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The transverse momentum (pT) dependence of the nuclear modification factor RAA and the centrality dependence of the average transverse momentum ⟨pT⟩ for inclusive J/ψ have been measured with ALICE for Pb-Pb collisions at sNN−−−√ = 2.76 TeV in the e+e− decay channel at mid-rapidity (|y|<0.8). The ⟨pT⟩ is significantly smaller than the one observed for pp collisions at the same centre-of-mass energy. Consistently, an increase of RAA is observed towards low pT. These observations might be indicative of a sizable contribution of charm quark coalescence to the J/ψ production. Additionally, the fraction of non-prompt J/ψ from beauty hadron decays, fB, has been determined in the region 1.5<pT<10 GeV/c in three centrality intervals. No significant centrality dependence of fB is observed. Finally, the RAA of non-prompt J/ψ is discussed and compared with model predictions. The nuclear modification in the region 4.5<pT<10 GeV/c is found to be stronger than predicted by most models.
Inclusive, prompt and non-prompt J/ψ production at midrapidity in p-Pb collisions at √sNN = 5.02 TeV
(2022)
A measurement of inclusive, prompt, and non-prompt J/ψ production in p-Pb collisions at a nucleon-nucleon centre-of-mass energy sNN−−−√ = 5.02 TeV is presented. The inclusive J/ψ mesons are reconstructed in the dielectron decay channel at midrapidity down to a transverse momentum pT = 0. The inclusive J/ψ nuclear modification factor RpPb is calculated by comparing the new results in p-Pb collisions to a recently measured proton-proton reference at the same centre-of-mass energy. Non-prompt J/ψ mesons, which originate from the decay of beauty hadrons, are separated from promptly produced J/ψ on a statistical basis for pT larger than 1.0 GeV/c. These results are based on the data sample collected by the ALICE detector during the 2016 LHC p-Pb run, corresponding to an integrated luminosity Lint = 292 ± 11 μb−1, which is six times larger than the previous publications. The total uncertainty on the pT-integrated inclusive J/ψ and non-prompt J/ψ cross section are reduced by a factor 1.7 and 2.2, respectively. The measured cross sections and RpPb are compared with theoretical models that include various combinations of cold nuclear matter effects. From the non-prompt J/ψ production cross section, the bb¯¯¯ production cross section at midrapidity, dσbb¯¯¯/dy, and the total cross section extrapolated over full phase space, σbb¯¯¯, are derived.
Inclusive, prompt and non-prompt J/ψ production at midrapidity in p−Pb collisions at √sNN = 5.02 TeV
(2021)
A measurement of inclusive, prompt, and non-prompt J/ψ production in p−Pb collisions at a nucleon--nucleon centre-of-mass energy sNN−−−√=5.02 TeV is presented. The J/ψ mesons are reconstructed in the dielectron decay channel at midrapidity down to a transverse momentum pT=0. The inclusive J/ψ nuclear modification factor RpPb is calculated by comparing the results in p−Pb collisions to a measured proton−proton reference at the same centre-of-mass energy. Non-prompt J/ψ mesons, which originate from the decay of beauty hadrons, are separated from promptly produced J/ψ on a statistical basis for pT larger than 1.0 GeV/c. These results are based on the data sample collected by the ALICE detector during the 2016 LHC p−Pb run, corresponding to an integrated luminosity Lint=292±11μb−1, which is six times larger than the previous publications. The total uncertainty on the pT-integrated inclusive J/ψ and non-prompt J/ψ cross section are reduced by a factor 1.7 and 2.2, respectively. The measured cross sections and RpPb are compared with theoretical models that include various combinations of cold nuclear matter effects. From the non-prompt J/ψ production cross section, the bb¯¯¯ production cross section at midrapidity, dσbb¯¯¯/dy, and the total cross section extrapolated over full phase space, σbb¯¯¯, are derived.
