Christoph Würnschimmel, Mike Wenzel, Francesco Chierigo, Rocco Simone Flammia, Zhe Tian, Fred Saad, Alberto Briganti, Shahrokh F. Shariat, Nazareno Suardi, Carlo Terrone, Michele Gallucci, Felix Chun, Derya Tilki, Markus Graefen, Pierre I. Karakiewicz
- Objectives: To test the effect of race/ethnicity on cancer-specific mortality after radical prostatectomy or external beam radiotherapy in localized prostate cancer patients. Methods: In the Surveillance, Epidemiology and End Results database 2004–2016, we identified intermediate-risk and high-risk white (n = 151 632), Asian (n = 11 189), Hispanic/Latino (n = 20 077) and African American (n = 32 550) localized prostate cancer patients, treated with external beam radiotherapy or radical prostatectomy. Race/ethnicity-stratified cancer-specific mortality analyses relied on competing risks regression, after propensity score matching for patient and cancer characteristics. Results: Compared with white patients, Asian intermediate- and high-risk external beam radiotherapy patients showed lower cancer-specific mortality (hazard ratio 0.58 and 0.70, respectively, both P ≤ 0.02). Additionally, Asian high-risk radical prostatectomy patients also showed lower cancer-specific mortality than white patients (hazard ratio 0.72, P = 0.04), but not Asian intermediate-risk radical prostatectomy patients (P = 0.08). Conversely, compared with white patients, African American intermediate-risk radical prostatectomy patients showed higher cancer-specific mortality (hazard ratio 1.36, P = 0.01), but not African American high-risk radical prostatectomy or intermediate- and high-risk external beam radiotherapy patients (all P ≥ 0.2). Finally, compared with white people, no cancer-specific mortality differences were recorded for Hispanic/Latino patients after external beam radiotherapy or radical prostatectomy, in both risk levels (P ≥ 0.2). Conclusions: Relative to white patients, an important cancer-specific mortality advantage applies to intermediate-risk and high-risk Asian prostate cancer patients treated with external beam radiotherapy, and to high-risk Asian patients treated with radical prostatectomy. These observations should be considered in pretreatment risk stratification and decision-making.
MetadatenAuthor: | Christoph WürnschimmelORCiDGND, Mike WenzelORCiDGND, Francesco ChierigoORCiD, Rocco Simone FlammiaORCiD, Zhe Tian, Fred SaadORCiDGND, Alberto BrigantiORCiD, Shahrokh F. ShariatORCiDGND, Nazareno Suardi, Carlo TerroneORCiDGND, Michele GallucciORCiD, Felix ChunORCiDGND, Derya TilkiORCiDGND, Markus GraefenORCiDGND, Pierre I. Karakiewicz |
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URN: | urn:nbn:de:hebis:30:3-645554 |
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DOI: | https://doi.org/10.1111/iju.14701 |
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ISSN: | 1442-2042 |
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Parent Title (English): | International journal of urology |
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Publisher: | Wiley-Blackwell |
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Place of publication: | Oxford [u.a.] |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2021/09/22 |
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Date of first Publication: | 2021/09/22 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2022/04/11 |
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Tag: | Epidemiology and End Results; Surveillance; cancer-specific mortality; external beam radiotherapy; localized prostate cancer; other-cause mortality; radical prostatectomy |
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Volume: | 2021 |
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Issue: | online version before inclusion in an issue |
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Page Number: | 8 |
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Note: | Open Access funding enabled and organized by Projekt DEAL. |
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Note: | Early View: Online Version before inclusion in an issue. |
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Note: | Version of Record: http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hebis:30:3-627718 |
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HeBIS-PPN: | 494883464 |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (English): | Creative Commons - Namensnennung-Nicht kommerziell 4.0 |
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