Emerging multianalyte biosensors for the simultaneous detection of protein and nucleic acid biomarkers

  • Traditionally, biosensors are designed to detect one specific analyte. Nevertheless, disease progression is regulated in a highly interactive way by different classes of biomolecules like proteins and nucleic acids. Therefore, a more comprehensive analysis of biomarkers from a single sample is of utmost importance to further improve both, the accuracy of diagnosis as well as the therapeutic success. This review summarizes fundamentals like biorecognition and sensing strategies for the simultaneous detection of proteins and nucleic acids and discusses challenges related to multianalyte biosensor development. We present an overview of the current state of biosensors for the combined detection of protein and nucleic acid biomarkers associated with widespread diseases, among them cancer and infectious diseases. Furthermore, we outline the multianalyte analysis in the rapidly evolving field of single-cell multiomics, to stress its significance for the future discovery and validation of biomarkers. Finally, we provide a critical perspective on the performance and translation potential of multianalyte biosensors for medical diagnostics.

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Author:Anna KlebesORCiDGND, Hatice Ceren AtesORCiD, René VerboketORCiDGND, Gerald A. UrbanORCiDGND, Felix von StettenORCiDGND, Can DincerORCiDGND, Susanna Maria FrühORCiDGND
Parent Title (English):Biosensors and bioelectronics
Place of publication:Amsterdam
Document Type:Article
Date of Publication (online):2023/11/03
Year of first Publication:2023
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/11/06
Tag:Biorecognition strategies; Medical diagnostics; Multianalyte detection; Nucleic acid biomarkers; Protein biomarkers
Article Number:115800
Page Number:13
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International