A case of Lymphangioleiomyomatosis (LAM) of the lung in a patient with a history of breast cancer
- Background: Lymphangioleiomyomatosis (LAM) is a rare progressive cystic and nodular disease of the lung characterized by smooth muscle cell proliferation. LAM predominantly affects young premenopausal women. This report is of a case of LAM presenting in a 47-year-old woman with a past history of breast cancer and discusses the possibility of an association between the two conditions. Case report: A 47-year-old woman presented as an emergency with an exacerbation of a four-month history of shortness of breath and dry cough. Her symptoms began following the start of anti-hormonal treatment with letrozole and goserelin acetate for a moderately differentiated (grade 2) invasive ductal carcinoma of the breast (pT2, pN0, M0) which was positive for expression of estrogen receptor (ER+), progesterone receptor (PR+), and human epidermal growth factor receptor 2 (HER2+). Until the previous four months, she had breast-conserving treatment with radiotherapy and tamoxifen therapy. Following hospital admission, she was found to be in type I respiratory failure. Chest X-ray, lung computed tomography (CT), and positron-emission tomography (PET) showed diffuse cystic and nodular lung lesions, consistent with a diagnosis of LAM, and antihormonal therapy was discontinued. She developed pericarditis that was treated with the anti-inflammatory agent, colchicine. Treatment with letrozole and sirolimus improved her respiratory symptoms. Conclusions: A rare case of LAM is presented in a woman with a recent history of breast cancer. Because both tumors were hormone-dependent, this may support common underlying gene associations and signaling pathways between the two types of tumor.
Author: | Sinem Koç-GünelORCiD, Nesrin TekeliGND, Christina SmacznyGND, Thomas J. VoglORCiDGND, Gernot Gerhard Ulrich RohdeORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-493017 |
DOI: | https://doi.org/10.12659/AJCR.914355 |
ISSN: | 1941-5923 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/30905927 |
Parent Title (English): | The American journal of case reports |
Publisher: | International Scientific Literature |
Place of publication: | New York, NY |
Document Type: | Article |
Language: | English |
Year of Completion: | 2019 |
Date of first Publication: | 2019/03/25 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2019/04/09 |
Tag: | Aromatase Inhibitors; Carcinoma, Ductal, Breast; Colchicum; Estrogen Receptor Modulators; Goserelin; Lymphangioleiomyomatosis |
Volume: | 20 |
Page Number: | 4 |
First Page: | 390 |
Last Page: | 393 |
Note: | This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially. |
HeBIS-PPN: | 450810119 |
Institutes: | Medizin / Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Open-Access-Publikationsfonds: | Medizin |
Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |