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Medizinstudenten sind im Rahmen ihrer klinischen Ausbildung einer erhöhten Infektionsgefährdung ausgesetzt. Dessen ungeachtet sind die Impfraten der Medizinstudenten ungenügend. Ein adäquater Impfstatus der Medizinstudenten vor Beginn ihres klinischen Ausbildungsabschnitts ist jedoch wichtig, um nosokomiale Infektionen zu vermeiden.
Im April und Mai 2007 wurden insgesamt 366 Serumproben von Medizinstudenten des ersten klinischen Semesters ausgewertet. Die serologischen Untersuchungen erfolgten mittels etablierter ELISA-Systeme. Untersucht wurde auf spezifische Antikörper gegen Masern, Mumps, Röteln, Varizellen, Hepatitis B (HBV), Hepatitis C (HCV) und HIV.
Insgesamt 63,9% (n=234) der Studenten waren gegen Hepatitis B geimpft (Grundimmunisierung, drei Impfdosen). Dagegen hatten 31,7% (n=116) der Studenten bisher noch keine Hepatitis B-Impfung und 4,4% (n=16) kein komplettes Impfschema erhalten (<drei Impfungen). Zwei Studenten zeigten serologische Marker einer abgelaufenen HBV-Infektion. Es wurde die Erstdiagnose einer HCV-Infektion sowie die Erstdiagnose einer HIV-Infektion gestellt. Bei 7,9% (Masern), 17,5% (Mumps), 6,5% (Röteln) und 2,2% (Varizellen) der Studenten konnten keine virusspezifischen Antikörper nachgewiesen werden.
Es sollten weitere Anstrengungen unternommen werden, um die Impfraten der Medizinstudenten zu verbessern. Es ist wichtig, Immunitätslücken zu identifizieren und vor dem ersten Patientenkontakt zu schließen. Im Hinblick auf die Erstdiagnose und die Folgen schwerwiegender blutübertragbarer Erkrankungen (z.B. HBV, HCV und HIV) sollten Medizinstudenten auf diese Infektionen untersucht werden.
Channelrhodopsin-2, or ChR2, is a light-gated inward rectifying cation channel. Ever since its first characterisation (Nagel et al., 2003), it has been used extensively in the light-activated control of neural cells in culture as well as in living animals like mice, Caenorhabditis elegans and Drosophila melanagaster. Despite its broad application in the field of neuroscience, little is known about the properties of this ion channel. The aim of this thesis is to elucidate the single channel conductance under different conditions using stationary noise analysis on whole cell recordings of a HEK293 cell line that stably expresses the truncated ChR2 (amino acids 1-315), which behaves identically to the full length protein (Nagel et al., 2003). Stationary noise analysis is based on the fact that the ion channel noise due their opening and closing has a characteristic form of a plateau at low frequency points and a following decrease of power with 1/f² in difference power spectra, which are composed of the difference of fast Fourier transformed (FFT) stationary whole-cell recordings with and without illumination. From the parameters yielded by an approximation of the power spectra with a Lorentzian function the single channel conductance can be estimated. The single channel conductance of ChR2 was determined at -60 mV applied for different cations, yielding values of 91 ± 25 fS (Guanidine+), 42 ± 7 fS (Na+), 61 ± 18 fS (Li+) and 37 ± 14 fS (Methylammonium+). With 200 mM Guanidine+ outside of the cells and measurements between 0 mV and -60 mV applied, it could be shown that the inward rectification is still present on the scale of the single channel. Noise Analysis with concentrations between 40 and 200 mM Guanidine+ showed a saturation of the single channel conductance with high Guanidine+ concentrations with a maximal conduction of 129 ± 9 fS (Michaelis Menten approximation: Km = 82 ± 14 mM). Activation Energies of the rate constants k (2πfc, with fc = corner frequency of the Lorentzian function) and koff (1/τoff, with τoff = closing time of the channel at -60 mV) were determined to be 75 ± 23 kJ/mol and 64 ± 11 kJ/mol, respectively, which are similar to the value determined for the Channelrhodopsin-1 closing times (~60 kJ/mol; Nagel et al., 2002). The activation energy of the ChR2 single channel conductance was determined to be 21.2 ± 20.8 kJ/mol, which also is similar to the activation energy of the ChR1 current amplitude (20 kJ/mol; Nagel et al., 2002). The amount of active ChR2 channels in the membrane (160,000 or 226 ChR2/μm²) as well as the single channel current (-7.5 ± 0.6 fA) could be determined by variation of the light intensity (0.05 mW mm-2 to 5.3 mW mm-2). In the course of this thesis, the single channel parameters of the ChR2 mutant H134R were also determined. H134R had been previously published as a “gainof- function” mutant (Nagel et al., 2005a). The increased macroscopic current amplitude of H134R could be explained by an increased lifetime of the channel in comparison to the wildtype ChR2. Within the margin of error both single channel conductances in the presence of 200 mM Guanidine+ of the wildtype (91.1 ± 24.9 fS) and the H134R (89.4 ± 30.7 fS) are the same. In the presence of 200 mM Lithium+ values of 60.6 ± 17.8 fS for the wildtype ChR2 and 50.8 ± 9.6 fS for the H134R mutant were determined. This thesis marks the first in depth analysis of the single channel conductance of ChR2. Using stationary noise analysis the single channel conductance of Channelrhodopsin-1 as well as interesting Channelrhodopsin-2 mutants can also be analysed in the future.
