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The paper presents two case studies from Nigeria and Burkina Faso, that differ in many respects, but show also some significant similarities. In both cases, previously existing claims on land were not recognised by the national authorities who implemented development projects. But as a contrast, in the Nigerian case people had to move out of the territories that were now claimed by the state, whereas in the Burkina case people were brought into an area that was declared state property. As a result in both cases, this had specific implications for the inter-ethnic relations in the respective regions. In Nigeria, Kanuri farmers moved to new fertile areas that incidentally emerged parallel to the development efforts of the state.
Background: Previous experimental research on testosterone (T) and psychological traits is inconclusive. Thus, we performed the first large-scale observational study of the association between T and dispositional optimism / pessimism.
Methods: We used prospective data from 6,493 primary-care patients (3,840 women) of the DETECT study (Diabetes Cardiovascular Risk-Evaluation: Targets and Essential Data for Commitment of Treatment), including repeated immunoassay-based measurement of serum T and optimism / pessimism assessed by the revised Life-Orientation Test (LOT-R). Cross-sectional and longitudinal associations of baseline T and one-year change in T with optimism and pessimism were investigated using age- and multivariable-adjusted regression models.
Results: Cross-sectional analyses showed no association of T with optimism or pessimism in both sexes. Longitudinal analyses also showed no association of baseline T with optimism or pessimism at four-year follow-up. Multivariable analyses of total LOT-R score yielded similarly non-significant results (β-coefficient per unit change in T for men: -0.01 (95% CI: -0.24–0.22), women: 0.08 (-0.03–0.20)). Furthermore, change in T was not related to optimism or pessimism at four-year follow-up.
Conclusions: The present observational study of a large-scale prospective sample showed no association of T with optimism or pessimism. Integrating further experimental and interventional evidence from alternative methodological approaches would strengthen this conclusion and establish stronger evidence about the potential hormonal basis of psychological traits.
The future heavy-ion experiment CBM (FAIR/GSI, Darmstadt, Germany) will focus on measurement of very rare probes at interaction rates up to 10 MHz with data flow of up to 1 TB/s. The beam will provide free stream of beam particles without bunch structure. That requires full online event reconstruction and selection not only in space, but also in time, so-called 4D event building and selection.
The FLES (First-Level Event Selection) reconstruction and selection package consists of several modules: track finding, track fitting, short-lived particles finding, event building and event selection. A time-slice is reconstructed in parallel between cores within a same CPU, thus minimizing the communication between CPUs. After all tracks are found and fitted in 4D, they are collected into clusters of tracks originated from common primary vertices, which then are fitted, thus identifying 4D interaction points registered within the time-slice. Secondary tracks are associated with primary vertices according to their estimated production time. After that, short-lived particles are found and the full event building process is finished. The last stage of the FLES package is the selection of events according to the requested trigger signatures.
Future FAIR experiments have to deal with very high input rates, large track multiplicities, make full event reconstruction and selection on-line on a large dedicated computer farm equipped with heterogeneous many-core CPU/GPU compute nodes. To develop efficient and fast algorithms, which are optimized for parallel computations, is a challenge for the groups of experts dealing with the HPC computing. Here we present and discuss the status and perspectives of the data reconstruction and physics analysis software of one of the future FAIR experiments, namely, the CBM experiment.
The main goal of modern heavy-ion experiments is a comprehensive study of the QCD phase diagram, in a region of Quark-Gluon Plasma (QGP) and possible phase transition to QGP phase.
Strange particles produced in the collision are sensitive probes of the created media. Reconstruction of Σ particles together with other strange particles completes the picture of strangeness production. Σ+ and Σ− have all decay modes with at least one neutral daughter, which can not be registered by the CBM detector.
For their identification the missing mass method is proposed: a) tracks of the mother (Σ−) and the charged daughter (π−) particles are reconstructed in the tracking system; b) the neutral daughter particle (n) is reconstructed from these tracks; c) a mass constraint is set on the reconstructed neutral daughter; d) the mother particle is constructed of the charged and reconstructed neutral daughter particles and the mass spectrum is obtained, by which the particle can be identified.
The method can be applied for other strange particles too. In total 18 particle decays with neutral daughter are now included into physics analysis.
In biological systems (cell culture media, cells, body fluids), drugs/toxicants are usually not freely dissolved but partially bound to biomolecules; only a fraction of the chemical is free/unbound (fu). To predict pharmacological effects and toxicity, it is important that the fu of the drug is known. As the differences between free and nominal concentrations are determined by test system parameters (e.g., the protein and lipid content, and the type of surface material), comparison of nominal concentrations between two different new approach methods (NAM) may lead to faulty conclusions. The same problem exists when in vitro concentrations are compared to those in human subjects. Therefore, the respective fu of a chemical in a test system needs to be determined for in vitro-to-in vivo extrapolations (IVIVE). Besides direct measurements, prediction models can help to obtain fu. Here we describe a simplified approach to approximate fu and provide background information on the underlying assumptions. Comparative predictions and measurements of fu of various drugs are shown to exemplify the approach. Basic input data, like protein and lipid concentrations, are also provided. Beyond such test systems data, the only required chemical-specific inputs are the lipophilicity of the candidate drug and its ionization state, as determined by the dissociation constants of its acidic or basic groups. This overview is intended to be used by any lab scientist without specific toxicokinetics training to obtain an estimate of fu in a given cell culture medium.
Der Artenschutz gehört zu den ältesten Instrumenten des Naturschutzes. Wo jedoch der Schutz innerhalb der natürlichen Lebensräume allein das Überleben gefährdeter Arten nicht mehr garantieren kann, dort sind weiterreichende Maßnahmen in Botanischen Gärten oder „Schutzgärten“ erforderlich. Die in dem Übersichtsbeitrag vorgestellten Verfahren gehen insofern auch über die reine Erhaltung von Sippen in „Genbanken“ hinaus, als die Wiederansiedlung am natürlichen Standort angestrebt wird.
Zu einer gemeinsam veranstalteten wissenschaftlichen Tagung luden am 7. und 8. Juli 1995 der Landesfachausschuss Botanik, das Institut für Geobotanik und Botanischer Garten der Martin-Luther-Universität Halle-Wittenberg und der Botanische Arbeitskreis Nordharz e.V. in das Museum "Kleines Schloss" in Blankenburg/Harz ein. Gastgeber waren hier die Stadt Blankenburg und der Botanische Arbeitskreis. Etwa 100 Teilnehmer waren angereist. Sie kamen überwiegend aus Sachsen-Anhalt, aber auch aus anderen Bundesländern wie Niedersachsen, Hessen, Thüringen und Bayern. Unter ihnen waren zwei Ururenkel des Blankenburger Apothekers und Botanikers Ernst Hampe sowie eine Ururenkelin von Hermann Blumenau, des späteren Stadtgründers in Brasilien, der als junger Mann in Hampes Apotheke die Apothekerkunst erlernt hatte.