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Batten disease refers to neuronal ceroid lipofuscinoses (NCLs), which are inherited lysosomal storage diseases with diverse ages of onset and cause progressive neurodegeneration. The most common NCL is Juvenile NCL (JNCL), which begins in early childhood and is characterized by lysosomal accumulation of subunit c of the mitochondrial ATP synthase (subunit c). JNCL is caused by mutations in the gene CLN3. This gene encodes the CLN3 protein, a transmembrane protein of unknown structure. Localization of CLN3 is ambiguous, and its exact cellular function is not known. Thereby, it is unclear what mechanisms lead to neurodegeneration in JNCL. Models of JNCL present disturbed membrane bound organelles and cytoskeleton as well as impaired autophagy and lysosomal function. The JNCL gene defect that most patients harbor is deletion of the exons 7 and 8 of CLN3. In the Cln3Δex7/8/Δex7/8 mouse model of JNCL, this deletion has been introduced to the mouse Cln3 gene.
The actin cytoskeleton consists of filaments formed through polymerization of actin and provides a framework which defines cellular morphology and also facilitates cell motility, cytokinesis, and cell surface remodeling. Rho GTPases are signaling proteins which regulate the assembly and dynamics of the actin cytoskeleton and play an important role in neuronal morphology. Rho GTPases need to be membrane-anchored in order to become active and initiate a signaling cascade. Their membrane anchorage is achieved through their geranylgeranyl tails, which they acquire through prenylation. Protein prenylation refers to the attachment of a geranylgeranyl or farnesyl group to the C-terminus of a protein. The enzyme geranylgeranyl transferase (GGTase) catalyzes geranylgeranylation, whereas geranylgeranyl pyrophosphate (GGPP) is the donor of the geranylgeranyl group. Cells produce GGPP as well as cholesterol and other lipids through the mevalonate pathway (MVA pathway).
The aim of this study was to analyze how the JNCL gene defect affects cellular morphology, especially the actin cytoskeleton and Rho GTPases, and the MVA pathway which is connected with Rho GTPase activation. These important cellular components play crucial roles in neurons and are implicated in other neurodegenerative diseases, but have received little attention in JNCL. The immortalized CbCln3Δex7/8/Δex7/8 cerebellar precursor cell line from Cln3Δex7/8/Δex7/8 mice was used for the experiments and provides a genetically accurate, neuronal cell model of JNCL. CbCln3Δex7/8/Δex7/8 cells present subunit c accumulation only when aged at confluency, but sub-confluent cells display other phenotypes. The experiments of this study were performed both with confluency-aged and sub-confluent cells. Filamentous actin was visualized, and protein levels as well as membrane localization of several small Rho GTPases was analyzed biochemically. Also the protein levels of GGTase and the key enzymes of the mevalonate pathway were determined.
Staining pattern of filamentous actin was disturbed in confluency-aged CbCln3Δex7/8/Δex7/8 cells. Additionally it was found out that these cells did not grow to wild-type size and exhibited an elongated peroxisomal morphology. Rho GTPases had reduced total levels and showed a tendency of decreased membrane localization. Levels of GGTase and the MVA pathway enzymes were altered. Results of sub-confluent CbCln3Δex7/8/Δex7/8 cells were similar with the exception of HMG-CoA reductase, which is the rate-limiting enzyme of the MVA pathway: while its level in confluency-aged CbCln3Δex7/8/Δex7/8 cells was increased, at sub-confluency it showed a reduced level. Also, in contrast with the confluency-aged cells, Rho GTPases presented a tendency of increased membrane localization.
The results of this study reveal that the accurate JNCL gene defect alters cellular morphology and the activity of the MVA pathway in neuronal cells. Small cell size and disrupted architecture of the actin cytoskeleton are confirmed as neuronal JNCL phenotypes, and the peroxisome is introduced as a novel cellular component affected in JNCL. Through defects in endocytosis, autophagy, lysosomal and mitochondrial function, and cytoskeleton, the JNCL gene defect may prevent cells from growing to wild-type size. The JNCL gene defect may attenuate the MVA pathway via mitochondrial dysfunction and/or upregulation of degradative processes. Attenuation of the MVA pathway may contribute to impaired membrane rafts, which are an established phenotype of JNCL cells. As indicated by reduced GGTase level and supported by downregulation of lipid production through the MVA pathway, the JNCL gene defect might also decrease prenylation of proteins.
We use data from the 2009 Internet Survey of the Health and Retirement Study to examine the consumption impact of wealth shocks and unemployment during the Great Recession in the US. We find that many households experienced large capital losses in housing and in their financial portfolios, and that a non-trivial fraction of respondents have lost their job. As a consequence of these shocks, many households reduced substantially their expenditures. We estimate that the marginal propensities to consume with respect to housing and financial wealth are 1 and 3.3 percentage points, respectively. In addition, those who became unemployed reduced spending by 10 percent. We also distinguish the effect of perceived transitory and permanent wealth shocks, splitting the sample between households who think that the stock market is likely to recover in a year’s time, and those who do not. In line with the predictions of standard models of intertemporal choice, we find that the latter group adjusted much more than the former its spending in response to financial wealth shocks.
Using data from the US Health and Retirement Study, we study the causal effect of increased health insurance coverage through Medicare and the associated reduction in health-related background risk on financial risk-taking. Given the onset of Medicare at age 65, we identify our effect of interest using a regression discontinuity approach. We find that getting Medicare coverage induces stockholding for those with at least some college education, but not for their less-educated counterparts. Hence, our results indicate that a reduction in background risk induces financial risk-taking in individuals for whom informational and pecuniary stock market participation costs are relatively low.
In this thesis hard probes are studied in the partonic transport model BAMPS (Boltzmann Approach to MultiParton Scatterings). Employing Monte Carlo techniques, this model describes the 3+1 dimensional evolution of the quark gluon plasma phase in ultra-relativistic heavy-ion collisions by propagating all particles in space and time and carrying out their collisions according to the Boltzmann equation. Since hard probes are produced in hard processes with a large momentum transfer, the value of the running coupling is small and their interactions should be describable within perturbative QCD (pQCD). This work focuses on open heavy flavor, but also addresses the suppression of light parton jets, in particular to highlight differences due to the mass. For light partons, radiative processes are the dominant contribution to their energy loss. For heavy quarks, we show that also binary interactions with a running coupling and an improved Debye screening matched to hard-thermal-loop calculations play an important role. Furthermore, the impact of the mass in radiative interactions, prominently named the dead cone effect, and the interplay with the Landau-Pomeranchuk-Migdal (LPM) effect are studied in great detail. Since the transport model BAMPS has access to all medium properties and the space time information of heavy quarks, it is the ideal tool to study the dissociation and regeneration of J/psi mesons, which is also investigated in this thesis.
Panama is a megadiverse country that together with Costa Rica constitutes Lower Central America (LCA). Western Panama's Cordillera Central accounts for the eastern part of the LCA highlands shared between these countries. The aim of the present study is to compile the most complete and updated picture possible of the taxonomy, diversity, and distribution of reptiles that occur from 500 m asl upwards along the Talamanca and Tabasará ranges. These two continuous mountain ridges account for the western two-thirds of the Cordillera Central between the Costa Rican border and 81°W Including specimens collected four own research travels, I morphologically examined more than 1800 specimens, analyzed 16S and/or COI barcodes of 300 specimens, and performed a thorough search in literature and databases to obtain locality records for specimens and species occurrences. My complete occurrence dataset comprises 14620 georeferenced occurrence records in three quality categories. Conceivable occurrences of species not yet documented from a given area are evaluated on the basis of existing data either as "plausible" or "possible". I provide all datasets which I generated for this study in Appendices. The previously published descriptions of Dactyloa ginaelisae Lotzkat, Hertz, Bienentreu & Köhler 2013, Norops benedikti (Lotzkat, Bienentreu, Hertz & Köhler 2011), Sibon perissostichon Köhler, Lotzkat & Hertz 2010, and Sibon noalamina Lotzkat, Hertz & Köhler 2012 are included in the present work. In the course of integrative taxonomic analyses, I classify 15 genealogical lineages revealed by DNA barcoding within 7 anole species as Deep Conspecific Lineages (DCLs) because they lack consistent morphological differences to their nominal conspecifics. I provisionally classify 18 mitochondrial lineages found within six other anole species as Unconfirmed Genealogical Lineages (UGLs) pending adequate analyses of their morphological variation. I regard the two additional UGLs Celestus sp. and Geophis sp. and the two Confirmed Genealogical Lineages (CGLs) Lepidoblepharis sp. 1 and 2 to represent undescribed species. My taxonomic analyses yield the hitherto most comprehensive survey of the variability exhibited by dozens of reptile species in western Panama. The 16S and/or COI barcodes I provide represent 65 species recognized herein and constitute the first DNA barcode reference library for LCA reptiles. The reptile fauna of Panama comprises 265 species, including the four UGLs and CGLs mentioned above and characterized for the first time in this study, as well as Dendrophidion crybelum Cadle 2012 whose presence in the country I consider plausible. My occurrence dataset reveals that 160 of these species have been documented to occur in my study area. Adding the 20 species whose occurrence therein I consider plausible, I report the total species richness of the Talamanca and Tabasará ranges as comprising 180 species representing 81 genera in 25 families. With 178.8 species per 10 000 km2, the relative species richness of the area is extremely high even in a tropical context. In view of their overall documented distribution, I regard the presence of 27 additional species in my study area as possible. For the 180 species occurring in my study area I provide standardized species accounts that, together with the taxonomic results, for the first time permit the doubtless identification of all 180 species, and illustrate 168 of these with color photographs. Concerning biogeography, my georeferenced dataset yields noteworthy distribution extensions for many species. Moreover, I present the hitherto most comprehensive, detailed, and reproducible assessments of the distribution patterns, historical origins, and conservation as well as of the occurrence among physiographic regions, climatic and altitudinal belts, political subdivisions, and protected areas, for my study area's reptile fauna. With 65 species, more than a third of the fauna is endemic to LCA. Among these, 42 Talamancan highland endemics are restricted to the LCA highlands, in the case of 16 small-scale highland endemics with documented ranges spanning less than 100 km. I assess many of these endemics as endangered. The fact that several of these species do not occur in any protected area renders the establishment of additional conservation areas necessary, especially in the central Serranía de Tabasará. Distributional range boundaries shared among different clades of highland anoles indicate physiographic and climatic barriers that may have effected in situ speciation within these lineages. As the largest study on Panamanian reptile diversity assembled to date, the present dissertation considerably increases our knowledge on the reptiles along the Cordillera Central and beyond, and thus constitutes a solid basis for future studies.
It has long been observed that subjects cross-linguistically have topic properties: they are typically definite, referential and/or generic (Givón 1976). Bantu languages are said to illustrate this generalization: preverbal position for NPs is equated with both subject and topic status and postverbal position with focus (and non-subject). However, there is a growing body of work showing that preverbal subjects are not necessarily syntactically or semantically equivalent to topics. For example, Zerbian’s (2006) careful study of preverbal position in Northern Sotho shows that preverbal subjects meet few of the semantic tests for aboutness topics. The study of restrictions on preverbal subjects in Durban Zulu presented in this paper builds on Zerbian (2006) and Halpert (2012). In particular, we investigate the interpretational properties of preverbal indefinite subjects. These subjects show us that preverbal subjects carry a presupposition of existence. We explore an analysis connecting the "strong reading" of preverbal subjects with how high the verb moves in Zulu (following Tsai’s 2001 work on Mandarin).
Locative inversion in Cuwabo
(2014)
This paper proposes a detailed description of locative inversion (LI) constructions in Cuwabo, in terms of morphosyntactic properties and thematic restrictions. Of particular interest are the use of disjoint verb forms in LI, and the co-existence of formal and semantic LI, which challenges the widespread belief that the two constructions cannot be found in the same language.
Introduction
(2014)
Bantu languages have been at the heart of the research on the interaction between syntax, prosody and information structure. In these predominantly SVO languages, considerable attention has been devoted to postverbal phenomena. By addressing issues related to Subjects, Topics and Object-Verb word orders, the goal of the present papers is to deepen our understanding of the interaction of different grammatical components (syntax, phonology, semantics/pragmatics) both in individual languages and across the Bantu family. Each paper makes a valuable contribution to ongoing discussions on the preverbal domain.
