Refine
Year of publication
Has Fulltext
- yes (15)
Is part of the Bibliography
- no (15)
Keywords
- Lewald, Fanny (2)
- Schriftstellerin (2)
- Ausstellungskatalog (1)
- Birch-Pfeiffer, Charlotte (1)
- Brain tumors (1)
- Brief (1)
- CVID (1)
- Cancer (1)
- Children and adolescents (1)
- Electron-pion identification (1)
Institute
- Medizin (4)
- Frankfurt Institute for Advanced Studies (FIAS) (3)
- Informatik (3)
- Physik (3)
Ophthalmo-acromelic syndrome (OAS), also known as Waardenburg Anophthalmia syndrome, is defined by the combination of eye malformations, most commonly bilateral anophthalmia, with post-axial oligosyndactyly. Homozygosity mapping and subsequent targeted mutation analysis of a locus on 14q24.2 identified homozygous mutations in SMOC1 (SPARC-related modular calcium binding 1) in eight unrelated families. Four of these mutations are nonsense, two frame-shift, and two missense. The missense mutations are both in the second Thyroglobulin Type-1 (Tg1) domain of the protein. The orthologous gene in the mouse, Smoc1, shows site- and stage-specific expression during eye, limb, craniofacial, and somite development. We also report a targeted pre-conditional gene-trap mutation of Smoc1 (Smoc1tm1a) that reduces mRNA to ~10% of wild-type levels. This gene-trap results in highly penetrant hindlimb post-axial oligosyndactyly in homozygous mutant animals (Smoc1tm1a/tm1a). Eye malformations, most commonly coloboma, and cleft palate occur in a significant proportion of Smoc1tm1a/tm1a embryos and pups. Thus partial loss of Smoc-1 results in a convincing phenocopy of the human disease. SMOC-1 is one of the two mammalian paralogs of Drosophila Pentagone, an inhibitor of decapentaplegic. The orthologous gene in Xenopus laevis, Smoc-1, also functions as a Bone Morphogenic Protein (BMP) antagonist in early embryogenesis. Loss of BMP antagonism during mammalian development provides a plausible explanation for both the limb and eye phenotype in humans and mice.
[Rezension zu:] Vanessa van Ornam: Fanny Lewald And Nineteenth-Century Constructions of Feminity
(2004)
Rezension zu: Vanessa van Ornam: Fanny Lewald And Nineteenth-Century Constructions of Feminity. New York, Washington, D.C./Baltimore, Bern, Frankfurt am Main, Berlin, Brüssel, Wien, Oxford: Peter Lang, 2002 (North American Studies in Nineteenth-Century German Literature, hrsg. v. Jeffrey L. Sammons, Bd. 29).
Zwischen 1843 und 1888 veröffentlichte Fanny Lewald 24 teils mehrbändige Romane, 27 Bände Novellen und Erzählungen, eine sechsbändige Autobiographie, fünf Reisetagebücher, zahlreiche Feuilletons, Erinnerungen an bekannte Persönlichkeiten, frauenemanzipatorische Schriften und soziale Appelle in Zeitungen und Zeitschriften - ein umfangreiches Werk. Über den Zeitraum von annähernd einem halben Jahrhundert spiegeln ihre Schriften die wechselvolle deutsche Geschichte wider - Vormärz, Märzrevolution 1848, Restauration, Reichseinigung, Kaiserreich - ebenso wie die Geschichte der deutschen Literatur von jungdeutscher Tendenz- und Reflexionsliteratur bis hin zum poetischen Realismus und Naturalismus. Denn mit zahlreichen romantheoretischen Äußerungen, die sich sowohl in ihren Prosawerken wie in Briefen und anderen nichtfiktiven Schriften finden lassen, macht Fanny Lewald wie wenige andere Autorinnen des Vormärz ihren poetologischen Standpunkt deutlich. Früh- und Spätwerk der Autorin sind, bezogen auf ihr erzählerisches Konzept und die Gestaltungsweise, sehr unterschiedlich. Doch in einem Punkt bleibt sich Fanny Lewald treu - ihre Prosa bleibt lebensnah, zeitlebens favorisiert sie den sozialen und psychologischen Roman.
Objective: To evaluate prognostic factors in pediatric patients with gonadal germ cell tumors (GCT). Methods: Patients <18 years with ovarian and testicular GCT (respectively OGCT and TGCT) were prospectively registered according to the guidelines of MAKEI 96. After resection of the primary tumor, patients staged ≥II received risk-stratified cisplatin-based combination chemotherapy. Patients were analyzed in respect to age (six age groups divided into 3-year intervals), histology, stage, and therapy. The primary end point was overall survival. Results: Between January 1996 and March 2016, the following patients were registered: 1047 OGCT, of those, 630 had ovarian teratoma (OTER) and 417 had malignant OGCT (MOGCT); and 418 TGCT, of those, 106 had testicular teratoma (TTER) and 312 had malignant TGCT (MTGCT). Only in MTGCT, older age correlated with a higher proportion of advanced tumors. All 736 teratomas and 240/415 stage I malignant gonadal GCT underwent surgery and close observation alone. In case of watchful waiting, the progression rate of OGCT was higher than that of TGCT. However, death from disease was reported in 8/417 (1.9%) MOGCT and 8/312 (2.6%) MTGCT irrespective of adjuvant chemotherapy and repeated surgery. Conclusions: The different pathogenesis and histogenesis of gonadal GCT reflects sex- and age-specific patterns that define clinically relevant risk groups. Therefore, gender and age should be considered in further research on the biology and clinical practice of pediatric gonadal GCT.