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Shared mechanism underlying unembedded and embedded enrichments:
evidence from enrichment priming
(2018)
In this paper, we use a priming paradigm to explore the mechanisms underlying unembedded and embedded scalar enrichments. In particular, the aim is to see if local pragmatic enrichment could be a shared mechanism, involved in both. The two experiments presented adopt Bott & Chemla's (2016) enrichment priming paradigm and test whether unembedded and embedded enrichments could prime each other. The goal is to investigate whether local pragmatic enrichment is indeed being accessed for the interpretation of the unembedded scalar and whether local enrichments, like other lexical semantic phenomena, are susceptible to priming.
The prevalence and specificity of local protein synthesis during neuronal synaptic plasticity
(2021)
To supply proteins to their vast volume, neurons localize mRNAs and ribosomes in dendrites and axons. While local protein synthesis is required for synaptic plasticity, the abundance and distribution of ribosomes and nascent proteins near synapses remain elusive. Here, we quantified the occurrence of local translation and visualized the range of synapses supplied by nascent proteins during basal and plastic conditions. We detected dendritic ribosomes and nascent proteins at single-molecule resolution using DNA-PAINT and metabolic labeling. Both ribosomes and nascent proteins positively correlated with synapse density. Ribosomes were detected at ~85% of synapses with ~2 translational sites per synapse; ~50% of the nascent protein was detected near synapses. The amount of locally synthesized protein detected at a synapse correlated with its spontaneous Ca2+ activity. A multifold increase in synaptic nascent protein was evident following both local and global plasticity at respective scales, albeit with substantial heterogeneity between neighboring synapses.