Institutes
Refine
Year of publication
- 2020 (245) (remove)
Document Type
- Article (196)
- Preprint (39)
- Doctoral Thesis (10)
Language
- English (245) (remove)
Has Fulltext
- yes (245)
Is part of the Bibliography
- no (245)
Keywords
- COVID-19 (9)
- SARS-CoV-2 (5)
- bladder cancer (4)
- Aortic stenosis (3)
- Hypoxia (3)
- Inflammation (3)
- Macrophages (3)
- Mortality (3)
- Peri-implantitis (3)
- Postural control (3)
- Quality of life (3)
- Stroke (3)
- TAVI (3)
- Treatment (3)
- inflammation (3)
- macrophage (3)
- miRNA (3)
- Ataxia telangiectasia (2)
- Bibliometrics (2)
- Clinical decision support systems (2)
- Computer-assisted diagnosis (2)
- EEG (2)
- Endoscopy (2)
- Epidemiology (2)
- Epilepsy (2)
- Genetics (2)
- Glioma (2)
- Healthy adults (2)
- Long-term potentiation (2)
- Outcome (2)
- Pneumonia (2)
- Rare diseases (2)
- Seizure (2)
- Wearable cardioverter-defibrillator (2)
- Women (2)
- bibliometrics (2)
- cancer (2)
- cerebral hemorrhage (2)
- cerebral venous thrombosis (2)
- coagulopathy (2)
- drug resistance (2)
- mTOR (2)
- obesity (2)
- patient blood management (2)
- polytrauma (2)
- post-translational modifications (2)
- psoriasis (2)
- public health (2)
- quality of life (2)
- sphingosine 1-phosphate (2)
- spinal dural leaks (2)
- stroke (2)
- sulforaphane (2)
- superficial siderosis (2)
- thymus (2)
- 3D printing (1)
- 3D rapid prototyping (1)
- 4-fluoroamphetamine (1)
- AAA+ disaggregase (1)
- ADAMTS13 (1)
- ADGRE1 (1)
- ADHD (1)
- AML (1)
- ARDS (1)
- ASPECTS (1)
- Abductor pollicis longus (1)
- Ablation (1)
- Abrasion (1)
- Abusive head trauma (AHT) (1)
- Accumulated degree days (1)
- Acute appendicitis (1)
- Acute elbow dislocation (1)
- Acute lymphoblastic leukemia (1)
- Acute-on-chronic subdural hematoma (1)
- Adherence (1)
- Administrative claims data (1)
- Adverse drug reaction (1)
- Age determination (1)
- Albumin ratio (1)
- Allogeneic (1)
- Amisulpride (1)
- Amitriptyline (1)
- Anal cancer (1)
- Anandamide (1)
- Anatomy (1)
- Anderson–Fabry (1)
- Angiogenesis (1)
- Animal model (1)
- Anti-inflammatory (1)
- Anti-rheumatic agents (1)
- Anticholinergic (1)
- Anticoagulant (1)
- Anticoagulation (1)
- Aortic input function (1)
- Appendectomy (1)
- Arrhythmia syndromes (1)
- Arthroplasty (1)
- Artificial intelligence (1)
- Ataxia score (1)
- Atm (1)
- Atrial fibrillation (1)
- Attention deficit (1)
- Autism spectrum disorder (1)
- Autoimmune vasculopathy (1)
- Autologous biomaterial (1)
- Axiography (1)
- BEZ235 (1)
- BMC (1)
- BMI (1)
- Bacterial abundance (1)
- Balloon-expandable TAVI (1)
- Benign enlargement of the subarachnoid spaces (BESS) (1)
- Bioenergetics (1)
- Biopsy (1)
- Bladder cancer (1)
- Bleeding (1)
- Blocked occlusion (1)
- Body modification (1)
- Bone defect (1)
- Bone regeneration (1)
- Bone remodelling (1)
- Bone substitute (1)
- Bone tissue engineering (1)
- Brain asymmetry (1)
- Brain injuries (1)
- Brain tumor surgery (1)
- Breast cancer survivers (1)
- Burden of illness (1)
- CAD/CAM (1)
- CCL2 (1)
- CD34 + cells (1)
- CD44 (1)
- CDI (1)
- CEBPD (1)
- COMP (1)
- COVID 19 pandemic (1)
- Calpain (1)
- Cancer (1)
- Capnography (1)
- Cardiac arrest (1)
- Cardiology (1)
- Cardiovascular magnetic resonance (1)
- Caspase-8 (1)
- Cell death and immune response (1)
- Cerebral hypoperfusion (1)
- Cerebrospinal fluid (1)
- Cerebrovascular disorders (1)
- Cezanne (1)
- Chemoradiotherapy (1)
- Child (1)
- Child abuse (1)
- Chronic inflammation (1)
- Classification (1)
- Clavien–Dindo classification (1)
- Climate inequity (1)
- Clinical genetics (1)
- Clinical trial (1)
- Coagulation (1)
- Cognition (1)
- Cold hardiness (1)
- Cold tolerance (1)
- Collagen-based biomaterial (1)
- Colonic neoplasms (1)
- Complications (1)
- Compression stocking (1)
- Computational biophysics (1)
- Confinement (1)
- Congenital diaphragmatic hernia (1)
- Connectivity (1)
- Conservative treatment (1)
- Constitution (1)
- Control (1)
- Cooperation (1)
- Copy number (1)
- Coronary artery disease (1)
- Cortical degeneration (1)
- Cortical thickness (1)
- Craniomaxillofacial injuries (1)
