Radiofrequency ablation in experimental bone metastases using a controlled and navigated ablation device

  • Background: Radiofrequency ablation is a minimal invasive therapy in the treatment of bone metastases. In this study we present a new ablation system enabling an ablation in multiple directions and with an adaptable size and shape. Material and methods: VX-2 tumor was used for the induction of experimental bone metastases in the femur of six New Zealand white rabbits. X-ray imaging as well as CT and MRI scans before and after treatment was carried out. After detecting bone tumor, radiofrequency ablation was performed. The ablation instrument contained a 10 g bipolar, articulated extendable electrode and a proprietary generator with an impedance controlled algorithm. All bones and the soft tissue were examined histologically. Results: All animals developed local bone tumor. Mean duration until first osteolytic lesions on CT-scans was 48±14 days. The mean lesion area was 26 mm(2). No systemic tumor spread was seen. 6 radiofrequency procedures were carried out with a mean application time of 6 min±2:30 and an average temperature in the region of effect of 55 °C±4. MRI imaging demonstrated an ablation zone of 23±6 mm around the electrode. Histopathology showed an extensive heat necrosis with no remaining tumor cells in the ablation area. Conclusion: Radiofrequency ablation is a quickly developing treatment option on the field of minimal invasive bone tumor therapy. The electrode enables an ablation adapted to size and shape of the metastases. Further clinical studies are necessary to test and enhance this radiofrequency system.

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Author:Dirk ProschekGND, Marcus TonakGND, Stephan ZangosGND, Martin G. Mack, Andreas Alois KurthGND
URN:urn:nbn:de:hebis:30:3-766996
DOI:https://doi.org/10.1016/j.jbo.2012.07.001
ISSN:2212-1374
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/26909257
Parent Title (English):Journal of bone oncology
Publisher:Elsevier
Place of publication:Amsterdam
Document Type:Article
Language:English
Date of Publication (online):2012/08/09
Date of first Publication:2012/07/04
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2024/04/11
Tag:Animal model; Bone tumor; Rabbit; Radiofrequency ablation; Tumor therapy; VX-2
Volume:1
Issue:2
Page Number:4
First Page:63
Last Page:66
HeBIS-PPN:519277066
Institutes:Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International