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The stories about the Vaser Valley in the northern Romanian Forest Carpathians have not only fascinated the population of the region, but also famous writers who have always tried to collect the stories and tales from the historical region of the Vaser Valley. The best-known author of this region, who turned his lifelong work into this spectacular project, is the German-speaking ethnologist and writer, of Romanian origin, Anton-Joseph Ilk. His book Die mythische Welt des Wassertales includes a remarkable collection of legends and tales from this region, presented in their orally transmitted stories. The main themes of the stories naturally include customs and traditions, whereby certain values and principles were passed on not only to he children and grandchildren, but also to all succeeding generations.
Acrostilicus Hubbard, 1896 and Pachystilicus Casey, 1905 are North American genera known from only one and two species, respectively, and have never been a subject of a modern revision. In fact, Acrostilicus was not even properly described as its author provided only a sketchy diagnosis of the genus and species. Here, we provide a redescription of the genus Acrostilicus and its species and illustrate the habitus and male genital features. For the first time, we also redescribe Pachystilicus and its two species, and provide their differential diagnoses. Additionally, we tested the phylogenetic position of both genera. They were scored into a morphological matrix supplemented with molecular data and the analyses were run using Bayesian inference and maximum likelihood methods. A total of 119 morphological characters and 4859 bp of nuclear (28S, TP, Wg, CADA, CADC, ArgK) and mitochondrial (COI) sequences were analysed for 46 taxa. The results confirmed that both Acrostilicus and Pachystilicus are members of the subtribe Stilicina, but at the same time challenged the monophyly of the subtribe in its current composition. Additionally, we provided further evidence for non-monophyly of the subtribe Medonina and discussed the biology of Acrostilicus and Pachystilicus.
Plagiognathus ozgurkocaki sp. nov. is described based on a long series of specimens from Karaman, Turkey. The new species is remarkable among its congeners in Palearctic Region due to the combination of following characters: remarkably small size, dense and unicolorous pale yellow vestiture, darkened cuneus and yellow first antennal segment with a basal ring and pre-apical dots. The new species is associated with the endemic Phlomis leucophracta P.H.Davis & Hub.-Mor. (Lamiaceae) which makes it unique among all its congeners. Additionally, Plagiognathus bipunctatus albicans (Reuter, 1901) and Plagiognathus marivanensis Linnavuori, 2010 are recorded from Karaman, former constitutes a new record for Turkey.
Background and purpose: Transient splenial oedema, also known as reversible splenial lesion syndrome (RESLES), is a rare magnetic resonance imaging (MRI) finding that presents as a round or ovoid focal oedema in the posterior corpus callosum, and is associated with a wide range of clinical conditions. The aetiology of RESLES is not fully clear. We aimed to investigate conflicting pathophysiological hypotheses by measuring local glucose metabolism in patients with RESLES.
Methods: We retrospectively analysed patients with RESLES after reductions in antiseizure medications during in-hospital video electroencephalography monitoring. We measured local glucose uptake using positron emission tomography/computed tomography and compared matched cohorts of patients with and without MRI evidence of RESLES using nonparametric tests.
Results: Local glucose metabolism in the splenium of seven patients with RESLES was not significantly different from the glucose metabolism of the seven patients in the matched cohort. This was true using both regular and normalized standardized glucose uptake value calculation methods (p = 0.902 and p = 0.535, respectively).
Conclusion: We found no evidence of local glucose hypometabolism in RESLES, which supports previous pathophysiological considerations that suggest that RESLES is an intercellular, intramyelinic oedema rather than a typical intracellular cytotoxic oedema, which is not reversible.
Academic self-efficacy (ASE) refers to a student’s global belief in his/her ability to master the various academic challenges at university and is an essential antecedent of wellbeing and performance. The five-item General Academic Self-Efficacy Scale (GASE) showed promise as a short and concise measure for overall ASE. However, of its validity and reliability outside of Scandinavia is limited. Therefore, this paper aimed to investigate the psychometric properties, longitudinal invariance, and criterion validity of the GASE within a sample of university students (Time 1: n = 1056 & Time 2: n = 592) in the USA and Western Europe. The results showed that a unidimensional factorial model of overall ASE fitted the data well was reliable and invariant across time. Further, criterion validity was established by finding a positive relationship with task performance at different time stamps. Therefore, the GASE can be used as a valid and reliable measure for general ASE.