In this thesis, Planck size black holes are discussed. Specifically, new families of black holes are presented. Such black holes exhibit an improved short scale behaviour and can be used to implement gravity self-complete paradigm. Such geometries are also studied within the ADD large extra dimensional scenario. This allows black hole remnant masses to reach the TeV scale. It is shown that the evaporation endpoint for this class of black holes is a cold stable remnant. One family of black holes considered in this thesis features a regular de Sitter core that counters gravitational collapse with a quantum outward pressure. The other family of black holes turns out to nicely fit into the holographic information bound on black holes, and lead to black hole area quantization and applications in the gravitational entropic force. As a result, gravity can be derived as emergent phenomenon from thermodynamics.
The thesis contains an overview about recent quantum gravity black hole approaches and concludes with the derivation of nonlocal operators that modify the Einstein equations to ultraviolet complete field equations.
The Generalized Uncertainty Principle (GUP) arises from Quantum Gravity thought experiments and contains a minimal lenght. In this thesis I calculate Schwarzschild Black Holes that are modified by the GUP. These Black Holes have the property, that their temperature does not diverge for small masses, although they still posses a curvature singularity. I calculate analytically that in more than 3+1 dimensions the temperature diverges again.
In this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-quinazoline ribonucleosides or acyclonucleosides by means of 1,3-dipolar cycloaddition between various O or N-alkylated propargyl-quinazoline and 1'-azido-2',3',5'-tri-O-benzoylribose or activated alkylating agents under microwave conditions. None of the compounds selected showed significant anti-HCV activity in vitro.
The measurement of dielectrons (electron-positron pairs) allows to investigate the properties of strongly interacting matter, in particular the Quark-Gluon Plasma (QGP), which is created in relativistic heavy-ion collisions at the LHC. The evolution of the collision can be probed via dielectrons since electrons do not interact strongly and are created during all stages of the collision. One of the interests in dielectron measurements is motivated by possible modifications of the electromagnetic emission spectrum in the QGP, where pp collisions are used as a medium-free reference. The dielectron spectrum consists of contributions from various processes. In order to estimate contributions of known dielectron sources, simulations of the so-called dielectron cocktail are performed. In this thesis, dielectron cocktails in minimum bias pp collisions at p s = 7 TeV, p–Pb collisions at p sNN = 5.02 TeV and in central (0-10%) and semi-central (20-50%) Pb–Pb collisions at p sNN = 2.76 TeV at the LHC are presented.
A checklist and classification of the species of Elateridae reported from mainland Ecuador are given. Anchastus boulardi Chassain, Cardiorhinus apicalis Golbach, Physorhinus marginatus Candèze, and P. sexnotatus Steinheil are reported from Ecuador for the first time. The recorded elaterid fauna of Ecuador is now represented by 140 species, 38 genera, and 9 subfamilies, which are low taxon richness numbers when compared to those of neighboring countries.
The papers in this volume take up some aspects of the preverbal domain(s) in Bantu languages. They were originally presented at the Workshop BantuSynPhonIS: Preverbal Domain(s), held at the Center for General Linguistics (ZAS), in Berlin, on 14-15 November 2014. This workshop was coorganized by ZAS (Fatima Hamlaoui & Tonjes Veenstra) and the Humboldt University (Tom Güldemann, Yukiko Morimoto and Ines Fiedler).
Noumenal Power
(2014)
In political or social philosophy, we speak about power all the time. Yet the meaning of this important concept is rarely made explicit, especially in the context of normative discussions. But as with many other concepts, once one considers it more closely, fundamental problems arise, such as whether a power relation is necessarily a relation of subordination and domination. In the following, I suggest a novel understanding of what power is and what it means to exercise it.
To overcome poor treatment response of pediatric high-risk acute lymphoblastic leukemia (ALL), novel treatment strategies are required to reactivate programmed cell death in this malignancy. Therefore, we take advantage of using small-molecule antagonists of Inhibitor of apoptosis (IAP) proteins, so called Smac mimetics such as BV6, which are described to overcome apoptosis resistance and thereby sensitize tumor cells for several apoptotic stimuli. To address the question whether redox alterations can sensitize leukemic cells for Smac mimetic-mediated cell death, we interfered with the cellular redox status in different ALL cell lines. Here, we show for the first time that redox alterations, mediated by the glutathione depleting agent Buthioninesulfoximine (BSO), prime ALL cells for BV6-induced apoptosis. Besides ALL cell lines, BV6/BSO cotreatment similarly synergizes in cell death induction in patient-derived primary leukemic samples. In contrast, the combination treatment does not exert any cytotoxicity against peripheral blood lymphocytes (PBLs) or mesenchymal stroma cells (MSCs) from healthy donors, suggesting some tumor selectivity of this treatment. We also identify the underlying molecular mechanism of the novel synergistic drug interaction of BSO and BV6. We demonstrate that both agents act in concert to increase reactive oxygen species (ROS) production, lipid peroxidation and finally apoptotic cell death. Enhanced ROS levels in the combination treatment account for cell death induction, since several ROS scavengers, like NAC, MnTBAP and Trolox attenuate BSO/BV6-induced apoptosis. BSO/BV6-induced ROS can be mainly classified as lipid peroxides, since the vitamin E derivate α-Tocopherol as well as Glutathione peroxidase 4 (GPX4), which both specifically reduce lipid-membrane peroxides, prevent lipid peroxidation, caspase activation and cell death induction. Vice versa, GPX4 knockdown and pharmacological inhibition of GPX4 by RSL3 or Erastin enhance BV6-induced cell death. Importantly, cell death induction critically depends on the formation of a complex consisting of RIP1/FADD/Caspase-8, since all complex components are required for ROS production, lipid peroxidation and cell death induction. Taken together, we demonstrate that BSO and BV6 cooperate to induce ROS production and lipid peroxidation which are eventually required for caspase activation and cell death execution. Collectively, findings of this study indicate that BV6-induced apoptosis is mediated via redox alterations offering promising new treatment strategy to overcome apoptosis resistance in ALL.
Euro area data show a positive connection between sovereign and bank risk, which increases with banks’ and sovereign long run fragility. We build a macro model with banks subject to moral hazard and liquidity risk (sudden deposit withdrawals): banks invest in risky government bonds as a form of capital buffer against liquidity risk. The model can replicate the positive connection between sovereign and bank risk observed in the data. Central bank liquidity policy, through full allotment policy, is successful in stabilizing the spiraling feedback loops between bank and sovereign risk.
Trust in policy makers fluctuates signi
cantly over the cycle and affects the transmission mechanism. Despite this it is absent from the literature. We build a monetary model embedding trust cycles; the latter emerge as an equilibrium phenomenon of a game-theoretic interaction between atomistic agents and the monetary authority. Trust affects agents' stochastic discount factors, namely the price of future risk, and through this it interacts with the monetary transmission mechanism. Using data from the Eurobarometer surveys, we analyze the link between trust and the transmission mechanism of macro and monetary shocks: Empirical results are in line with theoretical ones.
Changes in vitamin D serum levels have been associated with inflammatory diseases, such as inflammatory bowel disease (IBD), rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis (MS), atherosclerosis, or asthma. Genome- and transcriptome-wide studies indicate that vitamin D signaling modulates many inflammatory responses on several levels. This includes (i) the regulation of the expression of genes which generate pro-inflammatory mediators, such as cyclooxygenases or 5-lipoxygenase, (ii) the interference with transcription factors, such as NF-κB, which regulate the expression of inflammatory genes and (iii) the activation of signaling cascades, such as MAP kinases which mediate inflammatory responses. Vitamin D targets various tissues and cell types, a number of which belong to the immune system, such as monocytes/macrophages, dendritic cells (DCs) as well as B- and T cells, leading to individual responses of each cell type. One hallmark of these specific vitamin D effects is the cell-type specific regulation of genes involved in the regulation of inflammatory processes and the interplay between vitamin D signaling and other signaling cascades involved in inflammation. An important task in the near future will be the elucidation of the regulatory mechanisms that are involved in the regulation of inflammatory responses by vitamin D on the molecular level by the use of techniques such as chromatin immunoprecipitation (ChIP), ChIP-seq, and FAIRE-seq.
Immune cells are key players in several physiological and pathophysiological events such as acute and chronic inflammation, atherosclerosis and cancer. Especially in acute inflammation, macrophages are indispensable for the switch from the acute inflammatory phase to the resolution phase. Not only the phagocytosis of apoptotic cells, but especially the surrounding cytokines and mediators are able to switch macrophage polarization from inflammatory- to anti-inflammatory phenotypes. Within this cytokine environment, sphingosine-1-phosphate (S1P) plays an important role for immune cell activation, polarization and migration.
Tumor development usually follows predictable paths where tumor cells acquire common characteristics and features known as the hallmarks of cancer. Recently, additional characteristics have been added to these hallmarks since solid tumors are composed of a very heterogeneous population of transformed, formerly normal tissue cells and stromal cells, e.g. immune cells and fibroblasts. Compelling evidence suggests that stromal cells and tumor cells maintain a symbiotic relationship to build up the tumor microenvironment and to fuel tumor growth. In cancer therapies, common features of tumors such as unrestricted cell growth, suppression of immunological responses, and the ability to form new blood vessels (angiogenesis) have emerged as the main targets of interest. The lipid mediator prostaglandin E2 (PGE2) is known to promote all these features and thus, is connected to cancer progression in general. Its synthesis is triggered in response to stress factors or during inflammation. Inducible PGE2 production relies on the enzymes cyclooxygenase 2 (COX-2) and microsomal prostanglandin E synthase 1 (mPGES-1), which are simultaneously expressed in response to a variety of different stimuli and are functionally coupled. Inhibition of COX-2 with non-steroidal antiinflammatory drugs (NSAIDs) for cancer treatment is, however, limited by cardiovascular risks, since selective COX-2 inhibition disrupts the prostacyclin/thromboxane balance. Therefore targeting mPGES-1 downstream of COX-2 for PGE2 inhibition was evaluated in this work in different steps of carcinogenesis. Knockdown of mPGES-1 in DU145 prostate cancer cells revealed that the mPGES-1 status did not affect growth of monolayer tumor cells, but significantly impaired 3D growth of multi-cellular tumor spheroids (MCTS). Spheroid formation induced COX-2 in DU145 and other prostate cancer spheroids. High levels of PGE2 were detected in supernatants of DU145 MCTS as opposed to monolayer DU145 cells. Pharmacological inhibition of COX-2 and mPGES-1 confirmed the pivotal role of PGE2 for DU145 MCTS growth. Besides promoting spheroid growth, MCTS-derived PGE2 also inhibited cytotoxic T lymphocyte (CTL) activation. When investigating the mechanisms of COX-2 induction during spheroid formation, the typical tumor microenvironmental factors such as glucose deprivation, hypoxia or tumor cell apoptosis failed to enhance COX-2. Interestingly, when interfering with apoptosis in DU145 spheroids, the pan-caspase inhibitor Z-VAD-FMK triggered a Summary 12 shift towards necrosis, thus enhancing COX-2 expression. Coculturing viable DU145 monolayer cells with isolated heat-shocked-treated necrotic DU145 cells, but not with necrotic cell supernatants, induced COX-2 and PGE2, confirming the impact of necrosis for MCTS growth and CTL inhibition. As mentioned, in vivo tumors are very heterogenous mixtures of tumor cells and stromal cells e.g. immune cells. Hence, the interaction of the immune system with tumors was investigated in further experiments. When coculturing MCF-7 breast cancer spheroids with human peripheral blood mononuclear cells (PBMCs), only low levels of PGE2 were detected, since MCF-7 cells did not upregulate COX-2 during spheroid formation and did not induce PGE2 production by PBMCs. Under inflammatory conditions, by adding the toll-like receptor 4 (TLR4) agonist lipopolysaccharide (LPS) to cocultures, PGE2 production was triggered, spheroid sizes were reduced, and numbers of high levels of granzyme B expressing (GrBhi) CTLs were increased, while CD80 expression by tumor-associated phagocytes was also elevated. Inhibition of CD80 but not CD86 diminished numbers of GrBhi CTLs and attenuated spheroid lysis. To determine the role of ctivation-induced PGE2 production, use of the COX-2 inhibitor celecoxib and the experimental mPGES-1 inhibitor C3 further increased CD80 expression. Addition of PGE2, the prostaglandin E2 (EP2) receptor agonist butaprost, and the phosphodiesterase 4 (PDE4) inhibitor rolipram reduced LPS/C3-triggered CD80 expression, confirming the impact of COX- 2/mPGES-1-derived PGE2 on shaping phagocyte phenotypes in an EP2/cAMP-dependent manner. In a spontaneous breast cancer model (MMTV-PyMT), mPGES-1-deficiency significantly delayed tumor growth in mice, confirming an overall protumorigenic role of mPGES-1 in breast cancer development in vivo. However in tumors of mPGES-1-/- mice, tumor-infiltrating phagocytes expressed low levels of CD80 similar to their wildtype counterparts. These data suggest that the immunosuppressive microenvironment does not allow for immunostimulatory effects by mPGES-1 inhibition without an activating stimulus. Evidences in this study recommend the application of mPGES-1 inhibitors for treating cancer diseases, since mPGES-1 promotes tumor growth in multiple steps of carcinogenesis, ranging from well-characterized effects of tumor cell growth to immune suppression of CTL activity and phagocyte polarization. Regarding the latter, blunting PGE2 during immune activation may limit the tumor-favoring features of inflammation and improve the efficiency of TLR4 based immune therapies.
