Inga Harks, Raphael Koch, Peter Eickholz, Thomas Hoffmann, Ti-Sun Kim, Thomas Kocher, Jörg Meyle, Doğan Kaner, Ulrich Schlagenhauf, Stephan Doering, Birte Holtfreter, Martina Gravemeier, Dag Harmsen, Benjamin Ehmke
- Aim: We investigated the long-term impact of adjunctive systemic antibiotics on periodontal disease progression. Periodontal therapy is frequently supplemented by systemic antibiotics, although its impact on the course of disease is still unclear.
Material & Methods: This prospective, randomized, double-blind, placebo-controlled multi-centre trial comprising patients suffering from moderate to severe periodontitis evaluated the impact of rational adjunctive use of systemic amoxicillin 500 mg plus metronidazole 400 mg (3x/day, 7 days) on attachment loss. The primary outcome was the percentage of sites showing further attachment loss (PSAL) ≥1.3 mm after the 27.5 months observation period. Standardized therapy comprised mechanical debridement in conjunction with antibiotics or placebo administration, and maintenance therapy at 3 months intervals.
Results: From 506 participating patients, 406 were included in the intention to treat analysis. Median PSAL observed in placebo group was 7.8% compared to 5.3% in antibiotics group (Q25 4.7%/Q75 14.1%; Q25 3.1%/Q75 9.9%; p < 0.001 respectively).
Conclusions: Both treatments were effective in preventing disease progression. Compared to placebo, the prescription of empiric adjunctive systemic antibiotics showed a small absolute, although statistically significant, additional reduction in further attachment loss. Therapists should consider the patient's overall risk for periodontal disease when deciding for or against adjunctive antibiotics prescription.
MetadatenAuthor: | Inga Harks, Raphael Koch, Peter EickholzORCiDGND, Thomas Hoffmann, Ti-Sun Kim, Thomas Kocher, Jörg Meyle, Doğan Kaner, Ulrich Schlagenhauf, Stephan Doering, Birte HoltfreterORCiDGND, Martina Gravemeier, Dag Harmsen, Benjamin Ehmke |
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URN: | urn:nbn:de:hebis:30:3-428010 |
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DOI: | https://doi.org/10.1111/jcpe.12441 |
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ISSN: | 1600-051X |
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ISSN: | 0303-6979 |
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Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/26250060 |
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Parent Title (English): | Journal of clinical periodontology |
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Publisher: | Wiley-Blackwell |
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Place of publication: | Oxford [u. a.] |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2017/05/04 |
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Year of first Publication: | 2015 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2017/05/04 |
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Tag: | amoxicillin/metronidazole; attachment loss; clinical relevance; debridement; outcome parameter; periodontitis; randomised controlled trial; systemic antibiotics |
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Volume: | 42 |
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Issue: | 9 |
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Page Number: | 11 |
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First Page: | 853 |
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Last Page: | 842 |
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Note: | © 2015 The Authors. Journal of Clinical Periodontology Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
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HeBIS-PPN: | 423603973 |
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Institutes: | Medizin / Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |
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