Mathematik
Refine
Year of publication
Document Type
- Article (108)
- Doctoral Thesis (74)
- Preprint (42)
- diplomthesis (39)
- Book (25)
- Report (22)
- Conference Proceeding (18)
- Bachelor Thesis (8)
- Diploma Thesis (8)
- Master's Thesis (7)
Has Fulltext
- yes (362)
Is part of the Bibliography
- no (362)
Keywords
- Kongress (6)
- Kryptologie (5)
- Mathematik (5)
- Stochastik (5)
- Doku Mittelstufe (4)
- Doku Oberstufe (4)
- Online-Publikation (4)
- Statistik (4)
- Finanzmathematik (3)
- LLL-reduction (3)
- Moran model (3)
- coalescent (3)
- computational complexity (3)
- contraction method (3)
- point process (3)
- spike train (3)
- Algebraische Geometrie (2)
- Arithmetische Gruppe (2)
- Biographie (2)
- Brownian motion (2)
- Commitment Scheme (2)
- Frankfurt <Main> / Universität (2)
- Fuchsian groups (2)
- Fächerübergreifender Unterricht (2)
- Geometrie (2)
- Heat kernel (2)
- Hinterlegungsverfahren <Kryptologie> (2)
- Integral Geometry (2)
- Knapsack problem (2)
- Kombinatorische Optimierung (2)
- Krein space (2)
- Laplace operator on graphs (2)
- Lattice basis reduction (2)
- Martingal (2)
- Mathematiker (2)
- Musik (2)
- Oblivious Transfer (2)
- Perception (2)
- Quantum Zeno dynamics (2)
- San Jose (2)
- Semidefinite Programming (2)
- Shortest lattice vector problem (2)
- Stochastischer Prozess (2)
- Subset sum problem (2)
- Tropical geometry (2)
- Tropische Geometrie (2)
- Valuation Theory (2)
- Verzweigungsprozess (2)
- Vision (2)
- W*-dynamical system (2)
- X-Y model (2)
- Yule-Prozess (2)
- ancestral selection graph (2)
- binary search tree (2)
- collective intelligence (2)
- combinatorial optimization (2)
- complexity (2)
- duality (2)
- firing patterns (2)
- fixation probability (2)
- genealogy (2)
- level of difficulty (2)
- quantum spin systems (2)
- return to equilibrium (2)
- segments (2)
- task space (2)
- thought structure (2)
- Λ−coalescent (2)
- A-Discriminant (1)
- ADM1 (1)
- Abelian (1)
- Action potential (1)
- Actions in mathematical learning (1)
- Activity (1)
- Adaptive dynamics (1)
- Algebra (1)
- Algorithmus (1)
- Amoeba (1)
- Anaerobe Fermentation (1)
- Analyse von Algorithmen (1)
- Ancestral selection graph (1)
- Anisotropic Norm (1)
- Approximation (1)
- Approximation algorithm (1)
- Approximationsalgorithmus (1)
- Arbitrage (1)
- Assignment Problem (1)
- Asymptotically Even Nonlinearity (1)
- Ausreißer <Statistik> (1)
- Automorphismengruppe (1)
- Axon (1)
- Banach spaces (1)
- Bayesian Inference (1)
- Berkovich spaces (1)
- Binomialmodell (1)
- Binärsuchbaum (1)
- Black and Scholes Option Price theory (1)
- Black-Scholes (1)
- Blind Signature (1)
- Block Korkin—Zolotarev reduction (1)
- Blockplay (1)
- Bolthausen-Sznitman (1)
- Boolean Lattice (1)
- Bootstrap-Statistik (1)
- Boundary (1)
- Boundary Value Problems (1)
- Branch and Bound (1)
- Branching particle systems (1)
- Branching process approximation (1)
- Breaking knapsack cryptosystems (1)
- Bruhat-Tits-Gebäude (1)
- Burst (1)
- CAT(0)-Räume (1)
- CAT(0)-spaces (1)
- CIR-1 (1)
- Calderón problem (1)
- Cannings model (1)
- Catalan number (1)
- Cauchy-Anfangswertproblem (1)
- Cayley-Graph (1)
- China-Restaurant-Prozess (1)
- Chinese Remainder Theorem (1)
- Chinese restaurant process (1)
- Chinese-restaurant-process (1)
- Circuit (1)
- Closest Vector Problem (1)
- Coamoeba (1)
- Cognitive psychology (1)
- Commitment (1)
- Commitment schemes (1)
- Computational complexity (1)
- Concentration Inequality (1)
- Condensing (1)
- Containment (1)
- Contraction method (1)
- Datenbank (1)
- Datenstruktur (1)
- Degenerate Linear Part (1)
- Dehn (1)
- Derivate (1)
- Dessins d'enfants (1)
- Diagrams and mathematical learning (1)
- Dichte <Stochastik> (1)
