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Inflammatory serum markers up to 5 years after comprehensive periodontal therapy of aggressive and chronic periodontitis
- Aim: The aim of the study is to assess the long-term effect of active periodontal therapy on serum inflammatory parameters in patients with aggressive (AgP) and chronic (ChP) periodontitis in a non-randomised clinical study. Methods: Twenty-five ChP and 17 AgP were examined clinically prior to (baseline), 12 weeks and 60 months after subgingival debridement of all pockets within 2 days. Systemic antibiotics were prescribed if Aggregatibacter actinomycetemcomitans was detected (10 AgP, 8 ChP), flap surgery was rendered if required. Neutrophil elastase (NE), C-reactive protein (CRP), lipopolysaccharide binding protein, interleukin 6, 8, and leukocyte counts were assessed at baseline, 12 weeks and 60 months. Results: Clinical parameters improved significantly in both groups from 12 weeks to 60 months. Eleven AgP and 18 ChP patients received surgical treatment after the 12 weeks examination. Only 3 patients in each group attended ≥ 2 supportive maintenance visits per year. NE and CRP were significantly higher in AgP than ChP at baseline and 60 months (p < 0.01). For leukocyte counts in ChP, significant changes were observed (baseline: 6.11 ± 1.44 nl−1; 12 weeks: 5.34 ± 1.40 nl−1; 60 months: 7.73 ± 2.89 nl−1; p < 0.05). Multiple regression analysis identified African origin, surgical treatment and female sex to correlate with better clinical improvement. Conclusion: Despite comprehensive periodontal treatment, AgP patients exhibit higher NE and CRP levels than ChP patients up to 5 years after therapy. Clinical relevance: Systemic inflammatory burden in AgP patients is higher than in ChP patients even 5 years after periodontal treatment.
Verfasserangaben: | Tatjana Ramich, Anne Asendorf, Katrin NicklesORCiDGND, Gerhard OremekORCiDGND, Ralf SchubertORCiDGND, Luigi Nibali, Martin Wohlfeil, Peter EickholzORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-502440 |
DOI: | https://doi.org/10.1007/s00784-018-2398-x |
ISSN: | 1436-3771 |
ISSN: | 1432-6981 |
Pubmed-Id: | https://pubmed.ncbi.nlm.nih.gov/29484548 |
Titel des übergeordneten Werkes (Englisch): | Clinical oral investigations |
Verlag: | Springer |
Verlagsort: | Berlin ; Heidelberg |
Dokumentart: | Wissenschaftlicher Artikel |
Sprache: | Englisch |
Jahr der Fertigstellung: | 2018 |
Datum der Erstveröffentlichung: | 27.02.2018 |
Veröffentlichende Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Datum der Freischaltung: | 13.05.2019 |
Freies Schlagwort / Tag: | Aggressive periodontitis; C-reactive protein; Chronic periodontiti; Interleukin-6; Leukocyte elastase; Lipopolysaccharide-binding protein |
Jahrgang: | 22 |
Ausgabe / Heft: | 9 |
Seitenzahl: | 11 |
Erste Seite: | 3079 |
Letzte Seite: | 3089 |
Bemerkung: | Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
HeBIS-PPN: | 453767427 |
Institute: | Medizin / Medizin |
DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Lizenz (Deutsch): | Creative Commons - Namensnennung 4.0 |