Ubiquinone binding and reduction by complex I : open questions and mechanistic implications
- NADH: ubiquinone oxidoreductase (complex I) is the first enzyme complex of the respiratory chain. Complex I is a redox-driven proton pump that contributes to the proton motive force that drives ATP synthase. The structure of complex I has been analyzed by x-ray crystallography and electron cryo-microscopy and is now well-described. The ubiquinone (Q) reduction site of complex I is buried in the peripheral arm and a tunnel-like structure is thought to provide access for the hydrophobic substrate from the membrane. Several intermediate binding positions for Q in the tunnel were identified in molecular simulations. Structural data showed the binding of native Q molecules and short chain analogs and inhibitors in the access pathway and in the Q reduction site, respectively. We here review the current knowledge on the interaction of complex I with Q and discuss recent hypothetical models for the coupling mechanism.
Author: | Etienne Galemou YogaGND, Jonathan Schiller, Volker ZickermannORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-612487 |
DOI: | https://doi.org/10.3389/fchem.2021.672851 |
ISSN: | 2296-2646 |
Parent Title (English): | Frontiers in Chemistry |
Publisher: | Frontiers Media |
Place of publication: | Lausanne |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2021/04/30 |
Date of first Publication: | 2021/04/30 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2021/06/30 |
Tag: | NADH dehydrogenase; electron transfer; inhibitor; oxidative phosphorylation; proton pumping; respiratory chain; semiquinone |
Volume: | 9 |
Issue: | art. 672851 |
Page Number: | 9 |
First Page: | 1 |
Last Page: | 9 |
HeBIS-PPN: | 484658832 |
Institutes: | Medizin |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit | |
Sammlungen: | Universitätspublikationen |
Open-Access-Publikationsfonds: | Medizin |
Licence (German): | Creative Commons - Namensnennung 4.0 |