In mitochondria, biogenesis of oxidase is a crucial process involving the participation of an array of assembly factors. Studying the process of biogenesis in eukaryotes is highly complicated due to the presence and partaking of two genetic systems. Employing a bacterial model such as Paracoccus denitrificans that utilizes only one genetic system enables easy studying of the assembly process. The aa3 cytochrome c oxidase of P. denitrificans shows high structural and functional homology to its mitochondrial counterpart despite its simple subunit composition. The assembly of the core subunits I and II that house the active redox centers (heme a, and heme a3.CuB centre in subunit I; and the binuclear CuA centre in subunit II) along with the chaperons responsibly for their incorporation form the crux of this work. This work concentrates particularly on CtaG, a chaperone previously speculated to be involved in the delivery of copper to the CuB center in subunit I. As the full length structure of CtaG or its structural homologues have not been solved, attempts were made to obtain high-diffracting crystals of CtaG by heterologously expressing it in E. coli. Growth media, expression strains and induction parameters were some of the conditions screened in order to obtain optimal yield. Additives, pH and detergent were screened to yield a homogeneous preparation of CtaG. Crystallization trials were conducted by employing the sitting drop, vapour diffusion, method and later the bicelles were employed. Preliminary crystals obtained were further optimized employing seeding, detergent and additives, to improve diffraction. The diffraction improved from 30 Å to 15 Å. BN PAGE (Blue Native Polyacrylamide Gel Electrophoresis) analysis and cross-linking studies were undertaken to decipher the oligomeric condition of CtaG. Both the methods indicate that the protein is a dimer under native conditions. To study the importance of CtaG in the process of oxidase assembly, two deletion mutants were obtained from the lab; one with only ctaG deleted and the other with ctaG and most of the upstream ORF. The effect of the deletion was assayed on the assembly and activity of oxidase. The deletion mutants showed residual activity of approx. 20 %, while displaying a very low heme signal (both in membranes and in purified COX). In order to exclude polar effects arising due to gene manipulation, complementation strains were prepared, reintroducing ctaG alone into both the deletion strains. Complementation strains, where only ctaG was deleted and re-introduced assayed for COX activity showed a restoration in activity to approx. 70 %. Further, calculating the heme:protein ratio, the deletion strains displayed a value of 7 nmol/mg of oxidase which was increased to wild type levels of 16 nmol/mg in the complementation strains. To further confirm the absence of the copper in subunit I, total reflection X-ray fluorescence spectroscopy analysis was carried out, which showed a decrease in the copper content in the deletion strain, restored on complementation. The strain lacking in the ORF and ctaG when complemented with ctaG alone illustrated no increase in activity or heme signal in comparison to that of the deletion strain. These point at a possible role for ORF in the assembly of COX, which is still absent in the complementation strains. To further characterize the ORF, a series of bioinformatical analysis was carried out, the results from which were insufficient to characterize the ORF conclusively. In order to enlist the proteins involved in the biosynthesis of COX, two independent approaches were employed. Two-dimensional gel examinations of solubilised membranes from untreated and cross-linked cells were analyzed by Western blotting. The CtaG-COX interaction was observed in untreated membranes, which was additionally strengthened by cross-linking. To further confirm this association, pull-down assays were done employing protein A coated magnetic beads coated with different antibodies and incubated with solubilised membranes derived from untreated or cross-linked cells. The elutions were assayed by Western blotting and confirmed for the CtaG-COX interaction. These fractions were further analysed by mass spectrometry to identify other chaperons involved in biogenesis of oxidase. Along with CtaG, I also noticed Sco, Surf1c and other factors involved in the recruitment and transport of heme (CtaB, CtaA, and Ccm proteins). Interestingly, protein components of both ribosomal subunits and protein translocation factors were observed, which indicated a co-translational approach for co-factor insertion into COX.
We outline a procedure for consistent estimation of marginal and joint default risk in the euro area financial system. We interpret the latter risk as the intrinsic financial system fragility and derive several systemic fragility indicators for euro area banks and sovereigns, based on CDS prices. Our analysis documents that although the fragility of the euro area banking system had started to deteriorate before Lehman Brothers' file for bankruptcy, investors did not expect the crisis to affect euro area sovereigns' solvency until September 2008. Since then, and especially after November 2009, joint sovereign default risk has outpaced the rise of systemic risk within the banking system.
Irene Heim in unpublished work proposed a new syntax-semantics interface for propositional attitude reports based on an ontology without transworld individuals, but counterpart functions instead. We show that the approach can capture the 'de re'/'de dicto' distinction, but makes different predictions from accounts with transworld individuals. Specifically, the account uses a non-invertible counterpart functions: a single individual in an alternative world can be the counterpart of many individuals of the real world. The directionality of counterpart functions predicts that a 'de dicto' interpreted DP cannot be an argument of a 'de re' interpreted predicate. We show that the predicted restriction is corroborated by existing work on restrictions on 'de re' interpretation. The derivation of constraints on 'de re' interpretation argues empirically for the counterpart ontology and Heim’s implementation thereof.
The late physicist Carl Sagan, whom I quote in the first part of my title, skillfully phrased the common sense view on evidence in the mature sciences. In linguistics, however, evidence has become a controversial issue, especially so when it comes to the investigation of less well studied languages. In this paper, I argue that Sagan's principle should be applied to linguistics. The growing accessibility of a wide array of experimental techniques and computational tools to analyze such data makes it feasible to back up extraordinary claims with evidence from a variety of sources. At the same time, it is in many cases possible to agree on what constitutes an ordinary claim and focus the extra effort on extraordinary claims. For non-controversial claims no more than the minimum effort to establish the claim and properly document the evidence is necessary.
Decomposing coordination
(2014)
Natural languages display a surprising diversity of expression of elementary logical operations. The study of this variation is emerging as an important topic of cross-linguistic semantics. In this paper, we address the expression of coordination from this perspective, especially coordination of individual denoting expressions such as "John and Mary". We argue that there is an underlying universal structure for individual coordination, and that the cross-linguistic variation can be explained by assuming that languages pronounce different morphemes of this universal structure. In particular, we argue that there two main types of system for the expression of individual coordination: the J-type and the μ-type. In μ-type languages the morpheme used for individual coordination also has uses a quantificational or focus particle, while in the J-type languages it doesn't. Instead at least in many J-type languages the same morpheme is used for individual and propositional coordination. The evidence we present for our model comes from two sources: new data from specific data of the J-type and μ-type languages, and from a study of the historical development of the expression of individual coordination in Indo-European which switched from a μ-type to a J-type system.
Background: The aim of this study was to compare outcome of patients with previous cardiac surgery undergoing transapical aortic valve implantation (Redo-TAVI) to those undergoing classic aortic valve replacement (Redo-AVR) by using propensity analysis.
Methods: From January 2005 through May 2012, 52 high-risk patients underwent Redo-TAVI using a pericardial xenograft fixed within a stainless steel, balloon-expandable stent (Edwards SAPIEN™). During the same period of time 167 patients underwent classic Redo-AVR. Logistic regression analysis was used to identify covariates among 11 baseline patient variables including the type of initial surgery. Using the significant regression coefficients, each patient’s propensity score was calculated, allowing selectively matched subgroups of 40 patients each. Initial surgery included coronary artery bypass grafting in 30 patients, aortic valve replacement in 7 patients and mitral valve reconstruction in 3 patients in each group. Follow-up was 4 ± 2 years and was 100% complete.
Results: Postoperative chest tube drainage (163 ± 214 vs. 562 ± 332 ml/24 h, p = 0.02) and incidence of early permanent neurologic deficit (0 vs. 13%, p = 0.04) was lower in patients with Redo-TAVI and there was a trend towards improved 30-day survival (p = 0.06). Also we detected a decreased ventilation time (p = 0.04) and lower transfusion rate of allogenic blood products (p ≤ 0.05) in the Redo-TAVI group. At late follow up differences regarding incidence of major adverse events, including death and permanent neurologic deficits (25% vs. 43%, p = 0.01) statistically supported early postoperative findings.
Conclusion: The encouraging results regarding early and long-term outcomes following TAVI in patients with previous cardiac surgery show, that this evolving approach may be particularly beneficial in this patient cohort.
We study the effect of weakening creditor rights on distress risk premia via a bankruptcy reform that shifts bargaining power in financial distress toward shareholders. We find that the reform reduces risk factor loadings and returns of distressed stocks. The effect is stronger for firms with lower firm-level shareholder bargaining power. An increase in credit spreads of riskier relative to safer firms, in particular for firms with lower firm-level shareholder bargaining power, confirms a shift in bargaining power from bondholders to shareholders. Out-of-sample tests reveal that a reversal of the reform's effects leads to a reversal of factor loadings and returns.
The recent financial crisis highlighted the limits of the "originate to distribute" model of banking, but its nexus with the macroeconomy remains unexplored. I build a business cycle model with banks engaging in credit risk transfer (CRT) under informational externalities. Markets for CRT provide liquidity insurance to banks, but the emergence of a pooling equilibrium can also impair the banks’ monitoring incentives. In normal times and in face of standard macro shocks the insurance benefits of CRT prevail and the business cycle is stabilized. In face of financial/liquidity shocks the extent of informational asymmetries is larger and the business cycle is amplified. The macro model with CRT can also reproduce well a number of macro and banking statistics over the period of rapid growth of this banks’ business model.
We propose a novel approach on how to estimate systemic risk and identify its key determinants. For US financial companies with publicly traded equity options, we extract option-implied value-at-risks and measure the spillover effects between individual company value-at-risks and the option-implied value-at-risk of a financial index. First, we study the spillover effect of increasing company risks on the financial sector. Second, we analyze which companies are mostly affected if the tail risk of the financial sector increases. Key metrics such as size, leverage, market-to-book ratio and earnings have a significant influence on the systemic risk profiles of financial institutions.
We study the effect of weakening creditor rights on distress risk premia via a bankruptcy reform that shifts bargaining power in financial distress toward shareholders. We find that the reform reduces risk factor loadings and returns of distressed stocks. The effect is stronger for firms with lower firm-level shareholder bargaining power. An increase in credit spreads of riskier relative to safer firms, in particular for firms with lower firm-level shareholder bargaining power, confirms a shift in bargaining power from bondholders to shareholders. Out-of-sample tests reveal that a reversal of the reform's effects leads to a reversal of factor loadings and returns.
A selection of duplicates from the collection of Michel Edmond de Selys Longchamps was found at the Übersee-Museum Bremen/Germany (UMB). Selys determined a lot of Odonata in the UMB collection and sent 80 European and 76 exotic species to Bremen on 23 April, 1875. According to the labels 121 specimens could be assigned to this shipment and eleven specimens must have been sent to UMB in later years. This collection includes two paralectotypes (Progomphus gracilis Hagen inSelys, 1853;Palaemnema nathalia Selys, 1886) and seven syntypes (Rhinocypha trifasciata Selys, 1853; Dysphaea dimidiata limbata Selys, 1859; Argia sordida Hagen inSelys, 1865; Oxyagrion dissidens Selys, 1876; Oxyagrion haematinum Selys, 1876; Oxyagrion pavi-dum Hagen in Selys, 1876; Telagrion longum Selys, 1876). In addition, a male specimen of Euphaea tricolor subcostalis Selys, 1873 might also belong to the original syntype series. Altogether three specimens with labeled nomina nuda(Diplax catharina Selys, Diplax fausta Selys, Dythemis bilineata Hagen) and two labeled with manuscript names (Diplax marcellina Selys, Perithemis ovate Bates) are in this collection.
