Ute Lewitzka, Burkhard Jabs, Matthias Fülle, Vjera Holthoff, Georg Juckel, Idun Uhl, Sarah Kittel-Schneider, Andreas Reif, Christine Reif-Leonhard, Oliver Gruber, B. Djawid, S. Goodday, Robert Haussmann, Andrea Pfennig, Philipp Ritter, Jörn Conell, Emanuel Severus, Michael Bauer
- Background: Lithium has proven suicide preventing effects in the long-term treatment of patients with affective disorders. Clinical evidence from case reports indicate that this effect may occur early on at the beginning of lithium treatment. The impact of lithium treatment on acute suicidal thoughts and/or behavior has not been systematically studied in a controlled trial. The primary objective of this confirmatory study is to determine the association between lithium therapy and acute suicidal ideation and/or suicidal behavior in inpatients with a major depressive episode (MDE, unipolar and bipolar disorder according to DSM IV criteria). The specific aim is to test the hypothesis that lithium plus treatment as usual (TAU), compared to placebo plus TAU, results in a significantly greater decrease in suicidal ideation and/or behavior over 5 weeks in inpatients with MDE.
Methods/Design: We initiated a randomized, placebo-controlled multicenter trial. Patients with the diagnosis of a moderate to severe depressive episode and suicidal thoughts and/or suicidal behavior measured with the Sheehan-Suicidality-Tracking Scale (S-STS) will be randomly allocated to add lithium or placebo to their treatment as usual. Change in the clinician administered S-STS from the initial to the final visit will be the primary outcome.
Discussion: There is an urgent need to identify treatments that will acutely decrease suicidal ideation and/or suicidal behavior. The results of this study will demonstrate whether lithium reduces suicidal ideation and behavior within the first 5 weeks of treatment.
MetadatenAuthor: | Ute Lewitzka, Burkhard Jabs, Matthias Fülle, Vjera Holthoff, Georg Juckel, Idun Uhl, Sarah Kittel-SchneiderORCiDGND, Andreas ReifORCiDGND, Christine Reif-LeonhardORCiD, Oliver Gruber, B. Djawid, S. Goodday, Robert Haussmann, Andrea PfennigORCiDGND, Philipp Ritter, Jörn Conell, Emanuel SeverusORCiDGND, Michael BauerORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-380130 |
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DOI: | https://doi.org/10.1186/s12888-015-0499-5 |
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ISSN: | 1471-244X |
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Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/25986590 |
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Parent Title (English): | BMC psychiatry |
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Publisher: | BioMed Central |
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Place of publication: | London |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2015/05/19 |
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Date of first Publication: | 2015/05/19 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2015/09/06 |
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Tag: | Affective disorders; Lithium; Randomized controlled trial; Suicidal behavior; Suicidal thoughts |
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Volume: | 15 |
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Issue: | 117 |
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Page Number: | 7 |
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First Page: | 1 |
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Last Page: | 7 |
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Note: | © 2015 Lewitzka et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
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HeBIS-PPN: | 370944461 |
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Institutes: | Medizin / Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung 4.0 |
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