Raphael Wilhelm, Timon Sebastian Eckes, Gergely Imre, Stefan Kippenberger, Markus Meissner, Dominique Jeanette Thomas, Sandra Trautmann, Jean-Philippe Merlio, Edith Chevret, Roland Kaufmann, Josef Pfeilschifter, Alexander Koch, Manuel Alexander Jäger
- Cutaneous T cell lymphomas (CTCLs) represent a heterogeneous group of T cell lymphomas that primarily affect the skin. The most frequent forms of CTCL are mycosis fungoides and Sézary syndrome. Both are characterized by frequent recurrence, developing chronic conditions and high mortality with a lack of a curative treatment. In this study, we evaluated the effect of short-chain, cell-permeable C6 Ceramide (C6Cer) on CTCL cell lines and keratinocytes. C6Cer significantly reduced cell viability of CTCL cell lines and induced cell death via apoptosis and necrosis. In contrast, primary human keratinocytes and HaCaT keratinocytes were less affected by C6Cer. Both keratinocyte cell lines showed higher expressions of ceramide catabolizing enzymes and HaCaT keratinocytes were able to metabolize C6Cer faster and more efficiently than CTCL cell lines, which might explain the observed protective effects. Along with other existing skin-directed therapies, C6Cer could be a novel well-tolerated drug for the topical treatment of CTCL.
MetadatenVerfasserangaben: | Raphael WilhelmORCiDGND, Timon Sebastian EckesORCiDGND, Gergely ImreORCiD, Stefan KippenbergerORCiDGND, Markus MeissnerORCiDGND, Dominique Jeanette ThomasORCiDGND, Sandra TrautmannGND, Jean-Philippe MerlioORCiD, Edith ChevretORCiD, Roland KaufmannGND, Josef PfeilschifterGND, Alexander Koch, Manuel Alexander JägerGND |
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URN: | urn:nbn:de:hebis:30:3-624793 |
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DOI: | https://doi.org/10.3390/cancers13020270 |
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ISSN: | 2072-6694 |
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Titel des übergeordneten Werkes (Englisch): | Cancers |
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Verlag: | MDPI |
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Verlagsort: | Basel |
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Dokumentart: | Wissenschaftlicher Artikel |
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Sprache: | Englisch |
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Datum der Veröffentlichung (online): | 13.01.2021 |
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Datum der Erstveröffentlichung: | 13.01.2021 |
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Veröffentlichende Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Datum der Freischaltung: | 09.09.2021 |
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Freies Schlagwort / Tag: | C6 ceramide; cutaneous T cell lymphoma; short-chain ceramide; skin |
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Jahrgang: | 13 |
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Ausgabe / Heft: | 2, art. 270 |
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Seitenzahl: | 14 |
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Erste Seite: | 1 |
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Letzte Seite: | 14 |
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Bemerkung: | This work was supported by the German Research Foundation (SFB 1039). |
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Institute: | Medizin / Medizin |
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DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Lizenz (Deutsch): | Creative Commons - Namensnennung 4.0 |
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