Pseudoperonospora cubensis, an obligate biotrophic oomycete causing devastating foliar disease in species of the Cucurbitaceae family, was never reported in seeds or transmitted by seeds. We now show that P. cubensis occurs in fruits and seeds of downy mildew-infected plants but not in fruits or seeds of healthy plants. About 6.7% of the fruits collected during 2012–2014 have developed downy mildew when homogenized and inoculated onto detached leaves and 0.9% of the seeds collected developed downy mildew when grown to the seedling stage. This is the first report showing that P. cubensis has become seed-transmitted in cucurbits. Species-specific PCR assays showed that P. cubensis occurs in ovaries, fruit seed cavity and seed embryos of cucurbits. We propose that international trade of fruits or seeds of cucurbits might be associated with the recent global change in the population structure of P. cubensis.
Does austerity pay off?
(2014)
Policy makers often implement austerity measures when the sustainability of public finances is in doubt and, hence, sovereign yield spreads are high. Is austerity successful in bringing about a reduction in yield spreads? We employ a new panel data set which contains sovereign yield spreads for 31 emerging and advanced economies and estimate the effects of cuts of government consumption on yield spreads and economic activity. The conditions under which austerity takes place are crucial. During times of fiscal stress, spreads rise in response to the spending cuts, at least in the short-run. In contrast, austerity pays off, if conditions are more benign.
Kempfidris : a new genus of myrmicine ants from the Neotropical region (Hymenoptera: Formicidae)
(2014)
The new genus Kempfidris gen. nov. is described based on the workers of a single species, K. inusualis comb. nov., from Brazil, Ecuador, and Venezuela. Kempfidris inusualis comb. nov. was originally described by Fernández (2007) and provisionally placed in Monomorium awaiting a better understanding of the internal relationships in Myrmicinae. Kempfidris gen. nov. has a series of distinctive morphological characters including the mandibular configuration, vestibulate propodeal spiracle, propodeal carinae, and cylindrical micro-pegs on the posteromedian portion of abdominal tergum VI and anteromedian portion of abdominal tergum VII. This last trait appears to be autapomorphic for the genus.
One of the leading methods of estimating the structural parameters of DSGE models is the VAR-based impulse response matching estimator. The existing asympotic theory for this estimator does not cover situations in which the number of impulse response parameters exceeds the number of VAR model parameters. Situations in which this order condition is violated arise routinely in applied work. We establish the consistency of the impulse response matching estimator in this situation, we derive its asymptotic distribution, and we show how this distribution can be approximated by bootstrap methods. Our methods of inference remain asymptotically valid when the order condition is satisfied, regardless of whether the usual rank condition for the application of the delta method holds. Our analysis sheds new light on the choice of the weighting matrix and covers both weakly and strongly identified DSGE model parameters. We also show that under our assumptions special care is needed to ensure the asymptotic validity of Bayesian methods of inference. A simulation study suggests that the frequentist and Bayesian point and interval estimators we propose are reasonably accurate in finite samples. We also show that using these methods may affect the substantive conclusions in empirical work.
We examine both the degree and the structural stability of inflation persistence at different quantiles of the conditional inflation distribution. Previous research focused exclusively on persistence at the conditional mean of the inflation rate. As economic theory provides reasons for inflation persistence to differ across conditional quantiles, this is a potentially severe constraint. Conventional studies of inflation persistence cannot identify changes in persistence at selected quantiles that leave persistence at the median of the distribution unchanged. Based on post-war US data we indeed find robust evidence for a structural break in persistence at all quantiles of the inflation process in the early 1980s. While prior to the 1980s inflation was not mean reverting, quantile autoregression based unit root tests suggest that since the end of the Volcker disinflation the unit root can be rejected at every quantile of the conditional inflation distribution.
"I Am a Hottentot" : africanist mimicry and green xenophilia in Hans Paasche and Karen Blixen
(2014)
Claims that industrialized western countries must reform their environmental practices have often been made with reference to less-developed non-western societies living in greater "harmony" or "balance" with the natural world. Examples of what I call green xenophilia (from the Greek "xenos", meaning strange, unknown or foreign, and "philia", meaning love or attraction), are myriad, wide-ranging and culturally dispersed. They range from the appearance of the iconic "crying Indian" in anti-pollution TV and newspaper spots in the months leading up to the first Earth Day on April 22 1970 to numerous environmentalist individuals' and groups' use of the fabricated "Chief Seattle's Speech" as an authoritative touchstone of ecological consciousness, and from the British Schumacher College's endorsement of India as a source of simplicity, holism, humility, vegetarianism etc. to leading deep ecologists' advocacy of East Asian religions (especially Buddhism, Jainism and Taoism) as "biocentric" alternatives to "anthropocentric" Christianity (Rolston 1987; Dunaway 2008; Krupat 2011; Corrywright 2010). Invocations of non-western cultures, identities and worldviews have proved potent heuristic devices, enabling greens both to critique the status quo and to gesture (however schematically) towards the possibility of alternatives. Pervasive media-borne ideas and images like "the Green Tibet" (Huber 1997) and "the ecological Indian" (Krech 1999) have given environmentalist ideas about the good life physical incarnation, making them seem less remote and abstract. Yet the prevalence of xenophile dis course has also made environmentalism vulnerable to recurrent accusations of romantic primitivism, orientalism and exoticism, as western greens have sometimes (though not always) appeared to buttress traditional socio-cultural norms in the very act of challenging them (Guha 1989; Lohmann 1993; Bartholomeusz 1998). What is gained and what is risked when western greens speak about, with, for or as "the other"? In this essay I engage with two early-twentieth-century North European writers, the German Hans Paasche (1881-1921) and the Dane Karen Blixen (1885-1962), whose works bring this question to the forefront. Critical of European industrialization, and awkwardly positioned vis-a-vis their upper-class social milieus, Paasche and Blixen wrote as self-made "Africans", testing the limits between colonialism, anti-colonialism and emergent forms of environmentalism and green" lifestyle reform. More precisely, Paasche in "Die Forschungsreise des Afrikaners Lukanga Kukara ins Innerste Deutschland" ("The African Lukanga Mukara's Research Joumey into the Innermost of Germany" (1912-1913) and Blixen in "Out of Africa" (1937) deploy the ambiguous form of mimicry that Susan Gubar labels "racechange", impersonating or appropriating culturally other voices and perspectives on animals, food, physical embodiment and human-natural relations (Gubar 1997). Paasche and Blixen, I argue, used their considerable intercultural insight to construct images of Africa that they hoped would stand in redemptive contrast to the humanly and environmentally ruinous beliefs and practices of European modernity. I am interested in the acts of ethnic and textual self-alienation that these writers perform because they highlight the discursive, ethical and political ambiguities of green xenophilia - ambiguities that can be explored from different positions within the developing field of ecocritical studies.
Modeling the effects of neuronal morphology on dendritic chloride diffusion and GABAergic inhibition
(2014)
Poster presentation at the Twenty Third Annual Computational Neuroscience Meeting: CNS*2014 Québec City, Canada. 26-31 July 2014.
Gamma-aminobutyric acid receptors (GABAARs) are ligand-gated chloride (Cl−) channels which mediate the majority of inhibitory neurotransmission in the CNS. Spatiotemporal changes of intracellular Cl− concentration alter the concentration gradient for Cl− across the neuronal membrane and thus affect the current flow through GABAARs and the efficacy of GABAergic inhibition. However, the impact of complex neuronal morphology on Cl− diffusion and the redistribution of intracellular Cl− is not well understood. Recently, computational models for Cl− diffusion and GABAAR-mediated inhibition in realistic neuronal morphologies became available [1-3]. Here we have used computational models of morphologically complex dendrites to test the effects of spines on Cl− diffusion. In all dendritic morphologies tested, spines slowed down longitudinal Cl− diffusion along dendrites and decreased the amount and spatial spread of synaptically evoked Cl− changes. Spine densities of 2-10 spines/µm decreased the longitudinal diffusion coefficient of Cl− to 80-30% of its value in smooth dendrites, respectively. These results suggest that spines are able to limit short-term ionic plasticity [4] at dendritic GABAergic synapses.
Robustness, validity, and significance of the ECB's asset quality review and stress test exercise
(2014)
As we are moving toward a eurozone banking union, the European Central Bank (ECB) is going to take over the regulatory oversight of 128 banks in November 2014. To that end, the ECB conducted a comprehensive assessment of these banks, which included an asset quality review (AQR) and a stress test. The fundamental question is how accurately will the financial condition of these banks have been assessed by the ECB when it commences its regulatory oversight? And, can the comprehensive assessment lead to a full repair of banks’ balance sheets so that the ECB takes over financially sound banks and is the necessary regulation in place to facilitate this? Overall, the evidence presented in this paper based on the design of the comprehensive assessment as well as own stress test exercises suggest that the ECB’s assessment might not comprehensively deal with the problems in the financial sector and risks may remain that will pose substantial threats to financial stability in the eurozone.
The endemic Floridian milliped genus, Floridobolus Causey, 1957, more closely related to tylobolinines in the western United States (US), Mexico, and Guatemala than syntopic spirobolines, is incorporated into Spirobolidae (Spirobolida: Spirobolidea). With taxonomic priority by one year, its monotypic family is reduced to Floridobolinae, n. stat., comprising Floridobolini and Tylobolini, n. stats., the counterpart to Spirobolinae, comprising Spirobolini and Aztecolini, n. tribe; relationships are Floridobolini + (Tylobolini + (Aztecolini + Spirobolini)). Like F. penneri Causey, 1957, 208 km (130 mi) to the south in the Lake Wales Ridge, Polk and Highlands counties (cos.), F. orini n. sp., inhabits “Big Scrub” environments in the Ocala National Forest, Marion Co. Biogeographic reconstructions, compatible with broader hypotheses on the class’ evolutionary history, indicate that, from a presumptive source area in northern Mexico where the subfamilies overlap, spirobolid stock penetrated the “proto-US” four times, once per tribe, before the Western Interior Seaway developed in the Cretaceous Period, Mesozoic Era. Three expansions headed northeastward into future “Appalachia,” from which taxa spread southward as the Seaway receded. Floridobolini, the fi rst invader, had to be in “proto-Georgia” and positioned to penetrate Florida when the sand dunes that comprise the “Central Highlands” emerged from the sea in the Oligocene (Cenozoic), ~25 mya. As sea levels rose and fell, the dunes fragmented into islands and the subcontinuous Floridobolus population was partitioned. The southernmost became F. penneri; F. orini inhabited a northern island; and a graduate student is investigating other insular remnants for additional species. Shortly after Floridobolini began spreading, Hiltonius/ Tylobolini arose and expanded both southward to Guatemala and northwestward to California; Tylobolus Cook, 1904, diverged in the latter area and dispersed northward to Washington and eastward to Utah/Arizona. The third invader, and the second to disperse northeastward, was Aztecolini, which probably eradicated Floridobolini from some of its established range and was partitioned into Mexican (Aztecolus Chamberlin, 1943) and US (Chicobolus Chamberlin, 1947) taxa by the Seaway. The fi nal invader, Spirobolini, dispersed northwestward and northeastward to both the Pacifi c and Atlantic coasts; instead of Trans-Beringia, we prefer penetration of the Asian part of “Asiamerica,” when it temporarily formed during the Cretaceous, to explain the Mongolian fossil genus, Gobiulus Dzik, 1975, herein assigned to Tylobolini, and the occurrence of Spirobolus Brandt, 1833, in China and Taiwan today. In the east, Narceus Rafi nesque, 1820, spread across Appalachia, eradicated most remaining populations of Floridobolus and Chicobolus, and expanded to Maine and Québec after retreat of the Wisconsin glaciation. Chicobolus and Narceus also penetrated earliest Florida; the former established itself in the Central Highlands, spread through the widening peninsula as sea levels fell, and remained on insular refugia when waters rose. Apparently fueled by the different Floridian environments, Narceus underwent time-consuming speciation; consequently, Floridobolus and Chicobolus still survive on the peninsula, and an allopatric population of the latter inhabits coastal South Carolina. However, N. gordanus (Chamberlin, 1943) occurs syntopically with both in peninsular Florida and may be actively eradicating them from their last stronghold. Trigoniulus niger, takahasii, and segmentatus, all by Takakuwa, 1940, are removed from Spirobolidae and returned toTrigoniulidae (Trigoniulidea). New records in the Appendix include the fi rst of Aztecolus from Durango and Jalisco, Mexico.
Tynommatidae, n. stat., elevated from Tynommatinae, is established as a schizopetalidean family encompassing the western North American callipodidans previously assigned to the Mediterranean Schizopetalidae. It is considered a valid taxon despite somewhat anatomically dissimilar subfamilies, and Colactidinae, Texophoninae, Diactidinae, and Aspidiophoninae constitute tribal elevations and additional new statuses. With a subbasal telopodal prefemoral process, Diactis hedini, n. sp., requires rediagnoses of all three diactidine genera, Diactis Loomis, 1937, and Florea and Caliactis, both by Shelley, 1996, and suggests that telopodal branches ‘B’ in congeners and Florea represent distal relocations of the process along the stem. Similarities in the sizes and shapes of the pleurotergal carinae suggest a sister-group relationship with the other, and partly sympatric, New World family, Abacionidae, which is supported by gonopodal similarities between Colactidinae and Abacion Rafi nesque, 1820. The Western Interior Seaway of the Cretaceous Period, Mesozoic Era, ~141–66 million years ago, appears to have fueled divergence by isolating “proto-abacionid stock” in “Appalachia,” the Eastern North American land mass, which has subsequently spread well into previously inundated areas. The allopatric position of Texophoninae, on the Gulf Coast of south Texas around 1,136 km (710 mi) east of the most proximate familial records, is attributed to this waterway, which eradicated faunal linkages with “proto-Tynommatidae” in “Laramidia,” the Western North American land mass. Texophoninae probably survived the Cretaceous on insular refugia; however, it is rarely encountered anymore and seems destined for imminent extinction. Representatives of the east-Asian families, Caspiopetalidae, Paracortinidae, and Sinocallipodidae, also possess demarcated pleurotergal crests and, implausible though it seems, may share ancestry with the North American taxa vis-à-vis the “Asiamerica” and or “Boreotropic” concepts.
An adventive female Julidae (Julida), discovered in a moist, grassy depression in the Peninsula de Brunswick south of Punta Arenas, Chile, and assigned to Cylindroiulus Verhoeff, 1894, is the fi rst vouchered milliped from southern Patagonia. The southernmost milliped ever collected in Chile, South America, and the Western Hemisphere, it may also constitute the southernmost in the world as the site is only ~1,176 km (735 mi) northwest of the Antarctic Peninsula. Records are consolidated of the two families, three genera, and fi ve species of this Holarctic order that are known from South America. They are documented from Argentina, Chile, and southern Peru and Brazil; three species are known from the Juan Fernandez Islands.
Past concepts and synonymies of Anadenobolus monilicornis (Porat, 1876) (Spirobolida: Rhinocricidae), including the implied synonymy of Rhinocricus ectus Chamberlin, 1920, are consolidated into a formal account with the fi rst illustrations of the holotype. Prior to 1492, A. monilicornis was probably indigenous to an unknown number of southern Antillean islands, but through modern commerce, man has introduced it to Florida, Bermuda, Barbados, the Cayman Islands, and Jamaica, and probably repeatedly (re)introduced conspecifi c material to all the Lesser Antilles, resulting in subcontinuous gene pool mixing and reticulate evolution. A broad species concept is necessary to encompass the multitudinous variants, some of which have been recognized as species; only one true Caribbean species of Anadenobolus Silvestri, 1897, may exist, for which arboreus (Saussure, 1859) is the oldest name. The distribution of A. monilicornis presently extends from Bermuda and southern coastal Florida through the Greater and Lesser Antilles (excepting Cuba) to eastern coastal Venezuela and central Suriname, with outlier populations in Jamaica, the Cayman Islands, and Tampa Bay and the eastern Floridian panhandle; excepting Barbados, the indigenous range may have extended from Hispaniola through the same area. Introductions into Manitoba, Canada, and North Carolina, USA, have not yielded viable populations. Localities are newly recorded from St. Thomas, US Virgin Islands.
A summary of the milliped faunas of Pakistan, Bangladesh, and Kashmir (Arthropoda: Diplopoda)
(2014)
Three female callipodidan samples from northern Pakistan are assigned to Bollmania kohalana (Attems, 1936) (Caspiopetalidae), the only ordinal representative documented from the country; a new record of Kaschmiriosoma loebli Jeekel, 2003 (Polydesmida: Paradoxosomatidae), is also provided. Localities are summarized for the 14 Pakistani, 6 Kashmirian, and 5 Bangladeshi diplopods. The last include one unidentifi able female of Zephronia Gray, 1832 (Sphaerotheriida: Zephroniidae), and two adventive species, Trachyjulus calvus (Pocock, 1893) (Spirostreptida: Cambalopsidae) and Asiomorpha coarctata (Saussure, 1860) (Polydesmida: Paradoxosomatidae); all constitute new country records. Two obscurely documented Bangladeshi diplopods are Gonoplectus cautus (Attems, 1936) (Spirostreptida: Harpagophoridae), and Trichopeltis watsoni Pocock, 1895 (Polydesmida: Cryptodesmidae). The Pakistani polydesmidan, Quasidesmus puschtun Golovatch, 1991, is transferred from Pyrgodesmidae to Cryptodesmidae.
Characterized by small body size, apically rounded/lobed anterior gonopod telopodites, long slender posterior gonopod telopodites, and torsion in the cyphopod receptacles, Floridobolus fl oydi, n. sp., is described from the southern sector of the Brooksville Ridge in northwestern peninsular Florida. It inhabits sandy “Big Scrub” environments like F. penneri Causey, 1957, and F. orini Shelley, 2014, and is documented from the sector’s center and northern periphery, in Hernando and Citrus Counties, respectively, with a sight record from the eastern periphery. Its discovery supports the thesis that each sand ridge in peninsular Florida may harbor a unique species of this endemic genus.
A newly discovered population of Xystocheir brachymacris Shelley, 1996 (Polydesmida: Xystodesmidae: Xystocheirini), in Placer County (Co.), California, exhibits an unusual grayish-black color dorsally with mottled, ovoid patches at paranotal bases; it cons titutes northern generic and specifi c range extensions of ~28.4 km (17.6 mi). The gonopods differ from those in the El Dorado Co. population in having shorter/acuminate prefemoral processes and blade-like, rather than spatulate, processes “B” that angle away from the solenomere instead of overhanging it. Additionally, a strong distomedial prefemoral lobe, absent from the El Dorado population, arises from the stem in Placer Co. males. Authorship of Xystocheirini is properly attributed to Hoffman, 1980.
If we take Benjamin's definitions to their logical conclusion, then the monad and the reproduced copy are set unequivocally into binary opposition, as we, the masses capable and most needful of action, are implicitly denied the potential for liberation through aesthetic experience. This denial could not have been his long-term intention. When we take into account the breadth of his writings in response to Fascism, and we look at the artistic movements, Dada in particular, that Benjamin defines as 'politicizing art,' it seems as though we risk too narrow a reading of Benjamin's theories by assuming the aura can be, or must be, done away with. Rather, I would argue that this moment of auratic interaction is crucial to effectively politicizing art at all. Mechanically-produced art, in order to function politically, must allow its audience the space necessary to step back, awaken their 'Geistesgegenwart', and take action 'before' the present moment is finished and past. The elimination of aura - as per Benjamin’s own definitions of aura - neuters the interaction this awakening requires. While Benjamin provides the framework and asks the right questions, when determining what will allow his definitions to realize their aims most fully, I submit that he draws his line in the wrong place.
The flourishing of literature and thought during the age of Goethe may have inspired German nationalism in the 1930s, but Walter Benjamin identified other values in the period worth defending. 'Deutsche Menschen' is a short collection of edited letters by well-known German authors which Benjamin published in 1936 under the pseudonym Detlef Holz in order to hide his Jewish identity. In his inscription to Scholem's copy of the book, Benjamin wrote, "May you, Gerhard, find a chamber in this ark - which I built when the Fascist flood started to rise - for the memories of your youth," and in his sister’s copy Benjamin wrote, "This ark, built after a Jewish model, for Dora - From Walter." This essay considers what Benjamin may have meant by those inscriptions. Looking beyond discussions of "German," "Jewish," and even "German-Jewish" identity, this essay explores Benjamin's descriptions of his letter collection, asking how he conceptualized and framed it at first and how it may have changed between 1931 and 1936. The categories of tradition and agency will be my focus, which I will develop in the context of Benjamin's other writings and his particular interests in quotation and materialism. &e formation and reception of 'Deutsche Menschen' reveal a complex, ambitious project that combines many of Benjamin's ideas and goals.
Walter Benjamin had a revealing fascination with the legend of a Chinese artist who entered his painting and disappeared in it. In his writings this character becomes an emblematic figure that enables the philosopher to discuss the nature of representation in its various infections (in games and in painting, in theater and in cinema); to explore the status of the image and of the threshold that simultaneously separates and connects image and reality; to analyse the different bodily (i. e. "aesthetic") attitudes of the beholder in his/her close or distant relationship to the image; to investigate the manifold implications of empathy ('Einfühlung ') toward the figurative world; and finally, to approach a peculiar kind of dialectics, namely the "Chinese". My paper aims at considering such varied aspects in Benjamin's interpretation of the Chinese painter, understanding it as a true "dialectical image" that in its 'non-coincidentia oppositorum' provokes not only significant hermeneutic oscillations, but even a radical inversion of its fundamental meaning.
To explicate what distinguishes pain, Benjamin elaborates: "Of all corporeal feelings, pain alone is like a navigable river which never dries up and which leads man down to the sea. [...] Pain [...] is a link between worlds. This is why organic pleasure is intermittent, whereas pain can be permanent. This comparison of pleasure and pain explains why the cause of pain is irrelevant for the understanding of man's nature, whereas the source of his greatest pleasure is extremely important. For every pain, even the most trivial one, can lead upward to the highest religious suffering, whereas pleasure is not capable of any enhancement, and owes any nobility it possesses to the grace of its birth - that is to say, its source. (SW I, 397)" In these important lines, pain's unique strength is linked not to its origin (this is reserved for pleasure), but rather to the way that its strenuous flow throughout the suffering body has the power to lead it to infinite heights. In contrast to pleasure, which is forever seeking out its sources, pain manifests itself most consummately when it is intensified; it fulfills itself most deeply by gradually reenforcing its own fortitude. To make sense of pain, therefore, we must understand the nature of its 'movement': and in Benjamin's metaphor of the "navigable river" - its flow. In what follows, I develop Benjamin's idea of the nature of pain as manifested in the internal law of its ,ow in two other of Benjamin's texts: 'Berlin Childhood Around 1900' (1934) and 'Thought Figures' (1933).
One of the cruxes of Walter Benjamin’s work is the tension between an indebting and an expiating "memoria", i. e. the afflicting and the salvific insistence of history within the present moment. On the one hand, memory inscribes itself onto spaces and bodies in the violent and painful fashion of Kafka's "Penal Colony" apparatus. On the other hand, it can, in the form of rememoration ('Eingedenken'), sublate these very inscriptions. This sublation usually involves some form of redemptive, timely (re-)verbalization, but Benjamin’s conception of it varies. To gain a better insight into this inherent, varying tension, the article will take a closer look at the connection between pain, memory and law-positing violence in some Benjaminian texts, occasionally relating them to the historical background of his discussion.
Scolopendra morsitans L., 1758, is documented from Honolulu, Oahu, Hawaiian Islands, the fi rst record of this anthropochoric chilopod from both the archipelago and state. Hawaii thus becomes the second American state to harbor the species, the other being Florida, where an individual has been taken in Jacksonville, Duval County. Meristic and morphological data are presented for three Hawaiian specimens. At least two other species of Scolopendra, both introduced, occur on these islands: S. polymorpha Wood, 1861, known only from one specimen from Oahu, and one or more representatives of the “S. subspinipes Leach, 1815, complex,” which is widespread and even inhabits Midway Atoll.
