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Background The arterial in line application of the leukocyte inhibition module (LIM) in the cardiopulmonary bypass (CPB) limits overshooting leukocyte activity during cardiac surgery. We now studied in a porcine model whether LIM may have beneficial effects on cardiac function after CPB. Methods German landrace pigs underwent CPB (60 min myocardial ischemia; 30 min reperfusion)without (group I; n=6) or with LIM (group II; n=6). The cardiac indices (CI) and cardiac function were analyzed pre and post CPB with a Swan-Ganz catheter and the cardiac function analyzer. Neutrophil labeling with technetium, scintigraphy, and histological analyses were done to track activated neutrophils within the organs. Results LIM prevented CPB-associated increase of neutrophil counts in peripheral blood. In group I, the CI significantly declined post CPB (post: 3.26 +/- 0.31; pre: 4.05 +/- 0.45 l/min/m2; p<0.01). In group II, the CI was only slightly reduced (post: 3.86 +/- 0.49; pre 4.21 +/- 1.32 l/min/m2; p=0.23). Post CPB, the intergroup difference showed significantly higher CI values in the LIM group (p<0.05) which was in conjunction with higher pre-load independent endsystolic pressure volume relationship (ESPVR) values (group I: 1.57 +/- 0.18; group II: 1.93 +/- 0.16; p<0.001). Moreover, the systemic vascular resistance and pulmonary vascular resistance were lower in the LIM group. LIM appeared to accelerate the sequestration of hyperactivated neutrophils in the spleen and to reduce neutrophil infiltration of heart and lung. Conclusions Our data provide strong evidence that LIM improves perioperative hemodynamics and cardiac function after CPB by limiting neutrophil activity and inducing accelerated sequestration of neutrophils in the spleen.
Focus presuppositions
(2007)
This paper reviews notions related to focus and presupposition and addresses the hypothesis that focus triggers an existential presupposition. Presupposition projection behavior in certain examples appears to favor a presuppositional analysis of focus. It is argued that these examples are open to a different analysis using givenness theory. Overall, the analysis favors a weak semantics for focus not including an existential presupposition.
Poster presentation: The mammalian pineal organ is a peripheral oscillator, depending on afferent information from the so-called master clock in the suprachiasmatic nuclei of the hypothalamus. One of the best studied outputs of the pineal gland is the small and hydrophobic molecule melatonin. In all vertebrates, melatonin is synthesized rhythmically with high levels at night, signalling the body the duration of the dark period. Changes or disruptions of melatonin rhythms in humans are related to a number of pathophysiological disorders, like Alzheimer's disease, seasonal affective disorder or the Smith-Magenis-Syndrome. To use melatonin in preventive or curative interferences with the human circadian system, a complete understanding of the generation of the rhythmic melatonin signal in the human pineal gland is essential. Melatonin biosynthesis is best studied in the rodent pineal gland, where the activity of the penultimate and rate-limiting enzyme, the arylalkylamine N-acetyltransferase (AA-NAT), is regulated on the transcriptional level, whereas the regulatory role of the ultimate enzymatic step, achieved by the hydroxyindole O-methyltransferase (HIOMT), is still under debate. In rodents, Aa-nat mRNA is about 100-fold elevated during the night in response to adrenergic stimulation of the cAMP-signalling pathway, with AA-NAT protein levels closely following this dynamics. In contrast, in all ungulates studied so far (cow, sheep), a post-transcriptional regulation of the AA-NAT is central to determine rhythmic melatonin synthesis. AA-NAT mRNA levels are constantly elevated, and lead to a constitutive up-regulation of AA-NAT protein, which is, however, rapidly degraded via proteasomal proteolysis during the day. AA-NAT proteolysis is only terminated upon the nocturnal increase in cAMP levels. Similar to ungulates, a post-transcriptional control of this enzyme seems evident in the pineal gland of the primate Macaca mulatta. Studies on the molecular basis of melatonin synthesis in the human being are sparse and almost exclusively based on phenomenological data, derived from non-invasive investigations. Yet the molecular mechanisms underlying the generation of the hormonal message of darkness can currently only be deciphered using autoptic material. We therefore analyzed in human post-mortem pineal tissue Aa-nat and Hiomt mRNA levels, AA-NAT and HIOMT enzyme activity, and melatonin levels for the first time simultaneously within tissue samples of the same specimen. Here presented data show the feasibility of this approach. Our results depict a clear diurnal rhythm in AA-NAT activity and melatonin content, despite constant values for Aa-nat and Hiomt mRNA, and for HIOMT activity. Notably, the here elevated AA-NAT activity during the dusk period does not correspond to a simultaneous elevation in melatonin content. It is currently unclear whether this finding may suggest a more important role of the ultimate enzyme in melatonin synthesis, the HIOMT, for rate-limiting the melatonin rhythm, as reported recently for the rodent pineal gland. Thus, our data support for the first time experimentally that post-transcriptional mechanisms are responsible for the generation of rhythmic melatonin synthesis in the human pineal gland.
