Universitätspublikationen
Refine
Year of publication
Document Type
- Article (13815)
- Part of Periodical (3491)
- Doctoral Thesis (3336)
- Contribution to a Periodical (2163)
- Book (2110)
- Working Paper (1894)
- Preprint (1815)
- Review (1064)
- Report (909)
- Conference Proceeding (706)
Language
- English (17651)
- German (14027)
- Portuguese (231)
- Spanish (123)
- Italian (66)
- French (64)
- Multiple languages (64)
- Turkish (12)
- Ukrainian (10)
- slo (7)
Keywords
- Deutschland (132)
- COVID-19 (99)
- inflammation (96)
- Financial Institutions (92)
- ECB (69)
- Capital Markets Union (67)
- SARS-CoV-2 (64)
- Financial Markets (61)
- Adorno (58)
- Banking Regulation (52)
Institute
- Medizin (6702)
- Präsidium (5136)
- Physik (3711)
- Wirtschaftswissenschaften (2305)
- Gesellschaftswissenschaften (2022)
- Biowissenschaften (1775)
- Frankfurt Institute for Advanced Studies (FIAS) (1769)
- Informatik (1490)
- Sustainable Architecture for Finance in Europe (SAFE) (1409)
- Biochemie und Chemie (1400)
Cytokines play an important role in ischemic injury and repair. However, little is known about their prognostic value in cardiovascular disease. The aim of this study was to investigate the prognostic importance of chemokines CCL3/MIP-1α, CCL5/RANTES and CCL18/PARC for the risk of future cardiovascular events in patients with acute coronary syndromes (ACS). Baseline levels of CCL3/MIP-1α, CCL5/RANTES and CCL18/PARC were determined in ACS patients from the Bad Nauheim ACS II registry (n = 609). During the following 200 days, patients were monitored for the occurrence of fatal and non-fatal cardiovascular events. Patients with CCL3/MIP1α, CCL5/RANTES and CCL18/PARC concentrations in the highest tertile were associated with an increased risk of a fatal event during follow-up (HR: 2.19, 95%CI: 1.04–4.61 for CCL3/MIP1α, HR: 3.45, 95%CI: 1.54–7.72 for CCL5/RANTES and HR: 3.14, 95%CI: 1.33–7.46 for CCL18/PARC). This risk was highest for patients with all three biomarkers concentrations in the upper tertile (HR: 2.52, 95%CI: 1.11–5.65). Together with known risk predictors of cardiovascular events, CCL3/MIP-1α, CCL5/RANTES and CCL18/PARC combined improved the c-statistics from 0.74 to 0.81 (p = 0.007). In conclusion, CCL3/MIP-1α, CCL5/RANTES and CCL18/PARC are independently associated with the risk of short-term mortality in ACS patients. Combining all three biomarkers further increased their prognostic value.
We study the role mutual funds play in the recovery from fast intraday crashes based on data from the National Stock Exchange of India for a single large stock. During normal times, trading activity and liquidity provision by mutual funds is negligible compared to other traders at around 4% of overall activity. Nevertheless, for the two intraday market-wide crashes in our sample, price recovery took place only after mutual funds moved in. Market stability may require the presence of well-capitalized standby liquidity providers for recovery from fast crashes.
Leben bedeutet eine fortdauernde Anpassung an Umweltbedingungen durch ein hoch entwickeltes Informationsverarbeitungssystem. Diese Anpassung wird durch das neuroendokrine und autonome Nervensystem gewährleistet. Eine tages- und jahreszeitliche Organisation des neuroendokrinen und autonomen Systems findet durch das Photoneuroendokrine System (PNS) statt. Erst in jüngster Zeit konnte gezeigt werden, dass neben peptidergen Substanzen auch lipiderge Signalmoleküle des Endocannabinoidsystems eine essentielle Rolle bei der interzelluären Kommunikation spielen. Hierbei zählen Anandamid (AEA) und 2-Arachidonoylglycerol (2-AG) zu den umfassend erforschten Endocannabinoiden. ...
