Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response

  • The new variant of concern (VOC) of SARS-CoV-2, Omicron (B.1.1.529), is genetically very different from other VOCs. We compared Omicron with the preceding VOC Delta (B.1.617.2) and the wildtype (wt) strain (B.1) with respect to their interactions with the antiviral interferon (IFN-alpha/beta) response in infected cells. Our data indicate that IFN induction by Omicron is low and comparable to the wt, whereas Delta showed an increased IFN induction. However, Omicron exceeded both the wt and the Delta strain with respect to the ability to withstand the antiviral state imposed by IFN-alpha.

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Author:Lyudmila ShalamovaORCiDGND, Ulrike FelgenhauerORCiDGND, Jochen WilhelmORCiDGND, Andreas R. SchaubmarORCiDGND, Kathrin BüttnerGND, Andreas SchoenORCiDGND, Marek WideraORCiDGND, Sandra CiesekORCiDGND, Friedemann WeberORCiDGND
Parent Title (English):PNAS Nexus
Publisher:Oxford University Press
Place of publication:Oxford
Document Type:Article
Date of Publication (online):2022/05/23
Date of first Publication:2022/05/23
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/09/05
Tag:COVID-19; Omicron variant BA.1; SARS-CoV-2; interferon induction; interferon sensitivity
Issue:2, pgac067
Article Number:pgac067
Page Number:4
First Page:1
Last Page:4
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0