- Digital and analogue materials (1)
- Digital trees (1)
- Dimension 2 (1)
- Directional selection (1)
- Dirichlet bound (1)
- Dirichlet random measure (1)
- Dirichletsche L-Reihe; Nullstelle (1)
- Discrete Logarithm (1)
- Diskrete Geometrie (1)
- Diskrete Mathematik (1)
- Diskreter Markov-Prozess (1)
- Diversity in trait space (1)
- Donkers theorem (1)
- Dopamine (1)
- Doplicher-Haag-Roberts Axiomatik; Algebraische Quantenfeldtheorie; Superauswahlregeln und -sektoren; Quantenstatistik; Zopfgruppenstatistik (1)
- Dormancy (1)
- Dosis-Wirkungs-Modellierung (1)
- Dreiecksgruppe (1)
- Dreiecksgruppen (1)
- Duality (1)
- Early Childhood (1)
- Einbettung <Mathematik> (1)
- Elektronische Unterschrift (1)
- Elementar- und Primarbereich (1)
- Endliche Präsentation (1)
- Endlichkeitseigenschaften (1)
- Energie-Modell (1)
- Error Bound (1)
- Erwartungswert (1)
- Evolutionary branching (1)
- Evolving Yield Curves in the Real-World Measures (1)
- Ewens sampling formula (1)
- Examples (1)
- Extended RMJBN Modell (1)
- FEM-BEM-coupling (1)
- FID model (1)
- FIND algorithm (1)
- Face (1)
- Face recognition (1)
- Factoring (1)
- Familie (1)
- Family (1)
- Feller branching with logistic growth (1)
- Finite element methods (1)
- Finitely many measurements (1)
- Fixation probability (1)
- Fixpunkt (1)
- Fractional Brownian Motion (1)
- Fractional Laplacian (1)
- Frühe Bildung (1)
- Fuchs-Gruppe (1)
- Fuchssche Gruppe ; Modulare Einbettung (1)
- Fuchssche Gruppen (1)
- Functions (1)
- Funktionenkegel (1)
- Funktionenkörper ; Arithmetische Gruppe ; Auflösbare Gruppe ; Endlichkeit (1)
- Galerkin Approximation (1)
- Galois group (1)
- Galois-Gruppe (1)
- Game Tree (1)
- Gaussian Random Field (1)
- Gaussian process (1)
- Gelfand-Shilov space (1)
- Gemischte Volumen (1)
- Genealogical construction (1)
- Genealogische Konstruktion (1)
- Genetischer Fingerabdruck (1)
- Genus One (1)
- Geometrische Gruppentheorie (1)
- Geometry (1)
- Gespräch (1)
- Gestaenge (1)
- Girsanov transform (1)
- Gitter <Mathematik> ; Basis <Mathematik> ; Reduktion ; Algorithmus ; Laufzeit ; L-unendlich-Norm ; Rucksackproblem ; Kryptosystem (1)
- Gitter <Mathematik> ; Basis <Mathematik> ; Reduktion ; Gauß-Algorithmus (1)
- Gram-Hadamard inequalities (1)
- Graphen (1)
- Grenzwertsatz (1)
- Griffiths–Engen–McCloskey distribution (1)
- Group dynamics (1)
- Große Abweichung (1)
- Großinvestor (1)
- Gruppendynamiken (1)
- Gruppentheorie (1)
- Hadamard's Three-Lines Theorem (1)
- Halbeinfache algebraische Gruppe (1)
- Handelman (1)
- Handlung (1)
- Harmoniebox (1)
- Heisenberg algebra (1)
- Hidden Markov models (1)
- Hintertür <Informatik> (1)
- Hodge bundle (1)
- Holzklötzchen (1)
- Hopf algebroids (1)
- Householder reflection (1)
- Hyperfunktion ; Asymptotische Entwicklung (1)
- Hypotrochoid (1)
- Identification (1)
- Immigration (1)
- Index at Infinity (1)
- Infrared singularity (1)
- Integer relations (1)
- Integraldarstellung (1)
- Interaction (1)
- Internet (1)
- Invariante (1)
- Inverse problems (1)
- Iteration (1)
- Jahr der Mathematik (1)
- Kettenbruchentwicklung ; Dimension n ; Diophantische Approximation (1)
- Kieferorthopädie (1)
- Klassifizierender Raum (1)
- Klebsiella pneumoniae (1)
- Knotenabstand (1)
- Knotentiefe (1)
- Koaleszent (1)
- Kochen-Specker theorem (1)
- Kollektivintelligenz (1)
- Kombinatorische Gruppen (1)
- Konforme Feldtheorie (1)
- Konstruktiver Beweis (1)
- Kontaktprozess (1)
- Kontraktionsmethode (1)
- Konzentrationsungleichung (1)
- Korkin—Zolotarev reduction (1)
- Kreuzkorrelation (1)
- Kryptosystem (1)
- Kullback-Leibler Informational Divergence (1)
- L^p bounds (1)
- L^p means (1)
- Label cover (1)
- Lanzeitverhalten (1)
- Laplace-Differentialgleichung (1)
