Risk for latent and active tuberculosis in Germany
- Purpose: Few individuals that are latently infected with M. tuberculosis latent tuberculosis infection(LTBI) progress to active disease. We investigated risk factors for LTBI and active pulmonary tuberculosis (PTB) in Germany. Methods: Healthy household contacts (HHCs), health care workers (HCWs) exposed to M. tuberculosis and PTB patients were recruited at 18 German centres. Interferon-γ release assay (IGRA) testing was performed. LTBI risk factors were evaluated by comparing IGRA-positive with IGRA-negative contacts. Risk factors for tuberculosis were evaluated by comparing PTB patients with HHCs. Results: From 2008–2014, 603 HHCs, 295 HCWs and 856 PTBs were recruited. LTBI was found in 34.5% of HHCs and in 38.9% of HCWs. In HCWs, care for coughing patients (p = 0.02) and longstanding nursing occupation (p = 0.04) were associated with LTBI. In HHCs, predictors for LTBI were a diseased partner (odds ratio 4.39), sexual contact to a diseased partner and substance dependency (all p < 0.001). PTB was associated with male sex, low body weight (p < 0.0001), alcoholism (15.0 vs 5.9%; p < 0.0001), glucocorticoid therapy (7.2 vs 2.0%; p = 0.004) and diabetes (7.8 vs. 4.0%; p = 0.04). No contact developed active tuberculosis within 2 years follow-up. Conclusions: Positive IGRA responses are frequent among exposed HHCs and HCWs in Germany and are poor predictors for the development of active tuberculosis.
Author: | Christian Herzmann, Giovanni SotgiuORCiD, Oswald Bellinger, Roland Diel, Silke Gerdes, Udo GötschGND, Helga Heykes‑Uden, Tom Schaberg, Christoph Lange |
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URN: | urn:nbn:de:hebis:30:3-455540 |
DOI: | https://doi.org/10.1007/s15010-016-0963-2 |
ISSN: | 1439-0973 |
ISSN: | 0300-8126 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/27866367 |
Parent Title (English): | Infection |
Publisher: | Urban & Vogel ; Springer |
Place of publication: | München ; Berlin ; Heidelberg |
Document Type: | Article |
Language: | English |
Year of Completion: | 2016 |
Date of first Publication: | 2016/11/19 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Contributing Corporation: | TB or not TB consortium |
Release Date: | 2018/01/30 |
Tag: | Diabetes mellitus; Health care workers; Household contacts; IGRA; Incidence; LTBI |
Volume: | 45 |
Issue: | 3 |
Page Number: | 8 |
First Page: | 283 |
Last Page: | 290 |
Note: | Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
HeBIS-PPN: | 427780969 |
Institutes: | Medizin / Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung 4.0 |