht erzielen. Um den Input der Lernenden aus dem Englischen bewusst zu aktivieren, müssen optimale Lernsituationen bereitgestellt werden. In diesem Zusammenhang soll im Tertiärsprachenunterricht ein interkultureller Raum geschaffen werden, wo die Gemeinsamkeiten und Unterschiede zwischen dem Englischen und Deutschen bearbeitet werden können. Die Redewendungen können als soziokulturelle Kompetenz zu der Integrierung in den DaFnE-Unterricht bedeutend sein. Diese Arbeit konzentriert sich auf die Einbeziehung der Redewendungen in den Tertiärsprachenunterricht. Die englischen und deutschen Redewendungen wurden für den DaFnE-Unterricht analysiert und als Redewendungen mit absoluter Ähnlichkeit, Redewendungen mit teilweiser Ähnlichkeit und Redewendungen mit kontextueller Ähnlichkeit kategorisiert. Nach der Bestimmung der Redewendungen für den Tertiärsprachenunterricht DaFnE, war es wichtig, wie man diese Redewendungen als DaF-Lehrkraft im Tertiärsprachenunterricht in die Praxis umsetzen kann. Dazu wurden einige Einbeziehungswege mit Beispielen vorgeschlagen. Die Visualisierung der Redewendungen kann die Lehrkraft besonders beim Anfangsniveau effektiv einsetzen und damit einen wichtigen Antrieb zur Erweiterung des Wortschatzes geben. Die anderen zwei Einbeziehungsmöglichkeiten auf der Spur der Redewendungen und Kontextsituationen der Redewendungen können in weiteren Niveaus eingesetzt werden, nachdem sich die Lernenden an die Redewendungen gewöhnt haben. Mit dem interkulturellen Vergleich der Redewendungen können Lernmotivation, Sprachbewusstheit und zugleich Lernerautonomie gefördert werden.
O artigo traz um estudo das vanguardas, tais como elas foram apresentadas ao leitor brasileiro por algumas das primeiras histórias da literatura alemã escritas em língua portuguesa. Três histórias brasileiras da literatura alemã (KOHNEN, 1948; CARPEAUX, 1967; ROSENFELD, 1993) são confrontadas com definições teóricas e textos historiográficos mais recentes, levando-se em consideração tópicos referentes às vanguardas, como origens, período de vigência, características inerentes e autores relevantes. De 1948 até cerca de 1970, período em que as três histórias foram escritas, percebe-se um crescimento na valorização das vanguardas e uma maior complexidade em sua apresentação. O fato pode ser atribuído a um desenvolvimento dos estudos de língua e literatura alemã no Brasil da década de 1960, bem como à formação mais ampla dos historiadores, que é visível em suas produções e biografias.
Au Tchad, à cause de ses retombées financières une attention particulière est prêtée aux arbres à karité (Vitella- ria paradoxa C.F.Gaertn.). Cependant, cette culture est menacée par les plantes vasculaires parasites de la famille des Lo- ranthaceae. La présente étude a été effectuée dans 3 sites dans la région du Mandoul pour évaluer l’ampleur des attaques de Loranthaceae (gui africain) sur des arbres en fonction des classes de circonférence du tronc à 1,5 cm du sol. Elle a consisté à dénombrer sur une de surface, les arbres à karité infestés et les touffes de parasites rencontrées sur ces arbres, afin de dé- terminer leur taux et leur intensité d’infestation. Les résultats obtenus montrent que Tapinanthus dodoneifolus (DC) Danser a été trouvée comme la seule espèce de Loranthaceae qui parasite les arbres karité étudiés dans la zone d’étude. Le taux moyen d’infestation estimé à 73% augmente avec l’âge des arbres karité. La moyenne d’intensité de l’infestation/arbre (2,75 touffes à Békôh, 2,27 à Yomi and 2,04 à Bébopen) montre que Tapinanthus dodoneifolus constitue une réelle menace pour les peu- plements de karité dans la zone d’étude. Il reste à rechercher le seuil d’infestation qui provoque une réduction significative de la fructification. Pour l’instant, bien que pénible à cause de la hauteur des arbres adultes, la lutte mécanique contre les Ta- pinanthus par la coupe systématique des branches infestées est urgente dans les parcs à karité dans cette zone d’étude.
We study D and DS mesons at finite temperature using an effective field theory based on chiral and heavy-quark spin-flavor symmetries within the imaginary-time formalism. Interactions with the light degrees of freedom are unitarized via a Bethe-Salpeter approach, and the D and self-energies are calculated self-consistently. We generate dynamically the e D∗0(2300)and Ds(2317)state, and study their possible identification as the chiral We study Dand Dsmesons at finite temperature using an effective field theory based on chiral and heavy-quark spin-flavor symmetries within the imaginary-time formalism. Interactions with the light degrees of freedom are unitarized via a Bethe-Salpeter approach, and the Dand Dsself-energies are calculated self-consistently. We generate dynamically the D∗0(2300)and Ds(2317)states, and study their possible identification as the chiral partners of the Dand Dsground states, respectively. We show the evolution of their masses and decay widths as functions of temperature, and provide an analysis of the chiral-symmetry restoration in the heavy-flavor sector below the transition temperature. In particular, we analyse the very special case of the D-meson, for which the chiral partner is associated to the double-pole structure of the D∗0(2300).
A strong decline and thinning of the Arctic sea-ice cover over the past five decades has been documented. The former multiyear sea-ice system has largely changed to an annual system and with it the dynamics of sea-ice transport across the Arctic Ocean. Less sea ice is reaching the Fram Strait and more ice and ice-transported material is released in the northern Laptev Sea and the central Arctic Ocean. This trend is expected to have a decisive impact on ice associated (“sympagic”) communities. As sympagic fauna plays an important role in transmitting carbon from the ice-water interface to the pelagic and benthic food webs, it is important to monitor its community composition under the changing environmental conditions. We investigated the taxonomic composition, abundance and distribution of sea-ice meiofauna (here heterotrophs >10 μm; eight stations) and under-ice fauna (here metazoans >300 μm; fourteen stations) in Arctic 1.5 year-old pack ice north of Svalbard. Sampling was conducted during spring 2015 by sea-ice coring and trawling with a Surface and Under-Ice Trawl. We identified 42 taxa associated with the sea ice. The total abundance of sea-ice meiofauna ranged between 580 and 17,156 ind.m–2 and was dominated by Ciliophora (46%), Copepoda nauplii (29%), and Harpacticoida (20%). In contrast to earlier studies in this region, we found no Nematoda and few flatworms in our sea-ice samples. Under-ice fauna abundance ranged between 15 and 6,785 ind.m–2 and was dominated by Appendicularia (58%), caused by exceptionally high abundance at one station. Copepoda nauplii (23%), Calanus finmarchicus (9%), and Calanus glacialis (6%) were also very abundant while sympagic Amphipoda were comparatively rare (0.35%). Both sympagic communities showed regional differences in community composition and abundance between shelf and offshore stations, but only for the under-ice fauna those differences were statistically significant. Selected environmental variables moderately explained variations in abundances of both faunas. The results of this study are consistent with predictions of diversity shifts in the new Arctic.
Precipitation extremes with devastating socioeconomic consequences within the South American Monsoon System (SAMS) are expected to become more frequent in the near future. The complexity in SAMS behavior, however, poses severe challenges for reliable future projections. Thus, robust paleomonsoon records are needed to constrain the high spatiotemporal variability in the response of SAMS rainfall to different climatic drivers. This study uses Ti/Ca ratios from X‐ray fluorescence scanning of a sediment core retrieved off eastern Brazilian to trace precipitation changes over the past 322 Kyr. The results indicate that despite the spatiotemporal complexity of the SAMS, insolation forcing is the primary pacemaker of variations in the monsoonal system. Additional modulation by atmospheric pCO2 suggests that SAMS intensity over eastern Brazil will be suppressed by rising CO2 emissions in the future. Lastly, our record reveals an unprecedented strong and persistent wet period during Marine Isotope Stage 6 driven by anomalously strong trade winds.
