Refine
Year of publication
Document Type
- Article (150)
- Preprint (38)
- Conference Proceeding (4)
Language
- English (192) (remove)
Has Fulltext
- yes (192)
Is part of the Bibliography
- no (192)
Keywords
- LHC (7)
- breast cancer (7)
- Mammakarzinom (6)
- Behandlung (4)
- Breast cancer (4)
- Metastasen (4)
- ALICE (3)
- ALICE experiment (3)
- CDK4/6 (3)
- Hadron-Hadron Scattering (3)
- PD1/PDL1 (3)
- Prävention (3)
- Studien (3)
- pp collisions (3)
- prevention (3)
- treatment (3)
- Beauty production (2)
- HNSCC (2)
- Head and neck cancer (2)
- Machine learning (2)
- Risiko (2)
- Single electrons (2)
- Surgery (2)
- lapatinib (2)
- metastases (2)
- metastatic (2)
- neoadjuvant therapy (2)
- risk (2)
- trastuzumab (2)
- trials (2)
- 900 GeV (1)
- ATXN2 (1)
- Active middle ear implants (1)
- Advanced breast cancer (1)
- Alpelisib (1)
- Amyotrophic lateral sclerosis (1)
- Antihormone therapy (1)
- Arteria ophthalmica (1)
- Artificial Intelligence (1)
- Atezolizumab (1)
- Atoms (1)
- Auditory system (1)
- B cell malignancies (1)
- BCOR (1)
- BCORL1 (1)
- Bibliometrics (1)
- Biodiversity Data (1)
- Biomarker (1)
- Biomonitoring (1)
- Bipolar disorder (1)
- Blindness (1)
- Bone conduction devices (1)
- Bone metastases (1)
- Botanical Collections (1)
- Brain metastasis (1)
- Business strategy in drug development (1)
- C3M (1)
- C4M (1)
- CD74 (1)
- COVID (1)
- COVID-19 (1)
- CUP (1)
- CVID (1)
- Cancer of unknown primary (1)
- Capecitabine (1)
- Cell membranes (1)
- Cellular microbiology (1)
- Cellular stress (1)
- Central nervous system metastases (1)
- Cervical (1)
- Charm physics (1)
- Chemical biology (1)
- Chemical ecology (1)
- Citation analysis (1)
- Clinical Trials and Observations (1)
- Compact astrophysical objects (1)
- Comparison with QCD (1)
- Completed suicide (1)
- Consensus statement (1)
- Conservation (1)
- Cryoelectron microscopy (1)
- Cryoelectron tomography (1)
- DNA repair (1)
- Diagnostic markers (1)
- Diagnostik (1)
- Digital breast tomosynthesis (DBT) (1)
- Digital mammography (1)
- Digitization (1)
- Drug therapy (1)
- EBV (1)
- Endocrinology (1)
- Environmental chemistry (1)
- Epilepsy (1)
- European Society for Immunodeficiencies (ESID) (1)
- Exosomes (1)
- Extended donor criteria (1)
- FDG-PET/CT (1)
- Femtoscopy (1)
- Filler (1)
- First site of metastatic disease (1)
- Früherkennung (1)
- Galaktografie (1)
- Galaktomosynthese (1)
- Galaxies and clusters (1)
- Gene regulation (1)
- German PID-NET registry (1)
- Glabella (1)
- Global protein synthesis rates (1)
- Guanine nucleotide exchange factors (1)
- Guanosine triphosphatase (1)
- HBT (1)
- HER2 c-erbB2 (1)
- HER2-positive (1)
- HER2/neu (1)
- HLA class II (1)
- HLA peptidome (1)
- Hadron production (1)
- Head neck cancer (1)
- Health policy (1)
- Heavy Ions (1)
- Heavy flavor production (1)
- Heavy flavour production (1)
- Heavy ions (1)
- Heavy-flavour production (1)
- Heavy-ion collisions (1)
- Herbaria (1)
- Heregulin (1)
- High-energy astrophysics (1)
- Iceland (1)
- IgG substitution therapy (1)
- Immunophenotyping (1)
- Immunotherapy (1)
- Inclusive spectra (1)
- Induction therapy (1)
- Intensity interferometry (1)
- Ions (1)
- Isoflurane (1)
- Jets (1)
- KCGS (1)
- Katherine (1)
- Kidney diseases (1)
- LTER (1)
- LTP (1)
- Library screening (1)
- Loco-regional control (1)
- Lokalrezidiv (1)
- Long‐term ecosystem research (1)
- Luciferase (1)
- Lymph node (1)
- Lymphocyte subpopulations (1)
- MM-121 (1)
- MRI (1)
- MRT (1)
- Mamma (1)
- Metastatic (1)
- Metastatic breast cancer (1)
- MicroRNAs (1)
- Mid-rapidity (1)
- Mixed hearing loss (1)
- Molecular subtypes (1)
- Monte Carlo simulations (1)
- Multi-stakeholder approach (1)
- Multi-strange baryons (1)
- Multienzyme complexes (1)
- Myeloid Neoplasia (1)
- NK cell subsets (1)
- NPH insulin (1)
- Nachsorge (1)
- Nanoscale materials (1)
