Unleashing the power of NK cells in anticancer immunotherapy

Due to their physiological role in removing damaged cells, natural killer (NK) cells represent ideal candidates for cellular immunotherapy in the treatment of cancer. Thereby, the cytotoxicity of NK cells is regulated by signals on both, the NK cells as well as the targeted tumor cells, and the interplay and balance of these signals determine the killing capacity of NK cells. One promising avenue in cancer treatment is therefore the combination of NK cell therapy with agents that either help to increase the killing capacity of NK cells or sensitize tumor cells to an NK cell-mediated attack. In this mini-review, we present different strategies that can be explored to unleash the potential of NK cell immunotherapy. In particular, we summarize how modulation of apoptosis signaling within tumor cells can be exploited to sensitize tumor cells to NK cell-mediated cytotoxicity.

Metadaten
Verfasserangaben:	Meike Vogler ORCiD GND, Senthan Shanmugalingam, Vinzenz Särchen ORCiD GND, Lisa Marie Reindl ORCiD, Victoria Grèze, Leon Buchinger, Michael Kühn, Evelyn Ullrich ORCiD GND
URN:	urn:nbn:de:hebis:30:3-626191
DOI:	https://doi.org/10.1007/s00109-021-02120-z
ISSN:	1432-1440
Titel des übergeordneten Werkes (Englisch):	Journal of molecular medicine
Verlag:	Springer
Verlagsort:	Berlin; Heidelberg; New York, NY
Dokumentart:	Wissenschaftlicher Artikel
Sprache:	Englisch
Datum der Veröffentlichung (online):	09.08.2021
Datum der Erstveröffentlichung:	09.08.2021
Veröffentlichende Institution:	Universitätsbibliothek Johann Christian Senckenberg
Datum der Freischaltung:	14.10.2021
Freies Schlagwort / Tag:	Apoptosis; Cancer; Immunotherapy; Natural killer cells
Jahrgang:	2021
Ausgabe / Heft:	online version before inclusion in an issue
Seitenzahl:	13
Bemerkung:	Open Access funding enabled and organized by Projekt DEAL. This work has been supported by the Deutsche Forschungsge- meinschaft DFG (CRC 1292 / IRTG).
HeBIS-PPN:	489232299
Institute:	Medizin
DDC-Klassifikation:	6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:	Universitätspublikationen
Lizenz (Deutsch):	Creative Commons - Namensnennung 4.0

Open Access