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Each lifecycle of the Hepatitis C virus (HCV) produces structural and non-structural (NS) proteins in equimolar. Structural proteins were either assembled or degraded by host proteolysis systems, while NS proteins remain inside the host cells and don’t accumulate. Therefore, they must be degraded. Here, NS3 and NS5A half-lives were quantified in the presence of autolysosome and proteasome different modulators. Inhibitors of both systems increased the half-life, while inducers decreased the half-life. Furthermore, polyubiquitination of NS3 and NS5A was observed. Additionally, their intracellular co-localization with autolysosome (LAMP2) and proteasome (PSMB5) was observed, and inhibitors of both systems increased the degree of co-localization. A better understanding of NS protein degradation might help to improve medical interventions during HCV infections in the future.
The main purpose of Points is to give an insight into SAFE's two principal fields of activity – conducting research in finance and providing policy advice – and to introduce you to the people behind these two pillars of the institute. For both pillars, it is essential to point out the problems and phenomena the researchers at SAFE deal with and to have a point and state it clearly.
As such, Points also serves to keep readers informed about new perspectives as they open up in the development of SAFE. Initially, the magazine will be published once a year free of charge and advertising and is intended as a complementary product to SAFE's digital newsletter, which is currently published six times a year.
SAFE Update
(2021)
The digital newsletter format SAFE Update started in June 2021, is published six times a year, and offers selected news from SAFE along four recurrent sections:
* Focus on a specific topic
* Research Highlight
* #SAFEtheDATE, a combined outlook and review of events, and
* Handpicked, a recommendation worth reading, listening or watching from one of SAFE's Department Directors.
SAFE Update is free of charge and advertising and is designed for researchers in economics, law, and political science, as well as for readers who are interested in the areas in which financial research is applied.
The efl publishes the insights in the form of a periodic newsletter which appears two times a year. Besides a number of printed copies, the efl insights is distributed digitally via E-mail for reasons of saving natural resources. The main purpose of the newsletter is to provide latest efl research results to our audience. Therefore, the main part is the description of two research results on a managerial level – complemented by an editorial, an interview, and some short news.
SAFE Newsletter
(2013)
The Center of Excellence SAFE – “Sustainable Architecture for Finance in Europe” – is a cooperation of the Center for Financial Studies and Goethe University Frankfurt. It is funded by the LOEWE initiative of the State of Hessen (Landes-Offensive zur Entwicklung wissenschaftlich-ökonomischer Exzellenz). SAFE brings together more than 40 professors and just as many junior researchers who are all dedicated to conducting research in support of a sustainable financial architecture. The Center has two main pillars: excellent research on all important topics related to finance; and policy advice, including the dissemination of relevant research findings to European decision makers from the realms of politics, regulation and administration.
In order to promote a fruitful exchange with interested parties from politics, academia, business and the media, SAFE issues a newsletter on a quarterly basis. This aims to provide an overview of the Center‘s ongoing research and policy activities. The SAFE Newsletter succeeds the House of Finance Newsletter, which was published between 2009 and 2012.
SAFE is based at Goethe University’s House of Finance however extends beyond by drawing on scholars from other parts of Goethe University as well as from fellow research institutions. The Center builds on the reputation of the House of Finance institutions, serving as an interdisciplinary think tank on the issue of finance.
Ehemals NABE news. http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hebis:30-1149654
FIAS Scientific Report
(2011)
Das House of Finance hat im Sommer 2008 sein Gebäude bezogen. Unter seinem Dach führt das House of Finance drei Abteilungen aus den Fachbereichen Rechtswissenschaft und Wirtschaftswissenschaften der Goethe-Universität sowie sechs rechtlich selbstständige Institute – darunter auch das E-Finance Lab - zusammen. Neben den traditionellen Aufgaben in der Forschung und Lehre verfolgt das House of Finance das Vorhaben, die Ergebnisse der Forschung für die Praxis und auch für den Finanzplatz Deutschland nutzbar zu machen. Als ein Element dieses Wissenstransfers veröffentlicht das House of Finance die „Newsletter“. Der „Newsletter“ gibt Auskunft über - drei aktuelle Forschungsergebnisse, - die Entwicklungen in der Executive Education, - die neuesten Veröffentlichungen der im House of Finance ansässigen Wissenschaftler, - den Veranstaltungskalender. Der Newsletter umfasst jeweils 16 Seiten und erscheint vierteljährlich in englischer Sprache.
Insecta Mundi
(2007)
Insecta Mundi is a journal primarily devoted to insect systematics, but articles can be published on any non-marine arthropod. Manuscripts considered for publication include, but are not limited to, descriptions of new taxa, revisions, taxonomic or nomenclatural notes, bibliographies, checklists, catalogs, reviews, and life histories. For papers describing new taxa, Insecta Mundi provides authors rapid publication so the names may be included in other publications. As of 2007, Insecta Mundi (paper ISSN 0749-6737, cd-rom ISSN 1942-1362, on-line ISSN 1942-1354) is published irregularly throughout the year. As manuscripts are completed and published, they are individually, sequentially numbered from now into the future. There is no longer year-based volume or issue numbers. Further details about our policies and procedures can be found in 2007 Insecta Mundi 0001. http://centerforsystematicentomology.org/insectamundi/0001ProceduresComplete.pdf