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Passionsspiel und geistliche Malerei als Instrumente der Judenhetze in Frankfurt am Main um 1500
(1984)
Von Ahasver, dem ‚Ewigen Juden’ wird schon im Druck von 1602 erzählt, er habe, nachdem er von Christus zur ewigen Wanderschaft verdammt worden war, die Stadt Jerusalem verlassen und durch alle Teile der Welt wandern müssen. Als er nach Jahrhunderten wieder in das Heilige Land gekommen sei, habe er das Land verwüstet und Jerusalem so vollständig zerstört vorgefunden, dass er es nicht mehr erkannt habe. Mit dieser Bemerkung signalisiert der Autor des kleinen, aber überaus wirkungsmächtigen Traktats den Lesern, dass damit mehr gemeint ist als nur eine Episode auf der Wanderschaft Ahasvers. [...]
Low serum concentrations of the amino acid homoarginine (HA) are associated with increased cardiovascular mortality by incompletely understood mechanisms. This study sought to assess the influence of HA on cardiac remodeling in rats undergoing either transaortic banding or inhibition of nitric oxide synthesis by Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME). Male Wistar rats (n = 136) underwent sham operation (SH) or aortic banding (AB). Both groups were equally divided into 14 subgroups, receiving different doses of HA alone or in combination with lisinopril, spironolactone, or L-NAME for 4 weeks. HA treatment in AB animals resulted in a dose-dependent improvement of cardiac function up to a concentration of 800 mg·kg−1·day−1. Combining 800 mg·kg−1·day−1 HA with spironolactone or lisinopril yielded additional effects, showing a positive correlation with LV ejection fraction (+33%, p = 0.0002) and fractional shortening (+41%, p = 0.0014). An inverse association was observed with collagen area fraction (−41%, p < 0.0001), myocyte cross-sectional area (−22%, p < 0.0001) and the molecular markers atrial natriuretic factor (−74%, p = 0.0091), brain natriuretic peptide (−42%, p = 0.0298), beta-myosin heavy chain (−46%, p = 0.0411), and collagen type V alpha 1 chain (−73%, p = 0.0257) compared to placebo-treated AB animals. Co-administration of HA and L-NAME was found to attenuate cardiac remodeling and prevent NO-deficient hypertension following AB. HA treatment has led to a dose-dependent improvement of myocardial function and marked histological and molecular changes in cardiac remodeling following AB. Combining HA with standard heart failure medication resulted in additional beneficial effects boosting its direct impact on heart failure pathophysiology.