Saccade-related modulations of neuronal excitability support synchrony of visually elicited spikes
- During natural vision, primates perform frequent saccadic eye movements, allowing only a narrow time window for processing the visual information at each location. Individual neurons may contribute only with a few spikes to the visual processing during each fixation, suggesting precise spike timing as a relevant mechanism for information processing. We recently found in V1 of monkeys freely viewing natural images, that fixation-related spike synchronization occurs at the early phase of the rate response after fixation-onset, suggesting a specific role of the first response spikes in V1. Here, we show that there are strong local field potential (LFP) modulations locked to the onset of saccades, which continue into the successive fixation periods. Visually induced spikes, in particular the first spikes after the onset of a fixation, are locked to a specific epoch of the LFP modulation. We suggest that the modulation of neural excitability, which is reflected by the saccade-related LFP changes, serves as a corollary signal enabling precise timing of spikes in V1 and thereby providing a mechanism for spike synchronization.
Author: | Junji Ito, Pedro Maldonado, Wolf SingerORCiDGND, Sonja Grün |
---|---|
URN: | urn:nbn:de:hebis:30:3-272653 |
DOI: | https://doi.org/10.1093/cercor/bhr020 |
ISSN: | 1047-3211 |
ISSN: | 1460-2199 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/21459839 |
Parent Title (English): | Cerebral cortex |
Publisher: | Oxford Univ. Press |
Place of publication: | Oxford |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2011/03/31 |
Date of first Publication: | 2011/03/31 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2012/10/18 |
Tag: | free viewing; local field potential; phase locking; primary visual cortex; spike synchrony |
Volume: | 21 |
Issue: | 11 |
Page Number: | 16 |
First Page: | 2482 |
Last Page: | 2497 |
Note: | © The Authors 2011. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
HeBIS-PPN: | 358404002 |
Institutes: | Wissenschaftliche Zentren und koordinierte Programme / Frankfurt Institute for Advanced Studies (FIAS) |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell 3.0 |