- Introduction: Despite the poor prognosis for adults with relapsed or refractory (RR) Philadelphia chromosome (Ph)-negative B cell precursor acute lymphoblastic leukemia (ALL), long-term survival is possible and may even be considered as "cure".
Methods: This study used a Delphi panel approach to explore concepts of cure in RR Ph-negative B cell precursor ALL. Ten European experts in this disease area participated in a survey and face-to-face panel meeting.
Results: Findings showed that clinicians conceptualize "cure" as a combination of three broad treatment outcomes that vary depending on the treatment stage: complete remission early in treatment (1–3 months) indicates initial success; eradicating cancer cells (minimal residual disease negative status) consolidates the early clinical response; leukemia-free survival is required in the long term.
Conclusions: Although such terminology remains contested, clinicians would begin considering "cure" as early as 2 years provided the patient is off therapy, with most considering the term applicable by the third year.
Funding: Amgen Inc.
MetadatenAuthor: | Renato Bassan, Dieter HoelzerGND, Xavier Thomas, Pau MontesinosORCiD, Jiri Pavlu, Jan McKendrick, Amber Kudlac, Arie Barlev, Beth Barber, Ze Cong |
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URN: | urn:nbn:de:hebis:30:3-534387 |
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DOI: | https://doi.org/10.1007/s12325-019-00910-z |
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ISSN: | 1865-8652 |
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Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/30847777 |
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Parent Title (English): | Advances in therapy |
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Publisher: | Springer Healthcare Communications |
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Place of publication: | Tarporley |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2019/03/07 |
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Date of first Publication: | 2019/03/07 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2020/06/15 |
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Tag: | B cell precursor acute lymphoblastic leukemia; Cure; Oncology; Outcomes; Refractory ALL; Relapsed ALL; Survival |
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Volume: | 36 |
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Issue: | 4 |
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Page Number: | 10 |
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First Page: | 870 |
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Last Page: | 879 |
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Note: | Open Access: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
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HeBIS-PPN: | 466836376 |
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Institutes: | Medizin / Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (English): | Creative Commons - Namensnennung-Nicht kommerziell 4.0 |
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