The oomycete genus Ectrogella currently comprises a rather heterogeneous group of obligate endoparasitoids, mostly of diatoms and algae. Despite their widespread occurrence, little is known regarding the phylogenetic affinities of these bizarre organisms. Traditionally, the genus was included within the Saprolegniales, based on zoospore diplanetism and a saprolegnia/achlya-like zoospore discharge. The genus has undergone multiple re-definitions in the past, and has often been used largely indiscriminately for oomycetes forming sausage-like thalli in diatoms. While the phylogenetic affinity of the polyphyletic genus Olpidiopsis has recently been partially resolved, taxonomic placement of the genus Ectrogella remained unresolved, as no sequence data were available for species of this genus. In this study, we report the phylogenetic placement of Ectrogella bacillariacearum infecting the freshwater diatom Nitzschia sigmoidea. The phylogenetic reconstruction shows that Ectrogella bacillariacearum is grouped among the early diverging lineages of the Saprolegniomycetes with high support, and is unrelated to the monophyletic diatom-infecting olpidiopsis-like species. As these species are neither related to Ectrogella, nor to the early diverging lineages of Olpidiopsis s. str. and Miracula, they are placed in a new genus, Diatomophthora, in the present study.
In the absence of an active prophylactic vaccine against HIV-1, passively administered, broadly neutralizing antibodies (bnAbs) identified in some chronically infected persons were shown to prevent HIV-1 infection in animal models. However, passive administration of bnAbs may not be suited to prevent sexual HIV-1 transmission in high-risk cohorts, as a continuous high level of active bnAbs may be difficult to achieve at the primary site of sexual transmission, the human vagina with its acidic pH. Therefore, we used Lactobacillus, a natural commensal in the healthy vaginal microbiome, to express bn nanobodies (VHH) against HIV-1 that we reported previously. After demonstrating that recombinant VHHA6 expressed in E. coli was able to protect humanized mice from mucosal infection by HIV-1Bal, we expressed VHHA6 in a soluble or in a cell-wall-anchored form in Lactobacillus rhamnosus DSM14870. This strain is already clinically applied for treatment of bacterial vaginosis. Both forms of VHHA6 neutralized a set of primary epidemiologically relevant HIV-1 strains in vitro. Furthermore, VHHA6 was still active at an acidic pH. Thus, lactobacilli expressing bn VHH potentially represent an attractive vector for the passive immunization of women in cohorts at high risk of HIV-1 transmission.
In the course of a growing start-up market and strongly increasing investment volume, investors try to predict the success of a business as precisely as possible in advance. However, when assessing the personality of the founder or founding team, they still rely far too often on their gut feeling, thereby reducing the quality of their decisions. Our study therefore aimed at investigating whether there are any relationships between the founders' personality traits and their performance and thus justifying the need for more targeted and optimized diagnostics in the field of founder personality. With a total of 141 founders, clear correlations between personality traits (conscientiousness, emotional stability) and performance could be demonstrated in the present study. In addition, it became evident that perceived stress is also related to the founders’ personality (emotional stability negative, conscientiousness positive) and in turn has a negative effect on performance. Our findings contribute to raising awareness of the importance of personality as a predictor of founders' performance, improving decision-making, and, in the long run, replacing gut feeling as an inappropriate assessment criterion of investors.
Les données de l’effet d’affaiblissement de l’obviation (ou encore référence disjointe du subjonctif) dans la littérature linguistique sont soit fondées sur l’intuition des auteurs soit issues de publications d’autres chercheurs, bien que cet effet soit connu depuis longtemps et bien qu’il fasse partie de plusieurs modélisations théoriques. En conséquence, aucune réponse de nature empirique/expérimentale a été offerte à la question « A quel point les affirmations portant sur l'effet d'affaiblissement de l'obviation sont-elles solides ? ». Cet article se fixe en conséquence un double objectif : (i) mettre en oeuvre un jugement de grammaticalité afin de répondre expérimentalement à la question précédente, et (ii) proposer une analyse syntaxique provisoire des résultats obtenus. Ici, nous étudions six facteurs qui – selon Ruwet (1984/1991) – déclenchent l’affaiblissement. Les résultats montrent que seul un facteur (la coordination) déclenche l’affaiblissement. En conséquence, l’appareil théorique permettant de modéliser l’affaiblissement peut être réduit radicalement, et nous proposons des pistes de modélisation syntaxique n’intégrant que le facteur de coordination
The aim of this observational study was to follow-up patients with bedtime basal insulin (NPH insulin) added to metformin. In 285 patients with type 2 diabetes, a therapy with bedtime basal insulin added to metformin was started due to failure to achieve a glycaemic goal. Up until July 2019, 272 patients (95.4%) were followed-up (59.5 y, 92.6 kg, diabetes duration 6.6 y, HbA1c 8.4%/68.6 mmol/mol). HbA1c decreased by −1.2% and bodyweight by −1.7 kg after a duration of 31.7 ± 29.1 (range 2–133) months. Severe hypoglycaemia did not occur. In 144/272 patients (52.9%), the therapeutic goal for HbA1c was achieved over 32.7 months. In 69/272 patients (25.4%), the HbA1c target was achieved over 25.0 months (afterwards, therapy with basal insulin was discontinued because HbA1c was under target). In 36/272 patients (13.2%), the HbA1c goal was achieved until the submission of this manuscript (mean duration of treatment 57.4 ± 28.2 (range 13–121) months). Over 90% of patients with type 2 diabetes and failure of metformin reached their HbA1c goal with additional basal insulin at bedtime over several years in association with a reduction of bodyweight and without any event of severe hypoglycaemia.
In the present article we argue that all communication is medial in the sense that every human sign-based interaction is shaped by medial aspects from the outset. We propose a dynamic, semiotic concept of media that focuses on the process-related aspect of mediality, and we test the applicability of this concept using as an example the second presidential debate between Clinton and Trump in 2016. The analysis shows in detail how the sign processing during the debate is continuously shaped by structural aspects of television and specific traits of political communication in television. This includes how the camerawork creates meaning and how the protagonists both use the affordances of this special mediality. Therefore, it is not adequate in our view to separate the technical aspects of the medium, the ‘hardware’, from the processual aspects and the structural conditions of communication. While some aspects of the interaction are directly constituted by the medium, others are more indirectly shaped and influenced by it, especially by its institutional dimension – we understand them as second-order media effects. The whole medial procedure with its specific mediality is a necessary, but not a sufficient condition of meaning-making. We distinguish the medial procedure from the semiotic modes employed, the language games played and the competence of the players involved.
Rethinking superdeterminism
(2020)
Quantum mechanics has irked physicists ever since its conception more than 100 years ago. While some of the misgivings, such as it being unintuitive, are merely aesthetic, quantum mechanics has one serious shortcoming: it lacks a physical description of the measurement process. This “measurement problem” indicates that quantum mechanics is at least an incomplete theory—good as far as it goes, but missing a piece—or, more radically, is in need of complete overhaul. Here we describe an approach which may provide this sought-for completion or replacement: Superdeterminism. A superdeterministic theory is one which violates the assumption of Statistical Independence (that distributions of hidden variables are independent of measurement settings). Intuition suggests that Statistical Independence is an essential ingredient of any theory of science (never mind physics), and for this reason Superdeterminism is typically discarded swiftly in any discussion of quantum foundations. The purpose of this paper is to explain why the existing objections to Superdeterminism are based on experience with classical physics and linear systems, but that this experience misleads us. Superdeterminism is a promising approach not only to solve the measurement problem, but also to understand the apparent non-locality of quantum physics. Most importantly, we will discuss how it may be possible to test this hypothesis in an (almost) model independent way.
Vegetation responds to drought through a complex interplay of plant hydraulic mechanisms, posing challenges for model development and parameterization. We present a mathematical model that describes the dynamics of leaf water-potential over time while considering different strategies by which plant species regulate their water-potentials. The model has two parameters: the parameter λ describing the adjustment of the leaf water potential to changes in soil water potential, and the parameter Δψww describing the typical ‘well-watered’ leaf water potentials at non-stressed (near-zero) levels of soil water potential. Our model was tested and calibrated on 110 time-series datasets containing the leaf- and soil water potentials of 66 species under drought and non-drought conditions. Our model successfully reproduces the measured leaf water potentials over time based on three different regulation strategies under drought. We found that three parameter sets derived from the measurement data reproduced the dynamics of 53% of an drought dataset, and 52% of a control dataset [root mean square error (RMSE) < 0.5 MPa)]. We conclude that, instead of quantifying water-potential-regulation of different plant species by complex modeling approaches, a small set of parameters may be sufficient to describe the water potential regulation behavior for large-scale modeling. Thus, our approach paves the way for a parsimonious representation of the full spectrum of plant hydraulic responses to drought in dynamic vegetation models.
Mehr als 7 Prozent der Treibhausgase, die in Deutschland freigesetzt werden, stammen aus der Landwirtschaft: Von wiederkäuenden Rindern etwa, aus stickstoffhaltigen Düngemitteln. Hinzu kommen Emissionen aus trockengelegten Mooren oder aus verrottendem Humus umgepflügter Wiesen. Rund 58 Milliarden Euro fließen jährlich vom EU-Budget in die europäische Landwirtschaft. Dies gibt Bund und Ländern viele Möglichkeiten, etwas für den Klimaschutz zu tun.