- Neoadjuvant therapy (1)
- Nuclear modification factor (1)
- Occlusion (1)
- Ophthalmoplegia (1)
- Organ allocation (1)
- PARP (1)
- PD1/ PDL1 (1)
- PD‑L1 (1)
- PELICAN (1)
- PI3K (1)
- PID prevalence (1)
- PYTHIA (1)
- Paediatrics (1)
- Pancreas transplantation (1)
- Pandemic (1)
- Pathological complete response (1)
- Patterns of care (1)
- Pb–Pb (1)
- Pegylated liposomal doxorubicin (1)
- Perturbative methods (1)
- Phosphorylation (1)
- Population-based screening (1)
- Prediction of locoregional recurrence (1)
- Prognosefaktoren (1)
- Proton–proton (1)
- Prädiktivfaktoren (1)
- RNA processing (1)
- Radiochemotherapy (1)
- Radiomics (1)
- Radiotherapy (1)
- Recall rate (1)
- Red blood cell transfusion (1)
- Rehabilitation (1)
- Rejection (1)
- Relativistic heavy ion physics (1)
- Research Infrastructure (1)
- Research infrastructure (1)
- Retinal diseases (1)
- Ribosomal S6 phosphorylation (1)
- Ribosomal translation (1)
- Richtlinie (1)
- SARS-CoV2 (1)
- SCCHN (1)
- Salivary gland carcinoma (1)
- Scattering of atoms, molecules, clusters & ions (1)
- Scattering theory (1)
- Scientific publishing (1)
- Scientists (1)
- Semantics (1)
- Seribantumab (1)
- Single muons (1)
- Site networks (1)
- Small molecules (1)
- Spinocerebellar ataxia (1)
- Status epilepticus (1)
- Stem-cell therapies (1)
- Suicide attempt (1)
- Supportivtherapie (1)
- T-DM1 (1)
- TGFB-induced factor homeobox 1 (1)
- TGIF (1)
- Taxonomy (1)
- Technical data (1)
- Tomosynthese (1)
- Transverse momentum (1)
- Triple negative (1)
- Tumor heterogeneity (1)
- Tumor infiltrating lymphocytes (1)
- Type 2 diabetes (1)
- T‑DM1 (1)
- Ultraschall (1)
- Validation (1)
- Vesicles (1)
- accident (1)
- acute myeloid leukemia (1)
- adjuvant therapy (1)
- adjuvante Therapie (1)
- advanced (1)
- advanced breast cancer (1)
- aging (1)
- alpelisib (1)
- amblyopia (1)
- amyloid precursor protein (1)
- anaemia (1)
- anterior chamber depth changes (1)
- antibiotic therapy (1)
- antihormone therapy (1)
- archeological modeling (1)
- artificial magnetic lattices (1)
- ascites (1)
- atezolizumab (1)
- basal insulin (1)
- biomarker (1)
- breast (1)
- cataract surgery (1)
- chemogenomic set (1)
- chemotherapy (1)
- chloroplast membrane proteins (1)
- circadian variation (1)
- collagen degradation marker (1)
- continuous glucose monitoring (1)
- diabetes (1)
- diabetic macular edema (1)
- diagnosis (1)
- diclofenac (1)
- diffusion-weighted magnetic resonance imaging (1)
- drug discovery (1)
- druggable genome (1)
- early breast cancer (1)
- effective lens position (1)
- elderly patients (1)
- envelope membrane proteome approach comparison (1)
- everolimus (1)
- fluocinolone acetonide (1)
- focused electron beam induced deposition (1)
- follow‑up (1)
- fortgeschritten (1)
- frühes Mammakarzinom (1)
- galactography (1)
- galactomosynthesis (1)
- gene signature (1)
- guideline (1)
- head and neck squamous cell carcinoma (1)
- heavy ions (1)
- hippocampus (1)
- human–environment interaction (1)
- hypoglycaemia (1)
- image-based risk modelling (1)
- injury (1)
- iron deficiency (1)
- kinase inhibitor (1)
- liver cirrhosis (1)
- local recurrence (1)
- lockdown (1)
- loss-of-function (1)
- machine learning (1)
- magnetic nanostructures (1)
- mass spectrometry (1)
- membrane proteome (1)
- meta-analysis (1)
- metastasis (1)
- metastatic renal cell carcinoma (1)
- metformin (1)
- micro-Hall magnetometry (1)
- microdosimetry (1)
- microdosing (1)
- micromagnetic simulations (1)
- mitochondria (1)
- multidrug resistance (1)
- multiplexed immunofluorescence (1)
- nanolesions (1)
- neoadjuvant chemoradiotherapy (1)
- neoadjuvante Therapie (1)
- open science (1)
- oral cavity cancer (1)
- oral enzyme combination (1)
- osteoarthritis (1)
- paleoclimate modeling (1)
- paleoenvironment modeling (1)
- paleoenvironment reconstruction (1)
- patient blood management (1)