Spatial interpolation of precipitation data is uncertain. How important is this uncertainty and how can it be considered in evaluation of high-resolution probabilistic precipitation forecasts? These questions are discussed by experimental evaluation of the COSMO consortium's limited-area ensemble prediction system COSMO-LEPS. The applied performance measure is the often used Brier skill score (BSS). The observational references in the evaluation are (a) analyzed rain gauge data by ordinary Kriging and (b) ensembles of interpolated rain gauge data by stochastic simulation. This permits the consideration of either a deterministic reference (the event is observed or not with 100% certainty) or a probabilistic reference that makes allowance for uncertainties in spatial averaging. The evaluation experiments show that the evaluation uncertainties are substantial even for the large area (41 300 km2) of Switzerland with a mean rain gauge distance as good as 7 km: the one- to three-day precipitation forecasts have skill decreasing with forecast lead time but the one- and two-day forecast performances differ not significantly.
Zur Unterscheidung von Dipsacus pilosus L. und Dipsacus strigosus WILLDENOW ex ROEMER et SCHULTES
(2007)
Dipsacus strigosus WILLDENOW ex ROEMER et SCHULTES 1818 ist nach WISSKIRCHEN & HAEUPLER (1998) in Deutschland ein zumindest regional fest eingebürgerter Neophyt. Allerdings ist die Sippe in der Vergangenheit immer wieder mit der indigenen Dipsacus pilosus L. 1753 verwechselt worden und aus diesem Grunde wohl als bestimmungskritisch anzusehen, obwohl die Verschlüsselung in ROTHMALER, Band 4, seit der 9. Auflage (2002) eine eindeutige Bestimmung ermöglicht. In die verbreiteten Bestimmungswerke wurde Dipsacus strigosus erst im letzten Jahrzehnt aufgenommen. Die Sippe ist in den neueren Auflagen von SCHMEIL (2000), OBERDORFER (2001) und ROTHMALER (2002) verschlüsselt und in HAEUPLER & MUER (2000) abgebildet, fehlt aber noch in ROTHMALER, BAND 2 (1996).
Evidentiality is a grammatical category which has source of information as its primary meaning — whether the narrator actually saw what is being described, or made inferences about it based on some evidence, or was told about it, and so on. Evidentials are a particularly salient feature of Tibeto-Burman languages. This volume features in-depth studies of evidentiality systems in six languages: Rgyalthang, a Kham Tibetan dialect, by Krisadawan Hongladarom; Yongning Na (Naxi group; believed to be closely related to Lolo-Burmese), by Liberty Lidz; Darma (Almora branch of Western Himalayish), by Christina Willis; nDrapa (Qiangic), by Satoko Shirai; Magar (Himalayish), by Karen Grunow-Hårsta, and Tabo (or Spiti), a Tibetan dialect, by Veronika Hein. Each opens new perspectives on the composition and the semantics of evidential systems, on the marking of more than one information source in one sentence, and on the grammaticalized expression of mirativity.