Der Wald der Zukunft ... : ...braucht andere Bäume. Welche, versuchen Forscher herauszufinden
(2020)
Die Luft ist heiß und trocken, der sandige Boden hält kein Wasser: Es gibt nicht viele Wälder in Deutschland, denen es schlechter geht als dem Frankfurter Stadtwald. Für Wolfgang Brüggemann und Vera Holland ist er damit der perfekte Ort, um klimawandelresistente Bäume zu finden. Denn: Wer es hier schafft, der schafft es überall.
Literaturkanon und Identitätspolitik. Notizen zu den Wiener Schillerfeiern im 19. Jahrhundert
(2020)
Der vorliegende Beitrag befasst sich mit der Inszenierung Friedrich Schillers als Leitfigur einer deutschen Kulturnation bei der Wiener Dichterfeier 1859. Gemessen an der politischen Krisensituation der Habsburgermonarchie spiegelt die Zentenarfeier die kollektiven Sehnsüchte und Illusionen des deutschösterreichischen Bürgertums deutlich wider. Die einzelnen Veranstaltungen können hierbei als Medienereignisse und "Cultural Performances" aufgefasst werden, bei denen die politisch intendierten Festinhalte vermittelt und sinnlich erfahrbar gemacht wurden. Die Indienstnahme und Popularisierung Schillers trieb nicht zuletzt auch dessen Kanonisierung weiter voran – literatur- und theaterhistorisch betrachtet nicht immer zum Vorteil der "österreichischen Literatur" des 18. und 19. Jahrhunderts.
In recent years, reports of elephants causing damage in rural villages by destroying houses and foraging on stored food have been increasing, but little is known about the determinants and magnitude of this damage. In this study, we have examined the extent of property damage by elephants (Loxodonta africana and Elephas maximus), in one African and two Asian study areas over a six‐year period. A total of 1,172 damaged constructions were observed on site, involving detailed damage assessment by trained enumerators and standardized interviews with witnesses. Depending on the study area, between 67.1 and 86.4% of damage events were attributed to single, individual elephants or pairs of males. The majority of properties were damaged in search for food (62.5–76.7% respectively). Property damage caused higher mean losses than crop damage on farmland in all study areas. Results suggest that property damage by elephants has been largely underestimated and needs to form a focus in future human–elephant conflict research. We suggest a need to reduce the attractiveness of villages by storing food in locked and safe places, away from sleeping areas and to foster the development of elephant safe stores, appropriate to the particular cultural background of the target area.
Cet article cherche à rapprocher les pensées de Louis Althusser et de Theodor W. Adorno autour de trois grandes questions : le primat de la théorie, la théorie de la société et de l’histoire, et la critique du sujet. Dans chaque cas, il s’agit de mettre en évidence les points communs entre les deux penseurs tout en soulignant leur désaccord fondamental en ce qui concerne la manière dont chacun se rapporte à la philosophie de Hegel. Là où Althusser vise à repenser le marxisme sur des bases non hégéliennes, Adorno veut au contraire revenir à Hegel pour ressourcer le marxisme en temps de crise.
Tsetse flies are the transmitting vector of trypanosomes causing human sleeping sickness and animal trypanosomiasis in sub-saharan Africa. 3-alkylphenols are used as attractants in tsetse fly traps to reduce the spread of the disease. Here we present an inexpensive production method for 3-ethylphenol (3-EP) and 3-propylphenol (3-PP) by microbial fermentation of sugars. Heterologous expression in the yeast Saccharomyces cerevisiae of phosphopantetheinyltransferase-activated 6-methylsalicylic acid (6-MSA) synthase (MSAS) and 6-MSA decarboxylase converted acetyl-CoA as a priming unit via 6-MSA into 3-methylphenol (3-MP). We exploited the substrate promiscuity of MSAS to utilize propionyl-CoA and butyryl-CoA as alternative priming units and the substrate promiscuity of 6-MSA decarboxylase to produce 3-EP and 3-PP in yeast fermentations. Increasing the formation of propionyl-CoA by expression of a bacterial propionyl-CoA synthetase, feeding of propionate and blocking propionyl-CoA degradation led to the production of up to 12.5 mg/L 3-EP. Introduction of a heterologous ‘reverse ß-oxidation’ pathway provided enough butyryl-CoA for the production of 3-PP, reaching titers of up to 2.6 mg/L. As the concentrations of 3-alkylphenols are close to the range of the concentrations deployed in tsetse fly traps, the yeast broths might become promising and inexpensive sources for attractants, producible on site by rural communities in Africa.
Ein halbes Jahrhundert Judaistik in Frankfurt : das »kleine Fach« feiert 50-jähriges Bestehen
(2020)
Access to specialized care is essential for people with Parkinson´s disease (PD). Given the growing number of people with PD and the lack of general practitioners and neurologists, particularly in rural areas in Germany, specialized PD staff (PDS), such as PD nurse specialists and Parkinson Assistants (PASS), will play an increasingly important role in the care of people with PD over the coming years. PDS have several tasks, such as having a role as an educator or adviser for other health professionals or an advocate for people with PD to represent and justify their needs. PD nurse specialists have been established for a long time in the Netherlands, England, the USA, and Scandinavia. In contrast, in Germany, distinct PDS models and projects have been established. However, these projects and models show substantial heterogeneity in terms of access requirements, education, theoretical and practical skills, principal workplace (inpatient vs. outpatient), and reimbursement. This review provides an overview of the existing forms and regional models for PDS in Germany. PDS reimbursement concepts must be established that will foster an implementation throughout Germany. Additionally, development of professional roles in nursing and more specialized care in Germany is needed.
Es ist nicht zu übersehen, dass Migration und Flucht seit langem in Deutschland als Problem und besonders Integration für den sozialen Zusammenhalt als unbedingt notwendig dargestellt werden. Weder die Einheimischen noch die Einwanderer hatten von der Sprache und Kultur voneinander viel Ahnung und die Einheimischen verlangten bald die Integration, da sie dachten, dass alle Probleme, die die Arbeitsmigranten und Flüchtlinge verursachten, durch die Integration gelöst würden, und ein friedliches Zusammenleben in diesen Sprach- und Kulturkonflikten ermöglicht würde. So wurde das Wort "Integration" in Deutschland seit den 70er Jahren ein Zentralbegriff in der Migration. Es ist auch erfreulich zu beobachten, wie immer mehr deutsche AutorInnen die Migranten-und Flüchtlingskinder, ihr Konfliktpotential und ihre Integration in die deutsche Gesellschaft in ihren Werken behandeln, die zur Zeit in der problemorientierten realistischen Kinder- und Jugendliteratur einen wichtigen Platz einnehmen. Der vorliegende Beitrag konzentriert sich einerseits auf die aktuelle deutsche Kinder- und Jugendliteratur, in der es um Kinder und Jugendliche mit Migrations- und Fluchthintergrund geht, andererseits wird versucht, anhand der literarischen Textanalysen ausgewählter Kinder- und Jugendbücher aufzuzeigen, ob die Integrationsbestrebungen dieser Kinder und Jugendlichen erfolgreich waren oder gescheitert sind.
The production of haploid gametes through meiosis is central to the principle of sexual reproduction. The genetic diversity is further enhanced by exchange of genetic material between homologous chromosomes by the crossover mechanism. This mechanism not only requires correct pairing of homologous chromosomes but also efficient repair of the induced DNA double-strand breaks. Oocytes have evolved a unique quality control system that eliminates cells if chromosomes do not correctly align or if DNA repair is not possible. Central to this monitoring system that is conserved from nematodes and fruit fly to humans is the p53 protein family, and in vertebrates in particular p63. In mammals, oocytes are stored for a long time in the prophase of meiosis I which, in humans, can last more than 50 years. During the entire time of this arrest phase, the DNA damage checkpoint remains active. The treatment of female cancer patients with DNA damaging irradiation or chemotherapeutics activates this checkpoint and results in elimination of the oocyte pool causing premature menopause and infertility. Here, we review the molecular mechanisms of this quality control system and discuss potential therapeutic intervention for the preservation of the oocyte pool during chemotherapy.
In a previous study, EphB4 was demonstrated to be a positive regulator of A375-melanoma growth but a negative regulator of tumor vascularization and perfusion. To distinguish between EphB4 forward and ephrinB2 reverse signaling, we used the commercially available EphB4 kinase inhibitor NVP-BHG712 (NVP), which was later identified as its regioisomer NVPiso. Since there have been reported significant differences between the inhibition profiles of NVP and NVPiso, we compared the influence of NVP and NVPiso on tumor characteristics under the same experimental conditions. Despite the different inhibitory profiles of NVP and NVPiso, the comparative study conducted here showed the same EphB4-induced effects in vivo as in the previous investigation. This confirmed the conclusion that EphB4-ephrinB2 reverse signaling is responsible for increased tumor growth as well as decreased tumor vascularization and perfusion. These results are further substantiated by microarrays showing differences between mock-transfected and EphB4-transfected (A375-EphB4) cells with respect to at least 9 angiogenesis-related proteins. Decreased expression of vascular endothelial growth factor (VEGF), angiotensin 1 (Ang-1), and protein kinase B (Akt/PKB), together with the increased expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) and transforming growth factor beta-2 (TGF-β2), is consistent with the impaired vascularization of A375-EphB4 xenografts. Functional overexpression of EphB4 in A375-EphB4 cells was confirmed by activation of a variety of signaling pathways, including the Janus kinase/signal transducers and activators of transcription (JAK/STAT), rat sarcoma virus/rapidly accelerated fibrosarcoma/mitogen activated protein kinase kinase (Ras/Raf/MEK), and nuclear factor kappa-B (NFkB) pathways.
In this paper we present first-order reversal curve (FORC) diagrams of ensembles of three-dimensional Co3Fe nanostructures as 2 × 2 arrays of nano-cubes and nano-trees. The structures are fabricated and investigated by an advanced platform of focused electron beam induced deposition combined with high-resolution detection of magnetic stray fields using a home-built micro-Hall magnetometer based on an AlGaAs/GaAs heterostructure. The experimental FORC diagrams are compared to macrospin simulations for both geometries at different angles of the externally applied magnetic field. The measured FORC diagrams are in good agreement with the simulated ones and reflect non-uniform magnetization reversal dominated by multi-vortex states within, and strong magnetic coupling between, the building blocks of our nanostructures. Thus, a FORC analysis of small arrays of 3D magnetic nanostructures provides more detailed insights into the mechanisms of magnetization reversal beyond standard major hysteresis loop measurements.
Focused electron beam induced deposition (FEBID) is a direct-write nanofabrication technique able to pattern three-dimensional magnetic nanostructures at resolutions comparable to the characteristic magnetic length scales. FEBID is thus a powerful tool for 3D nanomagnetism which enables unique fundamental studies involving complex 3D geometries, as well as nano-prototyping and specialized applications compatible with low throughputs. In this focused review, we discuss recent developments of this technique for applications in 3D nanomagnetism, namely the substantial progress on FEBID computational methods, and new routes followed to tune the magnetic properties of ferromagnetic FEBID materials. We also review a selection of recent works involving FEBID 3D nanostructures in areas such as scanning probe microscopy sensing, magnetic frustration phenomena, curvilinear magnetism, magnonics and fluxonics, offering a wide perspective of the important role FEBID is likely to have in the coming years in the study of new phenomena involving 3D magnetic nanostructures.
Halkların millî kültürünü, yaşadıkları coğrafya ve inanç sistemi biçimlendirir. Çoban kültürü ve edebiyatı da millî kültürlere göre şekillenerek devam eder. Çoban edebiyatının kökeni mitolojiye dayanır. İtalya'da Rönesans döneminde şiirlerle başlar. İspanya’da pastoral romanla gelişimini sürdürür. Aynı dönemde İngiliz ve Fransız edebiyatına girer. Alman Edebiyatında ise Barok döneminde çeviriler yoluyla kazandırılır. Alman literatüründe bu alanda daha çok Barok, Aufklärung ve Rokoko dönemlerinde eserler verilmiştir. Masal, efsane, atasözü, şiir, roman, madrigal, opera, çoban oyunları türündeki eserleri kapsar. Bu çalışmanın amacı öncelikle çoban edebiyatının kaynağı, Avrupa'ya gelişi ve Alman Edebiyatına etkisini araştırmaktır. Araştırmada literatür tarama metodu kullanılacaktır.
In unserem Aufsatz beschäftigen wir uns mit dem Einsatz von Blended Learning im berufsbezogenen Deutschunterricht. Es ist keine neue Methode, sondern eine neue Form, die den Präsenzunterricht mit einer Phase des Selbststudiums und mit einer computergestützten Phase kombiniert. Jeder Fremdsprachenunterricht hat seine eigenen Besonderheiten, die bei der Suche nach einer geeigneten Kombination der drei genannten Unterrichtsformen berücksichtigt werden müssen, um dank des synergistischen Effekts einen möglichst starken Lerneffekt zu erzielen. Blended Learning im Fremdsprachenunterricht stellt ein aktuelles Thema der Fremdsprachendidaktik dar, das noch nicht ausreichend bearbeitet wurde. Es gibt mehrere Modelle, die das erfolgreiche Einbinden von Blended Learning in den Fremdsprachenunterricht anbieten. Wir möchten die Anwendung eines der Modelle im berufsbezogenen Deutschunterricht vorstellen und damit einige Fragen zum Thema Blended Learning im Fremdsprachenunterricht beantworten. Die zentrale Frage lautet: Welchen Mehrwert bietet Blended Learning im Vergleich zu dem klassischen Präsenzunterricht? Daraus ergeben sich weitere Fragen: Welche Risiken muss man beim Einsatz von Blended Learning berücksichtigen? Ist Blended Learning nur aus pragmatischen Gründen einzuführen, oder unterstützt diese Unterrichtsform das Erlernen von einer Fremdsprache in besonderem Maße?
The complexity of atmospherical processes has always yielded a multitude of ways of knowing about the weather. What has been lacking in the historiography of meteorology so far is a way to formulate differences between forms of knowledge in a way that does not privilege modern scientific structures, but focuses instead on the epistemological category of causality. Using causality as ground of comparison for different knowledge claims, I shall argue, may enable researchers to investigate meteorological knowledge across time periods, perhaps even geographical regions, in a more symmetrical manner. This review demonstrates this approach as a means to organize a large set of historical meteorological writings from German countries between 1750 and 1850. Three distinct forms of knowledge (Semiotics, Physics, and Organics of the weather) during that time and in that region are suggested and will be described. While a bibliography with a national perspective from the 1880s was the basis for the selection of historical sources, such a setup proved awkward even to contemporaries. In addition, the bibliography came with a number of biases and shortcomings that will be critically reviewed.
This article presents a case study of three different coin series (RRC 468-RRC 470) minted near contemporaneously in Hispania during the latter stages of the civil war, which present strikingly different representations of foreign peoples and places. While Caesar’s coin series (RRC 468) displays an image of submissive Gallic captives and a military trophy, Cnaeus Pompey Jr’s two series (RRC 469=470) feature personifications of the region and local cities and depicts them working together with their Pompeian counterpart in the pursuit of victory in the area. The article incorporates hoard evidence to further develop our understanding of how a contemporary viewer might have experienced these contrasting images of foreign peoples and places. It demonstrates which would have been the more common image in circulation and provides evidence for potential audience targeting with the Pompeian coin series. In light of recent scrutiny of Pompeian patronage networks in Spain, this hoard evidence for potential audience targeting allows a new interpretation of the Pompeian coin series as targeting a potentially wavering host community to be put forward.