- Large Deviation (1)
- Lattice Reduction (1)
- Leerverkauf (1)
- Lernen (1)
- Linear Filtering (1)
- Linear Preferential Attachment Trees (1)
- Linear-Implicit Scheme (1)
- Linkages (1)
- Loewner monotonicity and convexity (1)
- Logarithmic Laplacian (1)
- Long- Range Dependence (1)
- Long-Range Dependence (1)
- Long-time behaviour (1)
- Longitudinal Study (1)
- Lotka-Volterra system (1)
- Lovász Local Lemma (1)
- Low density subset sum algorithm (1)
- MINT-Bildung (1)
- Machine Learning (1)
- Malliavin calculus (1)
- Mallows model (1)
- Markov chain Monte Carlo Method (1)
- Markov chain imbedding technique (1)
- Markov model (1)
- Markov-Kette (1)
- Mathematical Giftedness (1)
- Mathematical Reasoning (1)
- Mathematical modelling (1)
- Mathematics Learning (1)
- Mathematische Bildung (1)
- Mathematische Modellierung (1)
- Max (1)
- McEliece (1)
- Mean Anisotropy (1)
- Message authentication (1)
- Methanogenese (1)
- Mixed Volumes (1)
- Modellierung (1)
- Modular Multiplication (1)
- Mooney faces (1)
- Morava K-theory (1)
- Mouse (1)
- Multi-Harmonie-Ansatz (1)
- Multiple lineare Regression (1)
- Multityp-Verzweigungsprozess mit Immigration (1)
- Multitype Branching with Immigration (1)
- NP-complete problems (1)
- NP-hard (1)
- NP-hardness (1)
- Nash-Gleichgewicht (1)
- Nelson-Siegel (1)
- Neural encoding (1)
- Neurophysiology (1)
- Neuroscience (1)
- Neurowissenschaft (1)
- Newton–Okounkov bodies (1)
- Non-Malleability (1)
- Noticeable Probability (1)
- Optimal Mean-Square Filter (1)
- Oracle Query (1)
- Parabolic SPDE (1)
- Parisi conjecture (1)
- Participation (1)
- Partizipation (1)
- Patientenbewertung (1)
- Pause (1)
- Permutation (1)
- Permutationsgruppen (1)
- Pfadeigenschaften (1)
- Phragmén-Lindelöf principle (1)
- Piecewise-constant coefficient (1)
- Poisson Process (1)
- Poisson boundary (1)
- Poisson-Prozess (1)
- Polyedrische Kombinatorik (1)
- Polymorphic evolution sequence (1)
- Polynomial Optimization (1)
- Pontrjagin space (1)
- Populationsdynamiken (1)
- Portfolios (1)
- Positivstellensatz (1)
- Potenzialtheorie (1)
- Prag <1999> (1)
- Preferential Attachment-Modelle (1)
- Private Information Retrieval (1)
- Probabilistic analysis of algorithms (1)
- Probabilistically checkable proofs (1)
- Probabilistische Analyse von Algorithmen (1)
- Probability distribution (1)
- Probability of fixation (1)
- Professionalisierung (1)
- Profil Likelihood (1)
- Projektionen (1)
- Public Key Cryptosystem (1)
- Public Parameter (1)
- Punktprozess (1)
- Pólya urn (1)
- Quadratic Residue (1)
- Quantenfeldtheorie ; Konforme Feldtheorie ; Algebraische Methode (1)
- Quantum Zeno Effect (1)
- Quantum Zeno effect (1)
- Quasi-Automorphismen (1)
- Quaternionenalgebra (1)
- Quickselect (1)
- RSA-Verschlüsselung (1)
- Radix sort (1)
- Random Oracle (1)
- Random Split Trees (1)
- Random String (1)
- Random environment (1)
- Random variables (1)
- Randomisieren (1)
- Ray-Knight representation (1)
- Reaction time (1)
- Reale vs. risikoneutrale Welt in der Finanzmathematik (1)
- Rechenzentrum (1)
- Rekursiver Algorithmus (1)
- Relaxation (1)
- Representation Problem (1)
- Research article (1)
- Riemann surfaces (1)
- Riemannsche Fläche (1)
- Riemannsche Flächen (1)
- Ringtheorie (1)
- Risikobewertung (1)
- Risikomanagement (1)
- Robustheit (1)
- Rückkopplungseffekt (1)
- S-arithmetic groups (1)
- SLLL-reduction (1)
- Sackgassen (1)
- San Francisco (1)
- Santa Barbara (1)
- Schizophrenia (1)
- Schwarz triangel functions (1)
- Schwinger model (1)
- Security (1)
- Security Parameter (1)
- Semidefinite Optimierung (1)
- Semidefinite Optimization (1)
- Semiotics according to C. S. Peirce (1)
- Sensory perception (1)
- Sensory processing (1)
