Prenatal and postnatal experiences associated with epigenetic changes in the adult mouse brain
- To analyze the influences of early-life history on the brain epigenome, the offspring of mouse dams kept in an enriched or standard environment were exposed postnatally to enriched, standard, or adverse conditions. The methylation patterns of 7 candidate genes (9 loci) involved in developmental programming of stress vulnerability/resilience and psychiatric disease were analyzed in 6 brain regions of adult male and female mice. Exposure to an enriched prenatal environment was associated with widespread epigenetic changes (all of small effect size), affecting 29 of 324 (9%) gene/region-specific methylation patterns. The effects of either adverse or enriched postnatal conditions were tested separately in the two prenatal cohorts. Significant changes were observed in 2 of 324 (0.6%) loci in offspring of dams in a standard environment and 6 of 324 (1.9%) loci in animals that were exposed prenatally to an enriched environment. Prenatal life experiences appear to have a bigger effect on the adult brain epigenome than postnatal experiences. Positive prenatal life experiences may increase epigenetic plasticity of the brain later in life. All observed between-group differences were sex-specific, consistent with largely different developmental trajectories of the male and female brain. Multiple changes of small effect size are consistent with a multifactorial model of developmental programming of adult behavior and disease susceptibility.
Author: | Felix MatternGND, Antonia PostGND, Franziska SolgerGND, Aet O'LearyORCiDGND, David A. SlatteryORCiDGND, Andreas ReifORCiDGND, Thomas HaafORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-775238 |
DOI: | https://doi.org/https://doi.org/10.1016/j.bbr.2018.10.037 |
ISSN: | 0166-4328 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/30385366 |
Parent Title (English): | Behavioural brain research |
Publisher: | Elsevier |
Place of publication: | Amsterdam |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2018/11/05 |
Date of first Publication: | 2018/10/29 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2024/03/18 |
Tag: | Brain DNA methylation; Developmental programming; Early (prenatal and postnatal) life experiences; Environmental enrichment; Maternal separation; Stress vulnerability/resilience genes |
Volume: | 359.2019 |
Page Number: | 6 |
First Page: | 143 |
Last Page: | 148 |
HeBIS-PPN: | 517755556 |
Institutes: | Medizin |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit | |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |