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Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis

  • Liver cirrhosis represents the common end-stage of chronic liver diseases regardless of its etiology. Patients with compensated disease are mostly asymptomatic, however, progression to a decompensated disease stage is common. The available stratification strategies are often unsuitable to identify patients with a higher risk for disease progression and a limited prognosis. SIBLINGs, soluble glycophosphoproteins, are secreted into the blood by immune-cells. While osteopontin, the most prominent member of the SIBLINGs family, has been repeatedly associated with liver cirrhosis, data on the diagnostic and/or prognostic value of bone sialoprotein (BSP) are scarce and partly inconclusive. In this study, we analyzed the diagnostic and prognostic potential of circulating BSP in comparison to other standard laboratory markers in a large cohort of patients with liver cirrhosis receiving transjugular intrahepatic portosystemic shunt (TIPS). Serum levels of BSP were similar in patients with different disease stages and were not indicative for prognosis. Interestingly, BSP serum levels did correlate inversely with portal pressure, as well as its surrogates such as platelet count, the portal vein cross-sectional area and correlated positively with the portal venous velocity. In summary, our data highlight that BSP might represent a previously unrecognized marker for portal hypertension in patients with liver cirrhosis.
Author:Fabian Benz, Andreas Bogen, Michael PraktiknjoORCiDGND, Christian Jansen, Carsten Meyer, Alexander Wree, Münevver DemirORCiDGND, Sven Loosen, Mihael Vucur, Robert SchierwagenORCiDGND, Frank Tacke, Jonel TrebickaORCiDGND, Christoph Roderburg
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/32302330
Parent Title (English):PLoS one
Place of publication:Lawrence, Kan.
Contributor(s):Pavel Strnad
Document Type:Article
Year of Completion:2020
Date of first Publication:2020/04/17
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/04/20
Tag:Ascites; Biomarkers; Cirrhosis; Liver diseases; Patients; Portal hypertension; Portal veins; Veins
Issue:(4): e0231701
Page Number:13
First Page:1
Last Page:13
Copyright: © 2020 Benz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0