- Sigma-Invariante (1)
- Sigma-invariant (1)
- Signalverarbeitung (1)
- Signature (1)
- Small Worlds (1)
- Small order expansion (1)
- Spectrahedra (1)
- Spiel (1)
- Spielbaum (1)
- Spielbaum-Suchverfahren (1)
- Stable reduction algorithm (1)
- State dependent branching rate (1)
- Stationarity (1)
- Stochastic Analysis of Square Zero Variation Processes (1)
- Stonesches Spektrum (1)
- Striatum (1)
- Strong Taylor Scheme (1)
- Stummel, Friedrich (1)
- Suchbaum (1)
- Suchoperation (1)
- Sudoku (1)
- Sum of Squares (1)
- Support (1)
- Symmetrie (1)
- Symmetrischer Raum (1)
- Symmetry (1)
- Sympatric speciation (1)
- Tail Bound (1)
- Tailschranke (1)
- Talk (1)
- Thorne Kishino Felsenstein model (1)
- Topic Model (1)
- Trapdoor (1)
- Trinomial (1)
- Tropical Geometry (1)
- Tropical Grassmannians (1)
- Tropical bases (1)
- Tropical varieties (1)
- Tropische Basen (1)
- Trotter's product formula (1)
- Turkish immigrants (1)
- Typ-In-Algebra (1)
- Typology (1)
- Türkisch (1)
- Uniform regularity (1)
- Uniform resource locators (1)
- Unterstützung (1)
- Valuation on functions (1)
- Varianz (1)
- Vertexoperator (1)
- Verzweigende Teilchensysteme (1)
- Virasoro-Algebra (1)
- Wahrscheinlichkeit (1)
- Wahrscheinlichkeitsverteilung (1)
- Wiener Index (1)
- Wiener index (1)
- Wiener-Index (1)
- Yule process (1)
- Yule-process (1)
- Zinsstrukturmodelle (1)
- Zinsänderungsrisiko (1)
- Zolotarev metric (1)
- Zolotarev-Metrik (1)
- Zopfgruppe ; Lineare Darstellung ; Kettengruppe ; Homologiegruppe ; Automorphismengruppe ; Kettenkomplex (1)
- Zufall (1)
- Zufallsgraph (1)
- Zufällige Umgebung (1)
- Zustandsabhängige Verzweigungsrate (1)
- Zweiphasen-Biogasreaktor (1)
- Zweistufen-Biogasreaktor (1)
- abelian differentials (1)
- abstract potential theory (1)
- algebraic curves (1)
- algebraic values (1)
- alpha-stable branching (1)
- ampleness (1)
- analysis of algorithms (1)
- anti-Zeno effect (1)
- arithmetic ball quotients (1)
- arithmetic group (1)
- assignment problem (1)
- augmented and restricted base loci (1)
- autocorrelograms (1)
- bid-ask spread (1)
- bordism theory (1)
- branching processes (1)
- branching random walk in random medium (1)
- buildings (1)
- cancer cell dormancy (1)
- canonical divisors (1)
- catastrophe modeling (1)
- central limit theorem (1)
- chosen ciphertext attack (1)
- clique problem (1)
- colorabdity (1)
- colored graphs (1)
- compact Riemann surfaces (1)
- complex multiplication (1)
- composition (1)
- computational geometry (1)
- concurrent composition (1)
- condensing (1)
- confirmatory factory analysis (1)
- consensus (1)
- contact process (1)
- continued fraction algorithm (1)
- controlled homotopy (1)
- convexity (1)
- convolution quadrature (1)
- cooperative systems (1)
- cross correlation (1)
- cryptography (1)
- cycle structure of permutations (1)
- dead ends (1)
- degenerate semigroup (1)
- delay equation (1)
- depth of a nod (1)
- dessins d’enfants (1)
- difference sets (1)
- digital search tree (1)
- discrete dynamical system (1)
- discrete logarithm (1)
- discrete logarithm (DL) (1)
- diskrete Mathematik (1)
- dose-resoponse modelling (1)
- doubly stochastic point process (1)
- eigenvalue (1)
- elastodynamic wave equation (1)
- emergence (1)
- endliche metrische Räume (1)
- error bounds (1)
- exponentiation (1)
- external branch (1)
- face inversion (1)
- face perception (1)
- fake projective planes (1)
- families of hash functions (1)
- feedback effect (1)
- finite resolution (1)
- finiteness-properties (1)
- flat surfaces (1)
- floating norms (1)
- floating point arithmetic (1)
- floating point errors (1)
- foliated Schwarz symmetry (1)
- forming a group (1)
- fractional Brownian motion (1)
- fractions of exponentiation (1)