Inclusive, prompt and non-prompt J/ψ production at midrapidity in p−Pb collisions at √sNN = 5.02 TeV
(2022)
A measurement of inclusive, prompt, and non-prompt J/ψ production in p−Pb collisions at a nucleon−nucleon centre-of-mass energy sNN−−−√=5.02 TeV is presented. The inclusive J/ψ mesons are reconstructed in the dielectron decay channel at midrapidity down to a transverse momentum pT=0. The inclusive J/ψ nuclear modification factor RpPb is calculated by comparing the new results in p−Pb collisions to a recently measured proton−proton reference at the same centre-of-mass energy. Non-prompt J/ψ mesons, which originate from the decay of beauty hadrons, are separated from promptly produced J/ψ on a statistical basis for pT larger than 1.0 GeV/c. These results are based on the data sample collected by the ALICE detector during the 2016 LHC p−Pb run, corresponding to an integrated luminosity Lint=292±11μb−1, which is six times larger than the previous publications. The total uncertainty on the pT-integrated inclusive J/ψ and non-prompt J/ψ cross section are reduced by a factor 1.7 and 2.2, respectively. The measured cross sections and RpPb are compared with theoretical models that include various combinations of cold nuclear matter effects. From the non-prompt J/ψ production cross section, the bb¯¯¯ production cross section at midrapidity, dσbb¯¯¯/dy, and the total cross section extrapolated over full phase space, σbb¯¯¯, are derived.
The Eurozone fiscal crisis has created pressure for institutional harmonization, but skeptics argue that cultural predispositions can prevent convergence in behavior. Our paper derives a robust cultural classification of European countries and utilizes unique data on natives and immigrants to Sweden. Classification based on genetic distance or on Hofstede’s cultural dimensions fails to identify a single ‘southern’ culture but points to a ‘northern’ culture. Significant differences in financial behavior are found across cultural groups, controlling for household characteristics. Financial behavior tends to converge with longer exposure to common institutions, but is slowed down by longer exposure to original institutions.
Background: More than 170 species of tabanids are known in Europe, with many occurring only in limited areas or having become very rare in the last decades. They continue to spread various diseases in animals and are responsible for livestock losses in developing countries. The current monitoring and recording of horseflies is mainly conducted throughout central Europe, with varying degrees of frequency depending on the country. To the detriment of tabanid research, little cooperation exists between western European and Eurasian countries.
Methods: For these reasons, we have compiled available sources in order to generate as complete a dataset as possible of six horsefly species common in Europe. We chose Haematopota pluvialis, Chrysops relictus, C. caecutiens, Tabanus bromius, T. bovinus and T. sudeticus as ubiquitous and abundant species within Europe. The aim of this study is to estimate the distribution, land cover usage and niches of these species. We used a surface-range envelope (SRE) model in accordance with our hypothesis of an underestimated distribution based on Eurocentric monitoring regimes.
Results: Our results show that all six species have a wide range in Eurasia, have a broad climatic niche and can therefore be considered as widespread generalists. Areas with modelled habitat suitability cover the observed distribution and go far beyond these. This supports our assumption that the current state of tabanid monitoring and the recorded distribution significantly underestimates the actual distribution. Our results show that the species can withstand extreme weather and climatic conditions and can be found in areas with only a few frost-free months per year. Additionally, our results reveal that species prefer certain land-cover environments and avoid other land-cover types.
Conclusions: The SRE model is an effective tool to calculate the distribution of species that are well monitored in some areas but poorly in others. Our results support the hypothesis that the available distribution data underestimate the actual distribution of the surveyed species.
According to embodied cognition accounts, viewing others’ facial emotion can elicit the respective emotion representation in observers which entails simulations of sensory, motor, and contextual experiences. In line with that, published research found viewing others’ facial emotion to elicit automatic matched facial muscle activation, which was further found to facilitate emotion recognition. Perhaps making congruent facial muscle activity explicit produces an even greater recognition advantage. If there is conflicting sensory information, i.e., incongruent facial muscle activity, this might impede recognition. The effects of actively manipulating facial muscle activity on facial emotion recognition from videos were investigated across three experimental conditions: (a) explicit imitation of viewed facial emotional expressions (stimulus-congruent condition), (b) pen-holding with the lips (stimulus-incongruent condition), and (c) passive viewing (control condition). It was hypothesised that (1) experimental condition (a) and (b) result in greater facial muscle activity than (c), (2) experimental condition (a) increases emotion recognition accuracy from others’ faces compared to (c), (3) experimental condition (b) lowers recognition accuracy for expressions with a salient facial feature in the lower, but not the upper face area, compared to (c). Participants (42 males, 42 females) underwent a facial emotion recognition experiment (ADFES-BIV) while electromyography (EMG) was recorded from five facial muscle sites. The experimental conditions’ order was counter-balanced. Pen-holding caused stimulus-incongruent facial muscle activity for expressions with facial feature saliency in the lower face region, which reduced recognition of lower face region emotions. Explicit imitation caused stimulus-congruent facial muscle activity without modulating recognition. Methodological implications are discussed.
