Kerstin E. M. Rhiem, Bernd Auber, Susanne Briest, Nicola Dikow, Nina Ditsch, Neda Dragicevic, Sabine Grill, Eric Thomas Hahnen, Judit Horváth, Bernadette Jäger, Karin Kast, Marion Kiechle, Elena Leinert, Susanne Morlot, Michael Püsken, Dieter Schäfer, Sarah Schott, Christopher Maximilian Schroeder, Ulrike Siebers-Renelt, Christine Solbach, Nana-Maureen Weber-Lassalle, Isabell Witzel, Christine Zeder-Göß, Rita Schmutzler
- Background: The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has established a multigene panel (TruRisk®) for the analysis of risk genes for familial breast and ovarian cancer. Summary: An interdisciplinary team of experts from the GC-HBOC has evaluated the available data on risk modification in the presence of pathogenic mutations in these genes based on a structured literature search and through a formal consensus process. Key Messages: The goal of this work is to better assess individual disease risk and, on this basis, to derive clinical recommendations for patient counseling and care at the centers of the GC-HBOC from the initial consultation prior to genetic testing to the use of individual risk-adapted preventive/therapeutic measures.
Metadaten| Author: | Kerstin E. M. RhiemGND, Bernd AuberORCiDGND, Susanne Briest, Nicola DikowORCiDGND, Nina DitschORCiDGND, Neda Dragicevic, Sabine GrillGND, Eric Thomas HahnenORCiDGND, Judit HorváthGND, Bernadette JägerGND, Karin KastORCiDGND, Marion KiechleORCiDGND, Elena Leinert, Susanne Morlot, Michael PüskenGND, Dieter Schäfer, Sarah SchottORCiDGND, Christopher Maximilian SchroederGND, Ulrike Siebers-ReneltORCiD, Christine SolbachORCiDGND, Nana-Maureen Weber-LassalleGND, Isabell WitzelORCiDGND, Christine Zeder-Göß, Rita SchmutzlerGND |
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| URN: | urn:nbn:de:hebis:30:3-629304 |
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| DOI: | https://doi.org/10.1159/000516376 |
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| ISSN: | 1661-3805 |
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| Parent Title (English): | Breast care |
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| Publisher: | Karger |
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| Place of publication: | Basel |
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| Document Type: | Article |
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| Language: | English |
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| Date of Publication (online): | 2021/07/19 |
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| Date of first Publication: | 2021/07/19 |
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| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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| Release Date: | 2023/06/28 |
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| Tag: | BRCA1; BRCA2; Consensus; Hereditary breast cancer; Hereditary ovarian cancer; Panel testing |
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| Volume: | 17 |
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| Issue: | 2 |
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| Page Number: | 9 |
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| First Page: | 199 |
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| Last Page: | 207 |
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| HeBIS-PPN: | 510030459 |
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| Institutes: | Medizin / Medizin |
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| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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| Sammlungen: | Universitätspublikationen |
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| Licence (German): |  Creative Commons - CC BY-NC - Namensnennung - Nicht kommerziell 4.0 International |
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