Calcipotriol/betamethasone dipropionate aerosol foam for the treatment of psoriasis vulgaris : case series and review of the literature

  • An aerosol foam formulation of a once-daily, fixed-dose combination of a synthetic vitamin D3 analog/synthetic corticosteroid (calcipotriol [Cal] 50 µg/g and betamethasone dipropionate [BD] 0.5 mg/g) has recently been introduced for the topical treatment of plaque psoriasis in adults. Data from several sources – randomized controlled trials, case reports (as highlighted in this review), and real-world evidence (RWE) – underscore the considerable and rapid clinical response, effectiveness, and favorable safety and tolerability of Cal/BD aerosol foam in mild-to-moderate psoriatic patients previously treated with class 3 or 4 topical corticosteroids, in patients unsatisfied with ongoing phototherapy in combination with topical therapy and in patients with moderate-to-severe psoriasis. In addition, our case series, considered together with other RWE, highlights that Cal/BD aerosol foam is more effective and with greater levels of patient preference and acceptability than comparator preparations. Thus, Cal/BD aerosol foam offers several treatment advantages, including relief of itch, and is an appropriate first-line topical therapy for consideration in patients with psoriasis of any severity.
Author:Andreas PinterORCiDGND, Henrik Thormann, Flavia Angeletti, Ahmad Jalili
Pubmed Id:
Parent Title (English):Clinical, cosmetic and investigational dermatology
Publisher:Dove Medical Press
Place of publication:Albany, Auckland
Contributor(s):Jeffrey Weinberg, Amy Norman
Document Type:Article
Year of Completion:2018
Date of first Publication:2018/10/09
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/10/25
Tag:aerosol; betamethasone dipropionate; calcipotriol; psoriasis
Page Number:9
First Page:451
Last Page:459
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Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell 3.0