- Critical care (1)
- Critical size (1)
- Cryoelectron microscopy (1)
- Cystic fibrosis (1)
- Cytokines (1)
- DBS (1)
- DNA methylation (1)
- DST (1)
- Data science (1)
- Decontamination (1)
- Deep vein thrombosis (1)
- Defibrillation (1)
- Density equalizing mapping (1)
- Density-equalizing mapping (1)
- Dental air (1)
- Dental casts (1)
- Dental implant (1)
- Dental implants (1)
- Dental practice (1)
- Dental students (1)
- Depression (1)
- Diagnosis (1)
- Diagnostic algorithm (1)
- Diagnostic error (1)
- Differential diagnosis (1)
- Disaster victim identification (1)
- Disintegration (1)
- Distribution limits (1)
- Dopamine (1)
- Double-blind placebo-controlled trial (1)
- Drug susceptibility testing (1)
- Dural onlays (1)
- Dysphagia (1)
- EGFR (1)
- EGFRvIII mutation (1)
- EMR1 (1)
- EMT (1)
- Edoxaban (1)
- Education (1)
- Ejection fraction (1)
- Elderly (1)
- Electrical stimulation (1)
- Emergency treatment (1)
- Endocrinology (1)
- Endometrial carcinoma (1)
- Endothelial cells (1)
- Endothelial protein C receptor (1)
- Energy metabolism (1)
- Enterobacteriaceae (1)
- Epidural abscess (1)
- Evaluation (1)
- Evidence-based dentistry (1)
- Evidence-based medicine (1)
- Exercise challenge (1)
- Exercise-induced asthma (1)
- Exhaled nitric oxide (1)
- F4/80 (1)
- FBK-R23 (1)
- FEV1 (1)
- FHIR (1)
- FIH1 (1)
- FTMT (1)
- Fasting (1)
- Feedback (1)
- Female subjects (1)
- Ferritinophagy (1)
- Ferroptosis (1)
- Finevo (1)
- Fluid therapy (1)
- Forced expiratory volume in 1 s (1)
- Forensic entomology (1)
- Forensic examination (1)
- Fracture (1)
- Fracture type (1)
- Functional characterization (1)
- G-CSF (1)
- GLA deficiency (1)
- Gait analysis (1)
- Gastroschisis (1)
- Gene regulation (1)
- General practice (1)
- Genetic heart disease (1)
- Genetic syndromes (1)
- Geographical disparities (1)
- Global warming (1)
- Graph theory (1)
- Greenhouse effect (1)
- Guided bone regeneration (GBR) (1)
- Guided tissue regeneration (GTR) (1)
- HADS (1)
- HDAC and BET inhibitor (1)
- HDAC4 (1)
- HIV (1)
- HOSO (1)
- Haematocrit (1)
- Health care (1)
- Healthcare costs (1)
- Healthcare resource utilization (1)
- Heart failure (1)
- Heat shock protein 27 (1)
- Hemispheric specialization (1)
- Hemodynamics (1)
- Heterogeneity (1)
- High oblique sagittal osteotomy (1)
- Hippocampal excitability (1)
- Hippocampus (1)
- Histological analysis (1)
- HoLEP (1)
- Human behaviour (1)
- Hyperactivity (1)
- Hyperscanning (1)
- Hypoxia-inducible factor-1α (HIF-1α) (1)
- ICAM-1 (1)
- ICD (1)
- IDH mutation (1)
- IL-1β (1)
- ISR (1)
- Identification (1)
- Identifikation (1)
- Identifizierung von Katastrophenopfern (1)
- Immunohistochemistry (1)
- Immunology (1)
- Immunomodulatory agents (1)
- Implant osseointegration (1)
- Imrt (1)
- In vitro (1)
- In vivo (1)
- Inducible nitric oxide synthase (iNOS) (1)
- Induction chemotherapy (1)
- Infections (1)
- Inflammatory pattern (1)
- Injury Severity Score (ISS) (1)
- Innate immunity (1)
- Integrated Pulmonary Index (1)
- Integration (1)
- IntelliCage (1)
- Interoperability (1)
- Interposition (1)
- Interstitial pneumonia (1)
- Interview (1)
- Intravenous antibiotic therapy (1)
- Iron (1)
- Isocitrate dehydrogenase (1)
- JNK (1)
- Joint actions (1)
- Joint loading (1)
- K-homology RNA-binding domain (1)
- Kidney diseases (1)
- Körpermodifizierung (1)
- L-DOPA (1)
- Language delay (1)
- Lennox-Gastaut syndrome (1)
- Lockdown (1)
- Longchain polyunsaturated fatty acids (1)
- Low-dose radiation therapy (1)
- Lung cancer (1)
- Lung development (1)
- Lung function (1)
- Lung ultrasound (1)
- Lysophosphatidic acids (1)
- M. Intracellulare (1)
- M. avium (1)
- M. avium complex (1)
- M. chimaera (1)
- MRI (1)
- MS (1)
- Machine learning (1)
- Machine-learning (1)
- Macrophage polarization (1)
- Magnetic resonance imaging (1)
- Management (1)
- Mass disaster (1)
- Massenkatastrophe (1)
- Maxillofacial surgery (1)
- Mean erythrocyte volume (1)
- Medical research (1)
- Meta-analysis (1)
- Metabolic diseases (1)
- Michael acceptor (1)
- Microparticles (1)
- Mitochondrial dysfunction (1)