To support future research based on natural sciences collection data, DiSSCo (Distributed System of Scientific Collections) – the European Research Infrastructure for Natural Science Collections – adopts Digital Object Architecture as the basis for its planned data infrastructure. Using the outputs of one Research Data Alliance (RDA) interest group (IG) and five working groups (WGs) we show how RDA recommendations and supporting documents have been applied to the various stages of the DiSSCo data lifecycle.
Incorporation of doxorubicin in different polymer nanoparticles and their anti-cancer activity
(2018)
Nanoparticles are under investigation as carrier systems for anti-cancer drugs. They have been shown to accumulate in cancer tissues through the enhanced permeability and retention (EPR) effect, to reduce toxicity to non-target tissues, and to protect drugs from preliminary inactivation. However, nanoparticle preparations are not commonly compared for their anti-cancer effects at the cellular level. Here, we prepared doxorubicin-loaded nanoparticles based on poly(lactic-co-glycolic acid) (PLGA), polylactic acid (PLA), and PEGylated PLGA (PLGA-PEG) by solvent displacement and emulsion diffusion approaches. The resulting nanoparticles covered a size range between 73 and 246 nm. PLGA-PEG nanoparticle preparation by solvent displacement resulted in the smallest nanoparticles. In PLGA nanoparticles, the drug load could be optimised using solvent displacement at pH7 reaching 53 µg doxorubicin/mg nanoparticle. In addition, these PLGA nanoparticles displayed sustained doxorubicin release kinetics compared to the more burst-like kinetics of the other preparations. In neuroblastoma cells, doxorubicin-loaded PLGA-PEG nanoparticles (presumably due to their small size) and PLGA nanoparticles prepared by solvent displacement at pH7 (presumably due to their high drug load and superior drug release kinetics) exerted the strongest anti-cancer effects. In conclusion, doxorubicin-loaded nanoparticles made by different methods from different materials displayed substantial discrepancies in their anti-cancer activity at the cellular level. Optimised preparation methods resulted in PLGA nanoparticles characterised by increased drug load, controlled drug release, and high anti-cancer efficacy. The design of drug-loaded nanoparticles with optimised anti-cancer activity at the cellular level is an important step in the development of improved nanoparticle preparations for anti-cancer therapy.
Incorporation of doxorubicin in different polymer nanoparticles and their anticancer activity
(2019)
Background: Nanoparticles are under investigation as carrier systems for anticancer drugs. The expression of efflux transporters such as the ATP-binding cassette (ABC) transporter ABCB1 is an important resistance mechanism in therapy-refractory cancer cells. Drug encapsulation into nanoparticles has been shown to bypass efflux-mediated drug resistance, but there are also conflicting results. To investigate whether easy-to-prepare nanoparticles made of well-tolerated polymers may circumvent transporter-mediated drug efflux, we prepared poly(lactic-co-glycolic acid) (PLGA), polylactic acid (PLA), and PEGylated PLGA (PLGA-PEG) nanoparticles loaded with the ABCB1 substrate doxorubicin by solvent displacement and emulsion diffusion approaches and assessed their anticancer efficiency in neuroblastoma cells, including ABCB1-expressing cell lines, in comparison to doxorubicin solution.
Results: The resulting nanoparticles covered a size range between 73 and 246 nm. PLGA-PEG nanoparticle preparation by solvent displacement led to the smallest nanoparticles. In PLGA nanoparticles, the drug load could be optimised using solvent displacement at pH 7 reaching 53 µg doxorubicin/mg nanoparticle. These PLGA nanoparticles displayed sustained doxorubicin release kinetics compared to the more burst-like kinetics of the other preparations. In neuroblastoma cells, doxorubicin-loaded PLGA-PEG nanoparticles (presumably due to their small size) and PLGA nanoparticles prepared by solvent displacement at pH 7 (presumably due to their high drug load and superior drug release kinetics) exerted the strongest anticancer effects. However, nanoparticle-encapsulated doxorubicin did not display increased efficacy in ABCB1-expressing cells relative to doxorubicin solution.
Conclusion: Doxorubicin-loaded nanoparticles made by different methods from different materials displayed substantial discrepancies in their anticancer activity at the cellular level. Optimised preparation methods resulted in PLGA nanoparticles characterised by increased drug load, controlled drug release, and high anticancer efficacy. The design of drug-loaded nanoparticles with optimised anticancer activity at the cellular level is an important step in the development of improved nanoparticle preparations for anticancer therapy. Further research is required to understand under which circumstances nanoparticles can be used to overcome efflux-mediated resistance in cancer cells.