- frühkindliche Erziehung (1)
- fuchsian group (1)
- functional limit theorem (1)
- functional limit theorems (1)
- fächerübergreifendes Lernen (1)
- generic algorithm (1)
- generic algorithms (1)
- generic complexity (1)
- generic group model (1)
- graph coloring (1)
- graph isomorphism (1)
- h-transform (1)
- hard bit (1)
- hardcore subsets (1)
- harmonic function (1)
- heavy tails (1)
- hidden Markov model (1)
- hierarchical mean-field limit (1)
- highly regular nearby points (1)
- hyperbolische Geometrie (1)
- hypergeometric functions (1)
- hypervariable region (1)
- höhere Momente (1)
- incremental schemes (1)
- indefinite inner product space (1)
- individual-based models (1)
- inner product (1)
- integer relation (1)
- integer vector (1)
- interacting particle Systems (1)
- interdisziplinäre Lehre (1)
- internal diffusion limited aggregation (1)
- internal path length (1)
- inverse coefficient problem, (1)
- iterated subsegments (1)
- key comparisons (1)
- kinetic fingerprint (1)
- knapsack cryptosystems (1)
- kontrollierte Homotopie (1)
- large deviations (1)
- large trader (1)
- latent variance (1)
- lattice basis reduction (1)
- lattices (1)
- leapfrog (1)
- length defect (1)
- limit order markets (1)
- local LLL-reduction (1)
- local LLLreduction (1)
- local coordinates (1)
- local randomness (1)
- local time (1)
- local time drift (1)
- logarithmic geometry (1)
- logical networks (1)
- lookdown construction (1)
- lower bounds (1)
- manifold and geodesic (1)
- market making (1)
- mathematical modeling (1)
- mathematical modelling (1)
- mathematics (1)
- measurement (1)
- mehrdimensionale Ausreißererkennung (1)
- message-passing algorithm (1)
- modelling (1)
- modular automorphism group (1)
- modular group (1)
- moduli spaces (1)
- multi-agents system (1)
- multi-drug treatment (1)
- multiharmony (1)
- multilevel branching (1)
- music (1)
- mutation parameter estimation (1)
- neuronal code (1)
- neuronaler Kode (1)
- nichtlineare stochastische Integration (1)
- non-archimedean geometry (1)
- non-autonomous dynamical systems (1)
- non-malleability (1)
- noncommutative ring spectra (1)
- nondetermmistlc Turing machines (1)
- nonlinear stochastic integration (1)
- numerical experiments (1)
- observable Funktion (1)
- one-more decryption attack (1)
- one-way function (1)
- one-way functions (1)
- operator algebra (1)
- optimal transport (1)
- pair HMM (1)
- parameter dependent semimartingales (1)
- parameterabhängige Semimartingale (1)
- partial match queries (1)
- path properties (1)
- perceptual closure (1)
- permutation groups (1)
- phage (1)
- phage therapy (1)
- phase coding (1)
- phase transitions (1)
- platonischer Körper (1)
- poisson process (1)
- polynomial random number generator (1)
- population dynamics (1)
- portfolio optimization (1)
- positivity of line bundles (1)
- preferential attachment (1)
- preferential attachment models (1)
- probabilistic analysis of algorithms (1)
- probability (1)
- probability metric (1)
- profile likelihood (1)
- projections (1)
- projective planes (1)
- q-binomial theorem (1)
- quantum field theory (1)
- quasi-automorphisms (1)
- quaternion algebra (1)
- quincunx (1)
- random assignment problem (1)
- random environment (1)
- random function generator (1)
- random graphs (1)
- random measures (1)
- random media (1)
- random metric (1)
- random move (1)
- random number generator (1)
- random oracle model (1)
- random partition (1)
- random recursive tree (1)
- random rekursiv tree (1)
- random trees (1)
- random walks (1)
- raum-zeitliche Muster (1)
- reactant-catalyst systems (1)
- recursive distributional equation (1)
- reguläre Parkettierung (1)
- resistance (1)