- Mobilization (1)
- Molecular autopsy (1)
- Molecular neuroscience (1)
- Monetary incentive delay (1)
- Mongolian spot (1)
- Monitoring (1)
- Monocytes (1)
- Morbidity (1)
- Morphologie (1)
- Morphology (1)
- Multidrug-resistance (1)
- Multimedication (1)
- Multimorbidity (1)
- Multiparametric MRI (1)
- Multiplate (1)
- Multiple-indication review (1)
- Myocardial infarction (MI) (1)
- Myocardial injury (1)
- Myocardial perfusion (1)
- NAFLD (1)
- NCOA4 (1)
- NCoR1 (1)
- NF-κB pathway (1)
- NIRS (1)
- NLRP3 inflammasomes (1)
- NTM (1)
- Negative appendectomy rate (1)
- Nek1 (1)
- Neonatal surgery outcome (1)
- Neurodegeneration (1)
- Neuron (1)
- Neurosurgery (1)
- Neurotransmitter (1)
- Nevus of Ito (1)
- Nevus of Ota (1)
- Next-generation sequencing (1)
- Non-abusive head trauma (NAHT) (1)
- Non-apoptotic functions (1)
- Non-tuberculous mycobacteria (1)
- Non-vitamin K antagonist oral anticoagulants (1)
- Normative modeling (1)
- Number of platelets (1)
- OSA (1)
- OTU domain-containing protein 7B (OTUD7B) (1)
- Omphalocele (1)
- Oncology (1)
- Oral anticoagulation (1)
- Orthognathic surgery (1)
- Osteoarthritis (1)
- Outcomes (1)
- Ovarian cancer treatment (1)
- Overwintering (1)
- PI3K/mTor inhibition (1)
- PV loop (1)
- PWI (1)
- Paediatric trauma patients (1)
- Pain (1)
- Parasympathetic (1)
- Patient blood management (1)
- Patient outcome assessment (1)
- Patient safety (1)
- Patterns of care (1)
- Pelvic (1)
- Percutaneous endoscopic gastrostomy (1)
- Periodontitis grades B and C (1)
- Periprocedural anticoagulation (1)
- Perrault syndrome (1)
- Phalangeal fractures (1)
- Phase I clinical trial (1)
- Phenotypic plasticity (1)
- Physical activity (1)
- Platelet-rich fibrin (1)
- Polygenic risk score (1)
- Polypharmacy (1)
- Post mortem interval (1)
- Pressure distribution (1)
- Pressure measuring plate (1)
- Prevalence (1)
- Prevention (1)
- Primary health care (1)
- Procedural skills (1)
- Prostate cancer (1)
- Pseudoprogression (1)
- Psychology (1)
- Pteridine (1)
- Pulmonary edema (1)
- Pulmonary embolism (1)
- Pulmonary hypertension (1)
- Pulmonary hypoplasia (1)
- Qualitative research (1)
- Quantitative (q)T2 mapping (1)
- Quantitative magnetic resonance imaging (1)
- Quantra (1)
- Questionnaire (1)
- Quinolones (1)
- RIPK1 (1)
- RNA chaperone (1)
- Radiomics (1)
- Ramadan (1)
- Refractory ALL (1)
- Refractory AML (1)
- RegJoint™ (1)
- Regeneration (1)
- Registries (1)
- Regret (1)
- Reliability (1)
- Rescue medication (1)
- Research investment (1)
- Respiratory distress syndrome (1)
- Retinal diseases (1)
- Retinoic acid (1)
- Return to work (1)
- Reward (1)
- Rheumatoid arthritis (1)
- Risk-stratification (1)
- S1P receptors (1)
- SCA2 (1)
- SCN5A (1)
- SEAP (1)
- SIDS (1)
- SLUG (1)
- SNORD95 (1)
- Safety (1)
- Saudi Arabia (1)
- Second donation (1)
- Self-expandable TAVI (1)
- Serious injured children (1)
- Serum biomarker (1)
- Sex (1)
- Sharp injuries (1)
- Shoulder luxation (1)
- Side effects (1)
- Signal intensity (1)
- Signs and symptoms (1)
- Social brain (1)
- Social differences (1)
- Socio-economic analysis (1)
- Socioeconomic analysis (1)
- Socioeconomic indices (1)
- Spine fractures (1)
- Spinocerebellar ataxia type 2 (1)
- Stage at presentation (1)
- Standard dataset (1)
- Standard reference values (1)
- Standard value (1)
- Status epilepticus (1)
- Stem cell (1)
- Sterols (1)
- Striatum (1)
- Stroke genetics (1)
- Sub-zero exposure (1)
- Sudden death (1)
- Sudden infant death syndrome (1)
- Surgery (1)
- Surgical therapy (1)
- Survey (1)
- Suspension (1)
- Swallowing (1)
- Sympathetic (1)
- Synaptic transmission (1)
- T cell receptor (1)
- T cells (1)
- T-cell receptor (1)
- T2 (1)
- TAMs (1)
- TGF-β (1)
- TGR(mREN2)27 (1)
- TRIMs (1)
- Targeted sequencing (1)
- Test assay (1)
- Therapies (1)
- Thrombotic thrombocytopenic purpura (1)
- Thumb carpometacarpal joint osteoarthritis (1)
- Tissue engineering (1)
- Tocilizumab (1)
- Total hip arthroplasty (1)
- Touchscreen (1)
- Transcription regulation (1)
- Transcriptional regulatory elements (1)
- Transfusion (1)
- Transfusion practice (1)
