Über die Abhängigkeit der bakteriziden Wirkung von Mitomycin C auf E. coli B und B/MC von der Temperatur und dem Nährmedium

  • The bactericidal effect of Mitomycin C on E. coli B and the partial reactivability of MC induced cell-inactivations depends on the genotype, the composition of the plating medium and the postincubation temperature in a way rather similar to that found in corresponding UV-experiments. This indicates that at least one type of MC-induced damage in E. coli must be identical or similar with lesions produced by UV. The kinetics of MC-bindung to the cells is the same for the wildtype and an MC-resistant mutant. The temperature coefficient Q10 for binding of MC is between 2 and 4 in the range from 20 °C to 45 °C ; this shows that the MC-uptake is propably not limited by physical reasons. The results have been discussed considering the hypothesis that MC acts by activating the cellular DNase.

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Author:Ulrich WinklerGND
Parent Title (German):Zeitschrift für Naturforschung, B
Publisher:Verlag der Zeitschrift für Naturforschung
Place of publication:Tübingen
Document Type:Article
Date of Publication (online):2014/06/02
Year of first Publication:1962
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/07/11
Page Number:6
First Page:670
Last Page:675
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 3.0