Hepatocellular carcinoma (HCC) is the fifth most common malignant tumor and third leading cause of cancer-related death worldwide. Most cases arise as a consequence of underlying liver disease, e.g. developed from chronic hepatitis B or C infectionsalcohol abuse or obesity, and are most often associated with liver cirrhosis. Hypoxiand the hypoxia inducible factors (HIF)-1α and -2α promote tumor progression of HCC, not only affecting tumor cell proliferation and invasion, but also angiogenesis and lymphangiogenesis and thus, increasing the risk of metastasis.
HCC is characterized as one of the most vascularized solid tumors. While HIF-1α and HIF-2α are frequently up-regulated in HCC only HIF-2α is correlated with high patientlethality. HIF-dependent regulation of HCC angiogenesis is controversially discussed.VEGFA, for example, as the most prominent factor inducing tumor angiogenesis represents not only a HIF-1 target, but also a HIF-2 target gene in HCC. This questions whether both isoforms have overlapping functions in regulating the angiogenic switch in HCC.
Besides angiogenesis also tumor-associated lymphangiogenesis significantly influences patient survival in HCC. Lymphatic spread is an important clinical determinant for the prognosis of HCC, but little is known how lymphangiogenesis is controlled in this context. To date, mainly HIF-1α was positively correlated with olymphatic invasion and metastasis in HCC, while a defined role of HIF-2α is missing. Thus, although HIF-1α and HIF-2α are structurally alike and regulate overlapping but not identical sets of target genes, they promote highly divergent outcomes in cancer progression and may even have counteracting roles. The aim of my work was to characterize the specific role of HIF-1α and HIF-2α in the angiogenic switch and lymphangiogenesis induction during HCC development.
Therefore, I created a stable knockdown of HIF-1α and HIF-2α in HepG2 cells and generated cocultures of HepG2 spheroids and embryonic bodies derived from embryonic mouse stem cells as an in vitro tumor model mimicking the cancer microenvironment to analyze which HIF isoform has key regulatory functions in HCC (lymph)angiogenesis. In cocultures with a HIF-2α knockdown angiogenesis was attenuated but lymphangiogenesis increased, while the knockdown of HIF-1α was without effect. Microarray analysis identified plasminogen activator inhibitor 1 (PAI-1)and insulin-like growth factor binding protein 1 (IGFBP1) as HIF-2 target genes.However, prominent angiogenic and lymphangiogenic factors such as VEGFs, PDGFB, ANG and their receptors were not regulated in a HIF-dependent manner. As PAI-1 was linked to angiogenesis in literature and IGF-signaling, which is negatively regulated by IGFBP-1, was correlated with lymphangiogenesis, I decided to investigate their HIF-2α-dependent influence on HCC (lymph)angiogenesis. The knockdown of PAI-1 in HepG2 cells also lowered angiogenesis in PAI-1k/d cocultures similar to the HIF-2α k/d phenotype. PAI-1 as the potent inhibitor of tPA and uPA, both inducing the conversion of plasminogen to plasmin, also inhibits plasmin directly. Therefore, I assumed an increase of plasmin in HIF-2α k/d and PAI-1 k/d cocultures as a result of the reduced PAI-1 levels. Blocking plasmin with aprotinin in HIF-2α k/d cocultures restored angioge nesis, suggesting that HIF-2α increases PAI-1 to lower concentrations of active plasmin, thereby supporting angiogenesis. In further experiments I could exclude PAI-1 to reduce angiogenesis by inducing plasmin-mediated apoptosis of differentiating stem cells in PAI-1 k/d and HIF-2α k/d cocultures, but demonstrated an increase of VEGFA165 degradation in these cocultures, suggesting plasmin-catalyzed proteolysis of VEGF as an additional layer of regulation required to explain the angiogenic phenotype. Besides the pivotal role of PAI-1 in angiogenesis I also investigated its potentialinfluence in lymphangiogenesis. Indeed, the knockdown of PAI-1 reduced lymphaticstructures and implied an important but opposing role in lymphangiogenesis comparedto induced lymphangiogenesis in HIF-2α k/d cocultures. However, blocking plasmin again with aprotinin in HIF-2α k/d cocultures restored lymphangiogenesis to the level of control virus, which indicates a divergent lymphangiogenic role of plasmin in PAI-1 k/d and HIF-2α k/d cocultures, possibly because of other essential pathways masking the lymphangiogenic effects of PAI-1 in HIF-2α k/d cocultures.
HIF-2α resulting in reduced IGFBP1 expression induced the differentiation of stem cells toward a lymphatic cell type and significantly enhanced the assembly of human dermal lymphatic endothelial cells into tubes. These data point the first time to an important impact of HIF-2 in the regulatin of lymphangiogenesis in vitro by inducing IGFBP1 and thus, scavenging IGF-1. Furthermore, matrigel plug assays to investigate the in vivorelevance of these observations confirmed HIF-2α as a crucial factor in the regulation of lymphangiogenesis in vivo
In conclusion, this work provides evidence that HIF-2α is a key regulator of angiogenesis and lymphangiogenesis in HCC by regulating PAI-1 and IGFBP1. HIF-2α positively influences the angiogenic switch via PAI-1 and negatively affects lymphangiogenesis via IGFBP1 expression. Targeting HIF-2α in HCC to reduce tumor angiogenesis should be approached carefully, as it might be overcome by induced lymphangiogenesis and metastasis.
Vasointestinal peptide metabolism plays a key physiological role in multimodular levels of vasodilatory, smooth muscle cell proliferative, parenchymal, and inflammatory lung reactions. In animal studies, vasointestinal peptide relaxes isolated pulmonary arterial segments from several mammalian species in vitro and neutralizes the pulmonary vasoconstrictor effect of endothelin. In some animal models, it reduces pulmonary vascular resistance in vivo and in monocrotaline-induced pulmonary hypertension. A 58-year-old woman presented with dyspnea and mild edema of the lower extremities. A bronchoscopy was performed without any suspicious findings suggesting a central tumor or other infiltrative disease. Endobronchial ultrasound revealed enlarged pulmonary arteries containing thrombi, a few enlarged lymph nodes, and enlarged mediastinal tissue anatomy with suspicion for mediastinal infiltration of a malignant process. We estimated that less than 10% of the peripheral vascular bed of the lung was involved in direct consolidated fibrosis as demonstrated in the left upper lobe apex. Further, direct involvement of fibrosis around the main stems of the pulmonary arteries was assumed to be low from positron emission tomography and magnetic resonance imaging scans. Assuming a positive influence of low-dose radiation, it was not expected that this could have reduced pulmonary vascular resistance by over two thirds of the initial result. However; it was noted that this patient had idiopathic pulmonary arterial hypertension mixed with "acute" (mediastinal) fibrosis which could have contributed to the unexpected success of reduction of pulmonary vascular resistance. To the best of our knowledge, this is the first report of successful treatment of idiopathic pulmonary arterial hypertension, probably as a result of low-dose radiation to the pulmonary arterial main stems. The patient continues to have no specific complaints concerning her idiopathic pulmonary arterial hypertension.
Introduction: Currently there are several advanced guiding techniques for pathoanatomical diagnosis of incidental solitary pulmonary nodules (iSPN): Electromagnetic navigation (EMN) with or without endobronchial ultrasound (EBUS) with miniprobe, transthoracic ultrasound (TTUS) for needle approach to the pleural wall and adjacent lung and computed tomography (CT) -guidance for (seldom if ever used) endobronchial or (common) transthoracical approach. In several situations one technique is not enough for efficient diagnosis, therefore we investigated a new diagnostic technique of endobronchial guided biopsies by a Cone Beam Computertomography (CBCT) called DynaCT (SIEMENS AG Forchheim, Germany). Method and Material: In our study 33 incidental solitary pulmonary nodules (iSPNs) (28 malignant, 5 benign; mean diameter 25 +/-12mm, shortest distance to pleura 25+/-18mm) were eligible according to in- and exclusion criteria. Realtime and onsite navigation were performed according to our standard protocol.22 All iSPN were controlled with a second technique when necessary and clinical feasible in case of unspecific or unexpected histological result. In all cases common guidelines of treatment of different iSPNs were followed in a routine manner. Results: Overall navigational yield (ny) was 91% and diagnostic yield (dy) 70%, dy for all accomplished malignant cases (n=28) was 82%. In the subgroup analysis of the invisible iSPN (n=12, 11 malignant, 1 benign; mean diameter 15+/-3mm) we found an overall dy of 75%. For the first time we describe a significant difference in specifity of biopsy results in regards to the position of the forceps in the 3-dimensional volume (3DV) of the iSPN in the whole sample group. Comparing the specifity of biopsies of a 3D-uncentered but inside the outer one third of an iSPN-3DV with the specifity of biopsies of centered forceps position (meaning the inner two third of an iSPN-3DV) reveals a significant (p=0,0375 McNemar) difference for the size group (>1cm) of 0,9 for centered biopsies vs. 0,3 for uncentered biopsies. Therefore only 3D-centered biopsies should be relied on especially in case of a benign result. Conclusion:The diagnostic yield of DynaCT navigation guided transbronchial biopsies (TBB) only with forceps is at least up to twofold higher than conventional TBB for iSPNs <2cm. The diagnostic yield of DynaCT navigation guided forceps TBB in invisible SPNs is at least in the range of other navigation studies which were performed partly with multiple navigation tools and multiple instruments. For future diagnostic and therapeutic approaches it is so far the only onsite and realtime extrathoracic navigation approach (except for computed tomography (CT)-fluoroscopy) in the bronchoscopy suite which keeps the working channel open. The system purchase represents an important investment for hospitals but it is a multidisciplinary and multinavigational tool with possible access via bronchial airways, transthoracical or vascular approach at the same time and on the same table without the need for an expensive disposable instrument use.
In spring and summer 2008, the Odonata fauna of the Khabr National Park (Iran) was studied for the first time. Here, we present records of the representatives of family Libellulidae only. A total of twelve libellulid Odonata were found. Most of them are common species in Iran and other parts of Kerman province. Scarce Iranian species are Trithemis arteriosa and Zygonyx torridus.
With its broad spectrum of cults and coexisting religions Graeco-Roman antiquity seems, at first glance, to be the embodiment of religious freedom. Yet, a closer analysis shows that a concept of tolerance or the idea of religious freedom did not exist. Political institutions could easily suppress religious practices that were regarded as offensive. Fighting against the oppression of Christians appears to have increased under the influence of oecumenical paganism during the reign of the Severans. In this time, the Christian thinkerTertullian discovered and articulated the concept of religious freedom. However, he did not do so emphatically and the concept was not very successful in antiquity. With the Christianization of the Roman Empire it disappeared soon, although its rediscovery in later epochs contributed heavily to the formation of the European norm of religious freedom.
Smac (second mitochondria-derived activator of caspase) mimetics are considered as promising anticancer therapeutics and used to induce apoptosis by antagonizing inhibitor of apoptosis proteins, which are often abundantly expressed in cancer cells. Here, we identify interferon regulatory factor 1 (IRF1) as a novel critical regulator of Smac mimetic BV6-induced apoptosis and proinflammatory cytokine secretion with impact on the immune response. IRF1 knockdown rescues cells from BV6-induced apoptosis and attenuates BV6-stimulated upregulation of tumor necrosis factor-α (TNFα), indicating that IRF1 mediates BV6-triggered cell death, at least in part, by inducing TNFα. This notion is supported by data showing that exogenous supply of TNFα restores BV6-induced cell death in IRF-knockdown cells. Interestingly, IRF1 selectively controls the induction of nuclear factor-κB (NF-κB) target genes, as IRF1 depletion attenuates BV6-stimulated upregulation of TNFα and interleukin-8 (IL-8) but not p100 and RelB. Concomitant knockdown of IRF1 and p65 cooperate to inhibit BV6-induced cell death, implying a cooperative interaction of IRF1 and NF-κB. In addition, IRF1 silencing hampers TNFα induction by TNFα itself as an another prototypical NF-κB stimulus. Importantly, IRF1 depletion impedes BV6-stimulated secretion of additional proinflammatory cytokines such as granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-8, IL-6 and monocyte chemoattractant protein-1, and migration of primary monocytes to BV6-treated tumor cells. In conclusion, this identification of IRF1 as a dual regulator of BV6-induced apoptosis and inflammatory cytokine secretion provides novel insights into determinants of sensitivity towards Smac mimetic and possible implications of Smac mimetic treatment on tumor microenvironment and immune response.