- Transgenic mice (1)
- Translation proteomics (1)
- TraumaRegister DGU® (TR-DGU) (1)
- Treatment effectiveness (1)
- Treatment rates (1)
- Treg cell (1)
- Tumor microenvironment (1)
- Type 2 diabetes (1)
- UBA domain (1)
- Ubiquitin ligase (1)
- Uncertainty (1)
- Undergraduate education (1)
- Upper body posture (1)
- VIM (1)
- Validation (1)
- Vascular endothelial growth factor (VEGF) (1)
- Venous thromboembolism (1)
- Ventricular arrhythmia (1)
- Ventricular arrhythmias (1)
- Videorasterstereography (1)
- Volume therapy (1)
- Volunteer donor (1)
- Watertight Dural closure (1)
- Western diet (1)
- Winter survival (1)
- Wound healing (1)
- Wounds (1)
- [18F]FET PET (1)
- activated clotting time measurement (1)
- adaptation (1)
- adhesion (1)
- adiabatic saturation (1)
- adipose-derived mesenchymal stem/stromal cells (1)
- adult (1)
- aging (1)
- alcoholic hepatitis (1)
- algorithm (1)
- allogeneic donor (1)
- allogeneic hematopoietic stem cell transplantation (1)
- alpha power (1)
- alpha-galactosidase A deficiency (1)
- alternative matrices (1)
- amyotrophic lateral sclerosis (ALS) (1)
- anaemia walk-in clinic (1)
- angiokeratoma diffuse (1)
- anti-inflammatory drug (1)
- aortic stenosis (1)
- apoptosis (1)
- arachidonate 12/15-lipoxygenase (Alox12/15) (1)
- aspiration (1)
- auditory fMRI (1)
- bacteria (1)
- bio imaging (1)
- bioactive lipids (1)
- bioavailability (1)
- bioluminescence (1)
- bipolar disorder (1)
- blinatumomab (1)
- blood pressure (1)
- blood transfusion (1)
- brain (1)
- brain shift (1)
- brain tumor (1)
- breast cancer (1)
- bypass (1)
- caesarean scar (1)
- caesarean section (1)
- cancer information (1)
- cancer specific survival (1)
- cardiothoracic surgery (1)
- cell death (1)
- ceramides (1)
- cerumen (1)
- cervical cancer (1)
- chemoprotection (1)
- chemoresistance (1)
- chemotaxis (1)
- chemotherapy (1)
- clinical immunology (1)
- coagulation (1)
- cognitive aging (1)
- colorectal cancer (1)
- colorectal cancer (CRC) (1)
- contamination (1)
- cortex (1)
- covalent drugs (1)
- curcumin (1)
- cyclin Y (1)
- cyclooxygenase 2 (1)
- cytokine storm (1)
- cytotoxic lymphocytes (1)
- cytotoxicity (1)
- data science (1)
- debris (1)
- deferred treatment (1)
- delayed treatment (1)
- delirium (1)
- demineralized bone matrix (1)
- dentoalveolar surgery (1)
- deubiquitinase (DUB) (1)
- deubiquitylation (deubiquitination) (1)
- donor safety (1)
- drug abstinence (1)
- dysphagia (1)
- early detection (1)
- electronic adherence measurement (1)
- electrophilic fatty acids (1)
- epidemics (1)
- epidemiology (1)
- epilepsy (1)
- episodic memory (1)
- epithelial-to-mesenchymal transition (EMT) (1)
- essential tremor (1)
- euthymic (1)
- everolimus (1)
- evolution (1)
- exercise (1)
- experimental pain models (1)
- fMRI (1)
- flow cytometry (1)
- focal cortical dysplasia (1)
- fractionation (1)
- fragile-X-associated tremor-ataxia syndrome (1)
- fronto-temporal lobar dementia (1)
- fronto-temporal-lobar-dementia (1)
- functional connectivity (1)
- gene regulation (1)
- geriatric patients (1)
- glioblastoma (1)
- glioblastoma cells (1)
- glioma (1)
- graph theory (1)
- growth (1)
- hemorrhage (1)
- hepatic stellate cells (1)
- hepatitis C virus (HCV) (1)
- hepatocellular cancer (1)
- hereditary dystopic lipidosis (1)
- high-throughput screening (1)
- hippocampus (1)
- histological outcomes (1)
- human genomics (1)
- hybrid abutment (1)
- hydroxylation (1)
- hypoxia (1)
- imaging (1)
- immune checkpoint (1)
- immune defense (1)
- immune response (1)
- immunity (1)
- immuno-oncotherapy (1)
- immunosuppression (1)
- immunotherapy (1)
- in vitro models (1)
- infection (1)
- inferior frontal gyrus (1)
- innate immunity (1)
- inositol signaling (1)
- integrated stress response (1)
- integrin (1)
- integrins (1)
- inter-individual variability (1)
- interferon type III (1)
- investigational (1)
- inflammation (1)
- iron deficiency (1)
- joint contact forces (1)
- knee adduction moment (1)
- lichen extracts (1)
- lipoxin A4 (1)
- liquid chromatography–mass spectrometry (1)
- liver fibrosis (1)