HINTERGRUND: Die BioPhysio™ (Edwards Lifescience LLC, Irvine, CA) Bioprothese wurde konstruiert um die hämodynamischen Eigenschaften bisher verfügbarer gerüsttragender Aortenklappenprothesen weiter zu verbessern. Ein flexibles Nitinolgerüst, welches die natürlichen Bewegungen der Aortenwurzel während des Herzzyklus zulässt und trotzdem einfach implantiert werden kann, ist die Hauptinnovation dieser Prothese. Das Ziel dieser Studie ist die klinische Evaluation dieser neuen Prothese. METHODEN: Zwischen Dezember 2004 und August 2005 wurden 50 BioPhysio Aortenklappenprothesen implantiert. Das mittlere Alter der Patienten betrug 75,9 ± 5,1 Jahre. Klinische Ergebnisse, Klappenöffnungsflächen, transvalvuläre Gradienten und der Rückgang der Linksventrikelhypertrophie wurden echokardiographisch vor der Entlassung, nach sechs Monaten, zwölf Monaten und 24 Monaten nachuntersucht. ERGEBNISSE: Die Gesamtsterblichkeit betrug 14,3% (n=6), wobei nach zwölf Monaten 9,5% (n=4) und nach 24 Monaten 4,8% (n=2). Alle Todesfälle waren nicht klappenbezogen. Ein Patient erlitt zwei Jahre nach der Operation eine Endokarditis und wurde erneut operiert. Es gab keine Fälle von Herz- oder Nierenversagen. Die Bioprothese zeigte gute hämodynamische Eigenschaften. Eine signifikante Reduktion des mittleren Gradienten auf 15,1 ± 8,3 mmHg konnte erzielt werden. Die mittlere Klappenöffnungsfläche betrug 1,5 ± 0,7 cm² und die mittlere Ejektionsfraktion 60,7 ± 7,2%. Es traten keine Aorteninsuffizienzen auf. Die New York Heart Association Funktionsklasse verbesserte sich bei allen Patienten und es konnte eine signifikante Reduktion des Linksventrikelmasseindex von 185,7 ± 49,6 g/m² festgestellt werden. KONKLUSION: Die klinische Darbietung der neuen BioPhysio Bioprothese ist vergleichbar mit den konventionellen gerüstlosen Herzklappenprothesen. Durch ihr einzigartiges Design ist sie jedoch schneller und einfacher zu implantieren als konventionelle gerüstlose Prothesen.
The interactions between human haptoglobin, Hp II (genetic types 2 - 1 and 2-2), and bovine hemoglobin, Hb, were investigated taking inhibition of complex formation and complex dissociation in various solvent media as criteria.
As shown by relative peroxidase activity and gel chromatography, complex dissociation occurs at high concentrations of guanidine HCl, urea, sodium chloride, dioxane, and formaldehyde, while in case of sodium dodecylsulfate a low molar ratio (SDS/Hb -Hp<5) is sufficient to split the complex. In general the formation of the complex stabilizes the structure of its constituents.
Excluding solvent conditions which lead to denaturation (as measured by optical rotation), ionpairs and H-bonds seem to prevail in the stabilization of the complex, while hydrophobic interactions should be of minor importance. Chemical modification of histidine and tyrosine with diazonium-1-H-tetrazole and N-acetylimidazole, respectively, prove histidyl-groups in Hb and tyrosylgroups in Hp to participate in the Hb-Hp contact, thus confirming earlier results.
In order to determine the intermolecular forces in the process of the heat aggregation of globular proteins in solution, selected proteins with different amounts of disulfide- and thiolgroups were investigated by specific inhibition experiments and by degradation analysis, using lightscattering and ultracentrifugation methods.