- pediatric eye screening (1)
- pediatric intensive care (1)
- personalised therapy (1)
- pertuzumab (1)
- phase IV (1)
- phenotypic screening (1)
- plant proteomics (1)
- postoperative radiochemotherapy (1)
- postoperative radiotherapy (1)
- predictive biomarker (1)
- predictive factors (1)
- pregnancy (1)
- preoperative anaemia management (1)
- preschool health examination (1)
- presynaptic active zone (1)
- primary immunodeficiency (PID) (1)
- prognostic factors (1)
- propensity score matching (1)
- protein kinase (1)
- pseudoexfoliative syndrome (1)
- radiation oncology (1)
- radiation-induced nanostructures (1)
- radiomic (1)
- randomized controlled trial (1)
- rat (1)
- registry for primary immunodeficiency (1)
- risk stratification (1)
- screening (1)
- screening routine (1)
- second-line (1)
- small molecules (1)
- spectra (1)
- studies (1)
- supportive therapy (1)
- surgery (1)
- survival (1)
- tomosynthesis (1)
- trauma (1)
- treatment/therapy (1)
- ultrasound (1)
- understudied kinase (1)
- √sN N = 2.76 TeV (1)
Institute
- Physik (93)
- Medizin (71)
- Frankfurt Institute for Advanced Studies (FIAS) (70)
- Informatik (69)
- Geowissenschaften (11)
- Biowissenschaften (9)
- Biochemie und Chemie (7)
- Pharmazie (3)
- ELEMENTS (2)
- Exzellenzcluster Makromolekulare Komplexe (2)
Filamentous enzymes have been found in all domains of life, but the advantage of filamentation is often elusive1. Some anaerobic, autotrophic bacteria have an unusual filamentous enzyme for CO2 fixation—hydrogen-dependent CO2 reductase (HDCR)2,3—which directly converts H2 and CO2 into formic acid. HDCR reduces CO2 with a higher activity than any other known biological or chemical catalyst4,5, and it has therefore gained considerable interest in two areas of global relevance: hydrogen storage and combating climate change by capturing atmospheric CO2. However, the mechanistic basis of the high catalytic turnover rate of HDCR has remained unknown. Here we use cryo-electron microscopy to reveal the structure of a short HDCR filament from the acetogenic bacterium Thermoanaerobacter kivui. The minimum repeating unit is a hexamer that consists of a formate dehydrogenase (FdhF) and two hydrogenases (HydA2) bound around a central core of hydrogenase Fe-S subunits, one HycB3 and two HycB4. These small bacterial polyferredoxin-like proteins oligomerize through their C-terminal helices to form the backbone of the filament. By combining structure-directed mutagenesis with enzymatic analysis, we show that filamentation and rapid electron transfer through the filament enhance the activity of HDCR. To investigate the structure of HDCR in situ, we imaged T. kivui cells with cryo-electron tomography and found that HDCR filaments bundle into large ring-shaped superstructures attached to the plasma membrane. This supramolecular organization may further enhance the stability and connectivity of HDCR to form a specialized metabolic subcompartment within the cell.
This paper introduces a new methodology for the fabrication of strain-sensor elements for MEMS and NEMS applications based on the tunneling effect in nano-granular metals. The strain-sensor elements are prepared by the maskless lithography technique of focused electron-beam-induced deposition (FEBID) employing the precursor trimethylmethylcyclopentadienyl platinum [MeCpPt(Me)3]. We use a cantilever-based deflection technique to determine the sensitivity (gauge factor) of the sensor element. We find that its sensitivity depends on the electrical conductivity and can be continuously tuned, either by the thickness of the deposit or by electron-beam irradiation leading to a distinct maximum in the sensitivity. This maximum finds a theoretical rationale in recent advances in the understanding of electronic charge transport in nano-granular metals.