- long-term potentiation (1)
- long-term success (1)
- lymphocytes (1)
- machine learning (1)
- medication adherence rate (1)
- mental distress (1)
- mesenchymal stromal cells (1)
- mesenchymal stromal/stem cells (1)
- metabolism (1)
- miR-142-3p (1)
- miR-181 (1)
- miR-6862-5p (1)
- microRNA (1)
- mid-IR spectroscopy (1)
- migration (1)
- minimal residual disease (1)
- mitochondria (1)
- mitochondrial antiviral signaling protein (MAVS) (1)
- mitochondrial metabolism (1)
- mitochondrial morphology (1)
- mixed lineage kinase domain-like (1)
- molecular adaptation (1)
- molecular biology (1)
- molecular dynamics (1)
- monotype abutment (1)
- monsoon (1)
- mortality analysis (1)
- mortality risk (1)
- musculoskeletal inflammation (1)
- musculoskeletal modeling (1)
- neural oscillations (1)
- neurexin (1)
- next-generation sequencing (1)
- nitroalkylation (1)
- noninvasive blood glucose analysis (1)
- nuclear magnetic resonance (NMR) (1)
- nutrient endocytosis (1)
- oncogenic signaling (1)
- oral and maxillofacial surgery (1)
- orthopaedic patients (1)
- osteoarthritis (1)
- outside-in signaling (1)
- pain (1)
- patient’s decree (1)
- perceptual closure (1)
- pericytes (1)
- periodontal risk factors (1)
- photothermal detection (1)
- placenta (1)
- planimetric measurement (1)
- plasma (1)
- pneumocystis (1)
- point of care (1)
- poly(A)-tail (1)
- portal hypertension (1)
- post-caesarean uterus (1)
- post-exercise hypotension (1)
- posterior fossa tumor (1)
- postmonsoon (1)
- posttranslational modification (PTM) (1)
- precision weighting (1)
- predictive coding (1)
- prevalence (1)
- prognosis (1)
- prognostic marker (1)
- proliferation (1)
- prostate cancer (1)
- protease inhibitor (1)
- protein-protein interaction (1)
- proteostasis (1)
- psoriatic arthritis (1)
- qRT-PCR (1)
- quantum cascade laser (QCL) (1)
- radical prostatectomy (1)
- radiosensitization (1)
- rat femur critical size defect (1)
- regulatory T cell (1)
- regulatory T helper cells (1)
- relaxometry (1)
- renal cell carcinoma (1)
- renal transplantation (1)
- replicative fitness (1)
- resistance mutation (1)
- resolution of inflammation (1)
- reticulocyte haemoglobin (1)
- risk factor (1)
- risk factors (1)
- rotational thromboelastometry (1)
- scanner noise (1)
- schizophrenia (1)
- screening (1)
- selection (1)
- serine protease (NS3-4A) (1)
- serum (1)
- severely injured (1)
- signaling (1)
- simulation training (1)
- sonography (1)
- sparse imaging (1)
- spatial learning (1)
- specialized pro-resolving lipid mediators (SPMs) (1)
- sphingosine 1-phosphate receptor (1)
- sphingosine kinase (1)
- sphingosine-1-phosphate (1)
- spreading (1)
- starvation (1)
- steady-state condition (1)
- steatosis (1)
- stem cell transplantation (1)
- stem cells (1)
- stress (1)
- structure constraints (1)
- supportive periodontal therapy (1)
- survival (1)
- swallowing (1)
- synaesthesia (1)
- synaptic plasticity (1)
- tauopathies (1)
- tauopathy (1)
- thrombosis (1)
- tooth loss (1)
- total hip replacement (1)
- tracking (1)
- transcriptome (1)
- transferrin (1)
- translatome (1)
- transplantation (1)
- trauma registry (1)
- traumaticbraininjury(TBI) (1)
- tumor microenvironment (1)
- tyrosine kinase inhibitor (1)
- tyrosine kinase receptor signaling (1)
- ubiquitin (1)
- ubiquitin hydrolase (1)
- ultrasonic cleaning (1)
- unconventional T cell (1)
- uterine wall (1)
- variable silent delay (1)
- ventralis intermedius nucleus (1)
- vertical transmission (1)
- viruses (1)
- vitamin k antagonists (1)
- waiting time (1)
- walking (1)
- white matter hyperintensity (1)
- xenograft (1)
- fibrogenesis (1)
- fingolimod (1)
Institute
- Medizin (245)
- Biowissenschaften (3)
- Ernst Strüngmann Institut (3)
- Frankfurt Institute for Advanced Studies (FIAS) (3)
- MPI für Hirnforschung (3)
- Psychologie (2)
- Biochemie und Chemie (1)
- Biochemie, Chemie und Pharmazie (1)
- Buchmann Institut für Molekulare Lebenswissenschaften (BMLS) (1)
- Informatik und Mathematik (1)
Highlights
• German patients with LGS identified using most specific algorithm to date.
