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Rezensionen zu: Karl-Heinz Wellmann (Hrsg.) : Haben Fische Durst? : 111 Antworten auf Fragen, die Ihnen schon immer auf den Nägeln brannten. Jonas-Verlag, Marburg 2003, ISBN 3894453168 , 128 Seiten, 10 Euro. Karl-Heinz Wellmann (Hrsg.) : Können Vögel husten? : 111 neue Antworten auf Fragen, die Ihnen schon immer auf den Nägeln brannten ; Das zweite Buch zur »Entdeckungsreise« in hr1, Jonas Verlag, Marburg 2005, ISBN 389445346X, 120 Seiten, 10 Euro.
Background: The APOBEC3G protein represents a novel innate defense mechanism against retroviral infection. It facilitates the deamination of the cytosine residues in the single stranded cDNA intermediate during early steps of retroviral infection. Most poxvirus genomes are relatively A/T-rich, which may indicate APOBEC3G-induced mutational pressure. In addition, poxviruses replicate exclusively in the cytoplasm where APOBEC3G is located. It was therefore tempting to analyze whether vaccinia virus replication is affected by APOBEC3G.
Results: The replication of vaccinia virus, a prototype poxvirus, was not, however, inhibited in APOBEC3G-expressing cells, nor did other members of the APOBEC3 family alter vaccinia virus replication. HIV counteracts APOBEC3G by inducing its degradation. However, Western blot analysis showed that the levels of APOBEC3G protein were not affected by vaccinia virus infection.
Conclusion: The data indicate that APOBEC3G is not a restriction factor for vaccinia virus replication nor is vaccinia virus able to degrade APOBEC3G.