Despite its popularity in practice, the Grit-O Scale has shown inconsistent factorial structures and differing levels of internal consistency in samples outside the USA. The validity of the Grit-O Scale in different contexts is, therefore, questionable. As such, the purpose of this paper was to determine whether the Grit-O Scale could be used as a valid and reliable measure to compare grit across different nations. Specifically, the aim was to investigate the factorial validity, reliability, and concurrent validity of the Grit-O Scale and to investigate measurement invariance across three national cohorts (Europe, the USA, and Hong Kong). Data were gathered from 1888 respondents stemming from one USA- (n = 471), two Hong Kong- (n = 361) and four European (n = 1056) universities. A series of traditional CFA and less restrictive ESEM models were estimated and systematically compared to determine the best factorial form of the Grit-O Scale. The results showed that a bifactor ESEM model, with one general factor of overall grit and two specific factors (consistency of interest and perseverance of effort), fitted the data best, showed strong measurement invariance across the three samples, and showed itself to be a reliable measure. Furthermore, concurrent validity was established by showing that the three grit factors were directly and positively related to task performance. Meaningful latent comparisons between the three cultural cohorts could therefore be made. The results imply that cross-national comparisons of grit may only be problematic when traditional CFA approaches are favoured. In contrast, ESEM modelling approaches may compensate for cross-national differences in understanding grit and control for differences in the interpretation of the scale’s items. Therefore, the bifactor ESEM approach may be more appropriate for cross-cultural and cross-national comparison studies, as it allows for these differences to be meaningfully captured, modelled, and controlled for.
We aimed to evaluate the factors associated with hemorrhage (HA) of melanoma brain metastases (MBM) after Cyberknife stereotactic radiosurgery (SRS) in the modern era of systemic therapy. A total of 55 patients with 279 MBM were treated in 93 fractions. The median age, SRS dose, radiological follow-up, and time to HA were 60.4 years, 20 Gy, 17.7 months, and 10.7 months, respectively. Radiologically evident HA was documented in 47 (16.8%) metastases. Of the 55 patients, 25 (45.4%) suffered an HA. Among those, HA caused grade 3 toxicity in 10 patients (40%) and grade 1 symptoms in 5 patients (20%). Ten patients (40%) with HA experienced no toxicity. Logistic regression revealed the use of anticoagulants and the administration of systemic therapy within 7/15 days from SRS to be predictive for HA. When considering the HA causing grade 3 symptomatology, only the use of anticoagulants was significant, with the delivery of whole brain radiation therapy (WBRT) before the HA narrowly missing statistical significance. Our retrospective analysis showed that the administration of modern systemic therapy within 7/15 days from SRS may contribute to HA of MBM, though it appears safe, at least concerning grade 3 toxicity. The use of anticoagulants by the time of SRS significantly increased the risk of HA.
Background: The aim of this study was to identify pre-operative parameters able to predict length of stay (LoS) based on clinical data and patient-reported outcome measures (PROMs) from a scorecard database in patients with significant aortic stenosis who underwent TAVI (transfemoral aortic valve implantation). Methods: 302 participants (51.7% males, age range 78.2–84.2 years.) were prospectively recruited. After computing the median LoS value (=6 days, range = 5–8 days), we implemented a decision tree algorithm by setting dichotomized values at median LoS as the dependent variable and assessed baseline clinical variables and PROMs (Clinical Frailty Scale (CFS), EuroQol-5 Dimension-5 Levels (EQ-5D) and Kansas City Cardiomyopathy Questionnaire (KCCQ)) as potential predictors. Results: Among clinical parameters, only peripheral arterial disease (p = 0.029, HR = 1.826) and glomerular filtration rate (GFR, cut-off < 33 mL/min/1.73 m2, p = 0.003, HR = 2.252) were predictive of LoS. Additionally, two PROMs (CFS; cut-off = 3, p < 0.001, HR = 1.324 and KCCQ; cut-off = 30, p = 0.003, HR = 2.274) were strong predictors. Further, a risk score for LoS (RS_LoS) was calculated based on these predictors. Patients with RS_LoS = 0 had a median LoS of 5 days; patients RS_LoS ≥ 3 had a median LoS of 8 days. Conclusions: based on the pre-operative values of the above four predictors, a personalized prediction of LoS after TAVI can be achieved.