• Prevalence of probable LGS with epilepsy diagnosis before age 6 was 6.5 per 100,000.
• High healthcare costs of €22,787 PPY; mostly due to inpatient and home nursing care.
• Costs were greater in patients prescribed rescue medications.
• Over 10 years, LGS patients had significant mortality vs. controls (2.88 vs. 0.01%).
Abstract
Objective: This retrospective study examined patients with probable Lennox-Gastaut syndrome (LGS) identified from German healthcare data.
Methods: This 10-year study (2007–2016) assessed healthcare insurance claims information from the Vilua Healthcare research database. A selection algorithm considering diagnoses and drug prescriptions identified patients with probable LGS. To increase the sensitivity of the identification algorithm, two populations were defined: all patients with probable LGS (broadly defined) and only those with a documented epilepsy diagnosis before 6 years of age (narrowly defined). This specific criterion was used as LGS typically has a peak seizure onset between age 3 and 5 years. Primary analyses were prevalence and demographics; secondary analyses included healthcare costs, hospitalization rate and length of stay (LOS), medication use, and mortality.
Results: In the final year of the study, 545 patients with broadly defined probable LGS (mean [range] age: 31.4 [2–89] years; male: 53%) were identified. Using the narrowly defined probable LGS definition, the number of patients was reduced to 102 (mean [range] age: 7.4 [2–14] years; male: 52%). Prevalence of broadly defined and narrowly defined probable LGS was 39.2 and 6.5 per 100,000 people. During the 10-year study, 208 patients with narrowly defined probable LGS were identified and followed up for 1379 patient-years. The mean annual cost of healthcare was €22,787 per patient-year (PPY); greatest costs were attributable to inpatient care (33%), home nursing care (13%), and medication (10%). Mean annual healthcare costs were significantly greater for those with prescribed rescue medication (45% of patient-years) versus those without (€33,872 vs. €13,785 PPY, p < 0.001). Mean (standard deviation [SD]) annual hospitalization rate was 1.6 (2.0) PPY with mean (SD) annual LOS of 22.7 (46.0) days. Annual hospitalization rate was significantly greater in those who were prescribed rescue medication versus those who were not (2.2 [2.3] vs. 1.1 [1.6] PPY, p < 0.001). The mean (SD) number of different medications prescribed was 11.3 (7.3) PPY and 33.8 (17.0) over the entire observable time per patient (OET); antiepileptic drugs only accounted for 2.1 (1.1) of the medications prescribed PPY and 3.8 (2.0) OET. Over the 10-year study period, mortality in patients with narrowly defined probable LGS was significantly higher than the matched control population (six events [2.88%] vs. one event [0.01%], p < 0.001).
Conclusion: Annual healthcare costs incurred by patients with probable LGS in Germany were substantial, and mostly attributable to inpatient care, home nursing care, and medication. Patients prescribed with rescue medication incurred significantly greater costs than those who were not. Patients with narrowly defined probable LGS had a higher mortality rate versus control populations.
100 Jahre Dieter Janz
(2020)
The 20 April 2020 marks the centenary of Dieter Janz’s birth. This issue of Zeitschrift für Epileptologie is published in his honor with the aim of tracing the work of Dieter Janz over the last five decades and summarizing new findings on the Janz syndrome (Juvenile Myoclonic Epilepsy), which is named after him.
Two-person neuroscience (2 PN) is a recently introduced conceptual and methodological framework used to investigate the neural basis of human social interaction from simultaneous neuroimaging of two or more subjects (hyperscanning). In this study, we adopted a 2 PN approach and a multiple-brain connectivity model to investigate the neural basis of a form of cooperation called joint action. We hypothesized different intra-brain and inter-brain connectivity patterns when comparing the interpersonal properties of joint action with non-interpersonal conditions, with a focus on co-representation, a core ability at the basis of cooperation. 32 subjects were enrolled in dual-EEG recordings during a computerized joint action task including three conditions: one in which the dyad jointly acted to pursue a common goal (joint), one in which each subject interacted with the PC (PC), and one in which each subject performed the task individually (Solo).
A combination of multiple-brain connectivity estimation and specific indices derived from graph theory allowed to compare interpersonal with non-interpersonal conditions in four different frequency bands. Our results indicate that all the indices were modulated by the interaction, and returned a significantly stronger integration of multiple-subject networks in the joint vs. PC and Solo conditions. A subsequent classification analysis showed that features based on multiple-brain indices led to a better discrimination between social and non-social conditions with respect to single-subject indices. Taken together, our results suggest that multiple-brain connectivity can provide a deeper insight into the understanding of the neural basis of cooperation in humans.