U radu se analizira latinski sintaktički utjecaj pri uporabi zamjenica u Marulićevu i Kašićevu prijevodu popularnoga srednjovjekovnog djela De imitatione Christi. Istražuju se ova sintaktička svojstava zamjenica: izricanje pripadanja 3. licu s pomoću genitiva ličnih zamjenica za 3. lice, uporaba posvojne zamjenice za 1. i 2. lice u odnosu na povratno-posvojnu zamjenicu svoj, uporaba povratno-posvojne zamjenice svoj u odnosu na posvojne za 3. lice, uporaba lične zamjenice za 1. i 2. lice u odnosu na povratnu zamjenicu, uporaba odnosnih zamjenica na početku rečenice te množina srednjega roda pokaznih, relativne (koji) i neodređenih (sav, svaki) zamjenica u značenju jednine. Na temelju promatranih kategorija autorice nastoje utvrditi sličnosti i razlike tih dvaju proznih prijevodnih tekstova te objasniti prevoditeljski postupak.
Ključne riječi: De imitatione Christi ; Marko Marulić ; Bartol Kašić ; uporaba zamjenica ; sintaktičke prevedenice
U radu se opisuju sintaktičke funkcije participa prezenta aktivnog i participa preterita aktivnog I. u Katančićevu prijevodu Svetoga pisma (1831.). Posebno se istražuje participska konstrukcija apsolutni nominativ (particip u nominativu + ime u nominativu) te se utvrđuju njezine sintaktičke funkcije.
Background: The standard electrode array for the MED-EL MAESTRO cochlear implant system is 31 mm in length which allows an insertion angle of approximately 720°. When fully inserted, this long electrode array is capable of stimulating the most apical region of the cochlea. No investigation has explored Electrically Evoked Compound Action Potential (ECAP) recordings in this region with a large number of subjects using a commercially available cochlear implant system. The aim of this study is to determine if certain properties of ECAP recordings vary, depending on the stimulation site in the cochlea. Methods: Recordings of auditory nerve responses were conducted in 67 subjects to demonstrate the feasibility of ECAP recordings using the Auditory Nerve Response Telemetry (ART™) feature of the MED-EL MAESTRO system software. These recordings were then analyzed based on the site of cochlear stimulation defined as basal, middle and apical to determine if the amplitude, threshold and slope of the amplitude growth function and the refractory time differs depending on the region of stimulation. Results: Findings show significant differences in the ECAP recordings depending on the stimulation site. Comparing the apical with the basal region, on average higher amplitudes, lower thresholds and steeper slopes of the amplitude growth function have been observed. The refractory time shows an overall dependence on cochlear region; however post-hoc tests showed no significant effect between individual regions. Conclusions :Obtaining ECAP recordings is also possible in the most apical region of the cochlea. However, differences can be observed depending on the region of the cochlea stimulated. Specifically, significant higher ECAP amplitude, lower thresholds and steeper amplitude growth function slopes have been observed in the apical region. These differences could be explained by the location of the stimulating electrode with respect to the neural tissue in the cochlea, a higher density, or an increased neural survival rate of neural tissue in the apex. Trial registration: The Clinical Investigation has the Competent Authority registration number DE/CA126/AP4/3332/18/05.
Unter der Abkürzung SZfG verbirgt sich die Slowakische Zeitschrift für Germanistik, die vom Verband der Deutschlehrer und Germanisten der Slowakei herausgegeben wird. Die Zeitschrift entstand 2009 und bietet Germanisten aus aller Welt die Möglichkeit, ihre linguistischen und literaturwissenschaftlichen Beiträge zu veröffentlichen.
Unter der Abkürzung SZfG verbirgt sich die Slowakische Zeitschrift für Germanistik, die vom Verband der Deutschlehrer und Germanisten der Slowakei herausgegeben wird. Die Zeitschrift entstand 2009 und bietet Germanisten aus aller Welt die Möglichkeit, ihre linguistischen und literaturwissenschaftlichen Beiträge zu veröffentlichen.
Nach einem Umbau des Redaktionsrates und einer gründlichen Überarbeitung des inhaltlichen Konzepts sowie des äußeren Erscheinungsbildes der früheren Zeitschrift für germanistische Sprach- und Literaturwissenschaft der Slowakei freut sich der Vorstand des Verbandes der Deutschlehrer und Germanisten der Slowakei (SUNG) Ihnen die zweite Nummer einer neuen Folge der slowakischen germanistischen Fachzeitschrift vorlegen zu können.
Unter dem neuen Titel Slowakische Zeitschrift für Germanistik bietet der Verband den slowakischen Germanisten, deren Forschungsinteressen er auch vertreten will, eine geeignete Plattform für produktive fachliche Auseinandersetzung und einen Ort für wissenschaftliche Begegnungen, der Anregungen zu eigenen Erkundungen geben und originelle Zugänge zu aktuellen Forschungsthemen motivieren kann. Die Zeitschrift möchte an alles Positive in den langjährigen Bemühungen um ein fachgermanistisches Forum in der Slowakei anknüpfen und die germanistische Zeitschriftenlandschaft bereichern. Wir hoffen auf einen Neustart dieses Periodikums, vor allem auf das Interesse einer breiten Leserschaft und auf positive Resonanz, die zur Intensivierung des wissenschaftlichen Austauschs beitragen soll.
According to the metalexicographical theory, there are three main components in a semasiological dictionary: macro-, micro- and middles structure. The aim of this article is to describe and analyze the microstructure of three general semasiological dictionaries of the German language. As methodological framework, it takes in account the distinction between formal and semantic comment and between definition and density of the constant information program.