Die Vergangenheitsbewältigung der Erfahrung von Krieg und Diktatur im 20. Jahrhundert in Deutschland ist ein zentrales Thema auch in der jüngsten Literatur und hat Anlass für verschiedene Studien gegeben. Im vorliegenden Beitrag wird eine vergleichende Analyse der Vergangenheitsbewältigung in zeitgenössischen Romanen der deutschen Literatur angestrebt, die die Figur des Nationalsozialisten und die Schuldfrage in den Mittelpunkt stellt. In diesem Zusammenhang wird u.a. folgenden Fragen nachzugehen sein: in welcher Täter-/Opferrolle erscheinen überzeugte Nazis und andere Deutsche? Handelt es sich um authentische oder um stereotypisierte Figuren? In welcher Hinsicht werden diese Texte heute, mehr als 70 Jahre nach dem Ende des Zweiten Weltkriegs, den Lesererwartungen gerecht bzw. verändern den Blick auf die dunkle Vergangenheit? Im Vergleich von deutschen Romanen des 21. Jahrhunderts soll versucht werden, die Gemeinsamkeiten der Aufarbeitung einer problematischen Vergangenheit in literarischer Form darzulegen, die Frage nach der Schuld an den Verbrechen, die in der Zeit des Nationalsozialismus verübt wurden. Dabei spielen die Begriffe Gedächtnis und Erinnerung eine wichtige Rolle, da dieses Forschungsfeld von großer Bedeutung sowohl in der Kultur- als auch in der Literaturwissenschaft ist. Die Debatten über die historische Vergangenheit Deutschlands erfordern einen kritischen Blick auf die Theorie der Erinnerungskultur und des kollektiven Gedächtnisses. Zu hinterfragen ist, wie diese Vergangenheit von der Kriegsgeneration und den nachfolgenden Generationen wahrgenommen wird. Diese Literatur entsteht also als ein bedeutsames Medium, das die Auseinandersetzung über Aufarbeitung von Vergangenheit und Schuld ermöglicht. Aus der Perspektive von vier Romanen der deutschsprachigen zeitgenössischen Literatur wird hier versucht, verschiedene Darstellungen dieser Thematik zu präsentieren. Der vorliegende Beitrag soll Wege für künftige, vertiefende Diskussionen öffnen und Interesse für diese Literatur wecken, um die ständige Präsenz der Vergangenheit in der Gegenwart besser analysieren und verstehen zu können. Die ausgewählten Romane, die hier vorgestellt werden, sind Günter Grass, "Im Krebsgang" (2002), Uwe Timm, "Am Beispiel meines Bruders" (2001), "Spione" von Marcel Beyer (2000) und "Der Vorleser" (1995) von Bernhard Schlink.
This paper explores how refugee families in Germany draw on me-diational repertoires to accomplish a range of digital literacy prac-tices on their smartphones. We introduce the concept of ‘mediation-al repertoire’, i.e. a socially and individually structured configuration of semiotic and technological resources for communication, and use it in an ethnographic case study with participants from Syria and Af-ghanistan in a refugee residence in Hamburg in 2017/18. The collect-ed data includes nine semi-directed interviews, video demonstra-tions of smartphone usage, and ethnographic fieldnotes. Qualitative analysis draws on mediagrams, i.e. visualizations of mediational re-pertoires in two families. Findings suggest that individual mediation-al repertoires in these families differ especially by generation and other factors, such as literacy competence, type of social relation-ship and purpose of online use, including smartphone-based lang-uage-learning.
Ferroptosis, a newly discovered form of cell death mediated by reactive oxygen species (ROS) and lipid peroxidation, has recently been shown to have an impact on various cancer types; however, so far there are only few studies about its role in hepatocellular carcinoma (HCC). The delicate equilibrium of ROS in cancer cells has found to be crucial for cell survival, thus increased levels may trigger ferroptosis in HCC.In our study, we investigated the effect of different ROS modulators and ferroptosis inducers on a human HCC cell line and a human hepatoblastoma cell line. We identified a novel synergistic cell death induction by the combination of Auranofin and buthionine sulfoxime (BSO) or by Erastin and BSO at subtoxic concentrations. We found a caspase-independent, redox-regulated cell death, which could be rescued by different inhibitors of ferroptosis. Both cotreatments stimulated lipid peroxidation. All these findings indicated ferroptotic cell death. Both cotreatments affected the canonical ferroptosis pathway through GPX4 downregulation. We also found an accumulation of Nrf2 and HO-1, indicating an additional effect on the non-canonical pathway. Our results implicate that targeting these two main ferroptotic pathways simultaneously can overcome chemotherapy resistance in HCC.
Objectives: The aim of this study was to compare the effects of acupuncture and medical training therapy alone and in combination with those of usual care on the pain sensation of patients with frequent episodic and chronic tension-type headache.
Design: This was a prospective single-centre randomised controlled trial with four balanced treatment arms. The allocation was carried out by pre-generated randomisation lists in the ratio 1:1:1:1 with different permutation block sizes.
Setting: The study was undertaken in the outpatient clinic of Rehabilitation Medicine of the Hannover Medical School.
Participants and interventions: Ninety-six adult patients with tension-type headache were included and randomised into usual care (n = 24), acupuncture (n = 24), medical training (n = 24), and combination of acupuncture and medical training (n = 24). One patient was excluded from analysis because of withdrawing her/his consent, leaving 95 patients for intention to treat analysis. Each therapy arm consisted of 6 weeks of treatment with 12 interventions. Follow-up was at 3 and 6 months.
Main outcome measures: Pain intensity (average, maximum and minimum), frequency of headache, responder rate (50% frequency reduction), duration of headache and use of headache medication.
Clinical results: The combination of acupuncture and medical training therapy significantly reduced mean pain intensity compared to usual care (mean = −38%, standard deviation = 25%, p = 0.012). Comparable reductions were observed for maximal pain intensity (−25%, standard deviation = 20%, 0.014) and for minimal pain intensity (−35%, standard deviation = 31%, 0.03). In contrast, neither acupuncture nor medical training therapy differed significantly from usual care. No between-group differences were found in headache frequency, mean duration of headache episodes, and pain medication intake. At 3 months, the majority of all patients showed a reduction of at least 50% in headache frequency. At 6 months, significantly higher responder rates were found in all intervention groups compared to usual care.
Conclusions: In contrast to monotherapy, only the combination of acupuncture and medical training therapy was significantly superior in reduction of pain intensity compared to usual care.
The concept of solidarity has been receiving growing attention from scholars in a wide range of disciplines. While this trend coincides with widespread unsuccessful attempts to achieve solidarity in the real world, the failure of solidarity as such remains a relatively unexplored topic. In the case of the so-called European Union (EU) refugee crisis, the fact that EU member states failed to fulfil their commitment to solidarity is now regarded as established wisdom. But as we try to come to terms with failing solidarity in the EU we are faced with a number of important questions: are all instances of failing solidarity equally morally reprehensible? Are some motivations for resorting to unsolidaristic measures more valid than others? What claims have an effective countervailing force against the commitment to act in solidarity?
Right-wing populist parties often resort to a xenophobic rhetoric which both exploits and fuels existing illiberal anti-immigrant sentiments. Since populist anti-immigrant sentiments are at odds with fundamental liberal values and challenge the implementation of any liberal ethics of migration, this essay argues that states should adopt civic education policies to counter such sentiments and persuade citizens to develop liberal attitudes towards immigrants. Empirical evidence suggests that sentiments may be malleable, and there are already examples of local governments devising or supporting initiatives aimed at dispelling prejudices and promoting positive interactions. It might be objected that a government’s involvement in shaping sentiments and opinions conflicts with liberal democratic states’ commitment to individual autonomy and electoral fairness. However, I argue that civic education policies are not necessarily incompatible with such values and I provide five criteria to identify policies that liberal democratic governments may legitimately adopt to counteract anti-immigrant sentiments.
Recent developments in Hungary and Poland have made democratic backsliding a major issue of concern within the European Union (EU). This article focuses on the secondary agents that facilitate democratic backsliding in Hungary and Poland: the European People’s Party (EPP), which has continually protected the Hungarian Fidesz government from EU sanctions, and the Hungarian ruling party Fidesz, which repeatedly promised to block any EU-level sanctions against Poland in the Council. The article analyses these agents’ behaviour as an instance of transnational complicity and passes a tentative judgment as to which of the two cases is normatively more problematic. The analysis has implications for possible countervailing responses to democratic backsliding within EU member states.
Current work on populism stresses its relationship to nationalism. However, populists increasingly make claims to represent ‘the people’ across beyond national borders. This advent of ‘transnational populism’ has implications for work on cosmopolitan democracy and global justice. In this paper, we advance and substantiate three claims. First, we stress populism’s performative and claimmaking nature. Second, we argue that transnational populism is both theoretically possible and empirically evident in the contemporary global political landscape. Finally, we link these points to debates on democracy beyond the state. We argue that, due to the a) performative nature of populism, b) complex interdependencies of peoples, and c) need for populists to gain and maintain support, individuals in one state will potentially have their preferences, interests, and wants altered by transnational populists’ representative claims. We unpack what is normatively problematic in terms of democratic legitimacy about this and discuss institutional and non-institutional remedies.
This article argues that populism, cosmopolitanism, and calls for global justice should be understood not as theoretical positions but as appeals to different segments of democratic electorates with the aim of assembling winning political coalitions. This view is called democratic realism: it considers political competition in democracies from a perspective that is realist in the sense that it focuses not first on the content of competing political claims but on the relationships among different components of the coalitions they work to mobilise in the pursuit of power. It is argued that Laclau’s populist theory offers a sort of realist critique of other populists, but that his view neglects the crucial dynamics of political coalition-building. When the relation of populism to global justice is rethought from this democratic realist angle, one can better understand the sorts of challenges each faces, and also where and how they come into conflict.
A link between populism and social media is often suspected. This paper spells out a set of possible mechanisms underpinning this link: that social media changes the communication structure of the public sphere, making it harder for citizens to obtain evidence that refutes populist assumptions. By developing a model of the public sphere, four core functions of the public sphere are identified: exposing citizens to diverse information, promoting equality of deliberative opportunity, creating deliberative transparency, and producing common knowledge. A wellworking public sphere allows citizens to learn that there are genuine disagreements among citizens that are held in good faith. Social media makes it harder to gain this insight, opening the door for populist ideology.
This paper critically engages the legal and political framework for responding to democracy and rule of law backsliding in the EU. I develop a new and original critique of Article 7 TEU based on it being democratically illegitimate and normatively incoherent qua itself in conflict with EU fundamental values. Other more incremental and scaleable responses are desirable, and the paper moves on to assess the legitimacy of economic sanctions such as tying access to EU funds to performance on democratic and rule of law indicators or imposing fines on backsliding states. I hold such sanctions to be a priori legitimate, and argue that in some cases economic sanctions are even normatively required, given that EU material support of backsliding member states can amount to material complicity in their backsliding. However, an economic conditionality mechanism would need to be designed to minimize unjust and counterproductive effects. One way to pursue this could be to complement sanctions against the backsliding government with investment for prodemocratic actors in that state.
This article sheds light upon the role of the audience in the construction and amendment of populist representative claims that in themselves strengthen representative-represented relationships and simultaneously strengthen ties between the represented who belong to different constituencies. I argue that changes in populist representative claims can be explained by studying the discursive relationship between a populist representative and the audience as a conversation in which both poles give and receive something. From this perspective, populist representative claims, I also argue, can be understood as acts of bonding with the intended effect of constituting ‘the people,’ and inputs from the audience can be seen as conversational exercitives. Populist appeals therefore may change when the audience enacts new permissibility facts and signals to populist representatives that there is another way to strengthen relationships between several individuals belonging to otherwise-different constituencies.
Simple Summary: Pseudoprogression detection in glioblastoma patients remains a challenging task. Although pseudoprogression has only a moderate prevalence of 10–30% following first-line treatment of glioblastoma patients, it bears critical implications for affected patients. Non-invasive techniques, such as amino acid PET imaging using the tracer O-(2-[18F]-fluoroethyl)-L-tyrosine (FET), expose features that have been shown to provide useful information to distinguish tumor progression from pseudoprogression. The usefulness of FET-PET in IDH-wildtype glioblastoma exclusively, however, has not been investigated so far. Recently, machine learning (ML) algorithms have been shown to offer great potential particularly when multiparametric data is available. In this preliminary study, a Linear Discriminant Analysis-based ML algorithm was deployed in a cohort of newly diagnosed IDH-wildtype glioblastoma patients (n = 44) and demonstrated a significantly better diagnostic performance than conventional ROC analysis. This preliminary study is the first to assess the performance of ML in FET-PET for diagnosing pseudoprogression exclusively in IDH-wildtype glioblastoma and demonstrates its potential.
Abstract: Pseudoprogression (PSP) detection in glioblastoma remains challenging and has important clinical implications. We investigated the potential of machine learning (ML) in improving the performance of PET using O-(2-[18F]-fluoroethyl)-L-tyrosine (FET) for differentiation of tumor progression from PSP in IDH-wildtype glioblastoma. We retrospectively evaluated the PET data of patients with newly diagnosed IDH-wildtype glioblastoma following chemoradiation. Contrast-enhanced MRI suspected PSP/TP and all patients underwent subsequently an additional dynamic FET-PET scan. The modified Response Assessment in Neuro-Oncology (RANO) criteria served to diagnose PSP. We trained a Linear Discriminant Analysis (LDA)-based classifier using FET-PET derived features on a hold-out validation set. The results of the ML model were compared with a conventional FET-PET analysis using the receiver-operating-characteristic (ROC) curve. Of the 44 patients included in this preliminary study, 14 patients were diagnosed with PSP. The mean (TBRmean) and maximum tumor-to-brain ratios (TBRmax) were significantly higher in the TP group as compared to the PSP group (p = 0.014 and p = 0.033, respectively). The area under the ROC curve (AUC) for TBRmax and TBRmean was 0.68 and 0.74, respectively. Using the LDA-based algorithm, the AUC (0.93) was significantly higher than the AUC for TBRmax. This preliminary study shows that in IDH-wildtype glioblastoma, ML-based PSP detection leads to better diagnostic performance.
This contribution develops a defence of a universalist conception of Global Citizenship Education (GCE) against three prominent critiques, which are, among others, put forward by postcolonial scholars. The first critique argues that GCE is essentially a project of globally minded elites and therefore expressive both of global educational injustices and of the values and lifestyles of a particular class or milieu. The second critique assumes that GCE is based on genuinely ‘Western values’ (e.g., in the form of a conception of human rights or conceptions of rationality or the self), which are neither universally accepted nor universally valid and therefore unjustly forced on members of non-Western cultures and societies. GCE, according to this critique, is assumed to be another version of the educational justification of a hegemonic and unjust global Western regime. The third critique focuses on the epistemological preconditions of GCE. It assumes that GCE relies on a particular, culturally embedded ‘Western epistemology,’ which perpetuates historically grown global educational and epistemic injustices by dominating and subjugating alternative epistemological approaches. With respect to the first critique I argue that it is to a certain extent sociologically plausible, but wrong when it is applied to the educational and political legitimacy of GCE. The second critique overestimates the consensus within the ‘Western tradition’ and underestimates the transnational dissemination of universalist ideals and values as well as its own reliance on universalist validity claims. I argue that in order to provide a plausible criticism of historically grown global educational and political injustices, it is imperative for GCE to integrate central insights provided by the postcolonial critique, without giving up on universalist ideals and values. The third critique is, according to my argumentation, based on flawed epistemological assumptions, which do not withstand critical scrutiny. Instead of identifying epistemic and scientific claims as the expressions of a particular ‘culture’ or geographical location (the ‘West’), I defend the position that philosophical and scientific research should ideally be conceived as a democratic and universalist project, whose emancipatory potential can only be realized on the basis of a universalist epistemology.
This paper explores how University as social entity has great potential to confront epistemic injustices by expanding epistemic capabilities. To do this, we primarily follow the contributions of scholars such as Miranda Fricker and José Medina. The epistemic capabilities and epistemic injustice nexus will be explored via two empirical cases: the first one is an experience developed in Lagos (Nigeria) using participatory video; the second is a service learning pedagogical strategy for final year undergraduate students conducted at Universidad de Ibagué (in Colombia). The Lagos experience shows how participatory action-research methodologies could promote epistemic capabilities and functioning, making it possible for the participants to generate interpretive materials to speak of their own realities. However, this experience is too limited to address testimonial and hermeneutical injustice. The Colombian experience is a remarkable experience that is building epistemic capabilities among students and other local participants. However, there is a hermeneutical and structural injustice that tends to give more value to disciplinary and codified knowledge at the expense of experiential and tacit knowledge.
Finding a bottle of milk in the bathroom would probably be quite surprising to most of us. Such a surprised reaction is driven by our strong expectations, learned through experience, that a bottle of milk belongs in the kitchen. Our environment is not randomly organized but governed by regularities that allow us to predict what objects can be found in which types of scene. These scene semantics are thought to play an important role in the recognition of objects. But when during development are the semantic predictions so far implemented that such scene-object inconsistencies would lead to semantic processing difficulties? Here we investigated how toddlers perceive their environments, and what expectations govern their attention and perception. To this aim, we used a purely visual paradigm in an ERP experiment and presented 24-month-olds with familiar scenes in which either a semantically consistent or an inconsistent object would appear. The scene-inconsistency effect has been previously studied in adults by means of the N400, a neural marker responding to semantic inconsistencies across many types of stimuli. Our results show that semantic object-scene inconsistencies indeed elicited an enhanced N400 over the left anterior brain region between 750 and 1150 ms post stimulus onset. This modulation of the N400 marker provides first indications that by the age of two toddlers have already established their scene semantics allowing them to detect a purely visual, semantic object-scene inconsistency. Our data suggest the presence of specific semantic knowledge regarding what objects occur in a certain scene category.