- resistance mutation (1)
- reversibility (1)
- riemann surfaces (1)
- risk assessment (1)
- risk theory (1)
- rotating plane method (1)
- rough paths theory (1)
- satlsfiablhty (1)
- scaling (1)
- search operation (1)
- searchtrees (1)
- secure bit (1)
- security analysis of protocols (1)
- security of data (1)
- self-organizing groups (1)
- self-organizing groups; population dynamics; collective intelligence; forming groups; metric on finite sets (1)
- semidefinite optimization (1)
- sequence alignment (1)
- set-valued pullback attractors (1)
- shadow price (1)
- short integer relation (1)
- shortest lattice vector (1)
- signature size (1)
- signed ElGamal encryption (1)
- simultaneous diophantine approximations (1)
- simultaneous security of bits (1)
- single block replacement (1)
- small worlds (1)
- spatio-temporal patterns (1)
- split tree (1)
- statistic analysis (1)
- statistical alignment (1)
- statistische Analyse (1)
- statistischer Test (1)
- stoch. Analyse von Algorithmen (1)
- stochastic filtering (1)
- stochastic modeling (1)
- stochastic population dynamics (1)
- stochastische Prozesse (1)
- strong transience (1)
- subgroup growth (1)
- subset sum problems (1)
- substitution attacks (1)
- sum of squared factor loadings (1)
- switching systems (1)
- synergistic interaction (1)
- therapy evasion (1)
- topological entropy (1)
- trading strategies (1)
- transcendence (1)
- transversal learning (1)
- treatment protocol design (1)
- treatment success (1)
- triangle group (1)
- triangle groups (1)
- tropical geometry (1)
- tropical universal Jacobian (1)
- tropicalization (1)
- universal compactified Jacobian (1)
- urn model (1)
- von Neumann algebra (1)
- von Neumann algebras (1)
- von Neumann-Algebra (1)
- weak convergence (1)
- zufälliger Algorithmus (1)
- zufälliger rekursiver Baum (1)
- zufälliges Assignment Problem (1)
- Λ-coalescent (1)
- σ-field (1)
Institute
- Mathematik (362)
- Informatik (54)
- Präsidium (20)
- Physik (6)
- Psychologie (6)
- Geschichtswissenschaften (5)
- Sportwissenschaften (5)
- Biochemie und Chemie (3)
- Biowissenschaften (3)
- Geographie (3)
Muller's ratchet, in its prototype version, models a haploid, asexual population whose size~N is constant over the generations. Slightly deleterious mutations are acquired along the lineages at a constant rate, and individuals carrying less mutations have a selective advantage. The classical variant considers {\it fitness proportional} selection, but other fitness schemes are conceivable as well. Inspired by the work of Etheridge et al. ([EPW09]) we propose a parameter scaling which fits well to the ``near-critical'' regime that was in the focus of [EPW09] (and in which the mutation-selection ratio diverges logarithmically as N→∞). Using a Moran model, we investigate the``rule of thumb'' given in [EPW09] for the click rate of the ``classical ratchet'' by putting it into the context of new results on the long-time evolution of the size of the best class of the ratchet with (binary) tournament selection, which (other than that of the classical ratchet) follows an autonomous dynamics up to the time of its extinction. In [GSW23] it was discovered that the tournament ratchet has a hierarchy of dual processes which can be constructed on top of an Ancestral Selection graph with a Poisson decoration. For a regime in which the mutation/selection-ratio remains bounded away from 1, this was used in [GSW23] to reveal the asymptotics of the click rates as well as that of the type frequency profile between clicks. We will describe how these ideas can be extended to the near-critical regime in which the mutation-selection ratio of the tournament ratchet converges to 1 as N→∞.
Motivated by the question of the impact of selective advantage in populations with skewed reproduction mechanims, we study a Moran model with selection. We assume that there are two types of individuals, where the reproductive success of one type is larger than the other. The higher reproductive success may stem from either more frequent reproduction, or from larger numbers of offspring, and is encoded in a measure Λ for each of the two types. Our approach consists of constructing a Λ-asymmetric Moran model in which individuals of the two populations compete, rather than considering a Moran model for each population. Under certain conditions, that we call the "partial order of adaptation", we can couple these measures. This allows us to construct the central object of this paper, the Λ−asymmetric ancestral selection graph, leading to a pathwise duality of the forward in time Λ-asymmetric Moran model with its ancestral process. Interestingly, the construction also provides a connection to the theory of optimal transport. We apply the ancestral selection graph in order to obtain scaling limits of the forward and backward processes, and note that the frequency process converges to the solution of an SDE with discontinous paths. Finally, we derive a Griffiths representation for the generator of the SDE and use it to find a semi-explicit formula for the probability of fixation of the less beneficial of the two types.
Motivated by the question of the impact of selective advantage in populations with skewed reproduction mechanims, we study a Moran model with selection. We assume that there are two types of individuals, where the reproductive success of one type is larger than the other. The higher reproductive success may stem from either more frequent reproduction, or from larger numbers of offspring, and is encoded in a measure Λ for each of the two types. Our approach consists of constructing a Λ-asymmetric Moran model in which individuals of the two populations compete, rather than considering a Moran model for each population. Under certain conditions, that we call the ``partial order of adaptation'', we can couple these measures. This allows us to construct the central object of this paper, the Λ−asymmetric ancestral selection graph, leading to a pathwise duality of the forward in time Λ-asymmetric Moran model with its ancestral process. Interestingly, the construction also provides a connection to the theory of optimal transport. We apply the ancestral selection graph in order to obtain scaling limits of the forward and backward processes, and note that the frequency process converges to the solution of an SDE with discontinous paths. Finally, we derive a Griffiths representation for the generator of the SDE and use it to find a semi-explicit formula for the probability of fixation of the less beneficial of the two types.
Motivated by the question of the impact of selective advantage in populations with skewed reproduction mechanisms, we study a Moran model with selection. We assume that there are two types of individuals, where the reproductive success of one type is larger than the other. The higher reproductive success may stem from either more frequent reproduction, or from larger numbers of offspring, and is encoded in a measure Λ for each of the two types. Λ-reproduction here means that a whole fraction of the population is replaced at a reproductive event. Our approach consists of constructing a Λ-asymmetric Moran model in which individuals of the two populations compete, rather than considering a Moran model for each population. Provided the measure are ordered stochastically, we can couple them. This allows us to construct the central object of this paper, the Λ−asymmetric ancestral selection graph, leading to a pathwise duality of the forward in time Λ-asymmetric Moran model with its ancestral process. We apply the ancestral selection graph in order to obtain scaling limits of the forward and backward processes, and note that the frequency process converges to the solution of an SDE with discontinuous paths. Finally, we derive a Griffiths representation for the generator of the SDE and use it to find a semi-explicit formula for the probability of fixation of the less beneficial of the two types.
Therapy evasion – and subsequent disease progression – is a major challenge in current oncology. An important role in this context seems to be played by various forms of cancer cell dormancy. For example, therapy-induced dormancy, over short timescales, can create serious obstacles to aggressive treatment approaches such as chemotherapy, and long-term dormancy may lead to relapses and metastases even many years after an initially successful treatment. The underlying dormancy-related mechanisms are complex and highly diverse, so that the analysis even of basic patterns of the population-level consequences of dormancy requires abstraction and idealization, as well as the identification of the relevant specific scenarios.
In this paper, we focus on a situation in which individual cancer cells may switch into and out of a dormant state both spontaneously as well as in response to treatment, and over relatively short time-spans. We introduce a mathematical ‘toy model’, based on stochastic agent-based interactions, for the dynamics of cancer cell populations involving individual short-term dormancy, and allow for a range of (multi-drug) therapy protocols. Our analysis shows that in our idealized model, even a small initial population of dormant cells can lead to therapy failure under classical (and in the absence of dormancy successful) single-drug treatments. We further investigate the effectiveness of several multidrug regimes (manipulating dormant cancer cells in specific ways) and provide some basic rules for the design of (multi-)drug treatment protocols depending on the types and parameters of dormancy mechanisms present in the population.
Highlights
• We study dormancy in the ‘rare mutation’ regime of stochastic adaptive dynamics.
• We first derive the polymorphic evolution sequence, based on prior work.
• Our evolutionary branching criterion extends a result by Champagnat and Méléard.
• In a classical model dormancy can favour evolutionary branching.
• Dormancy also affects several more population characteristics.
Abstract
In this paper, we investigate the consequences of dormancy in the ‘rare mutation’ and ‘large population’ regime of stochastic adaptive dynamics. Starting from an individual-based micro-model, we first derive the Polymorphic Evolution Sequence of the population, based on a previous work by Baar and Bovier (2018). After passing to a second ‘small mutations’ limit, we arrive at the Canonical Equation of Adaptive Dynamics, and state a corresponding criterion for evolutionary branching, extending a previous result of Champagnat and Méléard (2011).
The criterion allows a quantitative and qualitative analysis of the effects of dormancy in the well-known model of Dieckmann and Doebeli (1999) for sympatric speciation. In fact, quite an intuitive picture emerges: Dormancy enlarges the parameter range for evolutionary branching, increases the carrying capacity and niche width of the post-branching sub-populations, and, depending on the model parameters, can either increase or decrease the ‘speed of adaptation’ of populations. Finally, dormancy increases diversity by increasing the genetic distance between subpopulations.
For genus g=r(r+1)2+1, we prove that via the forgetful map, the universal Prym-Brill-Noether locus Rrg has a unique irreducible component dominating the moduli space Rg of Prym curves.
For genus g=2i≥4 and the length g−1 partition μ=(4,2,…,2,−2,…,−2) of 0, we compute the first coefficients of the class of D¯¯¯¯(μ) in PicQ(R¯¯¯¯g), where D(μ) is the divisor consisting of pairs [C,η]∈Rg with η≅OC(2x1+x2+⋯+xi−1−xi−⋯−x2i−1) for some points x1,…,x2i−1 on C. We further provide several enumerative results that will be used for this computation.
For genus g=2i≥4 and the length g−1 partition μ=(4,2,…,2,−2,…,−2) of 0, we compute the first coefficients of the class of D¯¯¯¯(μ) in PicQ(R¯¯¯¯g), where D(μ) is the divisor consisting of pairs [C,η]∈Rg with η≅OC(2x1+x2+⋯+xi−1−xi−⋯−x2i−1) for some points x1,…,x2i−1 on C. We further provide several enumerative results that will be used for this computation.
For genus g=2i≥4 and the length g−1 partition μ=(4,2,…,2,−2,…,−2) of 0, we compute the first coefficients of the class of D¯¯¯¯(μ) in PicQ(R¯¯¯¯g), where D(μ) is the divisor consisting of pairs [C,η]∈Rg with η≅OC(2x1+x2+⋯+xi−1−xi−⋯−x2i−1) for some points x1,…,x2i−1 on C. We further provide several enumerative results that will be used for this computation.