Article
Refine
Year of publication
Document Type
- Article (31510) (remove)
Language
- English (16108)
- German (13394)
- Portuguese (696)
- French (387)
- Croatian (251)
- Spanish (250)
- Italian (134)
- Turkish (113)
- Multiple languages (36)
- Latin (35)
Has Fulltext
- yes (31510)
Keywords
- Deutsch (503)
- taxonomy (454)
- Literatur (299)
- new species (198)
- Hofmannsthal, Hugo von (185)
- Rezeption (178)
- Übersetzung (163)
- Filmmusik (155)
- Johann Wolfgang von Goethe (131)
- Vormärz (117)
Institute
- Medizin (5449)
- Physik (2055)
- Biowissenschaften (1158)
- Biochemie und Chemie (1114)
- Extern (1108)
- Frankfurt Institute for Advanced Studies (FIAS) (813)
- Gesellschaftswissenschaften (804)
- Geowissenschaften (593)
- Informatik (459)
- Präsidium (453)
In den letzten Jahren gab es verstärkt Versuche, die komparatistische Literaturwissenschaft an kulturwissenschaftliche Methodiken anzuschließen. Ob es die Diskussionen um die so genannte Postmoderne waren, ob es das Aufkommen bestimmter methodischer Zugriffe war, die unter den Stichworten Poststrukturalismus, Cultural Studies, Historische Anthropologie usw. subsumiert werden, ob medientechnische Entwicklungen (globale Kommunikationsformen und -netzwerke) daran beteiligt waren oder ob es der selbstlegitimatorische Versuch war, literaturwissenschaftliche Kernbestände im Zeichen einer spätkapitalistischen Ökonomie an die so genannte Informationsgesellschaft anschließbar zu machen - wem diese Erweiterung letztlich zu verdanken ist, werden wohl erst die Historiker der Zukunft entscheiden. Was man auch immer von diesen Annäherungen halten mag, sie haben zu einer enormen Ausdehnung des komparatistischen Fachgebietes geführt. Und nicht nur das: Es dürfte schon jetzt klar sein, dass es keinen Weg zurück gibt, auch wenn die altehrwürdigen literaturwissenschaftlichen Disziplingrenzen der Komparatistik weiterhin Bestand haben. Allerdings ist die Adaption neuerer Methodiken relativ selektiv geschehen. Kann etwa für die Diskursanalyse, Systemtheorie, Dekonstruktion oder Medientheorie gesagt werden, dass sie nach mehr als zwanzig Jahren Diskussion für manche Bereiche literaturwissenschaftlicher Forschung, auch und gerade komparatistischer Provenienz, fast kanonischen Charakter haben, so gibt es zahlreiche andere Ansätze, die, zumal in Deutschland, bislang kaum gewürdigt wurden (vgl. Ernst 2000, 160). Einen dieser 'vergessenen' Ansätze hat der französische Philosoph Gilles Deleuze geliefert.
Referenz und Prominenz
(2017)
This paper studies the intergenerational effects of parental unemployment on students’ post-secondary transitions. Besides estimating the average treatment effect of parental unemployment on transition outcomes, we identify the economic, psychological or other intra-familial mechanisms that might explain any adverse impact of parental unemployment. Using longitudinal data from the German Socio-Economic Panel and propensity score matching estimators we find that paternal unemployment has an adverse impact on the likelihood of entering tertiary education, whereas maternal unemployment does not. We also find that the magnitude of the effect depends on the duration of unemployment. Even though we are unable to fully account for the underlying mechanisms, our mediation analysis suggests that the effect of paternal unemployment is not due to the loss of income, but relates to the negative consequences of unemployment for intra-familial well-being and students’ declining optimism about their academic prospects.
Second mitochondria-derived activator of caspase (Smac) mimetics are considered as promising anticancer therapeutics that are currently under investigation in early clinical trials. They induce apoptosis by antagonizing inhibitor of apoptosis proteins, which are frequently overexpressed in cancer. We previously reported that Smac mimetics, such as BV6, additionally exert non-apoptotic functions in glioblastoma (GBM) cells by stimulating migration and invasion in a nuclear factor kappa B (NF-κB)-dependent manner. Because NF-κB target genes mediating these effects are largely unknown, we performed whole-genome expression analyses. Here, we identify chemokine (C-C motif) ligand 2 (CCL2) as the top-listed NF-κB-regulated gene being upregulated upon BV6 treatment in GBM cells. BV6-induced upregulation and secretion of CCL2 are required for migration and invasion of GBM cells because knockdown of CCL2 in GBM cells abolishes these effects. Co-culture experiments of GBM cells with non-malignant astroglial cells reveal that BV6-stimulated secretion of CCL2 by GBM cells into the supernatant triggers migration of astroglial cells toward GBM cells because CCL2 knockdown in BV6-treated GBM cells impedes BV6-stimulated migration of astroglial cells. In conclusion, we identify CCL2 as a BV6-induced NF-κB target gene that triggers migration and invasion of GBM cells and exerts paracrine effects on the GBM's microenvironment by stimulating migration of astroglial cells. These findings provide novel insights into the biological functions of Smac mimetics with important implications for the development of Smac mimetics as cancer therapeutics.
Theologie als Wissenschaft – ist das nach der Aufklärung überhaupt noch möglich? Die europäischen Nachkommen der Aufklärer tun sich schwer, auch nur den "leisesten Duft von Theologie" in und neben ihren Fächern zu dulden. Ganz anders die amerikanischen Religionsphilosophen, die schon früh eine Brücke zwischen dem gelebten Glauben und der rational gesteuerten Vernunft zu schlagen versuchten. Die Theologin und Religionsphilosophin Gesche Linde zeigt auf, welche Impulse vom amerikanischen Pragmatismus für den Dialog der Religionen, aber auch der Wissenschaften ausgehen können.
As demonstrated by the Overlapping Waves Model (Siegler, 1996), children’s strategy use in arithmetic tasks is variable, adaptive, and changes gradually with age and experience. In this study, first grade elementary school children (n = 73), who scored high, middle, or low in a standardized scholastic mathematic achievement test, were confronted with different arithmetic tasks (simple addition, e.g., 3 + 2, simple subtraction, e.g., 7 – 2, and more advanced addition, e.g., 7 + 9) to evoke different calculation strategies. Video analysis and children’s self-report were used to identify individual strategy behavior. In accordance with the Overlapping Waves Model, children in all achievement groups showed variable and multiple strategy usage and adapted their behavior to the tasks of the different categories. We demonstrated that not only low achievers differed from normal achievers but also that high achievers exhibited a unique pattern of strategy behavior in early mathematics.
In the course of elementary school children start to develop an academic self-concept reflecting their motivation, thoughts, and feelings about a specific domain. For the domain of mathematics, gender differences can emerge which are characterized by a less pronounced math self-concept for girls. However, studies are rather sparse regarding the early years of elementary school education, hence, the point in time when such gender differences emerge yet remains a matter of debate. In our study, we found that the math self-concept of elementary school children (n = 81) declined from first to second grade. While no differences in math achievement were observed between girls and boys, it became apparent that girls’ math self-concept was already less pronounced than the math self-concept of boys in the first years of elementary school. Our findings emphasize the importance of considering such gender differences even at the beginning of school education.
Background: The use of cell salvage and autologous blood transfusion has become an important method of blood conservation. So far, there are no clinical data about the performance of the continuous autotransfusion device CATSmart.
Methods: In total, 74 patients undergoing either cardiac or orthopedic surgery were included in this prospective, bicenter and observational technical evaluation to validate red cell separation process and washout quality of CATSmart. The target of red cell separation process was defined as a hematocrit value in the packed red cell unit of 55–75% and of washout quality of 80–100% removal ratio.
Results: Hematocrit values measured by CATSmart and laboratory analysis were 78.5% [71.3%; 84.0%] and 73.7% [67.5%; 75.5%], respectively. Removal ratios for platelets 94.7% [88.2%; 96.7%], free hemoglobin 89.3% [85.2%; 94.9%], albumin 97.9% [96.6%; 98.5%], heparin 99.9% [99.9%; 100.0%], and potassium 92.5% [90.8%; 95.0%] were within the target range while removal of white blood cells was slightly worse 72.4% [57.9%; 87.3%].
Conclusion: The new autotransfusion device enables sufficient red cell separation and washout quality.