Bone vasculature provides protection and signals necessary to control stem cell quiescence and renewal1. Specifically, type H capillaries, which highly express Endomucin, constitute the endothelial niche supporting a microenvironment of osteoprogenitors and long-term hematopoietic stem cells2–4. The age-dependent decline in type H endothelial cells was shown to be associated with bone dysregulation and accumulation of hematopoietic stem cells, which display cell-intrinsic alterations and reduced functionality3. The regulation of bone vasculature by chronic diseases, such as heart failure is unknown. Here, we describe the effects of myocardial infarction and post-infarction heart failure on the vascular bone cell composition. We demonstrate an age-independent loss of type H bone endothelium in heart failure after myocardial infarction in both mice and in humans. Using single-cell RNA sequencing, we delineate the transcriptional heterogeneity of human bone marrow endothelium showing increased expression of inflammatory genes, including IL1B and MYC, in ischemic heart failure. Inhibition of NLRP3-dependent IL-1β production partially prevents the post-myocardial infarction loss of type H vasculature in mice. These results provide a rationale for using anti-inflammatory therapies to prevent or reverse the deterioration of vascular bone function in ischemic heart disease.
Background: Data on the arrhythmic burden of women at risk for sudden cardiac death are limited, especially in patients using the wearable cardioverter-defibrillator (WCD).
Objective: We aimed to characterize WCD compliance, atrial and ventricular arrhythmic burden, and WCD outcomes by sex in patients enrolled in the Prospective Registry of Patients Using the Wearable Cardioverter Defibrillator (WEARIT-II U.S. Registry).
Methods: In the WEARIT-II Registry, we stratified 2000 patients by sex into women (n = 598) and men (n = 1402). WCD wear time, ventricular and atrial arrhythmic events during WCD use, and implantable cardioverter-defibrillator (ICD) implantation rates at the end of WCD use were evaluated.
Results: The mean WCD wear time was similar in women and men (94 days vs 90 days; P = .145), with longer daily use in women (21.4 h/d vs 20.7 h/d; P = .001). Burden of ventricular tachycardia or ventricular fibrillation was higher in women, with 30 events per 100 patient-years compared with 18 events per 100 patient-years in men (P = .017), with similar findings for treated and non-treated ventricular tachycardia/ventricular fibrillation. Recurrent atrial arrhythmias/sustained ventricular tachycardia was also more frequent in women than in men (167 events per 100 patient-years vs 73 events per 100 patient-years; P = .042). However, ICD implantation rate at the end of WCD use was similar in both women and men (41% vs 39%; P = .448).
Conclusion: In the WEARIT-II Registry, we have shown a higher burden of ventricular and atrial arrhythmic events in women than in men. ICD implantation rates at the end of WCD use were similar. Our findings warrant monitoring women at risk for sudden cardiac death who have a high burden of atrial and ventricular arrhythmias while using the WCD.
Decline in physical activity in the weeks preceding sustained ventricular arrhythmia in women
(2020)
Background: Heightened risk of cardiac arrest following physical exertion has been reported. Among patients with an implantable defibrillator, an appropriate shock for sustained ventricular arrhythmia was preceded by a retrospective self-report of engaging in mild-to-moderate physical activity. Previous studies evaluating the relationship between activity and sudden cardiac arrest lacked an objective measure of physical activity and women were often underrepresented.
Objective: To determine the relationship between physical activity, recorded by accelerometer in a wearable cardioverter-defibrillator (WCD), and sustained ventricular arrhythmia among female patients.
Methods: A dataset of female adult patients prescribed a WCD for a diagnosis of myocardial infarction or dilated cardiomyopathy was compiled from a commercial database. Curve estimation, to include linear and nonlinear interpolation, was applied to physical activity as a function of time (days before arrhythmia).
Results: Among women who received an appropriate WCD shock for sustained ventricular arrhythmia (N = 120), a quadratic relationship between time and activity was present prior to shock. Physical activity increased starting at the beginning of the 30-day period up until day -16 (16 days before the ventricular arrhythmia) when activity begins to decline.
Conclusion: For patients who received treatment for sustained ventricular arrhythmia, a decline in physical activity was found during the 2 weeks preceding the arrhythmic event. Device monitoring for a sustained decline in physical activity may be useful to identify patients at near-term risk of a cardiac arrest.