During the course of sepsis in critically ill patients, kidney dysfunction and damage are among the first events of a complex scenario toward multi-organ failure and patient death. Acute kidney injury triggers the release of lipocalin-2 (Lcn-2), which is involved in both renal injury and recovery. Taking into account that Lcn-2 binds and transports iron with high affinity, we aimed at clarifying if Lcn-2 fulfills different biological functions according to its iron-loading status and its cellular source during sepsis-induced kidney failure. We assessed Lcn-2 levels both in serum and in the supernatant of short-term cultured renal macrophages (MΦ) as well as renal tubular epithelial cells (TEC) isolated from either Sham-operated or cecal ligation and puncture (CLP)-treated septic mice. Total kidney iron content was analyzed by Perls’ staining, while Lcn-2-bound iron in the supernatants of short-term cultured cells was determined by atomic absorption spectroscopy. Lcn-2 protein in serum was rapidly up-regulated at 6 h after sepsis induction and subsequently increased up to 48 h. Lcn-2-levels in the supernatant of TEC peaked at 24 h and were low at 48 h with no change in its iron-loading. In contrast, in renal MΦ Lcn-2 was low at 24 h, but increased at 48 h, where it mainly appeared in its iron-bound form. Whereas TEC-secreted, iron-free Lcn-2 was associated with renal injury, increased MΦ-released iron-bound Lcn-2 was linked to renal recovery. Therefore, we hypothesized that both the cellular source of Lcn-2 as well as its iron-load crucially adds to its biological function during sepsis-induced renal injury.
Motivation: Calculating the magnitude of treatment effects or of differences between two groups is a common task in quantitative science. Standard effect size measures based on differences, such as the commonly used Cohen's, fail to capture the treatment-related effects on the data if the effects were not reflected by the central tendency. The present work aims at (i) developing a non-parametric alternative to Cohen’s d, which (ii) circumvents some of its numerical limitations and (iii) involves obvious changes in the data that do not affect the group means and are therefore not captured by Cohen’s d.
Results: We propose "Impact” as a novel non-parametric measure of effect size obtained as the sum of two separate components and includes (i) a difference-based effect size measure implemented as the change in the central tendency of the group-specific data normalized to pooled variability and (ii) a data distribution shape-based effect size measure implemented as the difference in probability density of the group-specific data. Results obtained on artificial and empirical data showed that “Impact”is superior to Cohen's d by its additional second component in detecting clearly visible effects not reflected in central tendencies. The proposed effect size measure is invariant to the scaling of the data, reflects changes in the central tendency in cases where differences in the shape of probability distributions between subgroups are negligible, but captures changes in probability distributions as effects and is numerically stable even if the variances of the data set or its subgroups disappear.
Conclusions: The proposed effect size measure shares the ability to observe such an effect with machine learning algorithms. Therefore, the proposed effect size measure is particularly well suited for data science and artificial intelligence-based knowledge discovery from big and heterogeneous data.
In the context of data science, data projection and clustering are common procedures. The chosen analysis method is crucial to avoid faulty pattern recognition. It is therefore necessary to know the properties and especially the limitations of projection and clustering algorithms. This report describes a collection of datasets that are grouped together in the Fundamental Clustering and Projection Suite (FCPS). The FCPS contains 10 datasets with the names "Atom", "Chainlink", "EngyTime", "Golfball", "Hepta", "Lsun", "Target", "Tetra", "TwoDiamonds", and "WingNut". Common clustering methods occasionally identified non-existent clusters or assigned data points to the wrong clusters in the FCPS suite. Likewise, common data projection methods could only partially reproduce the data structure correctly on a two-dimensional plane. In conclusion, the FCPS dataset collection addresses general challenges for clustering and projection algorithms such as lack of linear separability, different or small inner class spacing, classes defined by data density rather than data spacing, no cluster structure at all, outliers, or classes that are in contact. This report describes a collection of datasets that are grouped together in the Fundamental Clustering and Projection Suite (FCPS). It is designed to address specific problems of structure discovery in high-dimensional spaces.
Hintergrund: Die Erstversorgung von Wunden und kleinere chirurgische Eingriffe gehören neben der hochspezialisierten Medizin zu den allgemein notwendigen Grundleistungen der Notfallversorgung in den Kliniken. Die Vergütung der ambulanten Notfallleistungen für gesetzlich Versicherte erfolgt derzeit nach dem Einheitlichen Bewertungsmaßstab (EBM), welchem die betriebswirtschaftliche Aufwandserfassung des niedergelassenen Sektors als Kalkulationsgrundlage dient. Krankenhäuser haben im Vergleich zu Arztpraxen wesentlich höhere Vorhaltungskosten.
Ziel der Arbeit: In dieser Arbeit wird das entstehende Kosten-Erlös-Verhältnis der ambulanten Wundversorgung in einer Notaufnahme durch die Vergütung nach EBM analysiert.
Material und Methoden: Die Daten wurden in der Notaufnahme des Universitätsklinikums Frankfurt am Main über 12 Monate erhoben. Eingeschlossen wurden alle Patienten, die in diesem Zeitraum eine Wundversorgung mittels Naht erhielten. Die Kosten wurden der Abrechnung nach EBM 01210 (bzw. 01212) mit der Zusatzpauschale für kleinchirurgische Eingriffe EBM 02301 gegenübergestellt.
Ergebnisse: Im Beobachtungszeitraum wurden 1548 Patienten versorgt; das entspricht 19,52 % aller unfallchirurgischen Fälle. Den Kosten einer Standardwundversorgung in Höhe von 45,40 € steht eine Vergütung von 31,83 € gegenüber. Die Berechnung des Gesamterlöses weist einen Defizitbetrag von 13,57 € pro ambulantem Fall auf; dies entspricht einem Jahresdefizit von 21.006,36 €.
Diskussion: Es konnte gezeigt werden, dass ohne Betrachtung der relevanten Vorhaltekosten in keinem Fall eine Kostendeckung erreicht werden kann.
Die bisherige Vergütung der ambulanten Wundversorgung nach EBM erscheint unzureichend. Eine Anpassung bzw. Zusatzvergütung scheint notwendig, um eine ausreichende Versorgungsqualität in Zukunft sicherstellen zu können.
Tankstellen im Alltag sind grundsätzlich unauffällig. Überlandstraßen und Autobahnen saumend, eingefaltet in urbane Raume oder als Element suburbaner, industrieller Zonen nimmt man sie kaum wahr. Werden sie jedoch gebraucht, sei es zum Tanken, sei es zum Einkaufen abseits der üblichen Öffnungszeiten, rücken sie aus ihrer Latenz von einem Augenblick auf den anderen in den Vordergrund der Wahrnehmung und können für Reisende zu einer Obsession werden – rettende Oasen in der Wüste...
Objective: Value frameworks in oncology have not been validated for the assessment of treatments in haematological malignancies, but to avoid overlaps and duplications it appears reasonable to build up experience on existing value frameworks, such as the European Society for Medical Oncology—Magnitude of Clinical Benefit Scale (ESMO-MCBS).
Methods: Here we present the results of the first feasibility testing of the ESMO-MCBS v1.1 for haematological malignancies based on the grading of 80 contemporary studies for acute leukaemia, chronic leukaemia, lymphoma, myeloma and myelodysplastic syndromes. The aims were (1) to evaluate the scorability of data, (2) to evaluate the reasonableness of the generated grades for clinical benefit using the current version and (3) to identify shortcomings in the ESMO-MCBS v1.1 that require amendments to improve the efficacy and validity of the scale in grading new treatments in the management of haematological malignancies.
Results: In general, the ESMO-MCBS v1.1 was found to be widely applicable to studies in haematological malignancies, generating scores that were judged as reasonable by European Hematology Association (EHA) experts. A small number of studies could either not be graded or were not appropriately graded. The reasons, related to the differences between haematological and solid tumour malignancies, are identified and described.
Conclusions: Based on the findings of this study, ESMO and EHA are committed to develop a version of the ESMO-MCBS that is validated for haematological malignancies. This development process will incorporate all of the usual stringencies for accountability of reasonableness that have characterised the development of the ESMO-MCBS including field testing, statistical modelling, evaluation for reasonableness and openness to appeal and revision. Applying such a scale will support future public policy decision-making regarding the value of new treatments for haematological malignancies and will provide insights that could be helpful in the design of future clinical trials.