The new insights on evidentiality and related issues from the Tibeto-Burman area are crucial for understanding evidentials in a cross-linguistic perspective.
"Es ist wohl eine Regel, daß in gewissen Jahren der Geschmack an allem bloß Individuellen und Besonderen, dem Einzelfall, dem 'Bürgerlichen' im weitesten Sinne des Wortes allmählich abhanden kommt. In den Vordergrund tritt: Das Typische, Immer-Menschliche, Immer- Wiederkehrende, Zeitlose, kurz: das Mythische." Mit diesen Worten umreißt Thomas Mann im Jahre 1942 in seinem Vortrag Joseph und seine Brüder einige Beweggründe für seine fast sechzehnjährige Arbeit an dem "abseitigen, fernliegenden Stoff [...] der biblischen Legende", die er zu einem vierbändigen Romanwerk ausarbeitete. Ein wenig seltsam mutet es hier an, wenn man Thomas Mann, den bürgerlichen Romanautor, der stets darauf bedacht war, eben gerade das ganz Besondere, den nicht alltäglichen Menschen, den Einzelgänger und Außenseiter seinen Lesern vor Augen zu führen, vom "bloß" Individuellen reden hört; ganz so, als seien seine früheren Werke – cum grano salis – lediglich Geburtswehen eines weit größeren Unterfangens gewesen, welches nun endlich im Stande sei, zum Kern vorzudringen, um die nötigen aber überständigen Randerscheinungen hinter sich zu lassen. Thomas Mann führt den Leser sicherlich etwas in die Irre, wenn er hier behauptet, das Interesse am Individuum sei ihm in gewissen – und dies meint späteren – Jahren abhanden gekommen. Der Protagonist seiner Tetralogie, Joseph, scheint doch gerade ein ganz außergewöhnlicher Mensch zu sein, der, mit einigen, später zu erörternden Besonderheiten, eben genau das Individuum par excellence darstellt. Oder verhält es sich in Josephs ganz spezifischem Fall noch etwas komplizierter und seine Besonderheit und das Typische schließen sich gar nicht gänzlich aus?
O ensaio investiga os pressupostos filosóficos e críticos de dois modos de conceber a representação literária dos sonhos, contrapondo as obras de André Breton ao livro de protocolos oníricos de Adorno, com o objetivo de refletir sobre o sentido do surrealismo e as relações entre arte, sociedade e psicanálise.
This paper discusses a foundation for writing Hunsrückisch as a German immigrant language in contact with Brazilian Portuguese. This foundation brings together the main conclusions obtained by the Group for the Studies of Hunsrückisch Writing (Grupo de Estudos da Escrita do Hunsrückisch – ESCRITHU). This group was formed at the Language Institute at the Federal University of Rio Grande do Sul with the goal of proposing not only a system of orthographic norms for a language that exists mostly just in oral forms, but also to encourage research on and linguistic education for speakers of this immigrant language. An already extant literature in Hunsrückisch includes journal and magazine texts such as Sankt Paulusblatt or the Brummbär-Kalendar, published between 1931 and 1935, as well as texts by authors such as Rambo (2002 [1937-1961]), Gross (2001), and Rottmann (1889 [1840]). From these texts various writing formats, guidelines, and goals for an orthographic norm are analyzed, be they for the written expression of the speakers or for useful instruments in the transliteration of ethnotexts within the ALMA-H project (Linguistic- Contactual Atlas of the German Minorities in the La Plata Basin: Hunsrückisch), with which ESCRITHU collaborates.
This paper discusses the assessment of German language learners in classes for beginners in a context gathering monolingual Portuguese speakers and bilingual speakers of Portuguese and Hunsrückisch, a German dialect derived from the contact of an immigration language and Portuguese. One of the challanges faced by the teachers of these heterogeneous classes is to assess learners’ classroom achievement once dialect speakers’ needs are considerably different from novice learners’. It is suggested that teachers make a compromise between the course objectives and the learners’ different proficiencies and needs to assess their language progress, incorporating and valuing students’ multicultural and experiential backgrounds.