Increased fat taste preference in progranulin-deficient mice
- Progranulin deficiency in mice is associated with deregulations of the scavenger receptor signaling of CD36/SCARB3 in immune disease models, and CD36 is a dominant receptor in taste bud cells in the tongue and contributes to the sensation of dietary fats. Progranulin-deficient mice (Grn−/−) are moderately overweight during middle age. We therefore asked if there was a connection between progranulin/CD36 in the tongue and fat taste preferences. By using unbiased behavioral analyses in IntelliCages and Phenomaster cages we showed that progranulin-deficient mice (Grn−/−) developed a strong preference of fat taste in the form of 2% milk over 0.3% milk, and for diluted MCTs versus tap water. The fat preference in the 7d-IntelliCage observation period caused an increase of 10% in the body weight of Grn−/− mice, which did not occur in the wildtype controls. CD36 expression in taste buds was reduced in Grn−/− mice at RNA and histology levels. There were no differences in the plasma or tongue lipids of various classes including sphingolipids, ceramides and endocannabinoids. The data suggest that progranulin deficiency leads to a lower expression of CD36 in the tongue resulting in a stronger urge for fatty taste and fatty nutrition.
Author: | Lana Schumann, Annett Wilken-Schmitz, Sandra TrautmannGND, Alexandra Vogel, Yannick Schreiber, Lisa Katharina HahnefeldORCiDGND, Robert GurkeORCiDGND, Gerd GeisslingerORCiDGND, Irmgard TegederORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-692765 |
DOI: | https://doi.org/10.3390/nu13114125 |
ISSN: | 2072-6643 |
Parent Title (English): | Nutrients |
Publisher: | MDPI |
Place of publication: | Basel |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2021/11/17 |
Date of first Publication: | 2021/11/17 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2024/02/12 |
Tag: | CD36; IntelliCage; lipids; progranulin; taste buds |
Volume: | 13 |
Issue: | 11, art. 4125 |
Article Number: | 4125 |
Page Number: | 16 |
First Page: | 1 |
Last Page: | 16 |
Note: | The study was supported by the Deutsche Forschungsgemeinschaft (CRC1039 A03 to I.T. and Z01 to G.G., and CRC1080, C02 to I.T.) and by the Fraunhofer Cluster of Excellence for Immune-Mediated diseases, CIMD) (to G.G.). |
HeBIS-PPN: | 521024269 |
Institutes: | Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | ![]() |