MicroRNA miR-181 - a rheostat for TCR signaling in thymic selection and peripheral T-Cell function
(2020)
The selection of T cells during intra-thymic d evelopment is crucial to obtain a functional and simultaneously not self-reactive peripheral T cell repertoire. However, selection is a complex process dependent on T cell receptor (TCR) thresholds that remain incompletely understood. In peripheral T cells, activation, clonal expansion, and contraction of the active T cell pool, as well as other processes depend on TCR signal strength. Members of the microRNA (miRNA) miR-181 family have been shown to be dynamically regulated during T cell development as well as dependent on the activation stage of T cells. Indeed, it has been shown that expression of miR-181a leads to the downregulation of multiple phosphatases, implicating miR-181a as ‘‘rheostat’’ of TCR signaling. Consistently, genetic models have revealed an essential role of miR-181a/b-1 for the generation of unconventional T cells as well as a function in tuning TCR sensitivity in peripheral T cells during aging. Here, we review these broad roles of miR-181 family members in T cell function via modulating TCR signal strength.
Background: Culture-derived mesenchymal stromal cells (MSCs) exhibit variable characteristics when manufactured using different methods and different source materials. The purpose of this study was to assess the impact on MSC characteristics when different laboratories propagated MSCs from cultures initiated with BM aliquots derived from the same donor source material.
Methods and Methods: Five aliquots from each of three different BM donors were distributed to five independent laboratories. Three laboratories plated whole BM and two laboratories a mononuclear BM cell fraction. Four laboratories cultured in media supplemented with fetal bovine serum (FBS) and one laboratory used human platelet lysate (hPL). Initial cell seeding densities (i.e., P0) ranged from 19.7 × 103/cm2–282 × 103/cm2 and for second seeding (i.e., P1) 0.05 × 103–5.1 × 103 cells/cm2. Post-thawed MSCs from each laboratory were analyzed for cell viability, immunophenotype, tri-lineage differentiation, fibroblast colony-forming units (CFU-F), gene expression, and immunosuppressive activity.
Results: Transit times from BM collection to receipt by laboratories located in the United States ranged from 16.0–30.0 h and from 41.5–71.5 h for a laboratory in Asia. Post-thaw culture derived MSCs rom BM #1, #2, and #3 exhibited viabilities that ranged from 74–92%, 61–96%, and 23–90%, respectively. CFU activity from BM #1, #2, and #3 per 200 MSCs plated averaged 45.1 ± 21.4, 49.3 ± 26.8 and 14.9 ± 13.3, respectively. No substantial differences were observed in immunophenotype, and immunosuppressive activities. Global gene expression profiles of MSCs revealed transcriptome differences due to different inter-laboratory methods and to donor source material with the center effects showing greater molecular differences than source material.
Conclusion: Functional and molecular differences exist among MSCs produced by different centers even when the same BM starting material is used to initiate cultures. These results indicated that manufacturing of MSCs by five independent centers contributed more to MSC variability than did the source material of the BM used in this study. Thus, emphasizing the importance of establishing worldwide standards to propagate MSCs for clinical use.
MicroRNAs (miRNAs) have emerged as critical posttranscriptional regulators of the immune system, including function and development of regulatory T (Treg) cells. Although this critical role has been firmly demonstrated through genetic models, key mechanisms of miRNA function in vivo remain elusive. Here, we review the role of miRNAs in Treg cell development and function. In particular, we focus on the question what the study of miRNAs in this context reveals about miRNA biology in general, including context-dependent function and the role of individual targets vs. complex co-targeting networks. In addition, we highlight potential technical pitfalls and state-of-the-art approaches to improve the mechanistic understanding of miRNA biology in a physiological context.
Editorial [2020, deutsch]
(2020)
Editorial [2020, english]
(2020)
Physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) models can serve as a powerful framework for predicting the influence as well as the interaction of formulation, genetic polymorphism and co-medication on the pharmacokinetics and pharmacodynamics of drug substances. In this study, flurbiprofen, a potent non-steroid anti-inflammatory drug, was chosen as a model drug. Flurbiprofen has absolute bioavailability of ~95% and linear pharmacokinetics in the dose range of 50–300 mg. Its absorption is considered variable and complex, often associated with double peak phenomena, and its pharmacokinetics are characterized by high inter-subject variability, mainly due to its metabolism by the polymorphic CYP2C9 (fmCYP2C9 ≥ 0.71). In this study, by leveraging in vitro, in silico and in vivo data, an integrated PBPK/PD model with mechanistic absorption was developed and evaluated against clinical data from PK, PD, drug-drug and gene-drug interaction studies. The PBPK model successfully predicted (within 2-fold) 36 out of 38 observed concentration-time profiles of flurbiprofen as well as the CYP2C9 genetic effects after administration of different intravenous and oral dosage forms over a dose range of 40–300 mg in both Caucasian and Chinese healthy volunteers. All model predictions for Cmax, AUCinf and CL/F were within two-fold of their respective mean or geometric mean values, while 90% of the predictions of Cmax, 81% of the predictions of AUCinf and 74% of the predictions of Cl/F were within 1.25 fold. In addition, the drug-drug and drug-gene interactions were predicted within 1.5-fold of the observed interaction ratios (AUC, Cmax ratios). The validated PBPK model was further expanded by linking it to an inhibitory Emax model describing the analgesic efficacy of flurbiprofen and applying it to explore the effect of formulation and genetic polymorphisms on the onset and duration of pain relief. This comprehensive PBPK/PD analysis, along with a detailed translational biopharmaceutic framework including appropriately designed biorelevant in vitro experiments and in vitro-in vivo extrapolation, provided mechanistic insight on the impact of formulation and genetic variations, two major determinants of the population variability, on the PK/PD of flurbiprofen. Clinically relevant specifications and potential dose adjustments were also proposed. Overall, the present work highlights the value of a translational PBPK/PD approach, tailored to target populations and genotypes, as an approach towards achieving personalized medicine.
Though the range of invariance in recognition of novel objects is a basic aspect of human vision, its characterization has remained surprisingly elusive. Here we report tolerance to scale and position changes in one-shot learning by measuring recognition accuracy of Korean letters presented in a flash to non-Korean subjects who had no previous experience with Korean letters. We found that humans have significant scale-invariance after only a single exposure to a novel object. The range of translation-invariance is limited, depending on the size and position of presented objects. To understand the underlying brain computation associated with the invariance properties, we compared experimental data with computational modeling results. Our results suggest that to explain invariant recognition of objects by humans, neural network models should explicitly incorporate built-in scale-invariance, by encoding different scale channels as well as eccentricity-dependent representations captured by neurons’ receptive field sizes and sampling density that change with eccentricity. Our psychophysical experiments and related simulations strongly suggest that the human visual system uses a computational strategy that differs in some key aspects from current deep learning architectures, being more data efficient and relying more critically on eye-movements.
Persönliches Feedback bei Vorlesungen mit Hunderten Studierenden erscheint bisher utopisch – auch nach dem Digitalisierungsschub in Corona-Zeiten. Tools aus dem Forschungsgebiet der »Learning Analytics« könnten künftig den Studierenden Rückmeldung geben und zugleich den Betreuern Hinweise liefern, wo noch Hilfestellung nötig ist.
Eine lebenswerte, schöne Stadt mit viel Grün und kurzen Wegen – das wünschen sich eigentlich alle. Wie wir dorthin kommen können, daran forscht die Arbeitsgruppe des Mobilitätsforschers Martin Lanzendorf. Im Fokus steht dabei der Mensch: Wie verhält er sich im öffentlichen Raum, was sind seine Beweggründe, Ziele und Wünsche – und wie ließe sich sein Verhalten beeinflussen?
So far, personal feedback in the case of lectures with hundreds of students still seems utopic – even after the digitalization boom in times of the coronavirus. Tools from the research field of »learning analytics« could in future give students feedback and at the same time provide their supervisors with clues about where help is still needed.
Background: The angiosperm family Bromeliaceae comprises over 3.500 species characterized by exceptionally high morphological and ecological diversity, but a very low genetic variation. In many genera, plants are vegetatively very similar which makes determination of non flowering bromeliads difficult. This is particularly problematic with living collections where plants are often cultivated over decades without flowering. DNA barcoding is therefore a very promising approach to provide reliable and convenient assistance in species determination. However, the observed low genetic variation of canonical barcoding markers in bromeliads causes problems.
Result. In this study the low-copy nuclear gene Agt1 is identified as a novel DNA barcoding marker suitable for molecular identification of closely related bromeliad species. Combining a comparatively slowly evolving exon sequence with an adjacent, genetically highly variable intron, correctly matching MegaBLAST based species identification rate was found to be approximately double the highest rate yet reported for bromeliads using other barcode markers.
Conclusion. In the present work, we characterize Agt1 as a novel plant DNA barcoding marker to be used for barcoding of bromeliads, a plant group with low genetic variation. Moreover, we provide a comprehensive marker sequence dataset for further use in the bromeliad research community.