In accordance with the mechanism of the heat aggregation, which in general (SH —SS-proteins) may be characterized as a coupled coagulation- and exchange-reaction, auxiliary valences and covalent bonds take part in the aggregation process.
Besides the pʜ-range of lanthionine-formation, the coagulation-mechanism by weak intermolecular forces exceeds the covalent type of aggregation.
If only one of the sulphur functional groups is present in the protein molecules the aggregation is merely the result of the coagulation-mechanism, i. e. the degradation by urea, guanidine·HCl, variation of pʜ etc. leads back to the monomer.
In the case of SH —SS-proteins the degradation rate depends on the temperature and duration of aggregation: In the range of predenaturation and under isoelectric conditions the native monomer is restored while increasing net charge leads more and more to covalently bound aggregates which are due to disulfide- and lanthionine-groups. High alkalinity promotes the formation of lanthionine.
Regarding the weak intermolecular bonds the application of specific criteria in degradation and inhibition experiments proves that Η-bonds and hydrophobic interactions participate in the aggregation process while ion pair bonds may be excluded. The hydrophobic interactions do not become apparent, until partial denaturation of the aggregating protein takes place.
The proportion of the total aggregation at extreme pʜ-values which is produced by the coagulation mechanism may be explained in a tentative way by assuming specific electrostatic short range interactions between the partially dehydrated molecules, leading to fibrillar associates.
The dynamics of development of Bronze Age fortified settlements in the territory of present-day Poland reflects a general trend visible in other regions of Europe. The first period when relatively few defensive settlements were built was the first half of the 2nd millennium BC. However, intensification of the discussed phenomenon can only be noticed with the development of the Lusatian culture. The older development stage of fortified settlements in Poland is characterised by a significantly lower number of sources. The sites identified until now form a small group of settlements, clearly connected with two cultural circles. The four settlements which have been discovered in Greater Poland and Silesia so far should be linked with local groups of Únětice culture. In south-eastern Poland, in the Polish part of the Western Carpathians, there are three known sites, which are the result of northern expansion of Otomani-Füzesabony culture settlements, as well as the development of local communities of Mierzanowice culture. The text aims at detailed description of archaeological sources concerning particular features and aspects of functioning of fortified settlements. Moreover the collected information will serve to attempt to locate the discussed settlements in wider contexts regarding the roles which are most frequently assigned to the archaeological sites of this kind.
In dieser Arbeit konnte gezeigt werden, daß die Proteinkinase Akt das
Zellzyklusprotein p21 in Endothelzellen an der Aminosäure Threonin 145
phosphoryliert und auf diese Weise p21 posttranskriptionell reguliert. So führt die Aktabhängige Phosphorylierung zur Aufhebung der PCNA-Bindungsfähigkeit und zu einer Abnahme der Komplexbildung von p21 mit Cdk2 und Cdk4. Dementsprechend reduziert die Akt-Phosphorylierung von p21 an Threonin 145 die Hemmung der Cdk2-Aktivierung durch p21, begünstigt damit die Phosphorylierung von Retinoblastoma-Protein und die Freisetzung des Transkriptionsfaktors E2F. Diese Daten weisen auf einen neuen Signaltransduktionsweg hin, über den Akt die Endothelzellproliferation reguliert.
Außerdem führt die Akt-vermittelte Phosphorylierung von p21 an T145 zur Stabilisierung von p21 gegenüber Caspase-abhängiger Degradation während der pro-apoptotischen Stimulation der Endothelzellen und schützt die Zellen gegenüber der Apoptose-Induktion durch TNFα. Die p21-Phosphorylierung durch Akt stellt dabei einen essentiellen Mechanismus der endothelzellprotektiven Wirkung von Akt dar, denn in Abwesenheit von p21 infolge Antisense-Transfektion vermag die Überexpression von Akt nicht mehr zu einer Senkung der endothelialen Apoptoserate nach TNFα -Stimulation führen.