The publication is the latest in the African Studies in Russia series of compilations and contains full articles and annotations of the most important - from the point of view of editors - works of Russian Africanists over a certain period. The authors work at the Institute for African Studies of the Russian Academy of Sciences (RAS). The present issue covers the years 2010 to 2013 and consists of two sections. The first section presents conceptual articles on Africa published in authoritative journals. The second section offers synopses of books by Russian authors on economics, cultural anthropology, social and political development, gender studies, and international relations of African countries. The main objective of the triennial series of compilations is to introduce new findings of Russian Africanists to interested foreign scholars who do not speak Russian.
Acacia
(2014)
Acacia is a strong and independent woman whose heart and heritage like rooted in Africa, while her reality in contemporary America finds itself in a very different time and place. In living her life, she must breach the distance between her current space and the ties that bind her. Straddling two sometimes opposing worlds of medicine and dance, Dr Acacia Graeme must find the balance between feeding her mind through work and study, and nourishing her soul and spirit through dance. And what happened when the music stops? Because it does, often. How will she get through the silence of her every day? This is the story of a flawed heroine whose intentions are pure, her truth perhaps less so. Torn between the enduring innocence of her first love and the life-long search that is her longing for one true love, she is compelled to come to terms with her own free nature and independent spirit and, in so doing, turn tragedy to triumph.
Bless me Father
(2014)
Bless Me Father is the true story of an incredible South African life. Born into a violent and broken family, and growing up in a variety of institutions, Cape Town based poet and writer Mario d'Offizi tells his remarkable, often shocking and ultimately inspiring life adventure - one that spans several decades in a country undergoing radical change. From his tough days at Boys Town to wild years in the advertising world, a stint in the restaurant business and a sharp edged journalistic adventure in the DRC, d'Offizi tells his critically acclaimed story with the unfailing sensitivity and warmth of a true poet.
Customary Law Ascertained Volume 2 is the second of a three volume series in which traditional authorities in Namibia present the customary laws of their communities. It contains the laws of the Bakgalagari, the Batswana ba Namibia and the Damara communities. The recognised traditional authorities in Namibia are expected to ascertain the customary law applicable in their respective communities and to note the most important aspects of the laws in written form. The Ministry of Regional and Local Government, Housing and Rural Development, and the Council of Traditional Leaders therefore initiated the ascertainment of customary law. The ascertainment project is housed in the Human Rights and Documentation Centre of the University of Namibia. The former Dean of the Faculty of Law of the University of Namibia, Professor Manfred O. Hinz, has directed the project since its inception.
This study raises awareness to the emergence of a new genre in world literature?hybridized literature. It rejects the assumption according to which literatures written in less commonly taught languages should be subsumed into one universally accessible global idiom. Instead, Vakunta challenges literary scholars and readers of literature to regard untranslatability as the key to cross-cultural engagement. The book?s multiple approaches and innumerable sources generate complex interdisciplinary connections and provide an excellent introduction to a complex literary phenomenon alien to literati resident outside the officially bilingual multicultural and multilingual Republic of Cameroon.
African Cultures, Memory and Space is an impeccable volume that powerfully grapples with a gamut of cultural heritage issues, challenges and problems from a vista of inter- and multi-disciplinary approach. The book, which is designed as a foundational text to the study of culture in ever-changing environments, makes an important argument that the dynamism of culture in highly globalised societies such as that of Zimbabwe can be studied from any perspective, but most importantly through careful examination of cultural elements such as memory, oral history and space, among others. While the book makes special reference to Zimbabwe, it profoundly and audaciously dissect and cut across different geographical and cultural spaces through its penetrating interrogation and scrutiny of different issues commonplace in many African contexts and even beyond. The book, written by scholars from different backgrounds and orientations, should appeal to scholars, researchers and students from various disciplines which include but not limited to Cultural Heritage Studies, Policy Studies, Social-Cultural Anthropology, Sociology, Development Studies and African Studies.
This book is about home. With Malawi as its focus, it seeks to understand ideas about home as expressed through poetry written by Malawians in English. Although African Literatures are studied those of Malawi have not received agreeable attention. This book surveys poetry by five Malawian writers - Felix Mnthali, Frank Chipasula, Jack Mapanje, Lupenga Mphande, and Steve Chimombo. The discussion negotiates scribed experience of exile, engendered by Dr. Banda's regime, and shows that the selected poets effectively converse with a sense of home, reflecting on its transformations in their work. Interrogating the strict definitions of home, the argument highlights that far from home-less exiles in fact clarify the sense of what 'home' is. The manoeuvre is one of thinking towards an unboundaried 'home'. This book will be of value not only to readers interested in the cultures of Africa but to all those with an interest in worldwide literary phenomena, and ideas therein of home and exile.
Elizabeth Stirredge's spiritual autobiography is a treasury of spiritual wisdom which paints all that which is needed to be a faithful servant of the Lord Jesus Christ and how God in His might works, transforms, and supports an ordinary soul to lead the life of extraordinary faithfulness. The text highlights Stirredge's intimate conviction as well as that of early Quakers. This translation is a welcomed venture because this is a central piece, deserving of much more attention than that which has been accorded to it until now.
Faith conversion experiences are first of all personal before being universal. While biblical history records relatively few conversion encounters as dramatic and as explosive as Saint Paul's on the road to Damascus, it is not rare for individuals in the throes of a religious conversion to fall prey to intensely agonizing confusion. That is what happened to Martin Jumbam when he marched for peace in his country alongside the charismatic and irrepressible Emeritus Archbishop of Douala in Cameroon, Christian Cardinal Tumi. He joined the prelate as a secular journalist but went back home more than ever conscious of his state as a fallen Christian, the first step in his journey of faith. Since then, all his writing, be it secular or religious, now bears the fruits of that encounter, characterized by intense empathy for the human person. This book recounts the myriad ways Jumbam's encounters with Christian Cardinal Tumi have activated, nourished and inspired his faith.
This book is an ethnographic study of a group of migrants in Cape Town from Malawi, Zimbabwe and South Africa. It seeks to understand how migrants overcome structural exclusion by forming and maintaining convivial relationships through the Bay Community Church and how this is facilitated by Information and Communication Technologies (ICTs). The book argues that ICTs are implicated in the negotiation of conviviality. ICTs allow for a negotiation of intimacy and distance; although their functions may facilitate more contact than is desired or further distance those already separated physically. This book interrogates the strict division between 'insiders' and 'outsiders' and highlights that migrants are able to sustain multiple networks and relationships, linking their home and host countries. Despite increasingly strict border control and animosity from host communities, migrants are able to overcome imposed identities such as 'outsider'. They do so by using ICTs such as cell phones and Facebook to emphasise their Christian identity, which is one of the main factors for inclusion in church-based networks. Membership with a mixed denominational church such as the Bay further challenges the notion that migrants stick to themselves. Inclusive communities such as the Bay and everyday desires for conviviality evoke the need to reconsider policies too narrowly articulated around the dichotomisation of 'foreigners' and 'nationals', 'home' and 'away', 'us' and 'them'.
Day and Night in Limbo
(2014)
With humour, insight and irony, Lonkog recounts the joys and contradictions of daily life in a Northern Cameroon village. Living in Carrefour Poli in Northern Cameroon was never easy. How far will one have to go for drinking water during the dry season? Will there be money for kerosene to fill the lamp tank? For batteries for the torch? For a bowl of corn to make 'fufu' for the family? Will there be a night encounter with the poison of a snake or scorpion? The man of Carrefour Poli imagines when he last had a bottle of beer and when he will next have another. Children sit in class staring at the teacher, while their work suffers. People sit under trees for shade only to cut them down for firewood. Ministers run up and down, working very hard and sweating, but little changes. Day and night people turn around on the same spot. It takes a long time to build a nation. Everything is in limbo.
Touring Girls
(2014)
Touring Girls tells the story of Jacob Mbuy a young Cameroonian whose primary objective in life is having affairs with as many women as possible. He is obsessed with abusing young girls as well as instilling hopeless hope in adult women. His demise comes when he changes his world from the Christian to the Moslem world where he confronts a new type of women who behave strangely and cannot dance to his tunes. Protected by Islamic traditions and strict government laws, Jacob lands into a hell of unprecedented problems.
Building on Fossungu's earlier works, and essentially providing Africa with original, critical, and multi-level analyses of the trio of globalization, democracy, and national determination, this book theorizes that African states have to unite in order to have any impact in the global economy. Using the failure of the Cameroon Goodwill Association of Montreal (CGAM) as a case study, the book urges Africans to make hard choices and avoid politickerization and midnight politics in favour of fossungupalogy (that is, the science of straightforwardness, necessitating the fearless looking at truth straight in the eye). The questions of the book are many but do all boil down to whether or not Africans fear the truth and do not therefore do politics. It is amazing that Africans in the West live in societies where fierce political competitors do embrace each other after one has defeated the other; but they are incapable of looking their so-called friends in the eye and saying, for example: 'Man, I think you've totally gotten it wrong this time.' Such comportment defines politickerization or negative competition. While attempting some possible responses to the numerous queries it raises, this book basically proffers the science of Four-Eyesism as a discipline that all African schools need to institute and make a compulsory subject: if the vandalized continent would have to be awakened to its realities. This book is rich in Fossungu's dazzling capacity to invent, define and use a multitude of new terminological constructs informed by African experiences.
What does it mean to be marginal? For residents of Cape Town?s Langa Township, being considered marginal is subject to a host of social, physical and sometimes materialistic qualifications ? not least of which is owning a mobile phone. Through various presentations of unique aspects of township life revealed through ethnographic snapshots, this book reveals the complex realities of marginalization experienced by some residents in Langa Township, located in Cape Town, South Africa. Mobile phones have been embraced and accommodated by both local South Africans and African immigrant residents living and working in Langa. Among other things, the technology has become a way of challenging (real and imagined) marginalities within the township in particular and South Africa in general. The book provides empirical data on the role of technology in regards to migration and notions of belonging; specifically the ways that technology has mitigated distance for residents, provided opportunities for development, facilitated the negotiation of various marginalities, and offered new ways of belonging for Langa residents.
Cameroon's Predicaments
(2014)
This book deals with a variety of socio-cultural, economic and political problems facing Cameroon and the rest of Africa, with particular reference to unemployment, corruption, poverty, criminality, violence, insecurity, and moral decadence. It presents a critical analysis of government policies from the colonial era to the present time; arguing that most of these policies have been stalled by an uncommitted leadership. The regime in Cameroon has drifted away from basic managerial and democratic principles in in favour of the ethnicisation of politics, sterile consumption, clientelism and patronage. The book contends that corruption has become the main instrument of governance whereby the political and economic elites control the wealth of the nation at the expense of a majority who wallow in abject poverty and misery. Faced with the difficult economic and political situation, most youth and the intelligentsia have adopted ?official and ?unofficial? means to circumvent all immigration rules to travel to affluent Western countries, the consequences notwithstanding. Brain drain is often the outcome. Further, it examines issues of social exclusion, political representation and marginalization with special focus on the predicament of Anglophone Cameroonians as a socio-cultural community. The inclusion of examples and case studies based on empirical and secondary data from Africa is intended to foreground the importance of comparison, and attract the interest of both academic and non-academic readership.
From his first research there in 1959 until shortly before his death in 2010, Victor Le Vine was a major Cameroon scholar. What he wrote during Cameroon's first half-century of independence carries implications for the years ahead. This volume introduces and presents eight of his short writings, 1961-2007, five never previously published. They demonstrate his mastery of the intricacies and the sweep of the country's governance history, and both his own and Cameroon's importance for African Studies at large.
In Chains for My Country is an account of the struggle of the Southern Cameroons National Council (SCNC), a nonviolent liberation movement, to wrestle British Southern Cameroons from the colonial claws of la République du Cameroun. It is an epic and thrilling account of the life of British Southern Cameroons, which passed from colonial rule to foreign domination through annexation and attempted assimilation into neighbouring la République du Cameroun. Under British trusteeship, British Southern Cameroons graduated to self-government in 1954 with all hopes of independence. Instead, the Trust Territory was doomed to subservience in a contested union with la République du Cameroun. Failure to implement United Nations Resolution 1608 of April 1961 to establish the envisioned federation of two states equal in status facilitated la République du Cameroun's annexation and colonial occupation of a defenseless United Nations Trust as Britain withdrew all its personnel and forces. The territory has been reduced to two provinces of la République du Cameroun under the rule of proconsuls backed by an imperial occupation force with an agenda of nipping in the bud any resistance.
Searching for Bate Besong
(2014)
The future of the country in Searching for Bate Besong is compromised by irresponsible leadership, falsehoods, blind tyranny, waste, and lawlessness. Visionaries like Dockinta (a literary incarnation of Bate Besong, one of Cameroon's most fiery and revolutionary authors) who try to question or expose the status-quo are incarcerated and tortured by the brute forces of dictatorship. It however only needs the strong will and audacity, the messianic self-sacrifice and determination (which are the values Dockinta incarnates), to expose, ridicule and destroy power drunkenness. This play is sine qua non to searching for the collective memory of a community marginalized and subjugated by successive regimes of exploitation and repression. It promises the rediscovery of the dignity and destiny of an active volcano wrongfully rendered docile. The Search will liberate a people who agonized from the whips by the Germans, the hypocrisy of the British, the outright exploitation of the French and the eternal domination of La Republique du Cameroun. The search will culminate in liberating not only Cameroonians, but Africa from corruption, nepotism, tribalism, organized crime, wars and the abuse of basic human rights and freedoms.
The Rising Sun and Boma
(2014)
The Rising Sun and Boma interrogate social evils such as moral decadence, corruption, and greed that are rife in the Cameroonian society. In both plays, Ipah, Paddy, Dinna, and Boma, for example, exemplify how waywardness and avarice can subvert moral integrity. At the same time, the plays problematise the intersection of tradition and modernity, articulating the tension inherent in both visions of life. Although the moral landscape of the drama appears sordid, characters like Abu Ipah and Joseph enkindle hope. Initially performed seventeen years ago, the plays are still as poignant as they are didactic and hilarious as they are refreshing. The characters are credible and compelling partly because of the felicitous language that is anchored in the local imagery.
Before the Rainbow
(2014)
Emmanuel Fru Doh, a native of Cameroon, holds a Ph.D. from the University of Ibadan, Ibadan, Nigeria. He taught at the University of Yaounde (E.N.S. Bambili) for almost a decade-the 90s-before leaving for the US. He then had a brief stint as an Adjunct Professor at the University of Minnesota before settling into the Department of English at Century, a College within the Minnesota State Colleges and Universities (MnSCU) System. Poet, novelist, social and literary critic, Emmanuel Fru Doh is the author of Nomads: The Memoir of a Southern Cameroonian.
Prevalent poverty and related problems in the East African region call for substantial action from various stakeholders, including social workers. This book, based on comprehensive empirical research, portrays an emerging yet powerful profession that has a significant role to play in the endeavour towards social development, social justice, human rights and gender equality. The book is the first of its kind to provide first-hand theoretical and empirical evidence about social work in East Africa.
This book addresses itself to mobilisation and involvement of rural people in development projects. It describes an imperfect but, nonetheless, exciting and thought-provoking exercise that drew social science researchers and students from four public universities in Kenya into an experiment in participatory research, community education and development in two locations. The experiment was grounded on the assumptions that the people of Kenya are a primary resource and that given proper roles and contribution of planners, researchers and programme implementers, self-sustainable development can become a reality. The contributors of this book have focused on the potential of the university to facilitate participation of the people in development. They have given specific suggestions on how this might be accomplished.
African land rights systems
(2014)
This book, from ethical, interdisciplinary, and African perspectives, unveils the root causes of the increasing land disputes. Its significance lies upon the effort of presenting a broad overview founded upon a critical analysis of the existing land-related disputes. It is a perspective that attempts to evaluate the renewed interest in evolving theories of land rights by raising questions that can help us to understand better differences underlying land ownership systems, conflict between customary and statutory land rights systems, and the politics of land reform. Other dimensions explored in the book include the market influence on land-grabbing and challenges accompanying trends of migration, resettlement, and integration. The methodology applied in the study provides a perspective that raises questions intended to identify areas of contention, dispute, and conflict. The study, which could also be categorized as a critical assessment of the African land rights systems, is intended to be a resource for scholars, activists, and organizations working to resolve land-related disputes.
Kpewi Durorp is the third attempt at bringing Durorp into the public domain, and is a more detailed introduction to the language. It contains sixteen chapters which address important elements of grammar, with some including mini bilingual dictionaries, with words organised not alphabetically but thematically, with the singular aim of facilitating learning and easy acquisition of the language. Durorp is an interesting and linguistically distinct semi-Bantu or Bantoid language spoken by a minority group of people known as Bororp or people of the Kororp ethnic group. A part of this ethnic group inhabits the Southwestern part of Cameroon while the other occupies the Southeastern tip of Nigeria. A minority group, Kororp has continued to suffer not only cultural and socio-economic shrinkage but also linguistic marginalisation characterised by an obvious erosion of some key elements of the language. Like any other language, however, Durorp has borrowings from languages such as Efik, Ejagham, and even English. There is a Durorp-English Dictionary to facilitate the development of Durorp vocabulary (Langaa, 2013).
The Clash of the Titans and Other Short Stories is a sundry, marvellous collection of short stories that reflect and capture diverse life experiences. Mabeza and Mawere offer with great dexterousness a snapshot, richness, and practical potentialities of childhood to adulthood experiences in shaping, inspiring and influencing moral rectitude, industriousness and determination. This is an incisive and invigorating exposé steeped in candour and earnestness. For aficionados of creative writing, cognoscenti, students and instructors of English Literature, this is a collection to enjoy and cherish.
Ruminations of Ipome
(2014)
Breadth taking in range of subject explored and profound in depth of emotions evoked, this collection of poems chronicles different shades of emotions resulting from personal loss and love, as well as celebrates and critiques issues of culture, nature, place, people, ethics, and politics. The language is luminous and honed by refreshing and suggestive imagery.
Kids: Africa in Childhood Poetry powerfully conveys the wishful thinking, imaginations, experiences and critical reflections of children as they grow up. The volume grapples with a wide range of topics, sensations, encounters, emotions, imaginations and vistas commonplace in the psyche of many children across different geographical and cultural spaces. While the audacity of Mawere's poetry finds its basis in the poet's profound ability to uncover a multi-layered journey of childhood to adulthood, its merit lies in the character building, psychological, axiological and pedagogical lessons it imparts in today's youths: it teaches the youths the values of moral rectitude, critical observation and thinking, and careful questioning and reflection. This is a collection for all parents, teachers and the youths of between ages 5-18 who cherish a world ruled by peace and unconditional love of all by all.
Tiger in an African palace collects eight essays about kinship and belonging that Richard Fardon wrote to complement his monographs on West Africa. The essays extend those book-length descriptions by pursuing their wider implications for theory in social anthropology: exploring the relationship between comparison and historical reconstruction, and questioning the fit between personal, ethnic and cosmopolitan identities in contemporary West African nations. In an Introduction written specially for this Langaa collection, Richard Fardon retraces the career-long development of his preoccupation with concepts of identification and transformation, and their relevance to understanding West African societies comparatively and historically.
Africa's dynamic security environment is characterized by great diversity - from conventional challenges such as insurgencies, resource and identity conflicts, and post-conflict stabilization to growing threats from piracy, narcotics trafficking, violent extremism, and organized crime taking root in urban slums, among others. This precarious environment jeopardizes security at the societal, community and individual levels. In a globalized and interconnected world, millions of people worldwide are affected by some form of human insecurity. Infectious and parasitic diseases annually kill millions. Internally displaced persons number millions, including 5 million in Sudan alone. In Zambia 1 million people in a population of 11 million are reported to be HIV-positive, a situation much worse in other countries. Potable water crisis looms almost everywhere. In this book Tatah Mentan points out the need to shift the focus away from a state-centric and military-strategic emphasis on security to an interdisciplinary and people-centric approach that embraces notions like global citizenship, empowerment and participation. The primary elements of economic, food, health, environment, personal, community and political security all comprise the broader understanding of human security in an intricately interconnected world.
This prolific collection of essays, with contributions from scholars from across several disciplines, on the practice and implications of naming 'Nomenclatural Poetization and Globalization' explores diverse concerns in onomastics, such as cultural and ethnic implications as well as individual identity formation processes in the age of Globalization and extends these to a variety of contemporary theories of appreciation and internationalization.
In the 1960s and 1970s, Third World governments prescribed and imposed a certain kind of journalism variously called 'objective' journalism or 'development journalism'. They understood this as journalism restricted to reporting 'facts' as dished out by their propagandists and did not tolerate the questioning of government policy. By 'development journalism', they meant the mere reporting of government efforts to provide services, amenities and infrastructures and the singing of praises anytime a bridge was inaugurated, irrespective of whether it was well-built or whether the contract to build was awarded according to the norms of transparency and probity. This one-sided journalism was prevalent especially in state-owned media and media practitioners in the few private news publications that existed who did not toe the line were subjected to constant harassment and incarceration. However, with the coming of well-trained journalism graduates into the scene in the 1970s and the advent of global liberalization in the late 1980s and 1990s, daring journalists like Sam-Nuvala Fonkem thought it was time to take the bull by the horn and start taking a more critical look at government pronouncements, matching policy statements with real action in the field; in short, moving from 'objective' journalism to interpretative and investigative journalism. This collection of Sam-Nuvala Fonkem's writings is a sampling of the fruit of that new spirit to dare where angels hitherto feared to tread, to hold public officials to account and to expose the falsehood cached behind the political masquerade of the ruling class.
On March 8, 2007, one of Cameroon's foremost scholars died in a ghastly traffic accident barely hours after launching his most forthright and acerbic collection of poems: Disgrace: Autobiographical Narcissus. Dr. Bate Besong was a social activist, a critic, troubadour, and playwright; an avant-garde, steeped in the tradition of the absurd, who fought against the corrupt system of governance that transmuted Cameroonians into a comatose and apathetic citizenry neutered by fear engendered by the workings of an existing Gestapo. For the first time, Emmanuel Fru Doh has gone beyond an analysis of Besong's plays into giving an in-depth appraisal of his poems which have, for a long time, held back critics because of their opacity. Doh examines each of Besong's plays and collections of poems in separate sections and succeeds in setting Besong's work in perspective - mindful of their concerns and
God was African
(2014)
When Kendem, a varsity instructor, returns to his native Lewoh countryside where he spent his childhood, he is seeking relief from the complexity of human civilization after attending the Fulbright Institute in the United States. Instead, he is confronted with two seething issues: how to reveal to his sick and troubled mother the situation in which he finds his elder brother, the successor of Mbe Tanju-Ngong's household, who travelled to the United States many years before and had never returned and the dispute over Fuo Beyano's funeral which is tearing the land apart, whether the deceased village chief, should be given a Christian burial or he should, according to the age-old tradition of Lewoh people, go through a ritual to enable him return and continue ruling his people.
In the 1980s, the University of Cape Town s social anthropology department was predominantly oriented by an expos style of critical scholarship. The enemy was the apartheid state, the ethical imperative was clear and a combative metaphor for doing research motivated the department. Andrew David Spiegel, known affectionately as Mugsy by his students and colleagues, has been a central, if understated, figure of this history and helped to frame the theoretical charge of a generation of students looking to counter apartheid from inside . In a series of interviews between the senior professor and one of his students Jessica Dickson Spiegel offers a unique perspective from the centre of anthropology s recent history in South Africa.
Divining the Future of Africa : Healing the Wounds, Restoring Dignity and Fostering Development
(2014)
This book explores the relationship between Africa, the West and China. It notes that while Africa is a continent of diverse cultures, raw materials, human resource, indigenous knowledges, and above all the biggest recipient of foreign aid globally, it continues to lag behind all regions of the world in terms of socio-economic development. The book grapples with the important question on why this has been the case. It provides crucial critical insights on how Africa's situation could be reversed and the tapestry of its socio-economic problems eased. The book draws a link between culture, globalisation and socio-economic development, breaking new grounds in the discourse on development in post-colonial Africa. This is an incisive clarion call to bypass the outlandish claims and sterile discussions on the parodying of Africa by Euro-centric scholars. It is a contribution on the imperative to re-think the future of development in Africa. It makes a compelling argument by self-reliant development processes in which Africans reclaim their voice, independence and autonomy unapologetically. The book provides some grist for the mills of policy makers, institutional planners, practitioners and students of anthropology, political studies, sociology, economic history, local governance, cultural economics, and gender, development, African, heritage and international studies.