Attention-Deficit/Hyperactivity Disorder (ADHD) and obesity are frequently comorbid, genetically correlated, and share brain substrates. The biological mechanisms driving this association are unclear, but candidate systems, like dopaminergic neurotransmission and circadian rhythm, have been suggested. Our aim was to identify the biological mechanisms underpinning the genetic link between ADHD and obesity measures and investigate associations of overlapping genes with brain volumes. We tested the association of dopaminergic and circadian rhythm gene sets with ADHD, body mass index (BMI), and obesity (using GWAS data of N = 53,293, N = 681,275, and N = 98,697, respectively). We then conducted genome-wide ADHD–BMI and ADHD–obesity gene-based meta-analyses, followed by pathway enrichment analyses. Finally, we tested the association of ADHD–BMI overlapping genes with brain volumes (primary GWAS data N = 10,720–10,928; replication data N = 9428). The dopaminergic gene set was associated with both ADHD (P = 5.81 × 10−3) and BMI (P = 1.63 × 10−5); the circadian rhythm was associated with BMI (P = 1.28 × 10−3). The genome-wide approach also implicated the dopaminergic system, as the Dopamine-DARPP32 Feedback in cAMP Signaling pathway was enriched in both ADHD–BMI and ADHD–obesity results. The ADHD–BMI overlapping genes were associated with putamen volume (P = 7.7 × 10−3; replication data P = 3.9 × 10−2)—a brain region with volumetric reductions in ADHD and BMI and linked to inhibitory control. Our findings suggest that dopaminergic neurotransmission, partially through DARPP-32-dependent signaling and involving the putamen, is a key player underlying the genetic overlap between ADHD and obesity measures. Uncovering shared etiological factors underlying the frequently observed ADHD–obesity comorbidity may have important implications in terms of prevention and/or efficient treatment of these conditions.
Inhibitors against the NS3-4A protease of hepatitis C virus (HCV) have proven to be useful drugs in the treatment of HCV infection. Although variants have been identified with mutations that confer resistance to these inhibitors, the mutations do not restore replicative fitness and no secondary mutations that rescue fitness have been found. To gain insight into the molecular mechanisms underlying the lack of fitness compensation, we screened known resistance mutations in infectious HCV cell culture with different genomic backgrounds. We observed that the Q41R mutation of NS3-4A efficiently rescues the replicative fitness in cell culture for virus variants containing mutations at NS3-Asp168. To understand how the Q41R mutation rescues activity, we performed protease activity assays complemented by molecular dynamics simulations, which showed that protease-peptide interactions far outside the targeted peptide cleavage sites mediate substrate recognition by NS3-4A and support protease cleavage kinetics. These interactions shed new light on the mechanisms by which NS3-4A cleaves its substrates, viral polyproteins and a prime cellular antiviral adaptor protein, the mitochondrial antiviral signaling protein MAVS. Peptide binding is mediated by an extended hydrogen-bond network in NS3-4A that was effectively optimized for protease-MAVS binding in Asp168 variants with rescued replicative fitness from NS3-Q41R. In the protease harboring NS3-Q41R, the N-terminal cleavage products of MAVS retained high affinity to the active site, rendering the protease susceptible for potential product inhibition. Our findings reveal delicately balanced protease-peptide interactions in viral replication and immune escape that likely restrict the protease adaptive capability and narrow the virus evolutionary space.
Relationship between regional white matter hyperintensities and alpha oscillations in older adults
(2020)
Objective: To investigate whether regional white matter hyperintensities (WMHs) relate to alpha oscillations (AO) in a large population-based sample of elderly individuals.
Methods: We associated voxel-wise WMHs from high-resolution 3-Tesla MRI with neuronal alpha oscillations (AO) from resting-state multichannel EEG at sensor (N=907) and source space (N=855) in older participants of the LIFE-Adult study (60–80 years). In EEG, we computed relative alpha power (AP), individual alpha peak frequency (IAPF), as well as long-range temporal correlations (LRTC) that represent dynamic properties of the signal. We implemented whole-brain voxel-wise regression models to identify regions where parameters of AO were linked to probability of WMH occurrence. We further used mediation analyses to examine whether WMH volume mediated the relationship between age and AO.
Results: Higher prevalence of WMHs in the superior and posterior corona radiata was related to elevated relative AP, with strongest correlations in the bilateral occipital cortex, even after controlling for potential confounding factors. The age-related increase of relative AP in the right temporal brain region was shown to be mediated by total WMH volume.
Conclusion: A high relative AP corresponding to increased regional WMHs was not associated with age per se, in fact, this relationship was mediated by WMHs. We argue that the WMH-associated increase of AP reflects a generalized and likely compensatory spread of AO leading to a larger number of synchronously recruited neurons. Our findings thus suggest that longitudinal EEG recordings might be sensitive to detect functional changes due to WMHs.
Relationship between regional white matter hyperintensities and alpha oscillations in older adults
(2020)
White matter hyperintensities (WMHs) in the cerebral white matter and attenuation of alpha oscillations (AO; 7–13 Hz) occur with the advancing age. However, a crucial question remains, whether changes in AO relate to aging per se or they rather reflect the impact of age-related neuropathology like WMHs. In this study, using a large cohort (N=907) of elderly participants (60-80 years), we assessed relative alpha power (AP), individual alpha peak frequency (IAPF) and long-range temporal correlations (LRTC) from resting-state EEG. We further associated these parameters with voxel-wise WMHs from 3T MRI. We found that higher prevalence of WMHs in the superior and posterior corona radiata was related to elevated relative AP, with strongest correlations in the bilateral occipital cortex, even after controlling for potential confounding factors. In contrast, we observed no significant relation of probability of WMH occurrence with IAPF and LRTC. We argue that the WMH-associated increase of AP reflects generalized and likely compensatory changes of AO leading to a larger number of synchronously recruited neurons.