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Each lifecycle of the Hepatitis C virus (HCV) produces structural and non-structural (NS) proteins in equimolar. Structural proteins were either assembled or degraded by host proteolysis systems, while NS proteins remain inside the host cells and don’t accumulate. Therefore, they must be degraded. Here, NS3 and NS5A half-lives were quantified in the presence of autolysosome and proteasome different modulators. Inhibitors of both systems increased the half-life, while inducers decreased the half-life. Furthermore, polyubiquitination of NS3 and NS5A was observed. Additionally, their intracellular co-localization with autolysosome (LAMP2) and proteasome (PSMB5) was observed, and inhibitors of both systems increased the degree of co-localization. A better understanding of NS protein degradation might help to improve medical interventions during HCV infections in the future.
Tropical Bryology was introduced in 1989 by Jan-Peter Frahm and Robbert Gradstein (who later became the first scientific editor) to provide scientists a platform to present bryological research concerning the tropics. Besides encouraging tropical bryology the journal wants to promote researchers from the tropics. Being the first fully computer-produced cryptogamic journal it was also the first to provide electronic versions of the published volumes.
The subtitle "An International Journal on the Biology of Tropical Bryophytes and Lichens" was added with publication of volume 5 (1992).
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